The invention discloses a compound feed for healthy aquaculture of grass carps in a large water area and a production method thereof. The compound feed is compounded from the following raw materials in parts by weight: 10-20 parts of bean cakes, 15-25 parts of rapeseed cakes, 10-20 parts of cotton cakes, 10-19 parts of wheat bran, 10-15 parts of wheat middling, 10-20 parts of rice bran, 3-6 parts of shell powder, 5-10 parts of wheat meal, 4-8 parts of straw powder, 0.1-0.2 part of southernwood powder, 0.01-0.05 part of dried medlar powder, 0.1-0.2 part of vitamin b complex, 10-20 parts of liquid lactobacillus, 20-40 parts of water, 0.1-0.5 part of salt and the like. The compound feed has the advantages that 1, the nutritional ingredients and mineral substances of the pellet feed are rich and replace the original fish meal, so that the cost is reduced, an animal albumen source is obtained, and the absorption utilization ratio is high; 2, the meat quality of the grass carps is improved, the growth rate of the grass carps after eating the feed can be improved by more than 8%, the production cost of a grass carp feed is reduced by more than 5%, and the culture cost of the grass carps is reduced by more than 10%; and 3, the immunologic function of the grass carps is improved, the capabilities of preventing diseases, curing diseases and resisting viruses of the grass carps are enhanced, and the recapture rate of the grass carps can be improved by 5%.