982results about How to "Good antiviral effect" patented technology

Novel antiviral combinations for the treatment or prevention of viral infections, in particular, HIV, are disclosed. This new antiviral therapy employs either DP-178 or DP-107, viral fusion inhibitors, in combination with at least one other antiviral therapeutic agent. The combinations of the invention are better than single therapies alone, and in certain cases are synergistic. The use of DP-178 or DP-107 is an ideal therapy to combine with another antiviral, given both the novel mechanism which this therapeutic blocks HIV transmission and the non-toxicity of the therapeutic.

Antiviral compositions comprising a modified nuclease, or a plurality of such modified nucleases having at least one non-natural amino acid residue substituted for a naturally occurring amino acid in a parent nuclease are provided, as are methods of use and kits providing unit dosages of such compositions.

Compositions for treating flu comprise an M2 inhibitor, and optionally a neuraminidase inhibitor, wherein at least one of said M2 inhibitor or said neuraminidase inhibitor is provided in an extended release dosage form.

The present invention relates to a combination therapy for treating an HIV infection or inhibiting integrase comprising (S)-6-(3-Chloro-2-fluorobenzyl)-1-(1-hydroxymethyl-2-methylpropyl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (“Compound A”) or a pharmaceutically acceptable solvate or salt thereof in combination with at least one other anti-HIV agent. In some embodiments of the present invention, the other anti-HIV agents are chosen from reverse transcriptase inhibitors and protease inhibitors. In certain embodiments of the present invention, the other anti-HIV agents are chosen from AZT, 3TC, PMPA, efavirenz, indinavir, nelfinavir, a combination of AZT/3TC, and a combination of PMPA/3TC. Since Compound A has a high inhibitory activity specific for integrases, when used in combinations with other anti-HIV agents it can provide a combination therapy with fewer side effects for humans.

Pig feed is disclosed. The feed is prepared from following components by weight: 40-50 parts of corn, 30-40 parts of wheat, 15-25 parts of soybean meal, 20-35 parts of sweet potato residue, 2-6 parts of lactic acid bacteria, 3-10 parts of yeast, 10-15 parts of medical stone, 10-15 parts of eggshell, 10-15 parts of shell powder, 20-30 parts of silene conoidea, 10-20 parts of cottonsedge-like thistle herb, 10-15 parts of sweet potato vine, 10-20 parts of purslane herb, 3-10 parts of composite vitamin, 10-25 parts of vegetable oil, 5-15 parts of isatis root, 5-15 parts of liquorice root, 5-15 parts of milkvetch root, 5-15 parts of medicated leaven, 5-15 parts of malt, 5-15 parts of hawthorn fruit and 5-15 parts of dried tangerine peel. The feed is reasonable in formula, comprehensive in nutrition, good in taste and high in feed absorption rate. By adopting a plurality of the proper raw materials and adopting reasonable using amounts, comprehensive nutrition of the feed is optimized, and three functions, namely functions of regulating feed palatability, increasing the lean meat percentage and boosting pig immunity are achieved.

The invention provides pellet feed for grass carp, and the raw material and weight share are as follows: bean of 10 to 20 shares, rapeseed cake of 15 to 25 shares, cottonseed cake of 10 to 20 shares, wheat bran of 10 to19 shares, secondary flour of 10 to 15 shares, rice bran of 10 to 20 shares, fishmeal of 3 to 6 shares, stone dust of 1 to 2.5 shares, salt of 0.1 to 0.5 shares, dry cactus powder of 0.4 to 0.6 shares, dry aloe powder of 0.3 to 0.5 shares, dry garlic powder of 0.1 to 0.3 shares and probiotics preparation of 0.2 to 0.6 shares. The preparation method for pellet feed is as follows: the raw material is firstly taken out and weighted and then crushed into powder, and then is stirred and mixed, finally, mixture is made into pellet feed which is the finished product. Pellet feed is rich in nutrient, the grass carp grows fast after eating pellet feed, the cost of raising the grass carp is greatly reduced and the immune function of the grass carp is greatly improved. The disease prevention, medical treatment and anti-virus capability of the grass carp are also enhanced.

The invention relates to a biogenic composite pork preservative. The biogenic composite pork preservative comprises 4.0-4.8% of a bacterial depressant, 10-14% of a synergist, 27-33% of Chinese herbal medicine extract A, 16-20% of Chinese herbal medicine extract B and the balance water. The bacterial depressant contains nisin, natamycin, lysozyme, chitosan and propolis supercritical CO2 extract. The synergist contains acetic acid, vitamin C, vitamin E and sodium lactate. The Chinese herbal medicine extract A is prepared through extracting grape seeds, garlic, clove, cassia bark, rosemary, pepper and ginger through an ethanol extraction method and then blending the extract products, Origanum vulgare L. essential oil and tea crude extract. The Chinese herbal medicine extract B is prepared through water extraction of konjak, Chinese honeylocust fruits, rheum officinale and pomegranate peel. The biogenic composite pork preservative has a reasonable formula, is safe for eating, can be prepared by simple processes, is convenient for operation in use and has good fresh-keeping effects.

The invention relates to a special feed for rabbits, which comprises the following ingredients in percentage by weight: 10-25% of corn, 5-10% of shorts, 6-12% of wheat bran, 3-12% of soybean meal, 3-6% of DDGS (Distillers Dried Grains with Solubles) feed, 10-50% of Ley-mus chinesis, 1-4% of cane molasses, 5-10% of alfalfa, 3-10% of chrysanthemum powder, 1.5-2.5% of mountain meal, 8-14% of corn germ meal, 3-6% of corn fiber, 0.2-5% of yeast powder, 2-8% of peanut hull meal and 1-6% of spices. The special feed for rabbits of the invention is rich in a variety of nutrients, and rabbits eating the special feed can rapidly grow, so as to greatly reduce rabbit raising cost. Also, the special feed can greatly enhance immunity, disease preventing and treating capacity and antiviral capacity of rabbits, and the formulation of the feed for rabbits is safety, environment-friendly, high-quality, and efficient.

The invention is a compound feedstuff used for goose, and the components and the weight percentage are as following: grass meal 15-18 percent, corn 30-46 percent, bean pulp 15-21 percent, wheat bran 6-15 percent, rice husk 6-15 percent, fine dust 1-4 percent, calcium hydrogen phosphate 0.2-0.6 percent, salt 0.3-0.5 percent, cactus dry powder 0.5-1.1 percent, aloe dry powder 0.4-0.9 percent, garlic dry powder 0.3-0.5 percent, honey 0.3-0.5 percent, probiotic preparation 0.4-0.8 percent. The product can be made by putting the components, which are weighed according to the required ratio, into the blender through sufficient mixing and blending. The invention provides a goose used compound feedstuff. The feedstuff has a low cost and various nutrient compositions, can improve the appetite of geese, can make the geese grow rapidly, and can make the female geese produce more eggs. After eating the compound feedstuff, the immune function of geese can be greatly improved, and the abilities of disease prevention, disease treatment and anti-virus of the geese can be strengthened.

The invention discloses a Chinese medicinal herb nonreactor biological feed additive which comprises the following effective ingredients in parts by weight: 1-4 parts of astragalus membranaceus, 1-2 parts of semen cuscutae, 1-2 parts of herba epimedii, 1-3 parts of pericarpium citri reticulatae, 1-3 parts of scorched hawthorn fruit, 1-3 parts of fructus aurantii, 1-2 parts of liquorice root, 1-3 parts of isatis root, 1-2 parts of dandelion, 1-3 parts of cordate houttuynia, 1-2 parts of herba portulacae, 1-3 parts of honeysuckle, 1-3 parts of rhizoma atractylodis and 1-3 parts of compound microbial starters. The Chinese medicinal herb nonreactor biological feed additive has functions of resisting bacteria and diminishing inflammation, regulating qi-flowing and helping digestion, benefiting the spleen and invigorating the stomach, enhancing immunity and the like, plays a role of completely replacing antibiotics, does not generate drug resistance; various growth performances and indexes are remarkably improved after beasts and birds are fed with the Chinese medicinal herb nonreactor biological feed additive; the beasts and the birds produced after the beasts and the birds are fed with the Chinese medicinal herb nonreactor biological feed additive are green, safe and pollution-free.

The invention discloses a selenium, zinc and calcium rich Chinese yam cultivation method including the steps of (1), soaking seedlings or roots of Chinese yam by selenium fertilizer diluent for two to four hours, planting or culturing seedlings after taking the seedlings or roots out of the selenium fertilizer diluent to dry the same, and applying 25-150kg of quick lime per mu according to the state of pH value of soil; (2), mixing selenium fertilizer and zinc fertilizer into base fertilizer during fertilizer applying; (3), mixing 10-50 g of selenium fertilizer per mu with water to water the roots and then applying topdressing; (4), spraying selenium fertilizer diluent, zinc fertilizer diluent and calcium fertilizer diluent to leaf surfaces of Chinese yam during the growth period by two to six times. By the selenium, zinc and calcium rich Chinese yam cultivation method, selenium, zinc and calcium contents of Chinese yam are increased further, nutritive value and health value of Chinese yam are enriched, and physical health of people eating the Chinese yam can be improved.

A compound Chinese herbal medicament preparation for preventing and treating white spot syndrome is prepared by following raw materials by weight: 20-35 parts of Corydalis bungeana Turcz., 25-40 partsof radix isatidis, 15-40 parts of radix astragali, 20-40 parts of dyers woad leaf, 25-35 parts of wrinkled giant hyssop, 10-30 parts of Japanese eupatorium, 15-25 parts of roughhaired holly root and5-15 parts of Gynostemma pentaphylla. The compound Chinese herbal medicament preparation can effectively prevent and treat the white spot syndrome. The invention also discloses a forage comprising thecompound Chinese herbal medicament preparation and a method for feeding the same. The forage comprising the compound Chinese herbal medicament has simple processing technology and convenient feeding.The method for feeding the forage comprising the compound Chinese herbal medicament is scientific and reasonable and has a good antiviral effect.

The invention provides a grape multi-resistance rootstock hard branch grafting nutrition bag seedling raising method in arid desert areas. The grape multi-resistance rootstock hard branch grafting nutrition bag seedling raising method in the arid desert areas adopts rootstocks which are selected from 5BB and /or S 04, and adopts following steps of gathering of scions, selection of rootstocks, pavement of double layers of electric heating hotbeds, grafting of the rootstocks and the scions, placement of cuttages on the electric heating hotbeds, placement of the cuttages in nutrition bags, and management after cutting of the rootstocks. A plurality of selection tests of rootstock varieties come to a discovery that after rootstocks S04 and rootstocks 5BB are grafted with local cladus, nursery stocks are good in resistances, low in infection rate of diseases and insect pests, strong in saline-alkaline resistance, high in survival rate, and rather good in local adaptability. Greenhouses are further used for carrying out large-scale fast breeding of grape hard branch grafting seedlings, breeding stage is short, and grafting, breeding and planting of the seedlings can be achieved in the same year. The grape multi-resistance rootstock hard branch grafting nutrition bag seedling raising method in the arid desert areas is particularly suitable for arid and saline-alkaline desertification areas, simple and practical in technology, and easy to popularize.

The invention discloses a traditional Chinese medicine composite for treating the Newcastle disease, belonging to the field of Chinese veterinary medicine. The traditional Chinese medicine composite for treating the Newcastle disease is mainly composed of Scutellaria baicalensis smashing objects, isatis root smashing objects, folium isatidis smashing objects, garlic smashing objects, Astragalus mongholicus smashing objects, folium mori smashing objects, mint smashing objects and liquorice smashing objects. Another traditional Chinese medicine composite for treating the Newcastle disease is mainly composed of Scutellaria baicalensis extractive, isatis root smashing extractive, folium isatidis extractive, garlic extractive, Astragalus mongholicus extractive, folium mori extractive, mint extractive and liquorice extractive. The traditional Chinese medicine composite has reasonable formula, can carry out synergism, has the action on resisting bacteria and virus, has small toxic and side effect and is safe to use. The healing rate of the Newcastle disease is above 85%, the Newcastle disease has small possibility of recurring, the traditional Chinese medicine composite does not generatemedicine resistance, and veterinary medicine residue can be avoided. The traditional Chinese medicine composite also can be used for treating henpox, influenza, bursal disease, infectious bronchitis of chicken, colibacillosis and Staphyococcosis.

The present invention relates to methods of imparting virus resistance to plants. In one aspect, this method involves silencing a gene encoding a translation initiation factor eIF4E in the plant. In another aspect, this method involves overexpressing a heterologous translation initation factor eIF4E in a plant. The present invention further relates to a genetic construct containing a nucleic acid molecule encoding a heterologous translation initiation factor eIF4E, as well as to an expression system containing the genetic construct and a host cell transformed with the genetic construct. The present invention also relates to transgenic plants, seeds, and plant parts transformed with the genetic construct. The present invention also relates to an isolated nucleic acid molecule encoding a mutant translation initiation factor eIF4E that is effective in imparting virus resistance in plants. The present invention also relates to a mutant translation initiation factor eIF4E and a method for making the mutant.

The invention provides a recombined porcine interferon Gamma, a coding gene thereof, and an expressing, purifying and inclusion body refolding method, and belongs to the field of biological gene engineering. The recombined porcine interferon Gamma serves as a non-specific broad-spectrum anti-viral biological preparation, and has a wide medicinal prospect in the field of veterinary medicines; but as most of gene engineering veterinary medicines, the porcine interferon Gamma has the problems of underproduction, high prices, non-uniform quality and the like. According to the recombined porcine interferon Gamma, the coding gene thereof and the expressing method, an escherichia coli expression system is used for performing heterologous expression for the recombined porcine interferon Gamma subjected to codon optimization. Besides, aiming at the problem that the porcine interferon Gamma in a prokaryotic expression system is usually expressed in a manner of an inclusion body, the invention further provides the purifying and refolding method for the inclusion body of the recombined porcine interferon Gamma, so that the prepared recombined porcine interferon Gamma has high activity and meets a standard for industrialized production.

The invention discloses a feed for weaned pigs. The feed comprises the following components: weaned pig feed core material, smashed microwave corn powder, smashed microwave bean powder, fermented bean meal, wheat middling, steam fish meal, high-fat whey powder, calcium hydrogen phosphate, an anthony pig compound premix, a compound acidifying agent, a compound emulsifying agent, choline chloride, an antioxidant, a mold removal agent, edible salt, 98 percent of lysine hydrochloride, DL-methionine and mountain flour. The preparation method for the feed comprises the following steps of: performing microwave treatment on corns and beans, then smashing and screening the corns and the beans, and proportionally mixing the components. According to the feed, the problem of weaning of anthony pigs is solved by weakening the weaning stress of the anthony pigs, improving the anti-virus capability of the anthony pigs and improving the immunity of the anthony pigs; the daily weight gain of the anthony pigs can be effectively increased; the material-to-meat ratio can be reduced; the diarrhea rate is reduced by over 3 percent; the daily feed intake is increased by over 6 percent, so that the anthony pigs have high stress resistance and immunity.

The invention relates to the technical field of rabbit breeding, in particular to a domestic rabbit breeding method capable of enriching nutrition, enhancing the immunity function and the appetite of the domestic rabbits and better promoting the growth of the domestic rabbits, wherein the bred domestic rabbits are firm and fresh in meat quality. The method specifically comprises the first step of selecting a field, building a rabbit house and selecting a plurality of stocking areas for artificial breeding, the second step of carrying out house allocating and crowd allocating management on rabbits according to different growth stages, breeding purposes, ages, sexes and seasons, and the third step of managing the rabbits with different sexes in different ways. The method has the advantages that breeding is carried out through the mutual combination of cage breeding and stocking breeding, on one hand, the advantages of the cage breeding are developed, the rabbits can fast grow, and the rabbit dung can be collected and cleaned conveniently; on the other hand, the rabbits can freely move and can freely forage through the stocking breeding method, and therefore the bred rabbits are in good health, immunity and strength and firm in muscle, and the nutritive value of the rabbit meat is improved.

The invention relates to a broad-spectrum antiviral nano traditional Chinese medicine and a preparation method thereof. The broad-spectrum antiviral nano traditional Chinese medicine is prepared by using 36 traditional Chinese medicines as the effective raw materials by weight: 30 to 60 of prepared common monkshood daughter root, 10 to 20 of ephedra herb, 15 to 30 of cassia twig, 30 to 60 of medicinal indianmulberry root and the like. The preparation method comprises the following steps of pretreatment grinding, high-frequency ultrasonic grinding, extraction and dispersion, microwave extraction, ultrasonic spraying, drying and grinding, nano grinding, mixing, Capsule filling and sterilizing. The formula has broad-spectrum antiviral and anti-tumor treatment effects, has no any toxic or side effect, and is suitable for treating various virus carriers. By syndrome differentiation and treatment, pharmacodynamics analysis, medicament channel tropism, yin and yang distinguishing, body resistance strengthening and pathogenic factor elimination and monarch, subject, assistant and envoy reasonable compatibility, the formula is subdivided into four morning, noon, evening and night preparation formulations which are suitable for the user to administrate at four times respectively. The traditional Chinese medicine is applied onto the local skins of the human body according to different times to carry out acupoint drug administration and percutaneous absorption treatment.

The invention discloses a compound feed for healthy aquaculture of grass carps in a large water area and a production method thereof. The compound feed is compounded from the following raw materials in parts by weight: 10-20 parts of bean cakes, 15-25 parts of rapeseed cakes, 10-20 parts of cotton cakes, 10-19 parts of wheat bran, 10-15 parts of wheat middling, 10-20 parts of rice bran, 3-6 parts of shell powder, 5-10 parts of wheat meal, 4-8 parts of straw powder, 0.1-0.2 part of southernwood powder, 0.01-0.05 part of dried medlar powder, 0.1-0.2 part of vitamin b complex, 10-20 parts of liquid lactobacillus, 20-40 parts of water, 0.1-0.5 part of salt and the like. The compound feed has the advantages that 1, the nutritional ingredients and mineral substances of the pellet feed are rich and replace the original fish meal, so that the cost is reduced, an animal albumen source is obtained, and the absorption utilization ratio is high; 2, the meat quality of the grass carps is improved, the growth rate of the grass carps after eating the feed can be improved by more than 8%, the production cost of a grass carp feed is reduced by more than 5%, and the culture cost of the grass carps is reduced by more than 10%; and 3, the immunologic function of the grass carps is improved, the capabilities of preventing diseases, curing diseases and resisting viruses of the grass carps are enhanced, and the recapture rate of the grass carps can be improved by 5%.