Tirofiban powder injection and its preparing method

A technology of rofiban powder and tirofiban, which is applied in the field of tirofiban powder injection, can solve the problems of poor physical stability of aqueous solution injection, difficult to maintain clarity, unstable pH value, etc. Stable properties and wide selection of effects
CN1820751AInactive Publication Date: 2006-08-23HUAZHONG UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUAZHONG UNIV OF SCI & TECH
Publication Date
2006-08-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to new preparation form of Tirofiban, especially Tirofiban powder for injection, as antiplatelet medicine and its preparation process. The powder for injection consists of Tirofiban as active component, freeze drying support agent and pH buffering agent. The present invention expands the administration range of Tirofiban and raises the clinical administration level of Tirofiban.
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Description

technical field

[0001] The invention provides a new preparation of tirofiban, in particular tirofiban powder injection. Background technique

[0002] The rupture of atherosclerotic plaque in coronary arteries and subsequent platelet adhesion, aggregation, and thrombus formation are the main causes of coronary heart disease events. Platelet membrane glycoprotein GPIIb / IIIa receptors exist on the surface of platelet membranes and are expressed in large quantities when platelets are activated, which is the last pathway that causes platelet aggregation. Platelet membrane glycoprotein GPIIb / IIIa receptor antagonists produce antithrombotic effect by blocking the binding of platelet membrane glycoprotein GPIIb / IIIa receptors to coagulation factors. Tirofiban is a potent platelet membrane glycoprotein GPIIb / IIIa receptor antagonist, it selectively binds to the platelet glycoprotein GPIIb / IIIa receptor, occupies the binding site on it, and makes the platelet membrane Glycoprotein G...

Claims

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