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Agent for suppressing elevation of blood alcohol concentration and method for suppressing elevation of blood alcohol concentration

一种酒精浓度、抑制剂的技术，应用在抑制摄取酒精饮料时血中酒精浓度急剧上升的抑制剂领域，能够解决效果不充分、饮料投予困难、实用化少等问题，达到容易投予、预防肝损伤、健康饮酒的效果

Active Publication Date: 2013-06-19
MATSUTANI CHEM INDS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the effect of the above-mentioned prior art is not sufficient, and there are difficulties in the administration of the beverage, etc., and few of them have been put into practical use.

Method used

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  • Agent for suppressing elevation of blood alcohol concentration and method for suppressing elevation of blood alcohol concentration
  • Agent for suppressing elevation of blood alcohol concentration and method for suppressing elevation of blood alcohol concentration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Purified water (H 2 O), 40% dextrin (TK-16) aqueous solution or 40% indigestible dextrin (Fibersol 2 (sometimes abbreviated as FS2)) aqueous solution and an equal amount of 40% ethanol aqueous solution. The total dose of the solution was set to 6 g per 1 kg of body weight, and blood was collected from the tail vein before the administration (0 minutes) and from 30 minutes to 240 minutes after the administration, and was used by Wako Pure Chemical Industries ( Co., Ltd.) ethanol assay kit (F-kit) to measure ethanol concentration in blood. The collected blood was mixed with 8 times the amount of 0.33M ice-cooled perchloric acid, centrifuged, and the obtained supernatant was used for measurement.

[0045] The evolution of blood ethanol concentration up to 240 minutes after administration of each solution is shown in figure 1 . The ethanol concentration in the blood showed a peak 60 minutes after administration, and almost disappeared after 240 minutes. In the FS2-admin...

Embodiment 2

[0047] Purified water (H 2 O), 20% indigestible dextrin (FS2) aqueous solution or 40% indigestible dextrin (FS2) aqueous solution and an equal amount of 40% ethanol aqueous solution. Table 1 shows the indigestible dextrin concentrations of the administered solutions.

[0048] The total dose of the solution administered was 6 g per 1 kg of body weight, and blood was collected from the tail vein before the administration (0 minutes) and after 30 minutes to 240 minutes after the administration, and measured using the F-kit blood alcohol concentration. The collected blood was mixed with 8 times the amount of 0.33M ice-cooled perchloric acid, centrifuged, and the obtained supernatant was used for measurement.

[0049] Table 1

[0050] group

Indigestible dextrin concentration (%)

Purified water (H 2 O)

0

20% FS2

10

40%FS2

20

[0051] The evolution of blood ethanol concentration up to 240 minutes after administration of each ...

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Abstract

The present invention provides an agent for suppressing elevation of blood alcohol concentration and a method for suppressing elevation of blood alcohol concentration, the agent and the method enabling prevention of an intoxication state upon drinking and further prevention of hepatic dysfunctions due to drinking such as fatty liver. Provided are an agent for suppressing elevation of blood alcohol concentration, comprising a dextrin as an active ingredient, and a method for suppressing elevation of blood alcohol concentration, comprising, when alcohol is ingested, ingesting 0.5 parts by mass or more of a digestible dextrin and / or an indigestible dextrin relative to 1 part by mass of the ingested alcohol.

Description

technical field [0001] The present invention relates to an inhibitor and a method for inhibiting a sharp rise in blood alcohol concentration when alcoholic beverages are ingested. Background technique [0002] In the case of excessive alcohol intake, acute and chronic symptoms of intoxication are often seen. Therefore, various studies have been conducted to find specific drugs to prevent drunkenness, promote sobriety, and prevent alcoholism. In particular, various substances including rumors from ancient times have been proposed regarding the prevention of drunkenness and promotion of sobering up. [0003] For example, it has previously been proposed that fructose and glucose, persimmon extracts, organic acids, sodium acetate, yeast cells, ω6 unsaturated fatty acids, carnitine chloride, bamboo ginseng, eleuthero, etc. As a hangover preventive or hangover malaise preventer. [0004] In addition, for example, Patent Document 1 discloses an alcohol absorption inhibiting compo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/718A61P39/02A61P1/16C12C5/00C12G3/04A23L33/00A23L29/269
CPCA61K31/718A23V2002/00A23L29/35A61K31/716A61P1/16A61P25/32A61P39/00A61P39/02A61P43/00A23V2200/334A23V2250/5114A23L33/00A23L29/269A61K31/721
Inventor 宫里祥子岸本由香
Owner MATSUTANI CHEM INDS CO LTD
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