13results about How to "Lessen liver damage" patented technology

The invention discloses a ginseng and nattokinase composition and a preparation method thereof, belongs to the technical field of microbial fermentation, and provides the ginseng and nattokinase composition which comprises ginsenoside, ginseng peptide, acid-soluble protein, a stabilizer, an additive and a ginseng body. The preparation method comprises the following steps: S1, cleaning ginseng, crushing, cooking, cooling to 25-36 DEG C, and standing for 24 hours to obtain cooked ginseng; s2, adding an auxiliary agent and a stabilizer into the ginseng cooked in the step S1, then inoculating bacillus natto, and culturing for 24-36 hours at the temperature of 32-35 DEG C to obtain fermentation liquor; and S3, adding the auxiliary agent into the fermentation liquid in the step S2 again, uniformly mixing, culturing for 24-48 hours at the temperature of 36-40 DEG C, and then drying at low temperature to obtain the ginseng and nattokinase composition. The preparation method is simple and easy to popularize.

This invention discloses a multi-target synergistic anti-liver cancer medical food granule and its preparation method. The granule uses medicinal and edible homologous foods and novel resource foods as raw materials, and is composed of curcumin extract, esterified fat-soluble EGCG, Moringa leaf powder, yeast β-glucan, Astragalus extract, Schisandra extract, Salvia miltiorrhiza extract, Poria cocos powder, resistant dextrin, and erythritol in a specific ratio to construct a three-dimensional synergistic system of "direct killing-immune regulation-liver protection," which can induce ferroptosis in liver cancer cells, inhibit protective autophagy, activate the body's immunity, and protect liver cells. This invention employs directional extraction, multi-layer coating, and high-pressure fusion granulation technology. Nanoparticle liposome encapsulation, esterification modification, and pH-responsive enteric coating improve the stability and bioavailability of the components, solving the problems of poor water solubility, low absorption, and easy degradation of natural active ingredients. The granule has clear efficacy, high safety, and stable process, and can be used as a medical food for adjuvant therapy and nutritional support during the recovery period of liver cancer.

Provided are a compound for alcoholic liver injury, a preparation method, a composition, a food and the use. The compound has the following formula (I), wherein M is a divalent metal cation selected from Cu, Fe and Zn; A is selected from glutathione and a derivative thereof, and the derivative of glutathione is selected from: at least one of amino or carboxyl in glutathione substituted with an amino protecting group and / or a carboxyl protecting group; B is a monovalent or divalent balance anion; and n is 1 or 2.         [M(A)2]·nB     (I)

This application belongs to the field of traditional Chinese medicine, specifically relating to a spleen-strengthening and blood-activating traditional Chinese medicine preparation that enhances the expression of metallothionein and its uses. This application provides a traditional Chinese medicine composition comprising, by weight, the following raw materials: 1-20 parts jujube, 1-20 parts yam, 1-10 parts Buddha's hand, 1-9 parts Lithospermum erythrorhizon, 1-9 parts corn silk, 1-9 parts lotus leaf, 1-15 parts ginseng leaf, and 1-20 parts hawthorn. This application also provides a traditional Chinese medicine preparation, as well as the uses of the above-mentioned traditional Chinese medicine composition and preparation. The traditional Chinese medicine preparation provided in this application effectively enhances the liver's detoxification, antioxidant, and anti-inflammatory capabilities by increasing the expression of hepatic metallothionein, thereby reducing the probability of liver damage and preventing and delaying the further development of liver diseases.

The traditional Chinese medicine composition for treating AIDS and consolidating basis is prepared from the following raw materials in parts by weight: 8-10 parts of raw radix astragali, 7-10 parts of American ginseng, 8-10 parts of poria cocos, 3-6 parts of lucid ganoderma, 4-6 parts of rhizoma atractylodis macrocephalae, 4-6 parts of rhodiola rosea, 8-10 parts of rhizoma atractylodis, 20-30 parts of semen coicis, 3-6 parts of cortex magnoliae officinalis, 7-9 parts of ginger processed pinellia, 4-6 parts of fructus tsaoko, 11-15 parts of rhizoma smilacis glabrae, 7-10 parts of radix salviae miltiorrhizae and 7-10 parts of polygala tenuifolia. According to the traditional Chinese medicine preparation and the preparation method thereof, the problems that the living quality of a patient is seriously affected and the immunity of the patient is low due to various adverse reactions, especially hepatotoxicity, in the existing treatment process can be solved.

This invention relates to the field of biopharmaceutical technology, specifically to... SARM1 The application of related reagents in the preparation of products for the diagnosis and / or treatment of hemophagocytic lymphohistiocytosis-like liver injury. The results of this invention demonstrate... SARM1 It is both a circulating biomarker in HLH and an intrinsic regulator of iNKT cell fate. SARM1 By stabilizing LCK and maintaining TCR signaling, excessive iNKT1 bias and IFN-γ-driven liver injury can be prevented. These findings highlight... SARM1 Its important value as a potential diagnostic biomarker and therapeutic target for HLH in children provides a new strategy for the treatment of hemophagocytic lymphohistiocytosis-like liver injury in children.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation, a pharmaceutical composition and application thereof. The traditional Chinese medicine composition consists of bulbus fritillariae cirrhosae, kelp, thunberg fritillary bulb, turmeric, endothelium corneum gigeriae galli, raw hawthorn and selfheal. According to the application, the bulbus fritillariae cirrhosae and the bulbus fritillariae thunbergii are compatible to synergistically exert the effects of reducing phlegm and resolving The endothelium corneum gigeriae galli and the raw hawthorn have the effect of removing food retention, the selfheal has the effect of clearing liver and removing stasis, and all the medicines are combined to achieve the effects of reducing phlegm, removing blood stasis, softening hard mass and eliminating diseases. Experiments show that the traditional Chinese medicine composition can significantly improve the liver function of Wilson disease model mice, reduce collagen deposition of liver tissues, down-regulate fibrosis markers and inhibit activation of hepatic stellate cells.

The invention relates to the technical field of pharmaceutical biology, in particular to application of (-)-epicatechin to inhibition of toxicity caused by MEZ. The toxicity caused by the MEZ is developmental toxicity or hepatotoxicity. The developmental toxicity comprises the following symptoms: embryo malformation, embryo apoptosis and developmental morphology abnormality. The hepatotoxicity comprises liver development delaying, cholesterol and lipid metabolism disorder, liver injury and liver cell apoptosis. According to the research, the effect of the L-epicatechin on inhibiting MEZ-induced developmental toxicity and hepatotoxicity is found, embryo injury and liver injury caused by MEZ can be effectively relieved, and the pathogenesis of the MEZ-induced developmental toxicity and hepatotoxicity can be further understood.

The application discloses application of delavaine in preparation of a medicine for preventing and treating liver fibrosis. The application first proposes and verifies that delavaine can promote cell ferroptosis, inhibit transcription and expression of fibrosis genes, effectively inhibit activity of cells abnormally activated in a liver fibrosis course, and avoid collagen deposition, so as to effectively relieve liver fibrosis progression while reducing liver damage, and has an excellent application prospect in clinical treatment of liver fibrosis.

The invention discloses a 7-azaindole photoacoustic imaging probe for detecting superoxide anions, a preparation method and application, the photoacoustic imaging probe is named as AIH-OTF and is a blue-green solid prepared from methyl trifluoromethanesulfonate, dye AIH-OH and the like; the AIH-OTF realizes high-contrast PA imaging of endogenous superoxide anions of living cells, in-situ evaluation of occurrence and repair of acetaminophen-induced liver injury is also determined by non-invasive monitoring of PA reaction of the AIH-OTF to superoxide anions, and the AIH-OTF probe can be used as a useful tool for accurately diagnosing drug-induced liver injury in vivo. The photoacoustic imaging probe disclosed by the invention can be used for detecting superoxide anions in vivo and diagnosing the DILI capability in real time through AIH-OTF; the cell toxicity is small, the biocompatibility is good, and the compound can be used for imaging of in-vivo DILI generation and repair.

The present invention relates to the technical field of microbial application, and specifically to a strain of Bifidobacterium bifidum for sobering up, protecting the liver, and reducing uric acid, and its postbiotics, compositions, and applications. The Bifidobacterium bifidum is Bifidobacterium bifidum ( Bifidobacterium bifidum )WZA‑BB02, Bifidobacterium bifidum WZA‑BB02 was deposited in the China Center for Type Culture Collection on July 1, 2024, with the deposit number CCTCC NO: M 20241442. The postbiotics made from Bifidobacterium bifidum WZA‑BB02 have a high inhibition rate of xanthine oxidase activity in vitro. The rat experiment verified that Bifidobacterium bifidum WZA‑BB02 postbiotics can significantly reduce the serum uric acid level of rats with hyperuricemia, and can effectively reduce alcohol-induced liver damage and inhibit the promotion of alcohol on the increase of uric acid levels.

The present application provides isolated mucinophilic Akkermansia, compositions comprising the same and uses thereof, which can be used for treating, preventing or relieving obesity, metabolic disorders caused by obesity, diabetes, inflammation, liver and kidney diseases, liver diseases, cardiovascular and cerebrovascular diseases, tumors and the like.

The invention relates to the technical field of medicine application, and discloses mulberry leaf polysaccharide, a preparation method and application of the mulberry leaf polysaccharide in treatment of AFB1-induced mouse liver injury. The mulberry leaf polysaccharide can be independently used, and can also be combined with other traditional Chinese medicine extracts to prepare a pharmaceutical composition together. Experimental results show that the liver injury symptom of the mouse treated by the mulberry leaf polysaccharide is obviously improved, the liver index decline trend is relieved, and the liver lesion degree is obviously relieved. Therefore, the mulberry leaf polysaccharide disclosed by the invention can effectively treat liver injury caused by AFB1 and accompanied oxidative stress, and has a wide application prospect in the research field of mulberry leaf polysaccharide antioxidant preparations. The discovery not only provides powerful support for subsequent research and development of the polysaccharide, but also provides a new thought and direction for further optimization and innovation.