The invention discloses a feed for preventing and treating contagious caprine pleuropneumonia and a preparation method of the feed. The feed comprises, by weight, herba houttuyniae, a pararuellia delavayana herb, folium ilicis purpureae, an artemisia integrifolia herb, radix tetrastigmatis hemsleyani, a ludwigia prostrata herb, radix puerariae, pachyrhizus erosus stems and leaves, pomelo peel, shrimp, fish, orange peel, eggshells, cornstalks, vinasse, sorghum stalks and rape stalks, and is prepared through the steps of material preparation, fermentation, material mixing, packaging and the like. According to the feed for preventing and treating contagious caprine pleuropneumonia and the preparation method of the feed, after the vinasse is utilized for fermenting radix puerariae, the pachyrhizus erosus stems and leaves and the pomelo peel, straw is added to conduct fermentation in a later period of fermentation; and during silage preparation, fermentation effects of the materials are further improved through residual microorganisms in the vinasse, the materials fermented by the vinasse have richer nutritional components, the content of sugar and acids in the feed is increased compared with the content of sugar and acids in general silage, after the materials fermented by the vinasse are mixed with a shrimp meal, a fish meal and the eggshells, the content of nutritional componentsis further increased, and meanwhile, the materials fermented by the vinasse more promote food intake of goats. Multiple traditional Chinese medicinal herbs are added so that contagious caprine pleuropneumonia can be effectively prevented and treated. The feed for preventing and treating contagious caprine pleuropneumonia is rich in nutrient, good in effect and low in cost.