90results about How to "Prevent liver damage" patented technology

There is disclosed a method for preventing CCL4 (carbon tetracloride) induced liver damage comprising the prophylactic administration of extracts of Morinda citrifolia. The Morinda citrifolia may be administered in solid or liquid forms. Several regimens are disclosed including the administration of 2 ounces twice daily in a liquid form such as that sold by Morinda, Inc.

The invention relates to a composite biological preparation with an obvious chemical hepatic injury protecting function, which consists of the following raw materials in weight ratio: 15-18 parts of glycine, 12-15 parts of arginine, 15-18 parts of cysteine, 16-18 parts of glutamine, 7-10 parts of S-adenosylmethionine and 7-12 parts of alpha-lipoic acid. The composite biological preparation has favorable therapeutic action and prevention action to all hepatic injury caused by various reasons, and has the effective rate (effectual rate) of 98.6% and the cure rate of 76.8%.

The invention discloses a special marine dietary food for patients with liver deficiency. The dietary food is prepared from the food-borne marine oligopeptides as the main raw materials, and marine bioactive polysaccharide, seaweed powder, nutritional amino acids, oligosaccharides, nutrients, vitamins and minerals by mixing. The special marine dietary food can be made into powder or particles anddissolved by warm water for use. The special marine dietary food can be easily dissolved, and has the greatest biological absorption and maximum bioavailability for human body. The special marine dietary food can provide body with marine protein with high-quality, activity factors and nutrients, and supplement essential vitamins and minerals for human body, and can be helpful to improve the nutritional condition of patients with liver deficiency. Through the coordination of the food-borne marine oligopeptides, the biological active ingredients in the marine bioactive polysaccharides in, the seaweed powder, the nutritional amino acids and other factors together, the special marine dietary food can protect human livers, and improve the immunity to prevent the occurrence of liver disease. The food is suitable for the patients with liver deficiency.

The invention provides a full-nutritional formula food, a specific full-nutritional formula food or a non-full-nutritional formula food for patients with deficiency of the kidney. The formula is on the basis of the requirements of general principles of formula food with special medical use, is combined with the constitutive characters of the patients with deficiency of the kidney, is integrated with the advanced research results of physiology, medicine, nutriology, clinical application and the like of Harvard University at present, and is developed according to the traditional Chinese medicine essence theory (with the main principle of homology of three internal organs including liver, spleen and kidney) of'reinforcing middle energizer to reside the dispelling Qi' and'balancing aftercare'. The product takes multiple medicine and food dual-purpose traditional Chinese medicine extract essences, multiple probiotics and oligopeptides as main raw materials, and takes prebiotics, carbohydrate, amino acid, multi-vitamins and mineral substances as auxiliary materials and is prepared by mixing the main raw materials and the auxiliary materials, thus being used as a single nutrition source to meet the demand for nutrition of the patients with deficiency of the kidney, but also having the effects of invigorating the kidney and strengthening Yang, boosting essence and replenishing marrow, relieving convulsion and calming the nerves, arresting sweating and securing essence, building body, tonifying kidney and strengthening yang-qi, and nourishing the liver to improve visual acuity.

An ester formed from an inositol or an inositol derivative and niacin, wherein the inositol or the inositol derivatives comprises a stereoisomer selected from allo-inositol, cis-inositol, epi-inositol, muco-inositol, neo-inositol, scyllo-inositol, D-chiro-inositol and L-chiro-inositol, or pharmaceutically acceptable salts thereof. Examples of esters include inositol hexaniacinates such as allo-inositol hexaniacinate and cis-inositol hexaniacinate. The esters can be used to treat any disorder that is treatable with niacin therapy such as dyslipidemia, hypercholesterolemia, hyperlipidemia or cardiovascular disease. The esters can be administered with other agents such as HMG-CoA reductase inhibitors, statins, fibrates, activators of peroxisome proliferator activated receptors poli-cosanol, phytosterols, tocotrienols, calcium, bile acid sequestrants, guar gum and free niacin. The invention includes pharmaceutical compositions containing these compounds.

The invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for treatment and/or prevention of liver injury. The invention further relates to the use of IL-18 inhibitors in the preparation of a medicament for treatment and/or prevention of arthritis, in particular rheumatoid arthritis. In addition to this, the invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for treatment and/or prevention of inflammatory bowel diseases, in particular of Crohn's disease and ulcerative colitis.

The invention provides a penthorum chinense pursh extract. The HPLC finger-print is characterized by comprising four characteristic peaks, wherein the retention time of the first peak is 10.4+/-0.25 min, and the peak area of the first peak is 1682000+/-8000; the retention time of the second peak is 12.5+/-0.25 min, and the peak area of the second peak is 36750+/-700; the retention time of the third peak is 13.0+/-0.25 min, and the peak area of the third peak is 2461000+/-3000; the retention time of the fourth peak is 14.9+/-0.25 min, and the peak area of the fourth peak is 1831000+/-5000. The treatment effect of the penthorum chinense pursh extract is excellent in treating hepatic ischemia reperfusion liver injuries and chemical liver injuries and has broad clinical application prospects.

The invention discloses application of adenosine and derivatives thereof in prevention and treatment of medicament-induced liver injury, relating to application of adenosine and derivatives thereof such as adenosine monophosphate, adenosine diphosphate and adenosine triphosphate in protection of acetaminophen-induced liver injury. A mouse model adopted in the application is an acetaminophen-induced mouse acute hepatic failure model, the dosage of the adenosine or derivatives thereof is 0.1 to 5mmol/kg, and the adenosine and derivatives thereof can reduce the activities of aspartate aminotransferase (AST) and alanine transaminase (ALT) in the medicament-induced liver injury, reduce the substantial cell necrosis area and improve the glutathione level so as to prevent and treat the acetaminophen-induced liver injury caused by liver toxic medicaments. Animal experiments prove that the adenosine and derivatives thereof have a significant effect on preventing and treating the medicament-induced liver injury, so the adenosine and derivatives thereof can be used for the preventing and treating processes of the medicament-induced liver injury, and a new method and means are provided for clinically treating the medicament-induced liver injury.

The invention provides an application of pinocembrin dihydrogen chalcone-7-O-[3'-O-galloyl-4',6'-hexahydroxydiphenodicarboxy]-beta-D-glucoside in preparation of a liver protection medicine. The penthorum chinense pursh macrocyclic polyphenol monomer namely pinocembrin dihydrogen chalcone-7-O-[3'-O-galloyl-4',6'-hexahydroxydiphenodicarboxy]-beta-D-glucoside has a liver protection effect, can be used for preventing and treating liver injuries, and has a definite curative effect on hepatic ischemia-reperfusion injuries and chronic liver injuries, and the effect is superior to that of positive medicine namely Gansu Granules, so that the penthorum chinense pursh macrocyclic polyphenol monomer can be used for replacing the Gansu Granules and has a good clinical application prospect.

The present invention discloses an application of corydalis saxicola and a preparation thereof in treating non-alcoholic fatty liver diseases and/or non-alcoholic steatohepatitis. According to the invention, through a large amount of experimental screening, it is found that corydalis saxicola total alkaloids have good effects of reducing synthesis in fatty acid cells, and can reduce the levels ofTG, TC, LDL cholesterol, HDL cholesterol and free fatty acid induced by HFD. Animal anatomical experiments show that the corydalis saxicola total alkaloids can effectively reduce the weight of livers,and pathological sections show that liver tissues are well protected. In addition clinical experiments show that corydalis saxicola total alkaloid capsules can obviously improve biochemical indexes and imaging evaluation results of fatty liver patients. The drug-induced liver injury experimental results show that the corydalis saxicola total alkali capsules can obviously improve drug-induced liver injury and have the effect of preventing liver injury.

The invention relates to a liver damage relevant drug target and application thereof. The drug target is stearoyl coenzyme A desaturase (Scd1), and liver damage of mammals can be obviously relieved bydescending the expression of Scd1. The invention also discloses application of antagonist of Scd1 in preparing a composite for inhibiting liver damage of mammals. The invention further discloses a method for screening a potential material for inhibiting liver damage of mammals.

The application of a peptide having sequence of formula I or its derivant in preparing the medicine for preventing or treating liver damage, especially liver damage and hepatitis C is disclosed, Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4 (formula I) wherein, Xaa1 is deletion, Ala,Gly,Val,Leu or Ile, Xaa2 is Thr or Ser, Xaa3 is Tyr, Phe or Trp, and Xaa4 is deletion, Ala, Gly, Val, Leu,Ile or Pro. The composite medicine containing the said peptide, its preparation method, and the polynucleotide for coding the said peptide are also disclosed.

The invention discloses application of an HLA-B (Human Leukocyte Antigen-B)*35: 01 allele. The HLA-B*35: 01 allele is characterized in that 1, the HLA-B*35: 01 allele can be used as a genetic marker and a treatment target point and is used for preparing a detection reagent for predicating liver injury causing risks of polygoni multiflori and components of the polygoni multiflori; 2, the HLA-B*35: 01 allele is used as the treatment target point and is used for preparing a medicine for treating polygoni multiflori caused liver injuries; 3, the HLA-B*35: 01 allele is used as the marker and is used for preparing a detection reagent for screening high-sensitivity crowd with the liver injuries caused by the polygoni multiflori and substances containing the polygoni multiflori matters.

The invention relates to an application of tanshinone II A, namely natural extract of radix salviae miltiorrhizae, in preparation of medicines used for treating or preventing the liver damage. The invention also relates to an application of the tanshinone II A in preparation of medicines used for treating or preventing diseases related to the activity increase of glutamic pyruvic transaminase.

The invention discloses a formula of a hyperosteogeny treatment emplastrum. The formula comprises 3-5g of pangolin, 3-5g of ground beetle, 6-10g of Ligusticum wallichii, 6-10g of Aconitum kusnezoffii, 6-10g of Boswellia carteri, 6-10g of myrrh, 10-15g of Viciaamoena Fisch, 10-15g of Rhizoma Cibotii, 10-15g of Eucommia ulmoides, 10-15g of Chinese Taxillus Twig, 10-15g of Malaytea Scurfpea Fruit, 10-15g of Fructus Aurantii, 10-15g of Achyranthes bidentata, 10-15g of Salvia miltiorrhiza and 10-15g of Millettia dielsiana. The above components are respectively ground to fine particles with the size of 200-300 meshes, and the fine particles are mixed and blended in proportion to obtain the emplastrum for the external application of an afflicted part. The hyperosteogeny treatment emplastrum has the advantages of very fast treatment effectiveness, lasting and non-bounce effect, fundamental removal of the hyperosteogeny after long-term lasting use, no toxic side effects, avoiding of the damages of the oral administration of traditional Chinese medicines the liver and the kidney because of direct action on acupuncture points, and protruding effect especially on joint swelling, aches and limited activity caused by the hyperosteogeny.

The invention discloses a Chinese medicine preparation for treating hepatitis and a preparation method thereof. The Chinese medicine preparation comprises the following main raw materials by weight parts: 6-100 of costus root, 9-200 of radices isatidis seu baphicacanthi, 8-150 of radices curcumae zedoariae, 8-150 of cortex magnoliae officinalis, 8-150 of herba artemisiae, 7-120 of milfoil herb extract, 9-200 of rhizoma cyperi and 8-150 of semen litchi. The preparation method comprises the following steps: cleaning, drying and crushing the medicinal materials, dipping in water, merging filtrate which is decocted twice to obtain extractive, concentrating the extractive into thick paste, crushing the thick paste to obtain medicine powder and adding proper quantity of excipients into the evenly mixed powder to be prepared into medicinal capsules, tablets, granules or guttate pills. The invention has the function for obviously improving the liver function and inhibiting liver damage and hepatitis virus, treats both the incidental and fundamental aspects, and has short treatment cycle, low recurrence rate and curative effect to hepatitis A, B and C, cirrhosis and hepatic adipose infiltration.

The invention relates to the technical field of traditional Chinese medicine and discloses application of walking fern and liver function revised tea. The liver function revised tea made of the walking fern serving as an active substance has remarkable curative effect on chemical liver injury and pathological liver injury caused by various reasons including alcohol, carbon tetrachloride, paracetamol, dexamethasone combined alcohol, concanavalin A and the like. The fact that the walking fern can be applied to preparation of pharmaceuticals for preventing and treating liver injury caused by various reasons and liver malfunction caused by the liver injury is demonstrated.

The present invention discloses alcoholism-dispelling and liver-protecting Chinese caterpillar fungus oligopeptide tableting candy. The tableting candy comprises the following components in parts by weight: 25-35 parts of Chinese caterpillar fungus polysaccharide compounds, 15-25 parts of kudzuvine root, 8-12 parts of Chinese yams, 14-18 parts of corn oligopeptide, 10-14 parts of Chinese wolfberryfruits, 16-20 parts of albumin peptide and the balance medical or food health-care accessory materials. The particularity of the Chinese caterpillar fungus polysaccharide compounds realizes the further enhancement of the functions of the albumin peptide, kudzuvine root powder, Chinese yams, corn oligopeptide and Chinese wolfberry fruits. The various ingredients are reasonably combined to realizethe purposes of accelerating alcohol metabolism, protecting liver and preventing liver damage. Moreover, the medicinally and edibly homologous raw materials are used; the food raw materials having thehighest safety level and not limited in use amount are reasonably combined; and the tableting candy has effects and safety, and is free of side effects and dose limiting value.

A drink composition for preventing alcohol-induced liver damage, which is effective for hangover relief and which contains 2 to 4 wt % of black ginseng, 4 to 7 wt % of blueberry, 0.3 to 1 wt % of dry yeast, 0.5 to 1.5 wt % of jujube pulp, and 2 to 4 wt % of oriental raisin tree fruit and is produced by hot-water extraction using the remaining wt % of purified water. The composition has a liver damage suppressing effect, reduces hepatitis activity index, and thus may be used as a composition capable of preventing or treating various liver diseases. Furthermore, it has very excellent effects on alcohol degradation and acetaldehyde degradation, alleviates headache and vomiting symptoms the next day after drinking, and thus is also very useful as a composition for liver protection or hangover relief, which is taken before and after alcohol drinking.

The invention relates to the medical biology field, in particular to a hydrogen-rich alcohol beverage without impairing the liver, and a preparation method and application of the hydrogen-rich alcohol beverage. Hydrogen is directly dissolved into an alcohol beverage to form the hydrogen-rich alcohol beverage, and liver injuries caused by ethyl alcohol are lightened; the hydrogen-rich alcohol beverage especially aims at crowds already with alcoholic and non-alcoholic fatty liver injuries to favorably prevent and treat the further liver injuries of alcoholic and non-alcoholic fatty liver patients when hydrogen concentration is 1ppm; and the protection function is especially obvious for beverages of which the alcohol content is 38% (including 38%) or below, and the hydrogen-rich alcohol beverage even can achieve an effect like drinking water.

The invention relates to the field of preparation of veterinary herbal medicine, provides traditional Chinese medicine for treating animal fever and a preparation method, and particularly relates to the traditional Chinese medicine for treating fever of pigs, chickens, cattles, goats, horses, dogs and rabbits during an initial period, and the preparation method. The invention has the beneficial effects that the traditional Chinese medicine for treating the animal fever is prepared from the following raw materials in parts by weight: 5 to 35 parts of honeysuckle flower, 5 to 35 parts of fructusforsythiae, 5 to 35 parts of radix bupleuri, 5 to 35 parts of rhizoma anemarrhenae, 5 to 35 parts of lightyellow sophora root, 5 to 35 parts of medulla tetrapanacis, 5 to 35 parts of radix platycodi,5 to 35 parts of radix paeoniae alba, 2 to 15 parts of liquorice root and accessory, wherein the accessory is prepared from dextrin and saccharose. The traditional Chinese medicine provided by the invention is guided by pharmaceutical theory of the veterinary herbal medicine and is mainly prepared aiming at flu fever of poultry and livestock; the traditional Chinese medicine is capable of nourishing blood, protecting liver and preventing liver damage caused by fever through the radix paeoniae alba, tonifying middle-jiao and benefiting qi through the liquorice root, clearing heat, detoxifying,diminishing inflammation and purging intense heat through the matching of the honeysuckle flower, the fructus forsythiae, the radix bupleuri, the rhizoma anemarrhenae, the lightyellow sophora root, medulla tetrapanacis, the radix platycodi and the like and purposefully relieving a series of symptoms of dizziness, nasal obstruction, coughing, throat discomfort and the like caused by the fever, sothat the purpose of rapidly treating the fever on the basis of protecting the body can be achieved.

A disclosed plaster formula for treating cervical spondylosis comprises 3 g of squama manis, 3 g of eupolyphaga seu steleophaga, 6 g of ligusticum wallichii, 6 g of radix aconiti kusnezoffii, 6 g of frankincense, 6 g of myrrh, 10 g of trberculate speranskia herb, 10 g of rhizoma cibotii, 10 g of cortex eucommiae, 10 g of herba taxilli, 10 g of fructus psoraleae, 10 g of fructus aurantii, 10 g of radix achyranthis bidentatae, 10 g of radix salviae miltiorrhizae and 10 g of caulis spatholobi. The plaster formula employs pure traditional Chinese medicines, has no hormones, and is capable of rapidly relieving symptoms such as dizziness, head numbness and the like caused by cervical spondylosis, and compared with conventional plasters, the plaster formula is rapid in effectiveness and durable in effect.