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Early-stage non-alcoholic steatohepatitis evaluation model, construction method and application thereof

A fatty liver disease, non-alcoholic technology, applied in the field of immunology, can solve the problems of no model, low proportion of severe NASH, etc., to achieve the effect of improving ability

Pending Publication Date: 2020-04-24
苏州和锐生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no particularly effective model so far. The newly invented Mack-3 evaluation model is considered to be the most effective model for nonalcoholic steatohepatitis in Europe and the United States. However, the highest area under the curve of Mack-3 for the evaluation of the Chinese population is about 0.7. The reason may be related to It is related to the low proportion of severe NASH in the Chinese population, which is obviously not ideal for the Chinese population. One of the reasons is that most of the non-alcoholic fatty liver disease in the Chinese population is mild to moderate, and the proportion of severe NASH is far lower than that of the European and American population.

Method used

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  • Early-stage non-alcoholic steatohepatitis evaluation model, construction method and application thereof
  • Early-stage non-alcoholic steatohepatitis evaluation model, construction method and application thereof
  • Early-stage non-alcoholic steatohepatitis evaluation model, construction method and application thereof

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Embodiment 1

[0054] The present invention uses the currently recognized pathological grouping method to analyze the samples of 457 cases, including 231 cases in the non-NASH group and 226 cases in the NASH group.

[0055] The grouping method used in this model is: the total score of 4 items of pathology is less than 5 in the non-NASH control group, and greater than or equal to 5 in the patient group;

[0056] The area under the ROC curve of the evaluation scoring model is as follows figure 1 As shown, the present invention simulates a more effective calculation formula by adding gender, age, TC, etc.:

[0057] Y=-12.037+1.488sex-0.048age+0.096BMI+0.004ALT-0.004GGT+0.032Hb+0.701TC-0.586LDL+1.525M30;

[0058] Among them, M30 means the choice of keratin 18-M30 as a marker of liver cell apoptosis, sex means the sex of the detected individual, TC means total cholesterol content, LDL means low-density lipoprotein, BMI means body mass index, age means age, Hb denotes hemoglobin, ALT denotes ala...

Embodiment 3

[0085] The embodiment of the present invention further discloses a computer-readable storage medium, on which a computer program is stored, and when the program is executed by a processor, the steps of the above-mentioned method for constructing an assessment model of early non-alcoholic fatty liver disease are realized.

Embodiment 4

[0087] The embodiment of the present invention further discloses an evaluation system for early non-alcoholic fatty liver disease in combination with the above computer-readable storage medium. The system is a device including a computer for predicting early non-alcoholic fatty liver disease according to physical examination indicators. The computer has the following parts,

[0088] a database storing longitudinal health management data;

[0089] memory, storing computer programs operable on the processor;

[0090] The input unit is used to input the information for predicting individuals and the physical examination indicators required for the assessment of early non-alcoholic fatty liver disease, including liver cell apoptosis markers, gender, total cholesterol, low-density lipoprotein, body mass index, age, Hemoglobin, alanine aminotransferase and gamma glutamyl transpeptidase;

[0091] The processor calls the data in the database, runs the program in the memory, generate...

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Abstract

The invention discloses an evaluation model for early prediction of non-alcoholic steatohepatitis (NASH) and a calculation formula. According to the model, large-sample-size hepatic puncture pathological diagnosis is used as a grouping basis, an M30 fragment of a hepatocyte apoptosis marker keratin 18 is introduced, a new algorithm and a calculation formula are obtained by adding age, gender, height, waistline, hemoglobin, glutamic-pyruvic transaminase and gamma-glutamyl transpeptidase for simulation, the negative prediction value of the formula applied to early-stage NASH reaches 0.902, and the area under an ROC curve reaches 0.826.

Description

technical field [0001] The invention relates to the field of immunology, in particular to an evaluation model for early non-alcoholic fatty liver disease suitable for Chinese population and its construction method and application. Background technique [0002] Non-alcoholic fatty liver disease is a disease characterized by abnormal apoptosis of liver cells. The incidence rate in the population is as high as 15%. will be diagnosed. [0003] At present, the gold standard for the diagnosis of steatohepatitis is liver biopsy plus pathological diagnosis. Few patients with fatty liver disease are willing to choose traumatic liver biopsy due to hidden symptoms. Hepatitis is not sensitive, and the latest liver cell apoptosis marker keratin 18-M30 is used as a supplementary indicator. The sensitivity of M30 alone for fatty liver disease is about 70%, and the negative predictive value is 0.85, which is significantly higher than the classic liver disease indicator ALT , AST, GGT and ...

Claims

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Application Information

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IPC IPC(8): G16H50/30G16H50/50
CPCG16H50/30G16H50/50
Inventor 陈菲钱俊豪
Owner 苏州和锐生物科技有限公司
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