4results about How to "No hemolytic activity" patented technology

This invention belongs to the field of antimicrobial peptide technology, and particularly relates to a broad-spectrum antimicrobial peptide with low hemolytic activity and its applications, as well as a broad-spectrum antibacterial drug. The antimicrobial peptide is named AY6, and its amino acid sequence is shown in SEQ ID NO.1. Antimicrobial peptide AY6 exhibits significant antibacterial effects against both Gram-positive and Gram-negative bacteria, with a bactericidal rate far exceeding that of traditional antibiotics, enabling highly effective responses to bacterial infections. AY6 has low hemolytic activity and good biocompatibility, making it suitable for medical anti-infective applications. The antimicrobial peptide provided in this application has a short sequence, is easy to synthesize chemically, can save on large-scale production costs, and has broad application prospects.

The invention belongs to the technical field of biological medicines, and discloses an artificially synthesized antibacterial peptide, a derivative thereof and an application of the artificially synthesized antibacterial peptide in resisting escherichia coli. The antibacterial peptide provided by the invention has a strong inhibition effect on escherichia coli and comprises multiple drug-resistant strains. Experiments show that the antibacterial peptide has high in-vitro antibacterial activity, excellent thermal stability, acid-base stability and no hemolytic activity, has no obvious toxicity to mammalian cells, and shows a remarkable treatment effect in a chicken escherichia coli infection model. The invention provides a novel antibacterial preparation for coping with escherichia coli, especially infection of drug-resistant strains.

The present application relates to the fields of animal nutrition and microbial fermentation technology, and particularly relates to a strain of Saccharomyces boulardii, a microecological preparation thereof and application thereof.The Saccharomyces boulardii is named as NCUTY 002, has been preserved in China Center for Type Culture Collection, and the preservation number is CCTCC NO:M 2025648.The Saccharomyces boulardii NCUTY 002 screened in the present application has excellent acid tolerance (pH≤2.5) and bile salt tolerance (0.5%), and shows high self-aggregation capacity, so that it can survive and stably colonize in the extreme environment of digestive tract of egg ducks, and can be used as a special feed additive for egg ducks.

The present application belongs to the field of microbial application and feed processing technology, and discloses a bacillus subtilis, named bacillus subtilis YT1, which is preserved in China Center for Type Culture Collection, located at Wuhan University, No. 299, Bayi Road, Wuchang District, Wuhan City, Hubei Province, with a preservation number of CCTCC NO: M 20242767 and a preservation date of December 10, 2024. The present application also discloses a microbial preparation and the application of the bacillus subtilis or the microbial preparation in the processing of silage. The present application first simultaneously possesses high efficient lignocellulose degradation ability, excellent fermentation promotion characteristics, significant antioxidant activity and good probiotic characteristics in a strain of bacillus subtilis. This characteristic enables a single bacterial agent to achieve multiple goals such as fiber degradation, fermentation promotion, oxidation protection, which traditionally requires multiple compounded bacterial agents, and fundamentally overcomes the problems of poor compatibility between strains, unstable synergistic effect and high application cost of existing compounded additives.