Developing polylactic acid microsphere blood vessel suppository containing antitumor agent

A technology of anti-tumor drugs and vascular embolisms, which is applied in the field of developing polylactic acid microspherical vascular embolisms, which can solve the problems of invisibility and achieve the effect of not easy reflux, good visibility and easy observation

Inactive Publication Date: 2007-08-08
李艳芳 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these vascular embolic materials containing anti-tumor drugs disclosed in the prior art are invisible under X-rays

Method used

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  • Developing polylactic acid microsphere blood vessel suppository containing antitumor agent

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Embodiment 1

[0016] Embodiment 1: Drug-containing developing polylactic acid (PLA) microspheres of the present invention

[0017] Angiographic contrast agents purchased in the market, such as ionic contrast agent Urografin, are processed by vacuum freeze-drying, and the remaining substances after freeze-drying are retained as developing materials (2).

[0018] Choose only one of the following drugs as an antineoplastic drug (3), or choose a mixture of two or more of the following drugs as an antineoplastic drug (3), these drugs include: Carboplatin, cisplatin , Paclitaxel, Docetaxel, Oxaliplatin, Cyclophosphamide, Ifosfamide, Doxorubicin, Pegylated Liposomal doxorubicin), Epirubicin, Topotecan, Irinotecan, Etoposide (or VP-16), Bleomycin, Fluorouracil (Fluorouracil), Gemcitabine, Vincristine, Actinomycin, paclitaxol (taxol), or a blend of two or more of the above drugs, or any of the above drugs Derivatives and blends of derivatives, etc.

[0019] Polylactic acid is used as the biodegra...

Embodiment 2

[0024] Embodiment 2: Developing poly(lactic-co-glycolic acid) (PLGA) microspheres of the present invention

[0025]The production method of the product of this embodiment is basically the same as that of Example 1, except that the biodegradable material (1) is selected as a poly(lactic-co-glycolic acid) copolymer, and the developing material (2) can be selected from one of the following substances: ion Type contrast agent diatrizoate meglumine after vacuum freeze-drying; non-ionic contrast agent iohexol (Iohexol) or iopromide (Iopamidol) after vacuum freeze-drying The remaining substances after the treatment; the remaining substances after the non-ionic dimer iotrolan (Iotrolan) and other angiographic contrast agents have been processed by vacuum freeze-drying. Antineoplastic drugs (3) can be selected from one of the following substances: Carboplatin, Cisplatin, Paclitaxel, Docetaxel, Oxaliplatin, Cyclophosphamide (Cyclophosphamide), Ifosfamide, Doxorubicin, Pegylated liposom...

Embodiment 3

[0027] Embodiment 3: Drug-containing developing polylactic acid-polyether copolymer microspheres of the present invention

[0028] The production method of the product of this embodiment is basically the same as that of Example 1, except that the biodegradable material (1) is selected as polylactic acid-polyether copolymer; the developing material (2) can be selected from one of the following substances: Ionic contrast agent diatrizoate meglumine is the remaining substance after vacuum freeze-drying; non-ionic contrast agent iohexol (Iohexol) or iopromide (Iopamidol) is vacuum freeze-dried The remaining substances after processing; the remaining substances after the non-ionic dimer iotrolan (Iotrolan) and other angiographic contrast agents have been processed by vacuum freeze-drying; antineoplastic drugs (3) can be selected from one of the following substances: Carboplatin, Cisplatin, Paclitaxel, Docetaxel, Oxaliplatin, Cyclophosphamide, Ifosfamide, Doxorubicin ), Pegylated l...

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Abstract

The invention relates to a developing polylactic acid micro ball vessel suppository which contains anti-tumor drug, formed by a biological degrade material plant in the vessel, a developing material for baffling the X-ray and the anti-tumor drug, wherein, the biological degrade material coats the developing material and the anti-tumor drug to form particle structure. The invention has the advantages that it can plug the vessel and feed drug targeted; it has better view property under X-ray to watch the plug part; it has biological degradable property to protect the organ; after plugging, the nuclear magnetic resonance (MRI) can be process; the invention can suspend in blood and approach to the end vessel along with blood, to deposit and plug the vessel; the diameter of micro ball can be controlled. The invention has low cost, while it provides a plug material especially the plug material used at terminal vessel.

Description

technical field [0001] The invention relates to a blood vessel embolization material, in particular to a developing polylactic acid microsphere type blood vessel embolism containing antitumor drugs. Background technique [0002] In the prior art, there are many kinds of vascular embolization materials for intervention, mainly including polyvinyl alcohol (Polyvinyl Alcohol, PVA) microspheres, sodium alginate microspheres, gelatin sponge, surgical thread, stainless steel coils, platinum microcoils, Detachable balloons, cyanoacrylates, dehydrated ethanol, iodized oil, sodium morrhuate, etc. In clinical use, spring steel coils, surgical thread, and gelatin sponge have good clinical effects in embolizing large blood vessels, but the long-term efficacy is affected by the establishment of collateral circulation. Liquid embolic agents such as cyanoacrylates, dehydrated ethanol, iodized oil, and sodium morrhuate are prone to misembolization during clinical operations and are difficu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/18A61L31/16A61L31/06
Inventor 李艳芳周泰立
Owner 李艳芳
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