Compound zinc-iron calcium granule and preparation method thereof

A zinc-iron-calcium compound technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of large differences in vitamin B2 content and unstable effects, and achieve the effect of avoiding discoloration

Active Publication Date: 2015-11-11
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of vitamin B2 in the compound zinc iron calcium granule product varies greatly, making the effect unstable

Method used

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  • Compound zinc-iron calcium granule and preparation method thereof
  • Compound zinc-iron calcium granule and preparation method thereof
  • Compound zinc-iron calcium granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]

[0030] (1) Adhesive: Dissolve vitamin B2 in ethanol to prepare vitamin B2 ethanol solution, and prepare 2% polyvinylpyrrolidone aqueous solution, mix vitamin B2 ethanol solution and 2% polyvinylpyrrolidone aqueous solution evenly, and put it in a spray tank for later use.

[0031] (2) Mixing: Weigh the raw and auxiliary materials of the prescription amount respectively, first pour zinc gluconate and ferrous gluconate into the mixer and mix, and finally add calcium gluconate, sucrose and essence and mix evenly, and set aside.

[0032] (3) Granulation: Open the pot cover, put the raw materials in step (2) into the feeder of the one-step granulator, turn on the fan and heat it, so that the material is evenly heated to 50°C in a fluidized state, turn on the spray button, and spray Adhesive, the liquid inlet speed is 27ml / min, the atomization pressure is 0.12MPa, the air inlet temperature is then controlled at 80°C, and the material temperature is then controlled at 60°C...

Embodiment 2

[0034]

[0035] (1) Adhesive: Dissolve vitamin B2 in ethanol to prepare vitamin B2 ethanol solution, and prepare 2% polyvinylpyrrolidone aqueous solution, mix vitamin B2 ethanol solution and 2% polyvinylpyrrolidone aqueous solution evenly, and put it in a spray tank for later use.

[0036] (2) Mixing: Weigh the raw and auxiliary materials of the prescription amount respectively, first pour zinc gluconate and ferrous gluconate into the mixer and mix, and finally add calcium gluconate, sucrose and essence and mix evenly, and set aside.

[0037] (3) Granulation: Open the pot cover, put the raw materials in step (2) into the feeder of the one-step granulator, turn on the fan and heat it, so that the material is evenly heated to 50°C in a fluidized state, turn on the spray button, and spray Adhesive, the liquid inlet speed is 30ml min, the atomization pressure is 0.12MPa, the air inlet temperature is then controlled at 85°C, and the material temperature is then controlled at 55°C...

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Abstract

The invention discloses compound zinc-iron calcium granule and a preparation method thereof. The compound zinc-iron calcium granule is prepared from the following raw materials in parts by weight: 20-50 parts of zinc gluconate, 1-5 parts of vitamin B2, 50-150 parts of ferrous gluconate, 300-600 parts of calcium gluconate, 1000-2000 parts of a filler, 3-6 parts of an adhesive, 3-6 parts of essence and 3-15 parts of ethyl alcohol. According to the preparation method, the vitamin B2 in the form of a vitamin B2 ethanol solution is mixed with the adhesive for pelletizing, so that the differential item of vitamin B2 is up to standard, and the quality of a finished product is ensured. Then one-step pelletizing is adopted to finish multi-step working procedures including mixing, pelletizing, drying and the like on one equipment, so that color change caused by solvent residue during the wet granulation process and pharmaceutical ingredient loss caused by heating during the drying process are avoided, and the problems that escaped dust is serious and cross contamination is easily caused in case of tabletting during the dry granulation process are also avoided.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a compound zinc-iron-calcium granule and a preparation method thereof. Background technique [0002] With the rapid development of science and food industry, fortified foods are also increasing. Zinc, iron, and calcium are essential nutrients for the human body. They participate in various enzyme reactions in the body and play an important role in maintaining normal body functions and production and development. effect. [0003] Compound zinc iron calcium granule is a compound preparation made of zinc gluconate, ferrous gluconate, calcium gluconate and vitamin B2. It is used for various diseases caused by zinc, iron and calcium deficiency. In the WS-10001-(HD-0448)-2002 standard, the compound zinc-iron-calcium granule is calculated as 1000 packs, and the prescription is as follows: zinc gluconate 30g, vitamin B23g, ferrous gluconate 100g, appropriate amou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/525A61K9/14A61P3/02A61K31/191
Inventor 刘景萍刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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