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Application of HLA-B (Human Leukocyte Antigen-B) allele to preparation of detection reagent for predicating liver injury causing risks of polygoni multiflori and components thereof

A technology of alleles and detection reagents, which is applied in the field of application of HLA-B alleles in the preparation of detection reagents for predicting the risk of liver damage caused by the plant Polygonum multiflorum and its components, which can solve the problem of irrelevant gender and age of patients and unavailable Prognosis, diagnosis and treatment methods, low incidence of liver injury, etc.

Active Publication Date: 2017-12-08
长沙都正医学检验有限责任公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the complex components of Polygonum multiflorum and various usages, the existing research has not been able to clarify its toxic components and pathogenic mechanisms, so there are still no effective prediction, diagnosis and treatment methods for liver damage in Polygonum multiflorum
[0003] Previous epidemiological studies have shown that the incidence of liver injury caused by Polygonum multiflorum is low, and it mostly occurs within 1 to 4 weeks after taking the medicine. It is not related to the gender and age of the patient, and it can also occur with low doses. There are also reactivation phenomena and familial cases. to report

Method used

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  • Application of HLA-B (Human Leukocyte Antigen-B) allele to preparation of detection reagent for predicating liver injury causing risks of polygoni multiflori and components thereof
  • Application of HLA-B (Human Leukocyte Antigen-B) allele to preparation of detection reagent for predicating liver injury causing risks of polygoni multiflori and components thereof
  • Application of HLA-B (Human Leukocyte Antigen-B) allele to preparation of detection reagent for predicating liver injury causing risks of polygoni multiflori and components thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1. HLA-B*35:01 allele as a genetic marker for predicting liver damage caused by the plant Polygonum multiflorum and its components

[0019] 1. Sample

[0020] The samples are human peripheral blood, including case samples, Polygonum multiflorum tolerance control samples and healthy control samples.

[0021] 1. Case samples

[0022] Included in the study were 20 patients with liver injury caused by Polygonum multiflorum of the Han nationality in China (11 for the discovery phase of the study and 9 for the verification phase of the study). It takes 10-240 days for patients to start taking Radix Polygoni Multiflori to develop symptoms of liver damage. Common symptoms include: yellow skin, tea-colored urine, nausea and vomiting, loss of appetite, fatigue, fever, etc. Laboratory tests showed that alanine aminotransferase exceeded 3 times the upper limit of normal or total bilirubin exceeded 40 μmol / L. All patients were diagnosed as drug-induced liver injury caused...

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Abstract

The invention discloses application of an HLA-B (Human Leukocyte Antigen-B)*35: 01 allele. The HLA-B*35: 01 allele is characterized in that 1, the HLA-B*35: 01 allele can be used as a genetic marker and a treatment target point and is used for preparing a detection reagent for predicating liver injury causing risks of polygoni multiflori and components of the polygoni multiflori; 2, the HLA-B*35: 01 allele is used as the treatment target point and is used for preparing a medicine for treating polygoni multiflori caused liver injuries; 3, the HLA-B*35: 01 allele is used as the marker and is used for preparing a detection reagent for screening high-sensitivity crowd with the liver injuries caused by the polygoni multiflori and substances containing the polygoni multiflori matters.

Description

technical field [0001] The present invention relates to the use of HLA-B*35:01 alleles, in particular to the use of HLA-B*35:01 alleles as genetic markers for the risk of liver damage caused by the plant Polygonum multiflorum, pharmaceutical preparations containing Polygonum multiflorum components, and health products containing Polygonum multiflorum components Applications. Background technique [0002] In my country, the liver injury caused by Chinese herbal medicines accounts for 21% of all drug-induced liver injuries, and the liver injury caused by Polygonum multiflorum is the most eye-catching. Polygonum multiflorum Thunb., a plant of Liao family, has been used for thousands of years in my country and is regarded as one of the "Four Immortal Herbs". Polygonum multiflorum has a wide range of uses. The dried roots are called "Polygonum multiflori (POLYGONIMULTIFLORI RADIX)" or "Shouwu"; the processed products are called "POLYGONI MULTIFLORIRADIX PRAEPARATA"; (POLYGONI M...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6895C12Q2600/106C12Q2600/156
Inventor 李超鹏欧阳冬生陈露露周露萍饶泰
Owner 长沙都正医学检验有限责任公司
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