The invention relates to a functional feed, in particular to the functional feed for preventing and treating a white liver lesion of micropterus salmoides, and a preparation method thereof. The feed comprises, by weight percentage, 15-25% of fish meal, 20-35% of chicken powder, 16-22% of soybean meal, 8-15% of flour, 4-8% of squid extractum, 1-2% of calcium dihydrogen phosphate, 1-2% of a multi-vitamin premix, 1-2% of a multi-mineral premix, 2-4% of fish oil, 1-2% of soybean oil, 1-2% of phosphatide oil, 2-7% of corn protein powder, 0.2-0.5% of pennisetum sinese herb extract, 0.1-0.5% of mulberry leaf fermentation liquid, and 0.1-0.3% of red rooted saliva root fermentation liquid. Compared with a common puffed feed for the micropterus salmoides, a feed formula provided by the invention can meet the basic nutrient demands of juvenile fishes, medium fishes and adult fishes of the micropterus salmoides, also can effectively enhance exchangeable backflow between artery blood and vein blood in hepatic tissue blood circulation, and has a good prevention effect and a repair treatment effect on the white liver lesion and hepatic tissue hypofunction caused by the white liver lesion.