2results about How to "Degradation has" patented technology

This disclosure relates to the field of anticancer drug technology, and discloses a 7-azaindole compound, its synthesis method, and its uses. The structure of the 7-azaindole compound is as follows: This 7-azaindole compound can be used as a fluorescent polarization probe or a degradation chemical probe targeting CSN5; wherein, the fluorescent polarization chemical probe has a good binding affinity to the metalloproteinase CSN5, laying an important foundation for the discovery of novel CSN5 inhibitors; at the same time, the degradation chemical probe exhibits good enzyme-level activity and cell-inhibitory activity, and has the potential to degrade CSN5 protein and its variants, providing a material basis for the development of related drugs targeting CSN5 and the study of its biological functions, and also has great potential in the discovery of cancer immunotherapy drugs and the treatment of other related diseases.

This invention relates to a synthetic microbial community for degrading polycyclic aromatic hydrocarbons (PAHs) and its applications, belonging to the field of environmental remediation microbial technology. First, a strain of *Bacillus polymyxa* C9-5 is provided, deposited on June 5, 2026, at the China General Microbiological Culture Collection Center (CGMCC) with accession number CGMCC No. 39269. Then, a synthetic microbial community for degrading PAHs is provided, comprising *Bacillus polymyxa* C9-5 and *Acinetobacter* B2-4. Finally, a composite microbial agent for degrading PAHs is provided, comprising a suspension of *Bacillus polymyxa* C9-5 and a suspension of *Acinetobacter* B2-4. This invention is the first to combine *Bacillus polymyxa* C9-5 and *Acinetobacter* B2-4 together to synergistically degrade PAHs in soil or wastewater. The degradation effect on PAHs is significantly better than that of any single strain, showing excellent efficacy in degrading high-ring PAHs and possessing broad application prospects.