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39 results about "Hepatocyte apoptosis" patented technology
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Hepatocyte apoptosis can be considered to be a pivotal step in most forms of liver injury (Fig. 1). Enhanced hepatocyte apoptosis is tightly coupled with inflammation and fibrosis (110, 252, 269). Hepatocyte injury and turnover are also essential for liver cell cancer, and cell deletion by apoptosis stimulates hepatocyte mitogenesis.
Application of antler polypeptide in preparation of products for preventing radioactive liver injury
The application discloses application of a pilose antler polysaccharide in preparation of a radioactive liver injury protection product and belongs to the technical field of biological pharmacy. The application of the pilose antler polysaccharide in preparation of the radioactive liver injury protection product shows that the polysaccharide can not only effectively reduce oxidative stress and inflammatory injury, but also specifically intervene in the core pathological mechanism of the radioactive liver injury, that is, the pilose antler polysaccharide can inhibit progressive liver fibrosis by down-regulating the expression of a TGF-beta signal path and regulate the expression balance of BAX / Bcl-2 genes to block liver cell apoptosis mediated by a mitochondrion path, thereby effectively relieving liver injury caused by ionizing radiation, and the pilose antler polysaccharide has no toxic side effects and has a wide application prospect.
Owner:DALIAN POLYTECHNIC UNIVERSITY