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40 results about "Hepatocyte apoptosis" patented technology
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Hepatocyte apoptosis can be considered to be a pivotal step in most forms of liver injury (Fig. 1). Enhanced hepatocyte apoptosis is tightly coupled with inflammation and fibrosis (110, 252, 269). Hepatocyte injury and turnover are also essential for liver cell cancer, and cell deletion by apoptosis stimulates hepatocyte mitogenesis.
Application of donepezil or gardenia jasminoides ellis-phellodendron amurense component in preparing medicine for resisting immunological liver injury based on cholinergic regulation and control
The invention provides an application of a donepezil or gardenia jasminoides ellis-phellodendron amurense component in preparation of a cholinergic regulation-based immune liver injury resisting medicine, and belongs to the technical field of biological medicines. The pharmaceutical composition for resisting immunological liver injury is a donepezil component or a gardenia jasminoides ellis-phellodendron amurense component. The invention solves the problems of single action target and incomplete regulation and control mechanism of the existing immunological liver injury treatment medicine, provides a treatment scheme with anti-inflammatory, anti-oxidation, liver cell apoptosis inhibition and cholinergic system regulation and control functions, explores a brand new medical application of donepezil, verifies the liver protection effect of donepezil in immunological liver injury, and provides a new application of donepezil in immunological liver injury. The application limitation is broken through; the treatment effect of the Jashima component in an immune liver injury model induced by concanavalin A is defined, a dual regulation mechanism of inhibiting AChE expression and increasing alpha7 nAChR expression is disclosed, and the application scene is expanded; a multi-dimensional regulation and control network of cholinergic anti-inflammatory pathway-NF-kappa B inflammatory pathway-hepatocyte apoptosis is constructed, and a more efficient and comprehensive treatment strategy is provided for immunological liver injury.
Owner:SHANXI UNIV OF CHINESE MEDICINE