Nanometer medicament microspheres
A nano-drug and microsphere technology, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, bulk delivery, etc., can solve incomplete release and burst release, low encapsulation rate, local microencapsulation and inflammation, etc. Problems, to achieve the effect of regular particles without adhesion, reduce drug burst release, and smooth and round particle surface
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Embodiment 1
[0059] Example 1 Preparation of microspheres loaded with small molecule drug doxorubicin (1)
[0060] Doxorubicin has antibacterial and anticancer effects. The preparation of polylactic-glycolic acid (PLGA) microspheres loaded with doxorubicin nano-medicine includes the following steps:
[0061] (1) Dissolve 20 mg of doxorubicin in 0.5 ml of water, then stir with 20 mg of porous silica nanoparticles for 24 hours, so that the doxorubicin is fully adsorbed in the porous silica nanoparticles, and centrifuge to remove the supernatant solution, fully washed 3 times, and then freeze-dried to form adriamycin nano-medicine;
[0062] (2) Mix the above-mentioned doxorubicin nanomedicine with 20% (w / w) PLGA in dichloromethane solution at a weight ratio of 1:9 and sonicate for 5 minutes to form a uniform suspension, that is, doxorubicin in oil Suspension of element nano drug (N / O);
[0063] (3) Add the doxorubicin in oil nano drug (N / O) suspension obtained in step (2) dropwise into 50...
Embodiment 2
[0070] Example 2 Preparation of microspheres loaded with small molecule drug doxorubicin (2)
[0071] The preparation of polycaprolactone (PCL) microspheres loaded with doxorubicin nanomedicine comprises the following steps:
[0072] (1) Dissolve 20 mg of doxorubicin in 0.5 ml of water, then stir with 20 mg of porous titanium dioxide nanoparticles for 24 hours, so that the doxorubicin is fully adsorbed in the porous titanium dioxide nanoparticles, centrifuge to remove the supernatant, and then fully Washed 3 times, then freeze-dried to form doxorubicin nanomedicine;
[0073] (2) Mix the above-mentioned doxorubicin nanomedicine with the ethyl acetate solution of PCL with a concentration of 0.5% (w / w) according to the weight ratio of 1:10 and ultrasonicate for 5 minutes to form a uniform suspension, that is, doxorubicin in oil Suspension of element nano drug (N / O);
[0074] (3) Add the doxorubicin in oil nano-drug (N / O) suspension obtained in step (2) dropwise to 50 ml conta...
Embodiment 3
[0079] Example 3 Preparation of Microspheres Loaded with Macromolecular Drug Growth Hormone (1)
[0080] Growth hormone has the effect of cell adhesion and promoting growth or delaying aging. The preparation of polylactic-glycolic acid (PLGA) microspheres loaded with growth hormone nano-medicine includes the following steps:
[0081] (1) Dissolve 10 mg of growth hormone and 10 mg of dextran into 0.4 ml of water to form a drug aqueous solution, and then transfer the above solution to 3.2 ml of 5% (w / w) polyethylene glycol (PEG8000) aqueous solution Mix well, then pre-freeze in a -80°C refrigerator for 12 hours, then freeze-dry with a lyophilizer, then dissolve PEG with dichloromethane and centrifuge to remove PEG to obtain growth hormone nanomedicine;
[0082] (2) Mix the above-mentioned somatotropin nanomedicine with 30% (w / w) PLGA acetonitrile solution at a weight ratio of 1:8, and ultrasonicate for 1 minute to form a uniform suspension, that is, somatotropin in oil drug (...
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