Stepronin powder injection and its preparing method

A technology of stilonine and powder injection, which is applied in the field of new dosage forms of stilonine, can solve the problems of low bioavailability, slow onset, slow absorption and distribution, etc., and achieve high bioavailability, fast distribution, and fast effect
CN1820746AInactive Publication Date: 2006-08-23HUAZHONG UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUAZHONG UNIV OF SCI & TECH
Publication Date
2006-08-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is new preparation form of Stepronin, especially Stepronin powder for injection, and its preparation process. The powder for injection consists of Stepronin or its metal salt or amino salt as active component and freeze drying support agent. Compared with available orally taken Stepronin preparation, the present invention has the advantages of high bioavailability, good medicine absorption, fast medicine dispersion, fast acting, etc. The present invention expands the administration range of Stepronin and raises the clinical administration level of Stepronin.
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Description

technical field

[0001] The invention provides a new dosage form of steironine, especially a powder injection. Background technique

[0002] Stepronine (also known as: steppro acid, English name: stepronin), invented by Italy's Bolasco company, Italy's Mediolanun Farmaceuticls company produced and listed for the first time. Steironine is a metabolism-improving antidote that can improve liver function in chronic liver diseases. It is clinically used to treat acute and chronic liver diseases and liver poisoning. It also has a mucolytic effect and is used to relieve bronchospasm.

[0003] Stilonine was first reported by Zanolo G et al. in Boll Clum Farm 1981 Jan: 120(1): 55-67. GaslandiM et al reported in Int J Clin Pharmacol Res 1988: 8(3): 223-225 the test of stiironine for mucolysis.

[0004] Stilonine is a prodrug, which is hydrolyzed into 2-mercaptopropionylglycine (tiopronin) by hydrolase in vivo. Tiopronin is also a metabolic improving antidote and can also be used in ...

Claims

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