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Medicine composition of rhodiola root and puerarin

A technology of Rhodiola rosea and its composition, applied in the field of medicine, to achieve the effect of remarkable curative effect, high safety, and better quality of medicines

Inactive Publication Date: 2011-07-20
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using the interaction of Rhodiola rosea and puerarin, there are no reports on the medicines for the treatment of cardiovascular and cerebrovascular diseases with compatible prescriptions.

Method used

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  • Medicine composition of rhodiola root and puerarin
  • Medicine composition of rhodiola root and puerarin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Example 1 Preparation of Rhodiola rosea extract

[0143] Take 20 kg of Rhodiola medicinal materials, crush them into coarse powder, extract with 70% ethanol three times for 1 hour each time, add 10 times the amount of alcohol for the first time, and 8 times and 8 times the amount for the second and third times respectively. Filter, combine the extracts and recover ethanol to 1g crude medicinal materials per 5ml. After degreasing with 2 times the amount of petroleum ether, discard the petroleum ether solution, then extract with saturated n-butanol, concentrate under reduced pressure to a thick paste, spray After drying, 3.07 kg of rhodiola extract was prepared, with a yield of 13.36%; the content of salidroside was 5.67%.

Embodiment 2

[0144] Example 2 Refining of rhodiola extract

[0145] Take 1.4 kg of the Rhodiola extract obtained in Example 1 and dissolve it with an appropriate amount of water, and add it to the pre-treated macroporous resin, followed by water, 10% ethanol, 15% ethanol, 20% ethanol, 30% ethanol The elution rate is 10ml / min. The ethanol was recovered under reduced pressure to a relative density of 1.03 to 1.06 (60° C.), and spray-dried to obtain 0.25 kg of rhodiola extract with a yield of 2.76%; the content of salidroside was 18.43%.

Embodiment 3

[0146] Example 3 Preparation of powder injection of the composition of the present invention

[0147] prescription:

[0148] Puerarin 150g

[0149] Rhodiola extract 27.6g (equivalent to 1000g of rhodiola medicinal material)

[0150] Polysorbate 80 100g

[0151] Mannitol 400g

[0152] Sterile water for injection up to 4000ml

[0153] 1000 pieces in total

[0154] Preparation Process:

[0155] 1) Firstly, aseptically treat the containers, glass antibiotic bottles and rubber stoppers for liquid preparation.

[0156] 2) Weigh the raw materials and auxiliary materials according to the prescription amount.

[0157] 3) Polysorbate 80 is made into a 20% aqueous solution, puerarin is added to heat and stirred to dissolve completely, and the rhodiola extract is added to 20% sterile water for injection to dissolve completely. Mannitol was added to 40% sterile water for injection with heating and stirring to dissolve completely, the above solutions were combined, and sterile water for injection was adde...

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Abstract

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition for treating cardiac and cerebral vascular diseases and its preparations and preparation process. The medicine composition consists of rhodiola root in 300-1800 weight portions, preferably 1000 weight portions, or its extract, and puerarin in 30-500 weight portions, preferably150 weight portions. The composition may be prepared into different pharmaceutically acceptable forms, preferably injection. The composition has synergistic effect and high stability.

Description

【Technical Field】 [0001] The invention belongs to the technical field of medicine, and relates to a medicinal composition made of rhodiola and puerarin, and a preparation containing the medicinal composition and a preparation method thereof. 【Background technique】 [0002] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myocardial infarction, blood stasis pulmonary heart disease, ischemic encephalopathy, cerebral thrombosis, hypertension, hyperlipidemia, etc. The main cause of these diseases is arteriosclerosis that causes stenosis of the lumen and blockage of the ducts, which leads to insufficient blood supply to the brain, which causes symptoms such as dizziness, dizziness, headache, chest tightness, and severe cases can lead to stroke and myocardial infarction. Myocardial infarction means that on the basis of coronary artery disease, the blood flow of the coronary arteries is interrupted, causing the corresponding myocardium to appe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P9/12A61K31/7048A61K9/08A61K36/41A61P7/02A61P9/10
Inventor 蔡军
Owner 海安江理工技术转移中心有限公司
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