3 results about "Cyanoacrylates" patented technology

A compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, represented by Formula (I)wherein Ring A is a ring represented by:wherein X is a single bond or the like, R2 is substituted or unsubstituted aromatic carbocyclyl or the like, R3c is substituted or unsubstituted aromatic carbocyclyl or the like, R3 is substituted or unsubstituted aromatic carbocyclyl or the like, R3a is a hydrogen atom or the like, R3b is a hydrogen atom, R8a is substituted or unsubstituted aromatic carbocyclyl or the like, and R8b is a hydrogen atom or the like,R1 is a substituted or unsubstituted aromatic heterocyclyl, m is 0 or the like, R5a is each independently a hydrogen atom or the like, R5b is each independently a hydrogen atom or the like, R6 is cyano or the like, and R7a and R7b are each independently a hydrogen atom or the like.

The invention discloses an olefin reductase SeER mutant and application thereof in synthesis of chiral drugs, and provides a series of novel olefin reductase SeER mutants capable of efficiently and asymmetrically reducing beta-alkyl / aryl-beta-cyanoacrylate compounds, and the olefin reductase SeER mutants have high conversion rate (gt; 99% conversion rate), good enantioselectivity (gt; 99% ee), the substrate range is wide (gt; according to the present invention, the screened olefin reductase SeER mutant can be successfully synthesized into the chiral GABA derivative drugs such as pregabalin and brivaracetam through the chemical-enzyme coupling method, such that the overall reaction yield is improved, and the route is simple;

Synergistic stabilizer compositions having a stabilizing amount of a co-synergist; optionally a stabilizing amount of a co-active agent; a stabilizing amount of an ultraviolet light absorber selected from an ortho-hydroxyphenyl triazines, ortho-hydroxy benzophenones, oxanilides, cyanoacrylates, benzoxazinones, optionally ortho-hydroxyphenyl benzotriazoles, and combinations thereof; and a stabilizing amount of a hindered amine light stabilizer, are provided herein. The total weight of co-synergist (IV) and co-active agent (when present) is from 1 wt. % to 99 wt. %, based on the total weight of the stabilizer composition; and the weight ratio of co-synergist to co-active agent (when present) is 1:99 to 99:1. Also disclosed are masterbatch concentrates, stabilized polymer compositions, and stabilized articles of manufacture, all containing the stabilizer composition.