Houttuynia injection and its processing technology

A Houttuynia cordata injection and processing technology, applied to medical preparations containing active ingredients, drug delivery, digestive system, etc., can solve problems such as inconsistent clarity and harmfulness of injections, and achieve low cost and simple process OK, good effect

Inactive Publication Date: 2005-01-05
姚仲青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the latter process, in addition to decanoyl acetaldehyde, the volatile oil of Houttuynia cordata contains various components, such as methyl nonanone, lauryl aldehyde, myrcene, d-limonene, linalool, and ethyl borneolate , clovene, etc., while sodium bisulfite only reacts with decanoyl acetaldehyde, and other volatile oils do not react with sodium bisulfite, but this part of the volatile oil makes the solution appear opalescent, and the injection made from it The clarity obviously does not meet the requirements of the National Pharmacopoeia, and some excess sodium bisulfite is also harmful to the human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Get 2000g of Houttuynia cordata, carry out steam distillation, collect 2000ml of distillate, carry out redistillation again, collect about 1000ml of redistillate; then add sodium chloride 7g, add polyethylene glycol (PEG400) 5g in the redistillate, Add 5ml of 95% ethanol; heat to reflux for 30 minutes, let cool to room temperature; Filter through a porous membrane; then sub-package, choose from 1ml to 1000ml / bottle, choose 1000ml / bottle in this example, and then carry out disinfection and sterilization to obtain Houttuynia cordata injection preparation.

Embodiment 2

[0012] Take 200 kg of Houttuynia cordata, carry out steam distillation, collect 200,000 ml of distillate, and then redistill, collect about 100,000 ml of heavy distillate; add 0.7 kg of sodium chloride, 0.5 kg of polyethylene glycol (PEG1000), 95 % ethanol 500ml; heat to reflux for 30 minutes, let cool to room temperature; adjust the pH value to 4.5 with sodium citrate, refrigerate at 8°C for 40 hours, filter with a 0.45um microporous membrane filter; then pack, and then sterilize , to obtain Houttuynia cordata injection preparation.

Embodiment 3

[0014] Houttuynia cordata injection preparation. Contains Houttuynia cordata 2000g, sodium chloride 7g, polyethylene glycol (PEG1000) 5g, 95% ethanol 5ml, water for injection appropriate amount, made into 1000ml, made into 1ml / branch.

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PUM

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Abstract

A houttuynia injection is prepared from houttuynia through distilling to obtain distilled liquid, adding polyethanediol, alcohol and sodium chloride, regulating isotonic pressure by physiological saline, thermal reflux, cooling, regulating pH=4-6 by citric acid, storage at 4-10 deg.C for 24-48 hr, millipore membrane filtering, and sterilizing.

Description

technical field [0001] The invention relates to a houttuynia injection preparation and a processing technology. Background technique [0002] At present, there are generally two kinds of Houttuynia injection preparations and processing techniques. One is to distill Houttuynia cordata with water and add Tween-80 as a solubilizer to make the volatile oil of Houttuynia cordata soluble in water and become clear; Sodium bisulfite is added to Houttuynia cordata water distillate, so that decanoyl acetaldehyde, the main volatile component in Houttuynia cordata distillate, reacts with sodium bisulfite to generate water-soluble Houttuyniatin. The former process has been banned in intravenous injection because of the hemolytic reaction of Tween-80, but in actual production, since there is no corresponding solubilizer that can replace Tween-80, Tween-80 is still Used as a solubilizer. In the latter process, in addition to decanoyl acetaldehyde, the volatile oil of Houttuynia cordata c...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61P1/16A61P31/00
Inventor 姚仲青
Owner 姚仲青
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