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Application of caffeic acid in preparation of drugs for treating hepatic microcirculation disturbance and hepatic injury

A technology for microcirculation disturbance and liver injury, applied in the application field of caffeic acid in the preparation of medicines for treating hepatic microcirculation disturbance and liver injury

Inactive Publication Date: 2016-06-29
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there is no report on whether caffeic acid can inhibit liver microcirculation disorder and alleviate liver tissue damage after hepatic ischemia-reperfusion; especially, caffeic acid plays an important role in the process of hepatic microcirculation disorder and liver injury caused by ischemia-reperfusion whether it has an intervening effect on the mitochondrial respiratory chain of liver tissue and its regulatory protein Srt3; whether it has an intervening effect on the membrane translocation of NADPH oxidase subunits P41 and P47 in liver cells; It has not been reported that hepatocyte apoptosis, which plays an important role, has an intervention effect on the cytoskeleton damage in hepatocytes, etc.

Method used

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  • Application of caffeic acid in preparation of drugs for treating hepatic microcirculation disturbance and hepatic injury
  • Application of caffeic acid in preparation of drugs for treating hepatic microcirculation disturbance and hepatic injury
  • Application of caffeic acid in preparation of drugs for treating hepatic microcirculation disturbance and hepatic injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0903] Embodiment 1, tablet

[0904] 【prescription】

[0905] Caffeic acid 100g

[0906] Microcrystalline cellulose 50g

[0907] Micropowder silica gel 3g

[0908] Magnesium stearate 1.5g

[0909] [Preparation method] Take raw materials and auxiliary materials and pass through 100-mesh sieve respectively; take caffeic acid and microcrystalline cellulose, mix well, use 60% ethanol as a binder to make soft material, pass through 20-mesh sieve to make granules, and dry at 60°C. Take it out, sieve through a 30-mesh sieve for granulation, add micropowder silica gel and magnesium stearate, mix well, press into tablets, and make 1,000 tablets, and you get it.

Embodiment 2

[0910] Embodiment 2, tablet

[0911] 【prescription】

[0912] Caffeic acid 75g

[0913] Microcrystalline cellulose 37g

[0914] Micropowder silica gel 2.3g

[0915] Magnesium stearate 1.1g

[0916] [Preparation method] Take raw materials and auxiliary materials and pass through 100-mesh sieve respectively; take caffeic acid and microcrystalline cellulose, mix well, use 60% ethanol as a binder to make soft material, pass through 20-mesh sieve to make granules, and dry at 60°C. Take it out, pass through a 30-mesh sieve for granulation, add appropriate amount of micropowder silica gel and magnesium stearate, mix well, and press into tablets to make 1,000 tablets.

Embodiment 3

[0917] Embodiment 3, tablet

[0918] 【prescription】

[0919] Caffeic acid 133g

[0920] Microcrystalline cellulose 66g

[0921] Micropowder silica gel 4g

[0922] Magnesium stearate 2g

[0923] [Preparation method] Take the raw materials and auxiliary materials and pass them through a 100-mesh sieve; take caffeic acid 1 and microcrystalline cellulose, mix them evenly, use 60% ethanol as a binder to make a soft material, pass through a 20-mesh sieve to make granules, and dry at 60°C , take it out, sieve through a 30-mesh sieve for granulation, add appropriate amount of micropowder silica gel and magnesium stearate, mix well, press into tablets, and make 1000 pieces, to obtain.

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Abstract

The invention relates to an application of caffeic acid in preparation of drugs for treating hepatic microcirculation disturbance and hepatic injury. Through a series of observation of caffeic acid on hepatic ischemia reperfusion rats, caffeic acid is found to improve the hepatic surface blood flow quantity by the action routes: AMPK[alpha] phosphorylation and PKC[delta] membrane translocation are inhibited, NADPH subunit P41 and P47 membrane translocation is inhibited and NADPH-derived peroxides are inhibited; the activity of a hepatic ischemia reperfusion rat mitochondria respiratory chain is improved, and peroxide production caused by mitochondria injury is reduced, so as to increase the production of ATP; hepatocyte apoptosis caused by ischemia reperfusion is inhibited; and hepatic cell internal cytoskeleton injury caused by ischemia reperfusion is attenuated. The new application in preparation of the drugs for treating hepatic microcirculation disturbance and hepatic injury is provided.

Description

technical field [0001] The invention relates to a new application of medicine, in particular to the application of caffeic acid in the preparation of medicine for treating hepatic microcirculation disorder and liver injury. Background technique [0002] Hepatic ischemia-reperfusion injury: During liver transplantation, partial hepatectomy, and treatment of severe liver trauma, it is necessary to temporarily block liver blood flow. After the blood supply is restored, liver ischemia-reperfusion injury may occur. [0003] Good blood circulation is the fundamental guarantee for tissue cells to obtain sufficient oxygen supply and nutrients and excrete metabolites. Ischemic injury occurs when the blood perfusion of tissues and organs is reduced due to various reasons, and after the blood perfusion is restored, the cell function metabolism and structural damage are aggravated. The damage caused by organs and organs is called ischemia-reperfusion injury (ischemiareperfusioninjury)....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P1/16A61P9/10
Inventor 韩晶岩牟洪娜刘育英李泉潘春水贺珂胡白和常昕
Owner TIANJIN TASLY PHARMA CO LTD
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