Adriamycin-containing nanometer medicament microspheres and preparation method thereof

A nano-drug, doxorubicin technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problem of low encapsulation rate, incomplete release and burst release, local microencapsulation and inflammation To achieve the effect of enhancing cell adhesion, reducing inflammation and microencapsulation, regular particles without adhesion
CN102885785BInactive Publication Date: 2014-01-15JINSHAN HOSPITAL FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINSHAN HOSPITAL FUDAN UNIV
Publication Date
2014-01-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses adriamycin-containing nanometer medicament microspheres, which comprises adriamycin, nanoparticles, a polymer and medicinal auxiliary materials. The invention further provides a preparation method of the microspheres. The method comprises the following steps of: preparing adriamycin and the medicinal auxiliary materials into a nanometer medicament; adding the nanometer medicament into a polymer-containing organic solvent mixed solution for emulsifying; adding a nanometer medicament-in-oil mixed suspension into a water mixed suspension containing nanoparticles or containing nanoparticles and a surfactant for emulsifying to obtain an oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil compound emulsion; and curing the obtained compound emulsion, and centrifugally collecting microspheres. An appropriate polymer material and an appropriate microsphere preparation method are selected, the prepared microspheres have high envelop rate, and a layer of self-assembled nanoparticles on the surfaces of the microspheres has the effects of improving cell adhesion and reducing inflammation and microencapsulation caused by local excessive acid and hydrophobic materials. The method disclosed by the invention can be applied to preparation of other medicament slow release or controlled release microspheres.
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Description

technical field

[0001] The invention relates to nano-medicine microspheres, in particular to nano-medicine microspheres containing doxorubicin and a preparation method thereof, belonging to the technical field of pharmacy. Background technique

[0002] Doxorubicin is a broad-spectrum anticancer drug that hinders the synthesis of nucleic acids in cancer cells, and has antibacterial and anticancer effects. It has strong anti-cancer activity, but it has high toxicity and side effects in clinical application, and it will cause serious damage to normal tissues and organs. In order to improve its drug effect and reduce its toxic and side effects, people explore its ultrafine particle controlled release and targeting system, and load it on a series of drug carriers such as liposomes, nanoparticles, polymer conjugates and polymer micelles. system.

[0003] Chinese patent document CN200510105254.0, published on April 4, 2007, discloses microspheres containing doxorubicin, its use a...

Claims

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