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194results about How to "Lessen liver damage" patented technology

Pediococcus pentosaceus and application thereof

The invention discloses pediococcus pentosaceus and application thereof. The Latin name of the pediococcus pentosaceus is Pediococcus pentosaceus LI05, and the pediococcus pentosaceus is preserved in the China General Microbiological Culture Collection Center and has a preservation number of CGMCC No.7049. The pediococcus pentosaceus disclosed by the invention has the morphological characteristics that the thallus is rod-shaped, dose not generate spores, does not have motility, and has masculine Gram staining. The whole-cell fatty acid of the pediococcus pentosaceus disclosed by the invention comprises the following main components in percentage by weight: about 1.45% of 14:0, about 3.26% of 16:1w7c / 16:1w6c, about 31.25% of 16:0, about 6.31% of 18:1w9c, about 38.59% of 18:1w7c, about 1.37% of 18:0 and about 14.59% of un18.846 / 19:1w6c. The invention also discloses a complete sequence of 16S ribosome DNA (16SrDNA) of the pediococcus pentosaceus. The pediococcus pentosaceus and a preparation thereof disclosed by the invention can be used for adjusting the micro-ecological balance of intestinal tracts of human or animals, promoting digestive absorption and slowing down the happening and development of liver failure of experimental animals.
Owner:ZHEJIANG UNIV

Bamboo liquid wine and preparation method thereof

The invention discloses a bamboo liquid wine and a preparation method thereof, and belongs to the healthcare wine field. The bamboo liquid wine is obtained through commonly fermenting 25-45 parts by weight of a bamboo product and 55-75 parts by weight of a grain. The preparation method of the bamboo liquid wine comprises the following steps: fully mixing the bamboo product with the grain, adding Saccharomyces cerevisiae, and fermenting. In the invention, the bamboo product added to the wine as a raw material and fermented together with the grain has the health caring and health preserving efficacies of liver injury mitigation and internal fire mitigation.
Owner:王铁军

Nutrient black soya bean powder prepared by fermentation of bacillus natto and preparation method thereof

The invention discloses nutrient black soya bean powder prepared by fermentation of bacillus natto and a preparation method thereof. The preparation method comprises the following steps: (1) peeling black soya bean; (2) superfine grinding; (3) cooking for sterilizing; (4) fermenting by using bacillus natto, namely inoculating the amplified bacillus natto to the sterilized material and cultivating for 1-5 days under the conditions that the agitating speed of a rotary shaker is 160rpm and the temperature is 30 DEG C; (5) carrying out compound enzyme enzymolysis, namely adding deionized water to adjust pH after fermentation is finished, adding cellulose, papain and lysozyme to carry out enzymolysis for 0.5-6 hours; and (6) carrying out spray drying, so as to obtain nutrient powder. The product nutrient black soya bean powder disclosed by the invention is rich in nattokinase and polypeptide, and is reasonable in process, abundant in nutrients, fine in texture, good in solubility and long in storage period. The product, namely the nutrient black soya bean powder obtained by the method, can be prepared into capsules, tablets and granules by a conventional method, can be used as a health-care food, and has significant effects of helping to dissolve thrombus, reducing blood fat and preventing liver injury.
Owner:厦门元之道生物科技有限公司

Hepatoprotectant acetaminophen mutual prodrugs

The present invention provides hepatoprotectant acetaminophen mutual prodrugs, which have an acetaminophen moiety covalently linked to a second moiety that may act as a hepatoprotectant against acetaminophen hepatotoxicity. Additionally, acetaminophen mutual prodrugs may have improved water solubility which may provide better suitability for parenteral and other dosage forms relative to administration of acetaminophen. Also provided are methods of treating a disease or condition that is responsive to acetaminophen (such as fever, pain and ischemic injury) using hepatoprotectant acetaminophen mutual prodrugs, as well as kits and unit dosages.
Owner:ACORDA THERAPEUTICS INC

Pharmaceutical composition of alanyl glutamine injection and compound amino acid injection

The invention relates to a pharmaceutical composition of an alanyl glutamine injection and a compound amino acid injection, in particular to combination application package. The pharmaceutical composition comprises the alanyl glutamine injection and the compound amino acid injection. When the pharmaceutical composition is in use, the alanyl glutamine injection and the compound amino acid injection are jointly utilized and are intravenously dripped. The combination application package greatly facilitates the requirement of clinical application.
Owner:灵康药业集团股份有限公司

Extractive of traditional Chinese medicine and capsule for treating fatty liver, and its preparing method

A Chinese medicine in the form of capsule for treating fatty liver, chronic hepatitis and hepatofibrosis is prepared from general coumarin, general curcumin, general ginsenoside and pharmacologically acceptable assistants. Its preparing process is also disclosed.
Owner:THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL

Traditional Chinese medicine composite for protecting livers and preventing liver injury and preparation method thereof

InactiveCN101869603AEmbody the idea of ​​"preventive cure"Lessen liver damageDigestive systemPlant ingredientsPathology studyGLYCYRRHIZA EXTRACT
The invention discloses a traditional Chinese medicine composite for protecting livers and preventing liver injury and a preparation method and application thereof. The composite comprises the following bulk drugs in parts by weight: 20-30 parts of astraglus base, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of tuckahoe, 10-15 parts of liquorice and 10-15 parts of Schisandra chinensis. The preparation method comprises the following steps of: adding water to the bulk drugs in percentage by weight and decocting, and concentrating until the concentration is equivalent to 0.55-0.75g.ml-1 which is the concentration of crude drugs. Proved by animal experiment pathological study, the spleen-tonifying and liver-protecting prescription of the invention does not have hepatotoxicity per se and has a certain function of preventing mice acute liver injury caused by CCl4. The prescription not only can relieve the liver injury of jasmine on normal mice but also can assist routine dosage of jasmine to prevent the mice acute liver injury caused by CCl4. The invention is safe and effective and has low price and is suitable for patients with chemical and medicament liver injury.
Owner:SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M

Method for enriching 2-diabetes mellitus target inhibitor from liquorice residue and medical application

InactiveCN107510710ASignificant activity inhibitionReasonable combination designAntipyreticMetabolism disorderPolyamideSolvent
The invention belongs to the technical field of medicines and provides a method for adsorbing, purifying and acquiring liquorice residue total flavone with clear component, clear structure, high active substance content and high activity from liquorice residue after extracting glycyrrhizic acid by using macroporous resin as a main material (above 50%), polyamide as an auxiliary material and a compound adsorbing material prepared from one or two MCI mixed at different ratio according to a compound adsorbing purifying method and a medical application thereof at the aspects of blood sugar regulation, liver injury protection, blood lipids regulation, tumor growth suppression, and the like. According to the invention, various adsorbing materials are reasonably combined and designed and the adsorbing purifying technical operation is simple and feasible; the solvent use is safe, environment-friendly and economical; and the liquorice residue total flavone has an obvious restraining effect for two important targets, namely, alpha-glucosidase and PTP1B for preventing and controlling 2-diabetes mellitus, and especially, the restraining effect strength for alpha-glucosidase is at least 10 times higher than that of clinic hypoglycemic drug acarbose.
Owner:SHENYANG PHARMA UNIVERSITY

Feed without public nuisance

A forage without environmental pollution for improving immunity and increasing the ratio of lean meat is prepared from the basic forage (98-99 Wt%) and the Chinese-medicinal mixture (1-2 Wt%) through mixing.
Owner:黑龙江省庆隆农业高科技综合推广有限公司

Pawpaw distilled liquor and preparation method thereof

The invention discloses a pawpaw distilled liquor and a preparation method thereof, belonging to the technical field of food processing and biological fermentation. The preparation method comprises the steps of: biologically fermenting papaya juice so as to transform carbohydrate into ethyl alcohol fully; and then preparing the pawpaw distilled liquor through twice distillation, storage, aging, mixing and filtration, wherein the distillation can improve an alcohol content, reduce contents of organic acids and polyphenols, and guarantee a relatively long expiration date and good mouth feeling of a finished liquor; and the contents of effective components in the finished liquor can be improved by mixing and adding a fermentation wine base into the distilled liquor. According to the invention, the pawpaw distilled liquor has the total content of the acids of 1-3 g / L, the total polyphenol content of 0.5-1.5 g / L and the alcoholic strength of 42-52%vol, is clear, transparent and full-bodied, rich in nutrition, fine and smooth as well as pure and mild in taste, has a full-bodied pawpaw smell, a soft taste and a refreshing feeling, and can be preserved for a long term at a normal temperature.
Owner:许臣中

Preparation of low deuterium spirit

The invention relates to the technical field of the white spirit preparation, in particular to a method for preparing low deuterium white spirit, comprising the following: (1) a step of blending materials; (2) a step of baking to enclose materials; (3) a step of stewing and pasting; (4) a step of ventilating to cool dregs; (5) a step of adding seriflux; (6) a step of stirring evenly to put into a cellar and of saccharifying to ferment; (7) a step of taking out of the cellar to distill; (8) a step of adjusting flavor and blending; and (9) a step of canning the finished product. The method is characterized in that in the processes of baking to enclose materials, adding seriflux and / or adjusting flavor and blending, low deuterium water is used and the low deuterium water with the content of the deuterium between 0 and 135ppm is taken as a raw material for the production processing. Compared with the prior art, the method has the advantages: 1. the product not only keeps the style of the prior white spirit but also has mellow quality and soft mouthfeel; and 2. the content of the deuterium in the white spirit body is low, and the white spirit has the physiological functions of improving the human immunity, delaying senility, reducing the blood fat, and reducing the liver injury, and the like.
Owner:上海池天超轻水生物工程有限公司 +1

Novel edaravone preparation and preparation method thereof

The invention provides a preparation by which an edaravone drug can be targeted to a brain by virtue of a nasal delivery route, and a preparation method of the preparation. The edaravone nasal delivery preparation of the invention consists of an active ingredient, namely edaravone, and pharmaceutically acceptable effective adjuvant materials. The edaravone nasal preparation disclosed by the invention, after administration, can be rapidly absorbed and can rapidly reach the brain and enrich in the brain, so that a drug concentration in the brain, higher than that of an injection, which is administrated by an equivalent dosage, is provided, and a therapeutic effect on corresponding diseases is improved; meanwhile, by reducing edaravone concentrations in blood and other tissues, edaravone adverse reactions such as liver function damage and the like can be relieved; in addition, the compliance of patients can be improved; and the preparation is suitable for self-administration, so that the preparation, in the case of diseases, can be timely administrated as soon as possible.
Owner:NANJING HAIHENG MEDICINE SCI & TECH CO LTD

Antialcoholism formula and preparation method thereof

The invention relates to the field of food and health-care products and particularly discloses an antialcoholism formula and a preparation method thereof. The antialcoholism formula comprises components in parts by weight as follows: 2-10 parts of hovenia acerba extract, 1-8 parts of kudzuvine root extract, 30-50 parts of hawthorn fruit powder, 5-15 parts of vine tea extract and 5-15 parts of propolis extract. The formula has the function of adjusting the viscera through reasonable matching and comprehensive utilization of methods for clearing away heat and toxic materials, promoting the circulation of qi, inducing diuresis, repairing liver injury and the like, further has the advantages of good nourishing, health care and antialcoholism effects and the like due to propolis with higher nutritional value, can effectively relieve alcoholic allergy, headache after drinking, acid stomach and other discomfort symptoms and also repair the liver injury caused by long-time drinking and doesn't have any toxic or side effects.
Owner:WUHAN HUASHITE IND BIOTECH DEV

Health care product with function of protecting alcoholic liver injury

The invention provides a health care product with a function of protecting alcoholic liver injury. The health care product is prepared from the following traditional Chinese medicines in parts by weight: 3-15 parts of roots of kudzu vines, 3-12 parts of Chinese wolfberries, 3-10 parts of turmeric and 2-6 parts of schisandra chinensis. The health care product with the function of protecting alcoholic liver injury provided by the invention can be used for accelerating ethanolic metabolism and protecting liver injury caused by excessive drinking in an auxiliary manner, further has a certain protective effect on chemical liver injury and can be used for preventing and treating liver injury caused by various reasons. The health care product is a liver protective agent which is quick in effect taking, low in cost and small in side effect. The composition provided by the invention is safe and easily available, can be taken for a long time, and is simple in preparation process and suitable for industrial production on a large scale.
Owner:LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE

Engineering rice with functions of alleviating hangover and protecting liver and preparation method of engineering rice

The invention relates to engineering rice with functions of alleviating hangover and protecting liver and a preparation method of the engineering rice. For people who drink for a long time or overdrink, the invention provides the engineering rice with functions of alleviating hangover and protecting liver and the reparation method of the engineering rice. The engineering rice comprises six raw materials of brown rice powder, soybean protein isolate, kudzuvine root extract, corn oligopeptide, purple sweet potato powder and hawthorn extract. The engineering rice is prepared by the following steps: premixing the raw materials; performing high-temperature high-pressure texturizing forming by using a double screw extruder; and drying, dedusting and packaging to obtain the engineering rice. Thecoarse cereal component of the engineering rice has the effects of balancing diet and guaranteeing nutrition ingestion of people who eat the engineering rice; and functional factors such as the corn oligopeptide, the kudzuvine root extract and the like have the functions of enhancing ethanol metabolism inside the bodies, reducing liver injury, alleviating hangover and protecting liver.
Owner:CHINA NAT RES INST OF FOOD & FERMENTATION IND CO LTD +3

Milk with auxiliary protection function for alcoholic liver injury

The invention discloses milk with auxiliary protection function for alcoholic liver injury, which comprises the following components in percentage by weight: 91 to 99 percent of raw material milk, 0.5 to 5 percent of water-soluble dietary fiber, 0.2 to 2 percent of lecithin, 0.15 to 1.5 percent of soybean polypeptide and 0.1 to 0.3 percent of stabilizing agent. The milk of the invention not only has rich nutrition and is helpful for improving the nutritive condition of alcoholic liver injury patients, but also has exquisite mouthfeel and mellow taste, and simultaneously can enhance the function of the liver, accelerate alcohol metabolism and aid to protect the liver injury caused by excessive drinking or chronic alcohol intake.
Owner:BRIGHT DAIRY & FOOD

Gardenia polysaccharide and preparation method and application thereof

The invention discloses gardenia polysaccharide and an extraction method thereof. The gardenia polysaccharide is prepared from the following raw materials (by mass): 41 to 56 percent of total sugar, 34 to 45 percent of uronic acid and 7 to 10 percent of protein. The preparation method of the gardenia polysaccharide comprises the following steps: crushing a gardenia medicinal material, degreasing,adding water, extracting, precipitating with ethanol, repeatedly freeze-thawing to remove protein, dialyzing, and freeze-drying. The gardenia polysaccharide prepared by the method can improve cholestatic liver injury induced by alpha-naphthalene isothiocyanate (ANIT) and 3, 5-diethoxycarbonyl-1, 4-dihydro-2, 4, 6-trimethylpyridine (DDC), and reduce fibrosis induced by carbon tetrachloride (CCL4).And the liver protection effect of the gardenia polysaccharide is not reported in literatures, which indicates that the gardenia polysaccharide has obvious application prospects in the preparation ofliver protection drugs, especially in the preparation of anti-cholestatic liver injury and anti-hepatic fibrosis drugs.
Owner:SHANGHAI UNIV OF T C M

Health-care tea

The invention relates to the technical field of drinks and particularly relates to a health-care tea. The health-care tea comprises the following raw materials: 4g of penthorum chinense pursh, 1.5g of tuckahoe, 1.5g of radix bupleuri, 1.5g of salvia miltiorrhiza, 2.5g of medlar, 1.3g of Chinese-date, 1.5g of herba lysimachiae, 1.2g of shizandra berry and 1g of semen cassiae. The raw materials are firstly crushed into powder; then, the power is stirred and mixed evenly; and finally the power is packaged with small bags; and powdery raw materials are obtained by pressing and grinding the raw materials dried in the sun. Compared with the prior art, the health-care tea is prepared from penthorum chinense pursh, tuckahoe, radix bupleuri, salvia miltiorrhiza, medlar, Chinese-date, herba lysimachiae, shizandra berry, semen cassia and the like, has the functions of protecting the liver, effectively improving human immunity and strengthening the body, and has no toxic or side effects.
Owner:张宗强

Antioxidant functional food prepared by probiotic solid-state fermentation and preparation method of antioxidant functional food

The invention provides an antioxidant functional food prepared by probiotic solid-state fermentation. According to the antioxidant functional food, a mixture of sea buckthorn, fructus jujubae, lens, and soybeans is taken as a fermentation substrate, lactobacillus reuteri, bifidobacterium longum, pediococcus acidilactici, lactobacillus plantarum, bifidobacterium animalis, lactobacillus paracasei, bifidobacterium adolescentis, bacillus coagulans and bacillus subtilis are adopted, and the antioxidant functional food is prepared through solid-state segmentation fermentation. The antioxidant functional food prepared by probiotic solid-state fermentation has the effects of anti-aging, detoxification and beautification, freckle removing and whitening, and the like.
Owner:天津创源生物技术有限公司

Preparation method and application of traditional Chinese medicine preparation with liver protection function

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a preparation method and application of a traditional Chinese medicine preparation with a liver protection function. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 3-5 parts of radix puerariae, 3-5parts of fructus lycii, 2-3 parts of semen hoveniae, 1-2 parts of ginseng and 1-2 parts of fructus schisandrae chinensis. The traditional Chinese medicine preparation is developed by combining the syndrome differentiation and treatment of traditional Chinese medicine and clinical practice, and has the characteristics of exact curative effect, safety, convenience, quick effect and no toxic or sideeffect in the aspect of liver protection.
Owner:森隆药业有限公司

Hepatoprotectant acetaminophen mutual prodrugs

The present invention provides hepatoprotectant acetaminophen mutual prodrugs, which have an acetaminophen moiety covalently linked to a second moiety that may act as a hepatoprotectant against acetaminophen hepatotoxicity. Additionally, acetaminophen mutual prodrugs may have improved water solubility which may provide better suitability for parenteral and other dosage forms relative to administration of acetaminophen. Also provided are methods of treating a disease or condition that is responsive to acetaminophen (such as fever, pain and ischemic injury) using hepatoprotectant acetaminophen mutual prodrugs, as well as kits and unit dosages.
Owner:ACORDA THERAPEUTICS INC

Lipopolysaccharide D galactosamine-induced liver injury animal protection model and construction method thereof

The invention belongs to the field of a medical medicine, and discloses a lipopolysaccharide D galactosamine-induced liver injury animal protection model and a construction method thereof. The mangiferin obviously inhibits generation of LPS / GalN-induced ALT and AST, and at the same time, the histology analysis hepatic tissue shows that the mangiferin obviously inhibits LPS / GalN-induced liver injury. The result shows that mangiferin has protection effect for LPS / GalN-induced liver injury. The mangiferin obviously inhibits generation of LPS / GalN-induced TNF-alpha, IL-1beta, iNOS, MCP-1 and RANTES. By inhibiting oxidative stress, cell apoptosis and inflammation reaction, the mangiferin can protect the LPS / GalN-induced liver injury, and the mangiferin can prevent a LPS / GalN-induced liver injury by activating Nrf2 / HO-1 signal pathway and inhibiting the activation of NLRP3 inflammasome.
Owner:THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE

Antiviral effect and application of epigenetic modifying enzyme SETD2

The invention discloses an antiviral effect and an application of an epigenetic modifying enzyme SETD2. The invention relates to the fields of biotechnology and medicine, and in particular to an anti-virus infection effect and an application of an immuno-regulatory molecule SETD2. Specifically, the invention relates to the SETD2 or an SETD2 coding sequence and an application of an accelerant of the SETD2 in preparing a medicine or a kit for inhibiting virus infection, and further relates to applications of the material in resisting virus infection and treating chronic inflammatory diseases caused by the virus infection, an application method and the corresponding medicine, a pharmaceutical composition or the kit. The SETD2 provided by the invention can be used for preventing and inhibiting the virus infection and enhancing a curative effect of interferon in resisting the virus infection, and the SETD2 has a broad application prospect.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

Method for improving anticancer activity of Codonopsis lanceolata Benth.et Hook.F

InactiveCN102091117AStop the progression of malignancyStop progressAntineoplastic agentsPlant ingredientsYeastCodonopsis pilosula
The invention relates to a method for improving the anticancer activity for Codonopsis lanceolata Benth.et Hook.F, which comprises: slicing or homogenizing fresh Codonopsis lanceolata Benth.et Hook.F, or crushing dry Codonopsis lanceolata Benth.et Hook.F, or powdering the dry Codonopsis Lanceolata Benth.et Hook.F; soaking in water; sterilizing under a high pressure; adding 0.5 to 5.0 percent of active yeast and 1 to 8 percent of glucose under a sterile condition when the temperature lowers to 30 DEG C; fermenting at 20 to 37 DEG C for 1 to 10 days, and adding a polar solvent after fermentation to extract for 5 to 24 hours at 0 to 100 DEG C; and filtering, recovering solvent and concentrating under reduced pressure or drying by freezing. The method can improve the inhibition effect of Codonopsis lanceolata Benth.et Hook.F on the growth of tumors.
Owner:YANBIAN UNIV

Engineered rice having alcoholism relief and liver protection function, and preparation method thereof

The present invention relates to a functional engineered rice having alcoholism relief and liver protection functions for those drinking alcohol over an extended period of time or drinking alcohol excessively, and preparation method thereof. The engineered rice comprises six starting materials: coarse rice powder, isolated soy protein, kudzu root extract, corn oligopeptide, purple sweet potato powder, and hawthorn extract, and is prepared by: premixing the starting materials; employing a double screw extruder to conduct texturized processing and forming under high temperature and high pressure; and then drying, dedusting and packaging. The coarse cereal components of the engineered rice have the effects of balancing the diet and ensuring nutrition ingestion for those consuming the rice; and the functional factors such as the corn oligopeptide, the kudzu root extract and the like have the functions of enhancing ethanol metabolism inside the body, reducing liver damage, relieving alcoholism and protecting the liver.
Owner:CHINA NAT RES INST OF FOOD & FERMENTATION IND CO LTD +1

Ganoderma lucidum low-fat pig skin jelly

The present invention discloses a ganoderma lucidum low-fat pig skin jelly which relates to the field of collagen protein food processing and consist of the following composition in parts by weight: 1-3 parts of ganoderma lucidum sporocarp extract, 5-7 parts of ganoderma lucidum sporocarp thick liquid, 100-125 parts of pig skin, and 4-5 parts of spicy seasonings. At the same time, the present invention discloses a preparation step of the ganoderma lucidum sporocarp extract and the ganoderma lucidum sporocarp thick liquid, the treatment steps of pig skin, and the composition of the spicy seasonings. In the treatment steps of pig skin, baking soda is added to heat the pig skin, pig skin fat is removed, pig skin is heated and rinsed with edible vinegar, which is beneficial to improve the separation degree of the oil and fat from pig skin, also can improve the boiling degree of pig skin, improves product flavor and taste, reduces costs, and improves economic efficiency; and at the same time, the ganoderma lucidum low-fat pig skin jelly enrich the pig skin jelly market, is a new pig skin jelly product, contains low fat, and has high nutritional health-care efficacy, good flavor and taste, and a high marketing value .
Owner:桐乡金橙云智科技有限公司
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