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A kind of composite water-based adhesive formed by polypeptide and glycyrrhizic acid and preparation method thereof

A technology of glycyrrhizic acid and adhesives, applied in the field of materials, can solve problems such as high heavy metal content, loss of viscosity, and potential safety hazards, and achieve the effects of easy degradation, easy formation, and poor stability

Active Publication Date: 2022-05-24
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this type of material still has the following disadvantages: 1) The adhesive can only exist stably in acidic aqueous solution, and it is easy to dissociate into a solution and lose its viscosity under neutral and physiological conditions; 2) The adhesive contains polymetallic oxides. Clusters, whose heavy metal content is extremely high, have great safety hazards and toxicity risks in clinical use

Method used

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  • A kind of composite water-based adhesive formed by polypeptide and glycyrrhizic acid and preparation method thereof
  • A kind of composite water-based adhesive formed by polypeptide and glycyrrhizic acid and preparation method thereof
  • A kind of composite water-based adhesive formed by polypeptide and glycyrrhizic acid and preparation method thereof

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preparation example Construction

[0041] The present invention provides a method for preparing the polypeptide / glycyrrhizic acid composite aqueous adhesive of the above technical solution, comprising the following steps:

[0042] The pH value of the glycyrrhizic acid aqueous solution is adjusted to 6.0-8.0 with a 0.01-0.1 mol / L sodium hydroxide aqueous solution to obtain a glycyrrhizic acid precursor solution;

[0043] Adjust the pH value of the polypeptide aqueous solution to 6.0-8.0 with 0.01-0.1 mol / L sodium hydroxide aqueous solution to obtain the polypeptide precursor solution;

[0044] Mix the polypeptide precursor solution and the glycyrrhizic acid precursor solution, control the charge ratio of the polypeptide to the glycyrrhizic acid to be 1-1.2:1, stir evenly at 22-25°C, and stand at room temperature for 0.5-1h to obtain the polypeptide / licorice Acid complex water-based adhesive.

[0045] In the present invention, the polypeptide and the glycyrrhizic acid are respectively dissolved in double distill...

Embodiment 1

[0049] 1) Preparation of polypeptide P1 / glycyrrhizic acid composite aqueous adhesive: Dissolve 100 mg of polypeptide (P1: molecular weight of 1220.34 g / mol) in 0.5 mL of double distilled water, and adjust the pH of the solution with 0.1 mol / L sodium hydroxide. 7.3, obtaining a polypeptide precursor. 67.43 mg of glycyrrhizic acid (molecular weight: 822.93 g / mol) was dissolved in 0.5 mL of double distilled water, and the pH of the solution was adjusted to 6.5 with 0.1 mol / L NaOH. At 25°C, the aqueous solution of glycyrrhizic acid was added dropwise to the aqueous solution of polypeptide P1, and the transparent solution gradually turned into a turbid state. The obtained mixed solution was stirred at 25°C for 0.5 h after being stirred by a vortex, and the solution turned from turbid to transparent. During this process, a milky white composite aqueous adhesive was gradually formed at the bottom of the solution.

[0050] 2) Performance test:

[0051] 1) figure 1 It is the digital...

Embodiment 2

[0075] As shown in Example 1, with other conditions unchanged, 100 mg of polypeptide P1 was changed to 100 mg of polypeptide P2 (AC-RRYNYQRR-NH 2 , the molecular weight is 1252.38g / mol), and the composite water-based adhesive is prepared according to the above method. Then, the adhesive property, tensile property, self-healing ability and rheological behavior of the composite water-based adhesive were tested according to the steps of Example 1. The bonding test of the composite water-based adhesive to solid materials such as polypropylene, polyether ether ketone, polycarbonate, titanium, stainless steel, wood, shell, stone, rubber, agate) shows that the composite water-based adhesive prepared has a wide range of performance. The adhesive properties of the spectrum. The tensile shear strength of polypeptide P2 / glycyrrhizic acid composite water-based adhesive to titanium, stainless steel, polyetheretherketone, polypropylene and pigskin in water environment are 55.1±1.5kPa, 30.2...

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Abstract

The invention discloses a composite water-based adhesive formed of polypeptide and glycyrrhizic acid, which comprises glycyrrhizic acid, polypeptide, twice distilled water, and a pH regulator of hydrochloric acid or sodium hydroxide; the pH value of the composite water-based adhesive is 5.5-8.0. The composite water-based adhesive of the present invention is a precursor solution formed from polypeptide and glycyrrhizic acid. Secondly, the polypeptide containing arginine residues was blended with the above precursor solution containing glycyrrhizic acid aggregates to form a composite water-based adhesive. The water-based adhesive provided by the present invention has stable and good self-healing ability, and has processability and degradability at the same time; the dry powder obtained after drying the adhesive of the present invention can immediately become an adhesive to restore viscosity after re-contacting water. It is a kind of composite water-based adhesive that is easy to store, recyclable and reusable.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a composite aqueous adhesive formed by polypeptides and glycyrrhizic acid and a preparation method thereof. Background technique [0002] Water-based adhesives are a kind of green and environmentally friendly functional materials, which play an irreplaceable and important role in the fields of national defense, navigation, underwater plugging, decoration, food hygiene and other fields. In particular, underwater adhesives can achieve effective bonding in water or humid environments, which is especially suitable for clinical adjuvant therapy, such as surgical hemostasis, tissue repair and plugging, wound healing, dental repair, bone bonding, etc. (Li Junming, Zhang Jiao, Wang Aijuan, Liu Lintao, Fan Xiaojie, et al. "Research Progress on Adhesive Properties of Medical Bone Adhesives", Materials Review, 2013, 27(7), 145). At present, the vast majority of artificial wat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09J177/00C09J11/06A61L24/00A61L24/10
CPCC09J177/00C09J11/06A61L24/10A61L24/00A61L24/001C08K5/1545
Inventor 李文刘晓欢程学良赵建武
Owner JILIN UNIV
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