8 results about "Imidic acid" patented technology

The invention discloses a cationic peptide compound for targeting cartilage as well as a preparation method and application of the cationic peptide compound. The cationic peptide compound has a structural general formula as shown in the specification: R-(Xa-Nlys-Yb) n, wherein R is H, a drug active molecule or a group containing a signal marker, and X and Y are independently selected from any one of glycine residues and imidic acid residues; nlys is a residue of N-(4-aminobutyl) glycine; a and b are independently selected from any integer between 0 and 3; n is any positive integer from 3 to 10. The compound can target a glycosaminoglycan chain in cartilage through electrostatic interaction, has an effect of resisting protease degradation, and is beneficial to prolonging the in-vivo circulation time. The compound supports systemic administration, can be used for marking whole body cartilage through intravenous injection, is used for monitoring cartilage development, aging and pathological changes in real time, and has wide application potential in the aspects of molecular imaging, drug delivery and biological materials for treating cartilage-related diseases.

The invention discloses a continuous synthesis method and device of MSH.The continuous synthesis method of MSH comprises the steps that 2, 4, 6-trimethylbenzenesulfonyl chloride and an acid binding agent are dissolved in a first solvent to form a first solution, N-hydroxy-acetic acid imino ethyl ester is dissolved in the first solvent to form a second solution, and the second solution is dissolved in a third solvent to form a second solution; respectively pumping the first solution and the second solution into a first reaction container for reaction to obtain a first effluent; the first effluent, perchloric acid and a second solvent respectively flow into a second reaction container for reaction, and second effluent containing MSH is obtained. According to the present invention, the flow chemical design idea is adopted to continuously synthesize MSH, the stability of the raw material is good, the intermediate high-energy product and the high-energy end product can be rapidly utilized, and the accumulation and the long-time retention are effectively avoided so as to effectively avoid the decomposition and reduce the safety risk; the device disclosed by the invention is simple in structure, suitable for being matched with a production line of MSH derivative products, and convenient for synthesizing MSH at present.

A method for producing an imidic acid or an imidic acid salt having a phosphoryl group by a method for producing an imidic acid or an imidic acid salt represented by the following formula [1], including a reaction of allowing a phosphoryl isocyanate represented by the following formula [2] to react with a compound represented by the following formula [3]:

The present invention relates to a method for producing bis(fluorosulfonyl)imide acid, which is economically feasible at industrial scale and which provides a high-purity product.

The invention discloses a preparation method and application of a comb-shaped amidino-grafted chitosan sterilization water treatment agent, and relates to the technical field of environmental functional materials.The preparation method comprises the steps that under the ice-water bath condition, hydrogen chloride gas is introduced into a mixed solvent of absolute ethyl alcohol and chloroform till saturation, terephthalonitrile is added to generate benzene-1, 4-dicarboximide acid diethyl ester hydrochloride, then the benzene-1, 4-dicarboximide acid diethyl ester hydrochloride is added to react, and the comb-shaped amidino-grafted chitosan sterilization water treatment agent is obtained; washing and drying to obtain a bis-imidoester monomer; the preparation method comprises the following steps: carrying out condensation polymerization on a diimidic acid ester monomer and bifunctional micromolecular diamine in a polar solvent to synthesize oligomeric amidine with active amino groups at two ends; the preparation method comprises the following steps: dissolving chitosan in a dilute acid solution, and reacting with cyanuric chloride to form a chitosan-triazine activated intermediate; and adding oligomeric amidine with active amino groups at two ends, dialyzing and purifying, and freeze-drying to obtain the comb-shaped amidino-grafted chitosan sterilization water treatment agent. Chitosan is used as a framework and connected with an oligomeric amidine side chain which is formed by alternation of benzene and 1, 4-butane groups and of which the tail end is an amino group, so that high-density electropositive amidine groups, molecular chain rigidity and water solubility are ensured.

The patent application relates to a kind of catalyst (for example trivalent rhodium catalyst) catalysis, additive (such as N-bromosuccinimide) promotes the tandem reaction of aromatic ring ortho vinyl group-containing imidic acid ester, oxidation C-H bond amination, and the C3 position to C4 position migration of olefin connected aryl group.This patent application discloses a kind of method for constructing isoquinoline compound based on aryl migration strategy, hole transport material molecule and its preparation method, perovskite solar cell and its preparation method.The oxidation amination, aryl migration tandem reaction has good site selectivity, atom economy, step economy, meet the requirements of green and sustainable chemistry, can quickly construct site diversity functional molecule library.The substrate of the method is widely used, and the target product C1-ethoxy isoquinoline can be further converted into isoquinoline ketone and C1 position halogenated isoquinoline derivative.The isoquinoline derivative obtained in the application patent can also be applied to potential perovskite battery hole transport layer material.