193results about How to "Lessen liver damage" patented technology

The invention discloses pediococcus pentosaceus and application thereof. The Latin name of the pediococcus pentosaceus is Pediococcus pentosaceus LI05, and the pediococcus pentosaceus is preserved in the China General Microbiological Culture Collection Center and has a preservation number of CGMCC No.7049. The pediococcus pentosaceus disclosed by the invention has the morphological characteristics that the thallus is rod-shaped, dose not generate spores, does not have motility, and has masculine Gram staining. The whole-cell fatty acid of the pediococcus pentosaceus disclosed by the invention comprises the following main components in percentage by weight: about 1.45% of 14:0, about 3.26% of 16:1w7c/16:1w6c, about 31.25% of 16:0, about 6.31% of 18:1w9c, about 38.59% of 18:1w7c, about 1.37% of 18:0 and about 14.59% of un18.846/19:1w6c. The invention also discloses a complete sequence of 16S ribosome DNA (16SrDNA) of the pediococcus pentosaceus. The pediococcus pentosaceus and a preparation thereof disclosed by the invention can be used for adjusting the micro-ecological balance of intestinal tracts of human or animals, promoting digestive absorption and slowing down the happening and development of liver failure of experimental animals.

The invention discloses nutrient black soya bean powder prepared by fermentation of bacillus natto and a preparation method thereof. The preparation method comprises the following steps: (1) peeling black soya bean; (2) superfine grinding; (3) cooking for sterilizing; (4) fermenting by using bacillus natto, namely inoculating the amplified bacillus natto to the sterilized material and cultivating for 1-5 days under the conditions that the agitating speed of a rotary shaker is 160rpm and the temperature is 30 DEG C; (5) carrying out compound enzyme enzymolysis, namely adding deionized water to adjust pH after fermentation is finished, adding cellulose, papain and lysozyme to carry out enzymolysis for 0.5-6 hours; and (6) carrying out spray drying, so as to obtain nutrient powder. The product nutrient black soya bean powder disclosed by the invention is rich in nattokinase and polypeptide, and is reasonable in process, abundant in nutrients, fine in texture, good in solubility and long in storage period. The product, namely the nutrient black soya bean powder obtained by the method, can be prepared into capsules, tablets and granules by a conventional method, can be used as a health-care food, and has significant effects of helping to dissolve thrombus, reducing blood fat and preventing liver injury.

The present invention provides hepatoprotectant acetaminophen mutual prodrugs, which have an acetaminophen moiety covalently linked to a second moiety that may act as a hepatoprotectant against acetaminophen hepatotoxicity. Additionally, acetaminophen mutual prodrugs may have improved water solubility which may provide better suitability for parenteral and other dosage forms relative to administration of acetaminophen. Also provided are methods of treating a disease or condition that is responsive to acetaminophen (such as fever, pain and ischemic injury) using hepatoprotectant acetaminophen mutual prodrugs, as well as kits and unit dosages.

A Chinese medicine in the form of capsule for treating fatty liver, chronic hepatitis and hepatofibrosis is prepared from general coumarin, general curcumin, general ginsenoside and pharmacologically acceptable assistants. Its preparing process is also disclosed.

The invention discloses a pawpaw distilled liquor and a preparation method thereof, belonging to the technical field of food processing and biological fermentation. The preparation method comprises the steps of: biologically fermenting papaya juice so as to transform carbohydrate into ethyl alcohol fully; and then preparing the pawpaw distilled liquor through twice distillation, storage, aging, mixing and filtration, wherein the distillation can improve an alcohol content, reduce contents of organic acids and polyphenols, and guarantee a relatively long expiration date and good mouth feeling of a finished liquor; and the contents of effective components in the finished liquor can be improved by mixing and adding a fermentation wine base into the distilled liquor. According to the invention, the pawpaw distilled liquor has the total content of the acids of 1-3 g/L, the total polyphenol content of 0.5-1.5 g/L and the alcoholic strength of 42-52%vol, is clear, transparent and full-bodied, rich in nutrition, fine and smooth as well as pure and mild in taste, has a full-bodied pawpaw smell, a soft taste and a refreshing feeling, and can be preserved for a long term at a normal temperature.

The invention relates to the field of food and health-care products and particularly discloses an antialcoholism formula and a preparation method thereof. The antialcoholism formula comprises components in parts by weight as follows: 2-10 parts of hovenia acerba extract, 1-8 parts of kudzuvine root extract, 30-50 parts of hawthorn fruit powder, 5-15 parts of vine tea extract and 5-15 parts of propolis extract. The formula has the function of adjusting the viscera through reasonable matching and comprehensive utilization of methods for clearing away heat and toxic materials, promoting the circulation of qi, inducing diuresis, repairing liver injury and the like, further has the advantages of good nourishing, health care and antialcoholism effects and the like due to propolis with higher nutritional value, can effectively relieve alcoholic allergy, headache after drinking, acid stomach and other discomfort symptoms and also repair the liver injury caused by long-time drinking and doesn't have any toxic or side effects.

The invention provides a health care product with a function of protecting alcoholic liver injury. The health care product is prepared from the following traditional Chinese medicines in parts by weight: 3-15 parts of roots of kudzu vines, 3-12 parts of Chinese wolfberries, 3-10 parts of turmeric and 2-6 parts of schisandra chinensis. The health care product with the function of protecting alcoholic liver injury provided by the invention can be used for accelerating ethanolic metabolism and protecting liver injury caused by excessive drinking in an auxiliary manner, further has a certain protective effect on chemical liver injury and can be used for preventing and treating liver injury caused by various reasons. The health care product is a liver protective agent which is quick in effect taking, low in cost and small in side effect. The composition provided by the invention is safe and easily available, can be taken for a long time, and is simple in preparation process and suitable for industrial production on a large scale.

The invention discloses milk with auxiliary protection function for alcoholic liver injury, which comprises the following components in percentage by weight: 91 to 99 percent of raw material milk, 0.5 to 5 percent of water-soluble dietary fiber, 0.2 to 2 percent of lecithin, 0.15 to 1.5 percent of soybean polypeptide and 0.1 to 0.3 percent of stabilizing agent. The milk of the invention not only has rich nutrition and is helpful for improving the nutritive condition of alcoholic liver injury patients, but also has exquisite mouthfeel and mellow taste, and simultaneously can enhance the function of the liver, accelerate alcohol metabolism and aid to protect the liver injury caused by excessive drinking or chronic alcohol intake.

The present invention relates to the treatment of nonalcoholic steatohepatitis (NASH), in particular to a compound that inhibits miR-21 expression for use in the treatment of nonalcoholic steatohepatitis.

The invention discloses gardenia polysaccharide and an extraction method thereof. The gardenia polysaccharide is prepared from the following raw materials (by mass): 41 to 56 percent of total sugar, 34 to 45 percent of uronic acid and 7 to 10 percent of protein. The preparation method of the gardenia polysaccharide comprises the following steps: crushing a gardenia medicinal material, degreasing,adding water, extracting, precipitating with ethanol, repeatedly freeze-thawing to remove protein, dialyzing, and freeze-drying. The gardenia polysaccharide prepared by the method can improve cholestatic liver injury induced by alpha-naphthalene isothiocyanate (ANIT) and 3, 5-diethoxycarbonyl-1, 4-dihydro-2, 4, 6-trimethylpyridine (DDC), and reduce fibrosis induced by carbon tetrachloride (CCL4).And the liver protection effect of the gardenia polysaccharide is not reported in literatures, which indicates that the gardenia polysaccharide has obvious application prospects in the preparation ofliver protection drugs, especially in the preparation of anti-cholestatic liver injury and anti-hepatic fibrosis drugs.

The invention relates to the technical field of drinks and particularly relates to a health-care tea. The health-care tea comprises the following raw materials: 4g of penthorum chinense pursh, 1.5g of tuckahoe, 1.5g of radix bupleuri, 1.5g of salvia miltiorrhiza, 2.5g of medlar, 1.3g of Chinese-date, 1.5g of herba lysimachiae, 1.2g of shizandra berry and 1g of semen cassiae. The raw materials are firstly crushed into powder; then, the power is stirred and mixed evenly; and finally the power is packaged with small bags; and powdery raw materials are obtained by pressing and grinding the raw materials dried in the sun. Compared with the prior art, the health-care tea is prepared from penthorum chinense pursh, tuckahoe, radix bupleuri, salvia miltiorrhiza, medlar, Chinese-date, herba lysimachiae, shizandra berry, semen cassia and the like, has the functions of protecting the liver, effectively improving human immunity and strengthening the body, and has no toxic or side effects.

The invention provides an antioxidant functional food prepared by probiotic solid-state fermentation. According to the antioxidant functional food, a mixture of sea buckthorn, fructus jujubae, lens, and soybeans is taken as a fermentation substrate, lactobacillus reuteri, bifidobacterium longum, pediococcus acidilactici, lactobacillus plantarum, bifidobacterium animalis, lactobacillus paracasei, bifidobacterium adolescentis, bacillus coagulans and bacillus subtilis are adopted, and the antioxidant functional food is prepared through solid-state segmentation fermentation. The antioxidant functional food prepared by probiotic solid-state fermentation has the effects of anti-aging, detoxification and beautification, freckle removing and whitening, and the like.

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a preparation method and application of a traditional Chinese medicine preparation with a liver protection function. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 3-5 parts of radix puerariae, 3-5parts of fructus lycii, 2-3 parts of semen hoveniae, 1-2 parts of ginseng and 1-2 parts of fructus schisandrae chinensis. The traditional Chinese medicine preparation is developed by combining the syndrome differentiation and treatment of traditional Chinese medicine and clinical practice, and has the characteristics of exact curative effect, safety, convenience, quick effect and no toxic or sideeffect in the aspect of liver protection.

The invention belongs to the field of a medical medicine, and discloses a lipopolysaccharide D galactosamine-induced liver injury animal protection model and a construction method thereof. The mangiferin obviously inhibits generation of LPS/GalN-induced ALT and AST, and at the same time, the histology analysis hepatic tissue shows that the mangiferin obviously inhibits LPS/GalN-induced liver injury. The result shows that mangiferin has protection effect for LPS/GalN-induced liver injury. The mangiferin obviously inhibits generation of LPS/GalN-induced TNF-alpha, IL-1beta, iNOS, MCP-1 and RANTES. By inhibiting oxidative stress, cell apoptosis and inflammation reaction, the mangiferin can protect the LPS/GalN-induced liver injury, and the mangiferin can prevent a LPS/GalN-induced liver injury by activating Nrf2/HO-1 signal pathway and inhibiting the activation of NLRP3 inflammasome.

Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.

The invention discloses an antiviral effect and an application of an epigenetic modifying enzyme SETD2. The invention relates to the fields of biotechnology and medicine, and in particular to an anti-virus infection effect and an application of an immuno-regulatory molecule SETD2. Specifically, the invention relates to the SETD2 or an SETD2 coding sequence and an application of an accelerant of the SETD2 in preparing a medicine or a kit for inhibiting virus infection, and further relates to applications of the material in resisting virus infection and treating chronic inflammatory diseases caused by the virus infection, an application method and the corresponding medicine, a pharmaceutical composition or the kit. The SETD2 provided by the invention can be used for preventing and inhibiting the virus infection and enhancing a curative effect of interferon in resisting the virus infection, and the SETD2 has a broad application prospect.

The invention relates to a method for improving the anticancer activity for Codonopsis lanceolata Benth.et Hook.F, which comprises: slicing or homogenizing fresh Codonopsis lanceolata Benth.et Hook.F, or crushing dry Codonopsis lanceolata Benth.et Hook.F, or powdering the dry Codonopsis Lanceolata Benth.et Hook.F; soaking in water; sterilizing under a high pressure; adding 0.5 to 5.0 percent of active yeast and 1 to 8 percent of glucose under a sterile condition when the temperature lowers to 30 DEG C; fermenting at 20 to 37 DEG C for 1 to 10 days, and adding a polar solvent after fermentation to extract for 5 to 24 hours at 0 to 100 DEG C; and filtering, recovering solvent and concentrating under reduced pressure or drying by freezing. The method can improve the inhibition effect of Codonopsis lanceolata Benth.et Hook.F on the growth of tumors.

The present invention discloses a ganoderma lucidum low-fat pig skin jelly which relates to the field of collagen protein food processing and consist of the following composition in parts by weight: 1-3 parts of ganoderma lucidum sporocarp extract, 5-7 parts of ganoderma lucidum sporocarp thick liquid, 100-125 parts of pig skin, and 4-5 parts of spicy seasonings. At the same time, the present invention discloses a preparation step of the ganoderma lucidum sporocarp extract and the ganoderma lucidum sporocarp thick liquid, the treatment steps of pig skin, and the composition of the spicy seasonings. In the treatment steps of pig skin, baking soda is added to heat the pig skin, pig skin fat is removed, pig skin is heated and rinsed with edible vinegar, which is beneficial to improve the separation degree of the oil and fat from pig skin, also can improve the boiling degree of pig skin, improves product flavor and taste, reduces costs, and improves economic efficiency; and at the same time, the ganoderma lucidum low-fat pig skin jelly enrich the pig skin jelly market, is a new pig skin jelly product, contains low fat, and has high nutritional health-care efficacy, good flavor and taste, and a high marketing value .

The invention discloses application of adenosine and derivatives thereof in prevention and treatment of medicament-induced liver injury, relating to application of adenosine and derivatives thereof such as adenosine monophosphate, adenosine diphosphate and adenosine triphosphate in protection of acetaminophen-induced liver injury. A mouse model adopted in the application is an acetaminophen-induced mouse acute hepatic failure model, the dosage of the adenosine or derivatives thereof is 0.1 to 5mmol/kg, and the adenosine and derivatives thereof can reduce the activities of aspartate aminotransferase (AST) and alanine transaminase (ALT) in the medicament-induced liver injury, reduce the substantial cell necrosis area and improve the glutathione level so as to prevent and treat the acetaminophen-induced liver injury caused by liver toxic medicaments. Animal experiments prove that the adenosine and derivatives thereof have a significant effect on preventing and treating the medicament-induced liver injury, so the adenosine and derivatives thereof can be used for the preventing and treating processes of the medicament-induced liver injury, and a new method and means are provided for clinically treating the medicament-induced liver injury.