The invention discloses a manufacturing process of a titanium cup with an arc-shaped bottom. The manufacturing process comprises the following preparation steps of S1, pressing an inner supporting ring; S2, carrying out primary crystallization; S3, preparing a cup rabbet; S4, welding the cup rabbet; S5, pressing a vacuum bottom of the titanium cup; S6, welding the vacuum bottom of the titanium cup; S7, carrying out secondary crystallization; S8, conducting vacuumizing; S9, detecting a heat preservation function; S10, welding a bottom piece; S11, polishing the surface; and S12: carrying out oxidation treatment. Compared with the prior art, the manufacturing process of the titanium cup with the arc-shaped bottom provided by the invention has the following remarkable beneficial effects that an inner supporting ring structure is adopted, the vacuum bottom of the titanium cup is rounded all the time through the inner supporting ring, and high roundness is kept, so that the surface of the welding position of a titanium cup shell and the vacuum bottom of the titanium cup is smooth; a mold is adopted for clamping the titanium cup with the arc-shaped bottom, the titanium cup with the arc-shaped bottom can be accurately limited, argon is injected, and an argon protection atmosphere can be formed at the welding position, so that the generation of an oxidation film is reduced; and the titanium cup bottom piece is arranged at the bottom of the titanium cup with the arc-shaped bottom, so that the titanium cup bottom piece can be prevented from falling off, and no liquid medicine remainsin the vacuum bottom of the titanium cup.