Medical absorbable polysaccharide composite material and application thereof

Abstract

The invention discloses a medical absorbable polysaccharide composite material and application thereof. According to the medical absorbable polysaccharide composite material, starch with poor water absorbability is used as one material in the polysaccharide composite material; furthermore, a polysaccharide material with good water absorbability is added; the composite polysaccharide material is obtained through directly mixing, or through adding water, uniformly mixing and then carrying out freeze drying, without the need of cross-linking reaction. The material has the advantages of high waterabsorption rate, rapid water absorption speed, higher gel strength, good biocompatibility and the like, and can be directly used on wound surfaces with blood and for stopping bleeding of body surfaces, tissue organs in inner parts of bodies and in body cavities; the material can be used for rapidly stopping bleeding, can be absorbed by human bodies and has a sticky plugging effect. The material also can be further used as a post-operative anti-adhering material, a tissue healing promoting material, a surgical sealant, a wound suture-free tissue adhesive, a tissue filling material and a tissuedebridement material.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a medical absorbable polysaccharide composite material and its application. Background technique [0002] Bleeding and oozing of surgical wounds are often encountered problems in surgery, and surgical blood loss can cause a large number of complications, even life-threatening. In recent years, medical absorbable materials have attracted great attention from the medical and industrial circles of various countries. The following types of absorbable materials are used clinically: [0003] 1. Chitosan material [0004] Including chitosan hemostatic powder, chitosan hemostatic sponge, chitosan hemostatic accessories, etc. Medical chitosan is mostly made of marine organisms such as shrimp shells and crab shells through decalcification, deproteinization, deacetylation, and carboxymethyl modification. Chitosan-based hemostatic products have low water absorption, are positively charged...

AI Technical Summary

Problems solved by technology

The process used in this type of product is emulsification and cross-linking. Starch and modified starch are cross-linked to form a porous material, which can absorb water in the blood and accelerate the process of hemostasis. However, this type of product has three common disadvantages: (1) Cross-linking The porous material formed after is a network structure, which limits its ability to absorb water, and the water absorption rate is low; (2) because it is a network particle, the strength or viscosity of the gel formed after absorbing water or after hemostasis is too small to be able to It can effectively block the bleeding point, and it is easy to cause secondary bleeding in the actual application of hemostasis; (3) The porous material formed after cross-linking has a small density and is light. When sprayed on the bleeding wound, it will float on the blood surface of the bleeding point and is not easy to reach Bleeding points form effective hemostasis

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