The invention discloses application of chicken-derived small molecule peptide in preparation of a product for preventing and improving liver injury and secondary symptoms thereof and the product, and relates to the field of food and medicine health. The small molecule peptide is a chicken-derived natural free active peptide, the small molecule peptide is specifically dipeptide Cyclo (L-Phe-L-Phe), the small molecule peptide shows strong antioxidant ability in cells, the oxidative stress state of the liver can be improved through the effects of increasing the activity of antioxidant enzyme GPx, reducing the level of oxidative stress product malonaldehyde MDA and the like, and the liver protection effect is achieved. The CPP has the advantages of low toxicity, wide medication window and high safety, and can be applied to functional foods, health foods, pharmaceuticals, compositions and other products for preventing or improving liver injury and related secondary symptoms thereof.