57 results about "Imidic acid" patented technology

The invention discloses a ratio-type variant receptor mercury ion fluorescent probe and its preparation method and use. The ratio-type variant receptor mercury ion fluorescent probe has the advantages of simple synthesis processes, good light stability, the largest emission wavelength of 550nm and good chemical stability under neutral conditions. Through amide functional group tautomerism, the receptor has a deformation capability of combination of an imidic acid isomer and mercury ions and combination of an amide isomer structure and other metal ions so that the receptor has mercury ion specific combination selectivity. The probe with the mercury ion produces fluorescence spectrum red shift to 633nm and the fluorescence spectrum is enhanced by 9 times. After bonding to other metal ions especially such as congener zinc ion and cadmium ions, the probe has no obvious fluorescence change and has mercury ion specific fluorescence signal selectivity. The probe realizes mercury ion specific ratio identification, can be used in detection of mercury ions in cells and has a wide application prospect in detection of mercury ions in other organisms and environments.

Provided is an actinic-ray- or radiation-sensitive resin composition including a resin (A) and any of compounds (B) of general formula (I) below. (In general formula (I), Rf represents a fluorine atom or a monovalent organic group containing at least one fluorine atom; R1 represents a hydrogen atom or a monovalent substituent containing no fluorine atom; X1 represents a monovalent organic group having at least two carbon atoms, or a methyl group in which a substituent other than a fluorine atom is optionally introduced, provided that X1 may be bonded to R1 to thereby form a ring; and Z represents a moiety that when exposed to actinic rays or radiation, is converted to a sulfonic acid group, an imidic acid group or a methide acid group.)

The present invention provides a cadmium ion fluorescence probe, a preparation method and applications thereof. According to the present invention, the probe has specific binding selectivity and fluorescence response to cadmium ions; 4-amno-7-nirobenzoxadiazole is used as a fluorophore and amide DPA is used as a receptor in the probe, and the acceptor can have the variation ability through the tautomerism of the amide functional group, wherein the isomer of the imidic acid binds the cadmium ions, and the structure of the amide isomer binds other metal ions so as to provide the specific binding selectivity to the cadmium ions; and the unique identification on the cadmium ions by the probe is achieved, the obtained probe can be used for detecting the cadmium ions in cells, and can further be used for the cadmium ion detection in other organisms and environments due to the wide pH value working range.

A process for preparing a divinylarene dioxide including reacting (a) at least one divinylarene; (b) at least one peroxycarboximidic acid; (c) at least one solvent; and (d) at least one basic compound, under conditions to form a reaction mixture containing a divinylarene dioxide product; and then separating the divinylarene dioxide product from the other reaction mixture components to obtain a purified divinylarene dioxide product.

The invention discloses a ferrocenyl imidazoline palladacycle complexe, the preparation method and its application in catalizing coupling product. The general formula of compound is in the right. The method comprises: carrying out reaction with ferrocenyl imidic acid methyl ester hydrochlorate and vicinal diamine, getting ferrocenyl imidazoline compound through post treatment; carrying out reaction with mentioned compound above with palladium lithium halides and NaOAc in organic solvent while being stirred at room temperature, and getting final product. The catalytic synthesis of coupling product with siad compound comprises following steps: dissloving catalyst, aryl boracic acid, alkali and halogenated aromatic compound in organic solvent, heating for reaction, cooling for extraction, purifying and getting coupling product. The invention is characterized by high catalytic property, environmental- friendly, insenstive to aor and water, good thermal stability of non-phosphine ligand, easy processing route, temperate reaction condition, and high specificity.

Derivatives of 9-deazaguanine of the formula I: are prepared by reacting an aldehyde or ketone of the formula II: with a dialkylaminomalonate to produce an enamine. The enamine is then reacted with a base to produce a pyrrole represented by the formula: The pyrrole is reacted with a compound represented by the formula R3OC(O)N═C(Z)NHC(O)OR3 or a derivative of carbamimidoic acid to provide a protected guanidine compound. The guanidine compound is converted to the desired deazaguanine by reaction with 1) trifluoracetic acid or 2) C1-C4 alkoxide or alkali metal or alkaline earth metal hydroxide followed by neutralization with an acid.

To provide an imide salt represented by the formulawherein, R represents a halosulfonyl group (—SO2X1 where X1 is a halogen such as fluorine, chlorine, bromine and iodine) or dihalophosphoryl group (—POX2X3 where X2 and X3 are the same or different halogens such as fluorine, chlorine, bromine and iodine), and M represents an alkali metal;with high selectivity and high efficiency by using a low-cost starting material.In the production of an imide salt, an alkali metal fluoride, a sulfuryl halide or phosphoryl halide, and ammonia or an ammonium salt are reacted. According to this method, a desired imide salt can be produced with high yield, while greatly suppressing the production of a by-product.

The invention discloses a method for efficiently preparing chiral deuterated amino acid ester, which is characterized in that in a common organic solvent, asymmetric transfer deuterization of imidic acid ester is realized by taking imidic acid ester as a raw material and taking deuterated methanol as a deuterium source and adopting transition metal catalysis. The target product namely chiral deuterated amino acid ester is obtained. The reaction general formula of the chiral deuterated amino acid ester is shown in the specification. The method for preparing the chiral deuterated amino acid ester by taking the deuterated methanol as the deuterium source comprises the steps of reaction system establishment, main reaction and post treatment. The preparation method of the deuterated chiral amino acid ester is simple to operate, mild, efficient, green and high in deuteration rate.

The invention discloses a method for preparing deuterated amino-acid ester by taking heavy water as a deuterium source. According to the method, an imino acid ester compound and heavy water are takenas reaction raw materials, Lewis acid is taken as a catalyst, the target deuterated amino acid ester compound is synthesized through reaction in an organic solvent under the action of a reducing agent, and a reaction formula is shown in the specification, in the formula, R1 and R3 are aryl, and R2 is alkyl. The invention provides the preparation method of the deuterated amino-acid ester. The preparation method is simple to operate, is mild, efficient, and green, and has a high level of deuterium doping.

The invention discloses a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid through multienzyme coupling. The method comprises the following steps: by taking raceme of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid or raceme of 1,2,3,4-tetrahydroisoquinoline-3-formate as a substrate, enabling (R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in the substrate to react to generate imidic acid shown in a formula (II) under the catalysis action of oxidative dehydrogenase; and converting the imidic acid shown in the formula (II) into the (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in the presence of piperidine acid reductase and a coenzyme capable of providing hydride ions. The method is gentle in reaction condition, good in stereoselectivity, high in reaction efficiency, high in conversion rate, and the like.

The invention relates to a preparation method of a biological microelectrode array based on a flexible substrate, which adopts secondary photolithography and electroforming technology, and sequentially coats polydimethylsiloxane sacrificial layer and polyimide acid on the substrate surface, Thermal curing forms a polyimide flexible substrate, and prepares metal circuits on the flexible substrate by sputtering, photolithography and electroforming processes, then etches the metal base film, coats polyimide acid, photolithography and etch polyimide Imino acid, electroformed metal electrodes, thermally cured to form polyimide, and the prepared biomicroelectrode array based on polyimide flexible substrate was peeled off from polydimethylsiloxane. The electrodes are located at both ends of the metal circuit, and the electrode array is arranged according to the application requirements. One end of the electrode is connected to the biological tissue, and the other end is connected to the stimulator or measuring instrument. The metal circuit at the bottom of the electrode connects the electrodes on both sides. The biological microelectrode array manufactured by the invention has the advantages of high yield, controllable electrode position, small impedance, biocompatibility and the like.

The invention provides a preparation method of 8-benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)octane, which comprises the following steps successively: taking N-(8-benzyl-8-azabicyclo(3.2.1)oct-3-yl)-isobutyramide as a raw material and heating to reflux with a chlorinating agent in an aprotic solvent, then reacting with alcohol under the action of triethylamine to obtain isobutyl-N-(8-benzyl-8-azabicyclo(3.2.1)oct-3-yl)imidate, and heating to reflux with acetohydrazide in alcohol of C2-C5 to obtain 8-benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo [3.2.1] octane crude, and finally purifying by n-heptane and ethyl acetate to obtain the target product with high purity. The 8-benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo [3.2.1] octane prepared by the method provided by the invention has the advantages of less byproducts, high yield and high product purity.