The invention discloses topical anti-inflammatory styptic powder combining the traditional Chinese medicine and the western medicine and a preparation method of the topical anti-inflammatory styptic powder. The topical anti-inflammatory styptic powder is prepared from the following main raw materials in parts by weight: 10-30 parts of broadbean pericarp, 42-100 parts of maesa japonica (leaves), 30-100 parts of tea begonia, 35-80 parts of pterospermum niveum, 36-72 parts of Japanese apricot, 40-80 parts of walnut shell, 15-35 parts of parmelia tinctorum despr, 13-30 parts of cyathocline purpurea, 10-18 parts of cupressin, 12-22 parts of tulostoma jourdanii pat, 28-50 parts of crateva unilocularis, 25-50 parts of trema dielsiana, 0.7-1.0 part of caffeic acid, 0.2-0.5 part of citric acid, 0.1-0.12 part of vitamin P, 3-10 parts of borneol, 0.4-0.6 part of glycyl-L-histidyl-L-lysine, 0.6-2.0 parts of an anti-infective agent, 1.2-4 parts of mineral powder and 0.1-0.13 part of epsilon-polylysine. By combination of the traditional Chinese medicine and the western medicine, by the effects of the the traditional Chinese medicine for stopping bleeding, relieving inflammation, clearing away heat and alleviating pain as well as the effects of the western medicine for resisting bacteria and resisting infection, the topical anti-inflammatory styptic powder plays a role in stopping bleeding; and the traditional Chinese medicines and the western medicines work together, so that the topical anti-inflammatory styptic powder is mild in medicine property, high in pertinence, good in compatibility, significant in curative effect, free of thrill and free of a side effect.