6results about How to "Lessen liver damage" patented technology

This invention discloses a multi-target synergistic anti-liver cancer medical food granule and its preparation method. The granule uses medicinal and edible homologous foods and novel resource foods as raw materials, and is composed of curcumin extract, esterified fat-soluble EGCG, Moringa leaf powder, yeast β-glucan, Astragalus extract, Schisandra extract, Salvia miltiorrhiza extract, Poria cocos powder, resistant dextrin, and erythritol in a specific ratio to construct a three-dimensional synergistic system of "direct killing-immune regulation-liver protection," which can induce ferroptosis in liver cancer cells, inhibit protective autophagy, activate the body's immunity, and protect liver cells. This invention employs directional extraction, multi-layer coating, and high-pressure fusion granulation technology. Nanoparticle liposome encapsulation, esterification modification, and pH-responsive enteric coating improve the stability and bioavailability of the components, solving the problems of poor water solubility, low absorption, and easy degradation of natural active ingredients. The granule has clear efficacy, high safety, and stable process, and can be used as a medical food for adjuvant therapy and nutritional support during the recovery period of liver cancer.

This application belongs to the field of traditional Chinese medicine, specifically relating to a spleen-strengthening and blood-activating traditional Chinese medicine preparation that enhances the expression of metallothionein and its uses. This application provides a traditional Chinese medicine composition comprising, by weight, the following raw materials: 1-20 parts jujube, 1-20 parts yam, 1-10 parts Buddha's hand, 1-9 parts Lithospermum erythrorhizon, 1-9 parts corn silk, 1-9 parts lotus leaf, 1-15 parts ginseng leaf, and 1-20 parts hawthorn. This application also provides a traditional Chinese medicine preparation, as well as the uses of the above-mentioned traditional Chinese medicine composition and preparation. The traditional Chinese medicine preparation provided in this application effectively enhances the liver's detoxification, antioxidant, and anti-inflammatory capabilities by increasing the expression of hepatic metallothionein, thereby reducing the probability of liver damage and preventing and delaying the further development of liver diseases.

This invention relates to the field of biopharmaceutical technology, specifically to... SARM1 The application of related reagents in the preparation of products for the diagnosis and / or treatment of hemophagocytic lymphohistiocytosis-like liver injury. The results of this invention demonstrate... SARM1 It is both a circulating biomarker in HLH and an intrinsic regulator of iNKT cell fate. SARM1 By stabilizing LCK and maintaining TCR signaling, excessive iNKT1 bias and IFN-γ-driven liver injury can be prevented. These findings highlight... SARM1 Its important value as a potential diagnostic biomarker and therapeutic target for HLH in children provides a new strategy for the treatment of hemophagocytic lymphohistiocytosis-like liver injury in children.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation, a pharmaceutical composition and application thereof. The traditional Chinese medicine composition consists of bulbus fritillariae cirrhosae, kelp, thunberg fritillary bulb, turmeric, endothelium corneum gigeriae galli, raw hawthorn and selfheal. According to the application, the bulbus fritillariae cirrhosae and the bulbus fritillariae thunbergii are compatible to synergistically exert the effects of reducing phlegm and resolving The endothelium corneum gigeriae galli and the raw hawthorn have the effect of removing food retention, the selfheal has the effect of clearing liver and removing stasis, and all the medicines are combined to achieve the effects of reducing phlegm, removing blood stasis, softening hard mass and eliminating diseases. Experiments show that the traditional Chinese medicine composition can significantly improve the liver function of Wilson disease model mice, reduce collagen deposition of liver tissues, down-regulate fibrosis markers and inhibit activation of hepatic stellate cells.

The present application provides isolated mucinophilic Akkermansia, compositions comprising the same and uses thereof, which can be used for treating, preventing or relieving obesity, metabolic disorders caused by obesity, diabetes, inflammation, liver and kidney diseases, liver diseases, cardiovascular and cerebrovascular diseases, tumors and the like.

The invention relates to the technical field of medicine application, and discloses mulberry leaf polysaccharide, a preparation method and application of the mulberry leaf polysaccharide in treatment of AFB1-induced mouse liver injury. The mulberry leaf polysaccharide can be independently used, and can also be combined with other traditional Chinese medicine extracts to prepare a pharmaceutical composition together. Experimental results show that the liver injury symptom of the mouse treated by the mulberry leaf polysaccharide is obviously improved, the liver index decline trend is relieved, and the liver lesion degree is obviously relieved. Therefore, the mulberry leaf polysaccharide disclosed by the invention can effectively treat liver injury caused by AFB1 and accompanied oxidative stress, and has a wide application prospect in the research field of mulberry leaf polysaccharide antioxidant preparations. The discovery not only provides powerful support for subsequent research and development of the polysaccharide, but also provides a new thought and direction for further optimization and innovation.