Use of piperic acid ester compound in preparation of drug or healthcare product for reducing blood fat

A technology of piperonic acid ester and compound, which is applied to the application field of piperonic acid ester compound in the preparation of blood lipid-lowering drugs or health care products, and can solve problems such as literature reports that the application of piperonic acid ester compound is not found.

Inactive Publication Date: 2005-07-06
INNER MONGOLIA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there is no bibliographical report on the application of piperona

Method used

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  • Use of piperic acid ester compound in preparation of drug or healthcare product for reducing blood fat
  • Use of piperic acid ester compound in preparation of drug or healthcare product for reducing blood fat
  • Use of piperic acid ester compound in preparation of drug or healthcare product for reducing blood fat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0088] The beneficial effect of the application of the piperonate compounds of the present invention in blood lipid-lowering drugs and health products will be further illustrated by test examples below.

[0089] Blood lipid-lowering efficacy test and data of piperonate compounds.

[0090] 1 Experimental animals and materials

[0091] Experimental animals: Secondary male Wistar rats, weighing 170±10g

[0092] (Provided by Animal Research Center of Inner Mongolia University).

[0093] experimental reagent :

[0094] Piperic acid ester compounds: piperic acid, methyl piperate, ethyl piperate, n-butyl piperate, isobutyl piperate, octyl piperate are extracted and synthesized by our institute;

[0095] The total cholesterol kit was produced by Zhongsheng Beikong Biotechnology Co., Ltd.;

[0096] Production batch number: 180091, certificate number: Beijing T20010069

[0097] The triglyceride kit is produced by Zhongsheng Beikong Biotechnology Co., Ltd.;

[0098] Production ...

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PUM

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Abstract

The invention relates to the use of piperic acid ester compound in preparation of drug or healthcare product for reducing blood fat, wherein R1, R2, R3 are defined in the description, the piperic acid ester compounds represented by formula (1) have the actions of substantially reducing cholesterin, triglyceride and increasing high density lipoprotein, fully activating lecithin cholesterol acyl transferase, forwarding extra-hepatic tissue cholesterol to liver, cleaning out plasma lipoproteins, plasma cholesterol and cholesterol esters, thus can be applied to the prevention and treatment of cardiovascular and cerebrovascular diseases, cerebrovascular, coronary artery and peribiliary vessel pathology and hyperlipemia.

Description

technical field [0001] The present invention relates to the application of piperine ester compounds, more specifically, the present invention relates to the application of piperine ester compounds in the preparation of blood lipid-lowering drugs or health care products. Background technique [0002] Medical research shows that lipid metabolism is closely related to cardiovascular diseases, hyperlipidemia is one of the main causes of atherosclerosis, especially the increase of serum total cholesterol level is a risk indicator of atherosclerosis. Blood lipids are the general term for various lipids in serum. Blood lipids mainly include cholesterol, triglycerides, and phospholipids. In addition, there are a small amount of free fatty acids and very small amounts of other lipids, including fat-soluble vitamins and steroid hormones. Two-thirds of cholesterol exists in the form of cholesteryl esters, and the remaining one-third is free cholesterol. [0003] Cholesterol is not onl...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61P3/06A61P9/00
Inventor 博日吉汗格日勒图昭日格图那日苏吴勇白国义那木拉邓承远
Owner INNER MONGOLIA UNIVERSITY
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