1226 results about "Keratin protein" patented technology

Present invention teaches the method of using a keratin hydrolysis peptide (“KHP”) solution to promote the growth of cotton under low light conditions. By selectively choosing specific weights of feathers and water, and treating the mixture to a high-temperature high-pressure hydrolysis process, the resulting solution is confirmed to contain at least 253 peptides and then apply to the cotton by leaf spray at seeding stage. Optionally, the KHP solution can be diluted by water, as disclosed in the specification, for infusing or leaf spraying.

The invention relates to a composition comprising at least one oxidation coupler chosen from 6-hydroxybenzomorpholine of formula (I), one of its addition salts, its solvates and / or the solvates of its salts, at least one oxidation coupler chosen from 2-amino-5-ethylphenol of formula (II), one of its addition salts, its solvates and / or the solvates of its salts, and at least one compound chosen from N, N-dicarboxymethyl glutamic acid, one of its salts, and mixtures thereof. The invention also relates to a process for dyeing keratin fibres, preferably the hair, comprising the application of the composition to said keratin fibres.

Present invention teaches the method of using a keratin hydrolysis peptide (“KHP”) solution to promote the growth of soybean plants under flood stress. By selectively choosing specific weights of feathers and water, and treating the mixture to a high-temperature high-pressure hydrolysis process, the resulting solution is confirmed to contain at least 253 peptides and then apply to the soil containing the soybean at a specific growth stage after germination. Optionally, the KHP solution can be diluted by water as disclosed in the application.

Present invention teaches the method of using a keratin hydrolysis peptide (“KHP”) solution to improve the efficacy of fertilizer usage and absorption by soybeans. By selectively choosing specific weights of feathers and water, and treating the mixture to a high-temperature high-pressure hydrolysis process, the resulting solution is confirmed to contain at least 253 peptides and then infused to the fertilized soil in which the soybean seeds are grown, as well as the plants after the seed start sprouting. Optionally, the KHP solution can be diluted by water, as disclosed in the specification, for applying to the soil around the soybean.

The present application provides a keratin and a nucleic acid sequence encoding the same. The present application further provides a keratin gel dressing comprising the keratin of the present application, bFGF and a gel matrix.

The invention belongs to the technical field of hair dyes, and particularly relates to a high-grease repairing ammonia-free low-sensitivity essential oil hair dye cream and a preparation method thereof. The ammonia-free low-sensitivity hair dye comprises the following raw materials in percentage by mass: 32-40% of ammonia-free low-sensitivity essential oil, 5-12% of an emulsifier, 5-10% of a thickener, 3-6% of a hair dye, 3-5% of a pH regulator, 1-3% of a humectant, 0.4-0.8% of an antioxidant, 0.1-0.5% of essence, 0.1-0.3% of a chelating agent, 0.05-0.15% of keratin and the balance of water. The ammonia-free low-sensitivity essential oil is a mixture of coconut oil, camellia seed oil, grape seed oil, macadamia nut seed oil, simmondsia chinensis seed oil and squalane. The high-grease repair ammonia-free low-sensitivity essential oil hair dyeing cream provided by the invention can simultaneously meet the effects of lasting color fixation, repair performance and stable storage.

The invention discloses keratinase Phyto-Keratinase and application of the keratinase Phyto-Keratinase. The keratinase Phyto-Keratinase comprises the following components: (1) protease which is coded by a nucleotide sequence as shown in SEQ ID NO.1; and / or (2) protease which is derived from bacillus subtilis, is coded by a nucleic acid sequence with more than 98% of identity with the SEQ ID NO.1 nucleotide sequence and has the characteristic of hydrolyzing keratin. According to the plant keratinase Phyto-Keratinase disclosed by the invention, the Phyto-Keratinase (plant keratinase) produced by utilizing microbial fermentation is a serine proteolytic enzyme, is also a biocompatible cutinase, and is obtained by fermenting saccharomyces cerevisiae. Phyto-Keratinase provides a nitrogen source for the growth of plants (beans), and contains various amino acids (functional peptides) and special proteolytic enzymes derived from the plants at the same time. The Phyto-keratinase can provide the effects of resisting inflammation, removing cutin and providing nutrition for skin regeneration at the same time, can relieve various inflammations by inhibiting PAR-2 receptors, and has potential value in the fields of cosmetics, beauty medicine and environment.

The invention provides transdermal recombinant keratin as well as a preparation method and application thereof, and relates to the technical field of genetic engineering. The transdermal recombinant keratin comprises a recombinant keratin and a cell penetrating peptide; the transdermal recombinant keratin has cell adhesion activity and transdermal property. The transdermal recombinant keratin comprises any one amino acid sequence as shown in SEQ ID NO.1, SEQ ID NO.2, SEQ ID NO.3 and SEQ ID NO.4 or consists of the amino acid sequence as shown in SEQ ID NO.1, SEQ ID NO.2, SEQ ID NO.3 and SEQ ID NO.4. According to the transdermal recombinant keratin, the transdermal performance and the cell adhesion activity of keratin are remarkably improved, and the problem that traditional recombinant keratin is poor in skin permeability is solved.

The invention discloses carbon-coated ferric sodium pyrophosphate as well as a preparation method and application thereof. The preparation method of the carbon-coated ferric sodium pyrophosphate comprises the following steps: 1) adding a phosphorus source, an iron source and a sodium source into an aqueous solution to obtain a mixed solution; dispersing a conductive agent into the mixed solution to obtain dispersion liquid; carrying out spray drying on the dispersion liquid to obtain a ferric sodium pyrophosphate precursor containing the conductive agent; 2) dissolving chitosan in an acetic acid aqueous solution to obtain a chitosan colloidal solution; then adding feather keratin into the chitosan colloidal solution, heating and stirring until the feather keratin is uniformly dispersed to obtain a dispersion liquid of double carbon sources; adding a conductive agent-containing ferric pyrophosphate sodium precursor into the double-carbon-source dispersion liquid, uniformly stirring and mixing, and heating and evaporating to dryness to obtain a carbon source-coated ferric pyrophosphate sodium precursor; and 3) carrying out heat treatment on the carbon source-coated ferric pyrophosphate sodium precursor in an inert atmosphere to obtain carbon-coated ferric pyrophosphate sodium.

The invention relates to self-curing keratin 3D printing ink integrated with shear activation microcapsules and a preparation method of the self-curing keratin 3D printing ink, and belongs to the technical field of biological 3D printing and intelligent materials.The preparation method comprises the steps that high-molecular-weight soluble keratin powder is dissolved in a biocompatible water-based medium with the pH being 6.5-8.5, and after even mixing and defoaming are conducted, a keratin base solution is obtained; wrapping the core material in a corresponding shell to obtain a microcapsule with the average particle size of 1-10 microns; under the stirring condition, the microcapsules are evenly dispersed into a keratin base solution at the temperature of 0-8 DEG C until a uniform suspension system is formed, and the self-curing keratin 3D printing ink integrating the shear activation microcapsules is obtained. And the curing process of the ink is internalized in the printing behavior, so that the printing process is simplified, and the equipment cost and the operation difficulty are reduced. The cross-linking agent is effectively isolated, so that the ink can be stably stored for several weeks before printing without gelling, and the problem that double-component ink must be immediately used after being mixed is solved.

Biomaterials disclosed herein can comprise a hydrogel comprising PEG, gelatin, and a glycosaminoglycan with sulfated moiety; and chondrogenic, osteogenic, and immunomodulatory cytokines; wherein the biomaterial is capable of potentiating bone regeneration in a compromised wound while reducing inflammatory response. The glycosaminoglycan with sulfated moiety can comprise heparin, heparan sulfate, keratin sulfate, chondroitin sulfate, dermatan sulfate, and / or similar materials. The biomaterial can further comprise mesenchymal stem cells (MSCs), a crosslinking initiator, microparticles and nanoparticles, and or other materials. The biomaterial can be injectable into a wound, or the biomaterial can be loaded in, or further comprise a porous scaffold providing mechanical support for other components of the biomaterial, such that it can be implanted into a wound.

Relates to the technical field of medicines, provides keratin CF5, a preparation method, a pharmaceutical composition and application thereof, and particularly relates to keratin CF5, a nucleic acid molecule for coding the keratin CF5, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, and a preparation method of the keratin CF5. The invention relates to a keratin CF5-containing pharmaceutical composition and application of the keratin CF5, nucleic acid molecules, expression vectors, host cells or the pharmaceutical composition in preparation of antipyretic and analgesic, cough-relieving and phlegm-eliminating drugs, anticonvulsion, antiepilepsy, blood pressure lowering drugs, anti-inflammatory drugs and antiviral drugs, in particular to application of the keratin CF5, the nucleic acid molecules, the expression vectors, the host cells or the pharmaceutical composition in preparation of antipyretic and analgesic drugs.

The present disclosure relates to a solid cosmetic make-up composition of a keratin material, in particular the skin and / or the lips, comprising at least one pigment, and at least one cavity such that the composition has a porosity of greater than or equal to 20% by volume relative to the total volume of the solid composition, as well as to associated production methods.

Belongs to the technical field of medicine, and provides keratin CF7, a preparation method, a pharmaceutical composition and application thereof. Specifically, the invention provides keratin CF7, a nucleic acid molecule encoding the keratin CF7, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, a preparation method of the keratin CF7, a pharmaceutical composition containing the keratin CF7, and a preparation method of the keratin CF7. The invention also discloses application of the keratin CF7, the nucleic acid molecule, the expression vector, the host cell or the pharmaceutical composition in preparation of antipyretic and analgesic, cough-relieving and phlegm-eliminating, anti-convulsion, anti-epilepsy, antihypertensive, anti-inflammatory and antiviral drugs.

The invention relates to a keratin bonding microcapsule as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The microcapsule comprises diethylhexyl maleate, keratin amino acids and hydrolyzed keratin which serve as main active components of a capsule core to form a keratin bonding agent and serve as a keratin reconstruction compound; the capsule wall is of a double-layer structure; the inner layer is a three-dimensional network formed by self-assembly of hydrolyzed keratin, keratin amino acids and a hydrophilic polymer interface; and the outer layer is a compact polymer film formed by copolymerization of an acrylate monomer and a cross-linking agent. The microcapsule disclosed by the invention can be applied to a perm agent, a hair dye or a hair care product, and is used for targeted repair of broken disulfide bonds in the perm and dyeing process, reversal of keratin damage, repair of damaged hair quality, improvement of hair breaking strength and reduction of broken hair.

The invention provides keratin CF3 as well as a preparation method, a pharmaceutical composition and application thereof, and belongs to the technical field of medicines. Specifically, the invention provides keratin CF3, a nucleic acid molecule encoding the keratin CF3, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, a preparation method of the keratin CF3, a pharmaceutical composition containing the keratin CF3, and a preparation method of the keratin CF3. The invention also discloses application of the keratin CF3, the nucleic acid molecule, the expression vector, the host cell or the pharmaceutical composition in preparation of antipyretic and analgesic drugs, antitussive and expectorant drugs, anticonvulsion drugs, antiepileptic drugs, antihypertensive drugs, anti-inflammatory drugs and antiviral drugs.

The present application relates to the field of cosmetic technology, in particular to a quick-drying and shaping spray and a preparation method thereof, in particular to a hair styling product which is quickly dried, permanently shaped and has hair care effect through the synergistic effect of specific film-forming agents and volatile systems, comprising the following components: ethanol 30-50%, aminomethyl propanol 0.1-1%, butanediol 1-5%, octyl acrylamide / acrylate / methyl acrylate copolymer 5-15%, PEG-12 dimethicone 0.5-2%, keratin 0.1-2%, hydrolyzed keratin 0.1-2%, oxidized keratin 0.1-2%, aloe barbadensis leaf extract 0.5-3%, selaginella kurata extract 0.5-3%, radix falatoniae extract 0.5-3%, radix salviae miltiorrhizae extract 0.5-3%, water 20-40%, essence 0.1-2%, cetrimonium chloride 0.1-1%, phenoxyethanol 0.5-1.5%, propylene glycol 1-5%, p-hydroxyacetophenone 0.5-1.5%, chlorphenesin 0.1-0.5%, ethylhexylglycerin 0.5-1.5%.

The invention provides keratin CF4 as well as a preparation method, a pharmaceutical composition and application thereof, and belongs to the technical field of medicines. Specifically, the invention provides keratin CF4, a nucleic acid molecule encoding the keratin CF4, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, a preparation method of the keratin CF4, a pharmaceutical composition containing the keratin CF4, and a preparation method of the keratin CF4. The invention also discloses application of the keratin CF4, the nucleic acid molecule, the expression vector, the host cell or the pharmaceutical composition in preparation of antipyretic and analgesic drugs, antitussive and expectorant drugs, anticonvulsion drugs, antiepileptic drugs, antihypertensive drugs, anti-inflammatory drugs and antiviral drugs.

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-6, its encoding nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-6 and other products in the preparation of drugs for treating benign prostatic hyperplasia, lymphoma, melanoma, analgesia, lactation, breast cancer, lung cancer, uterine fibroids, coagulation, etc.

The invention discloses an eggshell membrane peptide for enhancing bone mineral density as well as a preparation method and application thereof, belongs to the technical field of egg by-product processing, and particularly relates to a preparation method of the eggshell membrane peptide for enhancing bone mineral density, which comprises the following steps: carrying out vacuum freeze drying and crushing on an eggshell membrane to obtain eggshell membrane powder; mixing the eggshell membrane powder with deionized water to obtain an eggshell membrane solution; adding keratinase, performing enzymolysis, and taking supernate; adding collagenase, carrying out enzymolysis, and centrifuging to take supernate, so as to obtain primary enzymatic hydrolysate; adding alkaline phosphatase, performing enzymolysis and centrifugation, and taking supernate to obtain enzymatic hydrolysate; and performing ultrafiltration and drying to obtain the eggshell membrane peptide. According to the eggshell membrane peptide for enhancing the bone mineral density, keratin cross-linking is destroyed through enzymolysis of keratinase, active peptide capable of stimulating osteoblast proliferation is released through enzymolysis of collagenase, phosphopeptide calcium binding sites are further activated through enzymolysis of alkaline phosphatase, calcium salt deposition is promoted, and the eggshell membrane peptide for enhancing the bone mineral density is provided.

The invention provides a synergistic anti-aging composition based on a white truffle fungus extract, hydrolyzed keratin and soluble collagen and a preparation method of the synergistic anti-aging composition. The essence comprises the following components in percentage by mass: 0.5-5% of a white truffle fungus extract, 1-8% of hydrolyzed keratin and 2-10% of soluble collagen, and is supplemented with cross-linked modified hyaluronic acid, glycerol, ceramide, tocopheryl acetate, phenoxyethanol and a solvent. The preparation method comprises the following steps: preparing the cross-linked modified hyaluronic acid, performing low-temperature enzymolysis extraction on the white truffle bacteria, mixing and dissolving, and preparing the composition. The anti-aging effect of the composition is effectively improved and the stability of the composition is improved through the ternary synergistic effect (the white truffle bacteria can resist oxidation, the hydrolyzed keratin can repair a barrier and the collagen can promote regeneration) and process optimization.

The invention discloses a broad-spectrum antibacterial photo-thermal biological film as well as a preparation method and application thereof, and belongs to the technical field of daily chemistry and food science. Keratin and carboxymethyl cellulose are used as raw materials, phenolated lignin nanoparticles are used as an antibacterial agent, and the prepared biological film shows excellent mechanical toughness (elongation at break gt; 150%) and self-adhesion, can form a tight package after simple pressing, has rapid photoresponse ability, can be heated to 50 DEG C or above within 1 minute, has broad-spectrum photothermal antibacterial ability and antioxidant ability, has a staphylococcus aureus and escherichia coli inhibition rate of more than 90%, and has a DPPH free radical scavenging rate gt; and the fresh-keeping period of fresh vegetables and fruits can be effectively prolonged. The prepared biological film can replace a plastic film to be applied to packaging of foods such as vegetables, fruits and grains, loss is reduced while plastic pollution is reduced, and a solution is provided for construction of a sustainable packaging system.

The invention relates to preparation of hydrolyzed keratin capable of maintaining hair and application of the hydrolyzed keratin in shampoo. The shampoo capable of maintaining the hair and the keratin is prepared by compounding a surfactant, a modified silicone oil graft polymer, the hydrolyzed keratin and polydimethylsiloxane. According to the modified silicone oil graft polymer, hydrophilic sodium acrylate and hydrophobic N-vinyl pyrrolidone and acrylic ester are introduced into vinyl silicone oil, and N-vinyl pyrrolidone and acrylic ester can be adsorbed on the inner side of the hair surface; sodium acrylate with hydrophilicity is located on the outer side of the surface of the hair due to electrostatic repulsion between the negatively-charged hair and generates hydration with water molecules on the surface of the hair to form a water shell protection layer, so that the sodium acrylate can be more uniformly distributed on the hair to form an effective protection film, and during washing, the water washing property is greatly enhanced by the hydrophilic part of the sodium acrylate; non-specific deposition and residues in a scalp area are remarkably reduced, and the washed hair can be moisturized and lubricated.

The invention provides a hair care composition with oil control, hair loss prevention and repair effects and a preparation method of the hair care composition, and belongs to the technical field of hair care. The hair care composition comprises functional peptides such as myristoyl pentapeptide-4, palmitoyl tripeptide-1, acetyl tetrapeptide-3, hexapeptide-3, acetyl hexapeptide-8, palmitoyl tetrapeptide-7 and the like which are synergistically combined according to a specific proportion, and glycerin, water and a penetration enhancer are supplemented to form a basic system. By optimizing peptide structure modification, adding proportion and the steps of pH control, ultrasonic treatment and collaborative assembly in the preparation process, multi-path collaborative regulation and control of hair follicle activation, scalp inflammation inhibition and keratin synthesis enhancement are realized.

The present disclosure relates to a solid cosmetic composition for perfuming a keratin material, in particular the skin and / or the lips, comprising at least one perfuming agent, and one cavity, such that the composition has a porosity of greater than or equal to 20% by volume relative to the total volume of the solid composition, as well as to associated production methods.

Engineered, modified, or mutated Bacillus strains that produce keratinases or serine proteases (KerS) that biologically degrade keratin-containing materials, such as feathers; compositions containing these Bacillus strains or the keratinases they produce, and methods for biologically degrading keratin-containing materials using these strains or keratinases.

The invention relates to a preparation method of a biological membrane with a bionic cuticle'brick-slurry 'structure and a wound dressing application of the biological membrane, and belongs to the technical field of biological auxiliary materials. The preparation method comprises the following steps: dispersing prepared wool keratin microspheres in a fibroin solution, realizing a stable and firm brick-slurry structure by combining solvent volatilization with a photo-crosslinking technology, further crosslinking by utilizing metal ion coordination, and simultaneously endowing the dressing with the capabilities of effectively blocking bacterial permeation and sterilizing. The biological membrane exceeds the design of traditional layered wound dressings, and accurate reproduction of a natural skin structure is preferentially considered. The microspheres are assembled into a densely-arranged masonry structure material in a planned manner, so that the dressing has high moisture permeability, oxygen permeability and strong antibacterial barrier capacity, can promote repair of infectious wounds and burn and scald wounds, and has remarkable clinical application value.

Belongs to the technical field of medicines, and relates to keratin CF1, a preparation method, a pharmaceutical composition and application thereof, in particular to keratin CF1, a nucleic acid molecule for encoding keratin CFI, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, and a preparation method of the keratin CF1. The invention relates to a keratin CF1-containing pharmaceutical composition and application of the keratin CF1, nucleic acid molecules, expression vectors, host cells or the pharmaceutical composition in preparation of antipyretic and analgesic, cough-relieving and phlegm-eliminating drugs, anticonvulsion, antiepilepsy, blood pressure lowering drugs, anti-inflammatory drugs and antiviral drugs, in particular to application of the keratin CF1, the nucleic acid molecules, the expression vectors, the host cells or the pharmaceutical composition in preparation of antipyretic and analgesic drugs.

The invention provides a pet hair decomposer with synergistic effect of bacillus subtilis and keratinase, the pet hair decomposer comprises bacillus subtilis ZYpet-015 and keratinase, the preservation number of the bacillus subtilis ZYpet-015 is CGMCC (China General Microbiological Culture Collection Center) No.34790, and the preservation date is June 6, 2025; the protease activity of the bacillus subtilis is greater than or equal to 129.92 U, the survival rate of the bacillus subtilis in simulated gastric juice within 3 hours is greater than 50%, and the tolerance rate of the bacillus subtilis in intestinal juice within 4 hours is greater than 90%. According to the pet hair decomposing agent, hair keratin is synergistically degraded through protease secreted by the bacillus subtilis ZYpet-015 and keratinase, and the hair decomposing efficiency reaches 28.07% + / -2.79% and is remarkably higher than that of a single treatment group. Meanwhile, experiments prove that the pet hair decomposer can effectively destroy the hair cuticle structure, is suitable for a pet hair-melting nutritional supplement and can relieve the hair ball symptom.

An application device for applying a fluid product to keratin fibres includes a plurality of spikes that are distributed over an elongate core extending along a longitudinal axis X. Each spike has a first stage that extends from an anchoring end in the core towards an intermediate section, a second stage that extends from the intermediate section towards a free end, and a joint face parallel to the longitudinal axis X. Each spike has an intermediate point and an apical point.