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123 results about "Ketosis" patented technology

Ketosis is a metabolic state characterized by elevated levels of ketone bodies in the blood. Physiologic ketosis is a normal response to low glucose availability, such as low-carbohydrate diets or fasting, that provides an additional energy source for the brain in the form of ketones. In physiologic ketosis, ketones in the blood are elevated above baseline levels but the body's acid-base homeostasis is maintained. This contrasts with ketoacidosis, an uncontrolled production of ketones that occurs in pathologic states and causes a metabolic acidosis, which is a medical emergency. Ketoacidosis is most commonly the result of complete insulin deficiency in type 1 diabetes or late-stage type 2 diabetes.

System for optimizing the production performance of a milk producing animal herd

A system for optimising the production performance of a milk producing animal herd is provided. The system comprises a milk sampling apparatus, an analytical apparatus comprising separate equipment for analyzing compounds or parameters that in the presence of compounds indicative of the physiological or nutritional condition of the herd member, generates detectable signals, and apparatus directing a part of the milk sample (directing apparatus) to each separate equipment, which is controlled by data for the physiological and nutritional state of a herd member, so that the directing apparatus is only activated at pre-selected points in time or at pre-selected time intervals in the production and / or lactation cycles. Specific compounds are compounds indicative of mastitis, including beta-N-acetylhexosaminidase (NAGase) E.C. 3.2.1.52 and lactate dehydrogenase (LDH), protein balance, including milk urea nitrogen (MUN) and total protein, ketosis, including acetolactate, beta-hydroxybutyrate, acetone and lipids, fat and state in reproduction cycle, including a steroid or peptide hormone, e.g., progesterone. Furthermore, the system comprises equipment for signal detection to record and process the signals, equipment to store data and equipment to produce data output. Methods for optimizing the production performance of a milk producing animal herd and an apparatus therefor.
Owner:LATTEC

Mixed salt compositions for producing elevated and sustained ketosis

ActiveUS20170258745A1Improved metabolic healthLimiting, preventing, or improving an electrolyte imbalancePowder deliveryDispersion deliveryPotassiumExcipient
Ketogenic compositions including a beta-hydroxybutyrate (BHB) mixed salt are formulated to induce or sustain ketosis in a subject to which the ketogenic compositions are administered. The BHB mixed salt is formulated to provide a biologically balanced set of cationic electrolytes, and is formulated to avoid detrimental health effects associated with imbalanced electrolyte ratios. A ketogenic composition includes BHB salts of at least sodium, potassium, calcium, and magnesium. The BHB salts may also include at least other component such as a BHB compound containing other cations, such as transition metal cations (e.g., zinc or iron), a BHB-amino acid salts, medium chain fatty acid source, vitamin D3, flavorant, or other excipient.
Owner:AXCESS GLOBAL SCI LLC

Total mixed ration for high producing dairy cows

The invention relates to a total mixed ration for high producing dairy cows, which is characterized in that: the total mixed ration is formed by the following ingredients in part by weight: 9-13 parts of feed supplement, 24-28 parts of ensile, 2-5 parts of Chinese wildrye, 1-3 parts of bur clover, 1-3 parts of dried brewer's grains, 1-2 parts of whole cottonseed, 1-3 parts of beet pellet grains and 1-2 parts of molasses. The total mixed ration for the high producing dairy cows has the advantages that: the nutritional and metabolic diseases, such as rumen acidosis, parturient paresis and ketosis, easily occurred in the traditional feed feeding method are solved; the milk production potential of the high producing dairy cows can be developed, the feed can be saved, and the cost can be lowered, so that the economic benefits of the dairy cows are remarkably improved; and with the adoption of the total mixed ration and the combination of a scientific cultivation and management technique, the milk yield is averagely increased by 2Kg per cow every day, and the milk production life is increased by 2-3 parities.
Owner:包头北辰饲料科技股份有限公司

Nutrition regulating and controlling additive special for dairy cattle in perinatal period

The invention discloses a nutrition regulating and controlling additive special for dairy cattle in a perinatal period, which consists of rumen bypass fat 300-400g / kg, vitamin A 500,000-600,000 IU, vitamin E 5000-6000 IU, selenium 3-5mg / kg, compound Chinese herbal medicine 100-200g / kg and the balance carrier, wherein the compound Chinese herbal medicine is prepared by mixing, by weight, 10% of astragalus mongholicus, 10% of codonopsis pilosula, 5% of rhizoma cyperi, 5% of rhizoma atractylodis, 10% of angelica sinensis, 10% of radix paeoniae alba, 10% of rehmannia glutinosa, 10 % of herba epimedii, 10% of beautiful sweetgum fruit, 10% of cowherb seed and 10% of leonurus. The nutrition regulating and controlling additive special for the dairy cattle in the perinatal period has the advantages of being high in technological content, full in nutrition, comprehensive in functions, remarkable in effect and capable of improving energy negative balance state of postpartum dairy cattle and promoting body condition recovery, improves immune functions of the dairy cattle in the perinatal period, enhances disease resistance, reduces incidence of mammitis, endometritis, ketosis, puerperal feverand other diseases of the postpartum dairy cattle, promoting postpartum quick oestrus and improving reproductive performance.
Owner:天津天富莱溢佳生物科技有限公司

Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors

The present invention relates to novel 3-azabicyclo[3.1.0]hexane derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the said compounds. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.
Owner:RANBAXY LAB LTD

Postpartum dairy cow drenching nutritious supplementary and application method thereof

InactiveCN103340317AEffective maintenance levelLower levelAnimal feeding stuffDiseaseBeta-Hydroxybutyric acid
The invention discloses a postpartum new dairy cow drenching nutritious supplementary and application thereof in a nutritious supplementary for treating postpartum hypocalcemia, abomasum displacement or ketosis disease of dairy cow. The nutritious supplementary provided by the invention is capable of effectively maintaining the levels of blood calcium, blood magnesium and glucose and reducing the levels of NEFA (Non-Esterified Fatty Acid) and beta-hydroxybutyric acid, thereby effectively reducing the occurrence rate of metabolic diseases of postpartum paralysis, ketosis, abomasum displacement and the like of new dairy cow. As a result, the dairy cow can be rehabilitated in physical power and food intake quickly, and the health condition of the dairy cow can be improved and the milk yield of the dairy cow can be increased; and good economic benefit can be achieved.
Owner:CHANGCHUN BORUI FEED

L-aspartic acid for the treatment of assorted health problems

A method of treating or preventing one's health problem that are associated with one's cells having a poor metabolic capability to process fat includes ingesting a therapeutically effective dosage of an anaplerotic precursor. Examples of such health problems include obesity and the related health conditions that are aggravated by obesity, diabetes, hypertension, atherosclerosis, migraines and headaches, menstrual cramps, cholesterol excesses, multiple sclerosis and Alzheimer's disease, anemia, high blood uric acid levels, ketosis, tobacco and other drug addictions, and digestive problems. In a preferred embodiment, this method includes the daily ingestion of L-aspartic acid, or a pharmaceutically acceptable analog thereof, at the rate of 10-14 g / day and restricting from one's diet the intake of starchy foods.
Owner:INST DEL METABOLISMO CELULAR

Mixed salt compositions for producing elevated and sustained ketosis

ActiveUS20190167613A1Limiting, preventing, or improving an electrolyte imbalanceImprove balancePowder deliveryDispersion deliveryPotassiumExcipient
Ketogenic compositions including a beta-hydroxybutyrate (BHB) mixed salt are formulated to induce or sustain ketosis in a subject to which the ketogenic compositions are administered. The BHB mixed salt is formulated to provide a biologically balanced set of cationic electrolytes, and is formulated to avoid detrimental health effects associated with imbalanced electrolyte ratios. A ketogenic composition includes BHB salts of at least sodium, potassium, calcium, and magnesium. The BHB salts may also include at least other component such as a BHB compound containing other cations, such as transition metal cations (e.g., zinc or iron), a BHB-amino acid salts, medium chain fatty acid source, vitamin D3, flavorant, or other excipient.
Owner:AXCESS GLOBAL SCI LLC

Anionic-containing feed supplements having a low protein by-pass value

The present invention provides anionic-containing feed supplements having a low protein by-pass value that may be administered to animals. In particular, the invention provides anionic-containing feed supplements that are granular and may be utilized to treat several metabolic disorders in animals, such as hypocalcemia, milk fever, and ketosis.
Owner:NOVUS INTERNATIONAL INC

Pet food composition and method

InactiveUS20050042362A1Low carbohydrateConfectioneryAnimal feeding stuffKetosisBiology
The present invention relates to dimensionally stable low carbohydrate pet food products and method for producing such products. The resulting pet food products are capable of inducing desired levels of ketosis in pets which in turn can lead to weigh loss or weight control.
Owner:HILLS PET NUTRITION INC

Rumen glucose

The invention relates to rumen glucose, which is a rumen particle prepared from glucose by a microcapsule enveloping technique so that the glucose is not degraded in the rumen and is effectively released in intestinal canals. The enveloped substance not only can effectively treat bovine ketosis, but also can effectively prevent ketoses, and can provide rumen carbohydrates for cattle to improve the milk yield at the same time.
Owner:刘春海

Cancer with metabolic therapy and hyperbaric oxygen

The present invention demonstrates the therapeutic use of ketone esters for seizure disorders, Alzheimer's disease malignant brain cancer, and other cancers, which are associated with metabolic dysregulation. The administration of a ketogenic diet, such as ketone esters, while concurrently subjecting the patient to a hyperbaric, oxygen-enriched environment resulted in therapeutic ketosis. Optionally, the hyperbaric, oxygen-enriched environment is 100% oxygen at 2.5 ATA absolute. The ketone esters may be derived from acetoacetate and can include R,S-1,3-butanediol acetoacetate monoester, R,S-1,3-butanediol acetoacetate diester, or a combination of the two. The treatment may further include administering at least 10% ketone supplementation, such as acetoacetate, adenosine monophosphate kinase, 1,3-butanediol, or ketone ester, to the patient.
Owner:UNIV OF SOUTH FLORIDA

Ketogenic nutritional compositions

A nutritional composition comprises fat, protein and carbohydrate such that the fat provides from about 60 to about 90% of the total calories of the composition, the protein provides from about 10 to about 30% of the total calories of the composition, and the carbohydrate provides from about 0.1 to about 15% of the total calories of the composition, and the composition comprises from about 0.01 to about 10 wt % beta-hydroxy-beta-methylbutyrate (HMB). A method of achieving or sustaining metabolic ketosis in an individual comprises administering the nutritional composition to the individual. A method of maintaining lean body mass and muscle strength in an individual during dietary ketosis comprises administering the nutritional composition to the individual.
Owner:ABBOTT LAB INC

Drinking mixed feed after cow calving

The invention relates to drinking mixed feed after cow calving, which comprises a liquid component and a solid component; during application, the liquid component can be dissolved in 30-50 kg of saline water for oral administration or gavage of postpartum cow, and the solid component is also added; the liquid component is 500 ml, and comprises, by mass, 40-70% of propylene glycol, 20-40% of glycerin, and 10-20% of water; the solid component is 500 g, and comprises, by mass, 12-20% of calcium propionate, 26-34% of calcium gluconate, 12-20% of potassium chloride, 12-20% of sodium chloride, 6-12% of magnesium sulfate, 8-16% of sodium bicarbonate. The beneficial effects of the present invention are that: hypocalcemia and milk fever prevention; cow ketosis or low appetite prevention; blood acid-base balance improvement; bedridden syndrome due to magnesium deficiency prevention; feed digestion rate improvement and feed intake increase.
Owner:上海延华生物科技股份有限公司

Use of ketone esters for prevention of CNS oxygen toxicity

The present invention demonstrates the therapeutic use of ketone esters for seizure disorders, Alzheimer's disease and malignant brain cancer, which are associated with metabolic dysregulation. The administration of ketone esters resulted therapeutic ketosis and neuroprotection against seizures resulting from CNS oxygen toxicity. Supplemental ketones were also found to reduce superoxide production in cultured cortex neurons exposed to hyperbaric oxygen and Aβ-42, and to decrease proliferation and viability in U87 glioma cells. These observations support the therapeutic effect of ketones for seizure disorders, Alzheimer's disease and malignant brain cancer. The ketone esters may be derived from acetoacetate and can include R,S-1,3-butanediol acetoacetate monoester, R,S-1,3-butanediol acetoacetate diester, or a combination of the two.
Owner:UNIV OF SOUTH FLORIDA

Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate

Ketogenic compositions including beta-hydroxybutyrate (beta-hydroxybutyrate) and acetoacetate are formulated to induce, promote, or sustain ketosis in a mammal. The combined beta-hydroxybutyrate / acetoacetate compositions include an amount of acetoacetate that limits the reduction in available NAD+ in a subject without causing the formation of excess acetone in the bloodstream. In some aspects a composition for promoting and / or sustaining ketosis in a mammal contains a dietetically or pharmaceutically acceptable carrier and a beta-hydroxybutyrate / acetoacetate mixture of about 5% to about 45% acetoacetate by weight of the mixture and about 55% to about 95% beta-hydroxybutyrate by weight of the mixture.
Owner:AXCESS GLOBAL SCI LLC

Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the s-enantiomer and methods of use

Ketogenic compositions including a non-racemic mixture of beta-hydroxybutyrate (BHB) enriched with the S-enantiomer are formulated to control ketone body levels in a subject. The non-racemic mixture of BHB is enriched with the S-enantiomer to modulate the effect of ketone bodies in the subject and control the rate at which ketosis is achieved. In some aspects a composition for controlling ketone body level in a subject contains a dietetically or pharmaceutically acceptable carrier and a non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate, wherein the non-racemic mixture contains from about 52% to 99% by enantiomeric equivalents of S-beta-hydroxybutyrate enantiomer and from about 48% to about 1% by enantiomeric equivalents of R-beta-hydroxybutyrate enantiomer.
Owner:AXCESS GLOBAL SCI LLC

Method for measuring beta-hydroxybutyric acid by using enzyme colorimetric reaction, matched kit and application thereof

The invention provides a method for measuring beta-hydroxybutyric acid by using enzyme colorimetric reaction, a matched kit and application thereof. Under the system of Tris-HCL buffer solution, serum beta-hydroxybutyric acid and coenzyme I are dehydrogenized under the catalysis of beta-hydroxybutyric acid dehydrogenase to generate acetoacetic acid and reduced coenzyme I, the generated reduced coenzyme I and iodonitrotetrazole chloride are reacted under the catalysis of diaphorase to generate a red substance formazane of which the highest absorbance is 505 nanometers, and then the content of the beta-hydroxybutyric acid in a biological sample is quantified by measuring the change of the absorbance of the red product at the wavelength of 505 nanometers. The method can linearly measure the concentration range (0 to 4.5 mmol / L) of the beta-hydroxybutyric acid in the biological sample, the measurement is used for judging the human ketosis for acid poisoning diagnosis, the reagent used by the method is liquid dual-reagent, and the quantity of the sample required for measuring the beta-hydroxybutyric acid is little; moreover, the reaction time during measuring is short, the operation is simple, and the method is suitable for mass detection.
Owner:NINGBO RUI BIO TECH

Traditional Chinese medicine composition for treating cow ketosis

The invention relates to a traditional Chinese medicine composition for treating cow ketosis. The traditional Chinese medicine composition is prepared from the following ingredients in parts by weight: 75-85 parts of radix codonopsitis, 75-85 parts of rhizoma atractylodis, 55-65 parts of radix astragali, 55-65 parts of honeysuckle, 95-105 parts of ordate houttuynia, 45-55 parts of tuckahoe, 55-65 parts of angelica, 45-55 parts of motherwort, 35-45 parts of hemlock parsley, 55-65 parts of red paeonia, 55-65 parts of prepared rehmannia root, 75-85 parts of fructus amomi, 35-45 parts of jujube kernel, 35-45 parts of poria with hostwood, 25-35 parts of milkwort, 45-55 parts of fried fennel, 45-55 parts of costus root, 95-105 parts of medicated leaven, 45-55 parts of Atractylis ovata, 55-65 parts of Magnolia officinalis, 45-55 parts of bitter orange and 45-55 parts of licorice. The combination and preparation method of the traditional Chinese medicine composition provided by the invention are simple, and the traditional Chinese medicine composition has low cost and is safe and reliable; after the traditional Chinese medicine composition is administered, the symptoms of the cow suffering from ketosis is rapidly alleviated, the cow rapidly recovers, and the curative effect is obvious; and 58 cases of the cows suffering from ketosis are treated with the traditional Chinese medicine, and the curative rate reaches 86%.
Owner:GREAT BIOLOGY PHARMA TIANJIN

Formula of bypass rumen protection niacin for preventing dairy cow ketosis and preparation method

The invention discloses a formula of bypass rumen protection niacin for preventing dairy cow ketosis and a preparation method. The formula comprises a coating and a coated core, wherein the coating adopts rumen fatty powder; the active composition of the coated core adopts niacin; and the ratio of the coating to the coated core is (40-70): (30-60). The formula ensures that the active composition niacin is efficiently absorbed by a dairy cow through a bypass rumen coating technology, improves the feed intake of the dairy cow, further reduces the incidence rates of perinatal diseases, such as ketosis, fatty liver and left displaced abomasums, of the dairy cow, increases the milk production of the dairy cow, and realizes cost decreasing and benefit increasing for a pasture, and the niacin has the effects of restraining body fat mobilization of the dairy cow and improving the dry matter intake of the dairy cow; the formula greatly reduces the degradation of the active composition niacin in the rumen of the dairy cow; the coating technology is reasonable, coating is uniform and complete, bypass rumen effect is ideal, the niacin content is high, the niacin has an ideal physical form, the particles are small and even, the flowability is high, and the niacin is easy to directly use in production.
Owner:BEIJING ORIENTAL KINGHERD BIOTECH

Agent for improving ketosis

InactiveUS6677363B1Improving ketosisImproving acidosisBiocideOrganic active ingredientsKetosisEndocrinology
An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity.
Owner:TAKEDA PHARMA CO LTD

Breath ketone detector

Ketoacidosis is an extreme and uncontrolled form of ketosis, which is a normal response to prolonged fasting. Embodiments of this invention test the ketone level of a patient by measuring the ketone bodies in breath condensation. Some embodiments include a device for medical testing comprising a hollow container, comprising powder mixture of sodium nitroferricyanide, ammonium sulfate and silica and a liquid including an ammonium hydroxide solution.
Owner:AKERS BIOSCI

Licking brick for preventing and treating dairy cow ketosis

The invention relates to a licking brick for preventing and treating dairy cow ketosis, relates to a dairy cow licking brick, and is used for solving the problems of being short in pharmaceutical effect lasting time, treated in symptoms, instead of root causes, high in recurrence rate and recurrence frequency and poor in palatability in the existing medicine for treating dairy cow ketosis. The licking brick for preventing and treating dairy cow ketosis is mainly composed of 20-30 g of chloral hydrate, 150-250 g of xylitol, 200-300 g of propylene glycol, 4-5 g of nicotinic acid, 25-35 g of nicotinic acid, 25-35 g of lysine, 40-60 g of methionine and 700-1000 g of molasses. According to the invention, dairy cow ketosis treatment components are prepared into the licking brick; and therefore, the licking brick has the advantages of being high in palatability, simple in drug administration manner, automatic for dairy cows to lick, manpower-saving and the like.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Agent for improving acidosis

InactiveUS20040106649A1Easy to useImproving ketosisBiocideMetabolism disorderKetosisLow toxicity
An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity.
Owner:TAKEDA PHARMA CO LTD
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