38 results about "Sodium ethoxide" patented technology

The invention relates to the field of pesticide synthesis, in particular to a synthesis method of ethonicotinic acid. 5-ethyl pyridine-2. 3-dicarboxylic acid diethyl ester and 2-amino-2. 3-dimethyl butyramide are used as raw materials and react in a sodium ethoxide ethanol solution at the temperature of 50-70 DEG C, hydrogen chloride gas is introduced into a system for acidification after the reaction is completed, and imazethapyr and a by-product sodium chloride are obtained. The hydrogen chloride gas is directly introduced in the acidification process, and the acidification process is free of hydration, so that on one hand, no direct wastewater is generated, the generation of wastewater with high salt content and high organic matter content is avoided, the treatment cost is reduced, on the other hand, the byproduct sodium chloride is firstly removed from the system by controlling the ethanol amount of the system, and then concentration and crystallization are performed; the high-purity imazethapyr of which the purity is greater than 99% is obtained by utilizing the solubility of the solvent ethanol to impurities, and the quality of both byproducts and main products is at a higher level in the industry.

The invention discloses a preparation method of 1-amino-2-cyano-1-cyclopentene, which comprises the following steps: 1, preparing a mixed solution, namely mixing a first organic solvent with super alkali in a protective gas atmosphere, heating by adopting a nano infrared energy-saving electric heating coil, stirring, uniformly mixing and dissolving to obtain the mixed solution; the super base is selected from one of potassium tert-butoxide, sodium tert-butoxide, sodium ethoxide, sodium methoxide and sodium hydroxide; 2, cyclization reaction: dropwise adding adiponitrile into the mixed solution, and continuously carrying out infrared heat preservation reaction for 3-8 hours to obtain a reaction solution of 1-amino-2-cyano-1-cyclopentene; 3, cooling crystallization and filtration: cooling the reaction liquid to-10-5 DEG C, standing for crystallization, and carrying out pressure filtration in a protective gas atmosphere to obtain an ACCP crude product and a filtrate; and 4, recrystallizing and refining to obtain a pure product. The method is mild in reaction condition, low in energy consumption, good in product yield and high in product purity, solves the problems of high solvent toxicity, low yield and high environmental protection pressure in the prior art, and is suitable for production of medicine and pesticide intermediates.

This invention relates to a method for preparing a graphene-based coated iron catalyst for the deep removal of trace amounts of acetylene and ethylene impurities from electronic-grade hydrogen chloride, belonging to the field of catalyst technology. The method involves dispersing phenolic resin and graphene quantum dots in toluene, adding allyltrimethylammonium bromide, ferrocene methylamine, and sodium ethoxide, heating and stirring the reaction, and adjusting the pH with acetic acid. Citric acid and ferric acetylacetone are then added, and the mixture is stirred. Sodium borohydride is added in two stages, and the reaction is continued with stirring to obtain a gel precursor. The gel precursor is then ultrasonically dispersed, dried, and subjected to staged heating in a nitrogen-hydrogen atmosphere to obtain the resin-based coated iron catalyst. The catalyst prepared by this invention can effectively remove trace amounts of acetylene and ethylene impurities from electronic-grade hydrogen chloride, improving the purity of electronic-grade hydrogen chloride.

The application discloses a preparation method of 2-cyano-3-hydroxy-2-buten-(4-trifluoromethyl-phenyl)amide, which comprises the following steps: reacting a compound of formula (II) with acetyl chloride or acetic anhydride under the action of a base; wherein the base comprises sodium ethoxide and / or sodium methoxide. In the application, sodium hydride with a relatively high risk coefficient is replaced by sodium alcoholate, the operation difficulty is reduced, the yield is improved compared with sodium hydride, and the application is more suitable for industrial production.

This invention provides a method for synthesizing the compound DDAO-Sulfate, belonging to the field of chemical synthesis technology. The method includes the following steps: mixing DDAO and sodium ethoxide with anhydrous dimethylformamide to obtain a mixed solution; adding pyridine sulfur trioxide to the mixed solution and heating and stirring the reaction under light-protected conditions; subsequently concentrating under vacuum to obtain a residue; and purifying the residue by column chromatography using an eluent to obtain the final product. This synthetic method effectively improves the yield while selecting and optimizing the reactants, avoiding the use of easily deteriorated reagents and interference caused by the introduction of irrelevant substances, thus providing an efficient pathway for the preparation of fluorescent detection probes for sulfatase.

The invention relates to a preparation method of a skeleton embedded compact asphalt mixture, and belongs to the technical field of asphalt mixture preparation. Putting the preheated coarse aggregate and fine aggregate into stirring equipment, carrying out dry mixing, then adding the modified asphalt, carrying out wet mixing, finally adding the modified filler, and continuously carrying out wet mixing, so as to obtain an asphalt mixture; loading the asphalt mixture into a test mold, adopting a double-sided static pressure molding process, performing static pressure, cooling and demolding to obtain a skeleton-embedded compact asphalt mixture; the modified filler is prepared from limestone mineral powder, gamma-methacryloxy propyl trimethoxy silane, 8-anilino-1-naphthalene sulfonic acid magnesium salt, absolute ethyl alcohol and sodium perethoxide; the Marshall stability, the low-temperature bending strain and the freeze-thaw splitting strength ratio of the prepared asphalt mixture are remarkably improved, and the asphalt mixture can effectively resist high-temperature rutting, low-temperature cracking and water damage.

This invention relates to the field of organic synthesis technology, specifically a method for synthesizing 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile and its application, comprising the following steps: S1. Compound 1a is added to a first organic solvent under inert gas protection and reacted with vinyl isobutyl ether under the conditions of a catalyst and potassium carbonate to obtain a system containing compound 2a; S2. The pH of the system containing compound 2a obtained in step S1 is adjusted to 2-3, and after reaction, compound 1 is obtained through post-treatment; S3. Compound 1 is added to a second organic solvent, and ethyl formate and sodium ethoxide are added to react and obtain a system containing compound 4a; S4. Acetic acid is added to the system containing compound 4a obtained in step S3 for neutralization, and under inert gas protection, hydrazine hydrate is added dropwise to react and the product is obtained through post-treatment. The synthesis method provided by this invention uses readily available raw materials, has a simple processing procedure, does not require column chromatography, simplifies the operation, and facilitates industrial-scale production.

The invention discloses a preparation method of (S)-(2-oxotetrahydrofuran-3-yl)-carbamate, which is characterized by comprising the following steps: S1, taking L-homoserine and dimethyl carbonate as reaction raw materials, and reacting in a methanol solvent under the action of a concerted catalytic system consisting of sodium ethoxide and zinc acetate to obtain a compound (1); s2, the compound (1) is subjected to a cyclization reaction under the acidic condition, and (S)-(2-oxotetrahydrofuran-3-yl)-carbamate is obtained. The preparation method provided by the invention does not use a large amount of acid-binding agent, has high use efficiency and low catalyst consumption, selects the amino protective agent with low price, reduces the cost and three wastes, and is beneficial to large-scale production.

The invention relates to a preparation method of aldehyde group functionalized halogen-containing helicene, which comprises the following steps: S1, dissolving terephthalaldehyde and p-halobenzyl cyanide in ethanol, adding sodium ethoxide into the solution for reaction, and washing, filtering and drying a reaction product to obtain a solid A; s2, dissolving the solid A in methylbenzene, then adding iodine and epoxypropane for reaction, and washing, filtering and drying a reaction product to obtain a solid B; s3, dissolving the solid B in dichloromethane, adding n-butyllithium into the dichloromethane, sequentially and slowly adding methanol, water and hydrochloric acid after the color of the solution is changed, extracting an organic filtrate after the reaction is completed, carrying out rotary evaporation on the organic filtrate, washing, filtering and drying to obtain aldehyde group functionalized halogen-containing helicene; the invention provides the aldehyde group functionalized halogen-containing helicene and the preparation method thereof, the method is simple to operate, the reaction is simple and convenient, the expansion is flexible, the aldehyde group is successfully introduced into the compound, the reaction steps are reduced, and the experiment complexity is reduced.

The invention provides an industrial preparation method of tipiracil hydrochloride, which comprises the following steps: A) reacting 5-chloro-6-chloromethyl uracil and 2-aminopyrrolidine hydrochloride in the presence of a solvent and a sodium ethoxide catalyst to obtain a reaction solution; b) controlling the temperature of the reaction liquid to be 0-10 DEG C, adding an acidic medium, adjusting the pH value of the reaction liquid to be 6.0-8.0, adding ethyl acetate, stirring and filtering; c) adding an acidic medium into the filtrate obtained in the step B) to adjust the pH value to 2.0-6.0, and stirring and filtering at 10-30 DEG C to obtain tipiracil hydrochloride; the acid medium in the step B) and the step C) is independently selected from one or more of hydrochloric acid methanol, hydrochloric acid ethanol and concentrated hydrochloric acid. According to the method disclosed by the invention, the product quality is ensured, impurities are not increased, the product purity is 99.95% or above, the operation is simple, the energy consumption is low, the solvent is low in toxicity, harmless, green and environment-friendly, and the yield can be doubled.

The application belongs to the technical field of diboron compound synthesis, and particularly relates to a synthesis method of 1,3-diboron compound. The method comprises the following steps: taking an olefin compound, pinacol diboron and iodo-methylene boronic acid ester as raw materials, performing an olefin carbon boronation reaction in a reaction system composed of a Cu-based catalyst, sodium ethoxide and a solvent under a protective atmosphere to obtain the 1,3-diboron compound. The application provides a copper-catalyzed olefin boronation strategy, uses iodo-methylene boronic acid ester as an electrophilic reagent, constructs a series of racemic 1,3-diboron compounds through a Cu-catalyzed olefin carbon boronation reaction with an excellent yield, realizes an effective 1,3-diboron compound modular synthesis method, and the reaction has the characteristics of mild reaction condition, wide raw material source, simple reaction process and high yield.

The invention relates to a synthesis process of a polythiol compound containing seven sulfur atoms. The invention discloses a continuous flow-kettle type coupling synthesis method of a hepta-sulfur atom polythiol compound. The process adopts a continuous flow and kettle type combined process. Starting from hydrogen sulfide and epoxy chloropropane, an intermediate 1 is generated by using a continuous flow device; reacting the intermediate 1 reaction liquid and a sodium mercaptoethoxide solution by using a kettle type device to generate an intermediate 2; generating an intermediate 3 from the intermediate 2, an acidic reagent, thiourea and the like by using a kettle type device; and hydrolyzing the intermediate 3 and an alkaline solution by using a kettle type device, acidifying by using an acidic reagent, and extracting by using toluene to obtain the polythiol compound containing seven sulfur atoms. The continuous flow device is used for solving the problems of poor kettle type gas-liquid reaction effect of hydrogen sulfide and epoxy chloropropane, serious reaction heat release and the like, and the purity of the intermediate 1 is more than or equal to 90%; the kettle type device is adopted to complete synthesis of an intermediate 2, an intermediate 3 and a product, so that the device process is simple to operate as far as possible, safe and reliable.

The invention discloses a preparation method of 4, 6-dichloro-5-methoxypyrimidine, and belongs to the technical field of organic synthesis. The method comprises the following steps: by taking dimethyl methoxymalonate as a raw material, generating 2-amino-4, 6-dihydroxy-5-methoxypyrimidine from dimethyl methoxymalonate and guanidine salt under the action of sodium ethoxide; then under the action of tert-butyl nitrite, lithium chloride, salicylic acid and tris (pentafluorophenyl) boron, 4, 6-dihydroxy-5-methoxypyrimidine is generated; finally, under the action of phosphorus oxychloride, 4, 6-dichloro-5-methoxypyrimidine is generated. According to the route, in the first step, a 2-aminopyrimidine product is generated through guanidine salt, in the second step, amino is eliminated through azotization, and the synthesis method of the compound is enriched.

The application discloses a preparation method of (S)-(2-oxotetrahydrofuran-3-yl)-carbamate, characterized in that the method comprises the following steps: S1: taking L-homoserine and dimethyl carbonate as reaction raw materials, and performing reaction in a methanol solvent under the action of a synergistic catalytic system composed of sodium ethoxide and zinc acetate to obtain compound (1); and S2: performing a cyclization reaction on the compound (1) under an acid condition to obtain (S)-(2-oxotetrahydrofuran-3-yl)-carbamate. The preparation method does not use a large amount of an acid-binding agent, uses a catalyst with high efficiency and low dosage, selects an amino protecting agent with low price, reduces costs and three wastes, and is beneficial to scale-up production.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of 2-oxoglutaric acid, which comprises the following steps: by taking diethyl 2-oxosuccinate and diethyl 2-bromomalonate as raw materials, carrying out condensation reaction in an absolute ethyl alcohol solvent under the catalytic action of sodium ethoxide; adjusting the pH value of the obtained condensation product, performing intermediate purification, transferring into a mixed system of sulfuric acid and ethanol, performing hydrolysis and decarboxylation reaction, and finally crystallizing and refining to obtain a target product. The invention provides a brand new synthesis route, the reaction conditions are mild, the use of raw materials with higher toxicity and the reaction conditions with great danger are avoided, and the safety of the production process is high. And by setting a key intermediate product purification step, the purity of the final product is effectively ensured, and the product quality is high. Meanwhile, raw materials used in the method are commercially available conventional chemicals, operation is easy and convenient, cost is controllable, and the method is suitable for industrial production.

The application provides a condensate oil nano demulsifier and a preparation method and application thereof, and the preparation method comprises the following steps: S1, 1,3-propylenediamine and methyl acrylate are added into an ethanol solution containing sodium ethoxide, and then reaction is conducted to obtain a prepolymer; S2, nano silicon dioxide and a coupling agent are added into an ethanol solution, pH is adjusted, and then reaction is conducted to obtain a modifier; and S3, the obtained prepolymer and modifier are added into an ethanol solution containing sodium ethoxide, and then reaction is conducted to obtain the condensate oil nano demulsifier. The condensate oil nano demulsifier is a space network structure polymer with nano silicon dioxide as a core connecting point, and the size of a repeating unit structure is 100-200 nm. The condensate oil nano demulsifier provided by the application has excellent performance, has a good demulsification effect on condensate oil emulsion, and can significantly improve the oil-water separation efficiency of the condensate oil emulsion.

This invention discloses a catalytic synthesis method for 1-arylmethyl-4-arylmethyl-3-hydroxypyrrole-2-( 5H A method for reacting 1-arylmethyl-4-arylmethylenepyrrole-2,3-dione compounds and diethyl phosphonate in an organic solvent under the presence of a base catalyst undergoes a Michael addition and a 1,4-P-Brook rearrangement tandem reaction. Sodium ethoxide is then added for hydrolysis to yield 1-arylmethyl-4-arylmethyl-3-hydroxypyrrole-2,3-dione compounds and their derivatives. 5H )-ketone. This invention achieves 3-hydroxypyrrole-2-( )-ketone in one step through a series of reactions in a one-pot reaction mode. 5H Alkylation of ketones at the C(4) position: The catalyst used is mild and readily available, enabling highly efficient catalytic reactions with good yields of the target product. It is both economical and environmentally friendly, making it suitable for large-scale applications.

The invention belongs to the technical field of sodium ethoxide preparation, and particularly relates to a process for preparing sodium ethoxide by adopting a ball milling method. According to the grinding medium, in the ball milling process, PMS oxidizing agents are continuously released through gradual denudation of the MgO shell, an oxidation film on the sodium surface can be rapidly eliminated, the fresh sodium surface is exposed, the reaction rate is increased, the ionic liquid pre-wetting layer can reduce the sodium surface energy and improve the wettability, and the mass transfer resistance is reduced by combining the interface wetting layer formed by ionic liquid; the reaction rate is further improved, and the efficiency is remarkably improved. The ionic liquid forms a hydrophobic microenvironment to block water molecules, the modified molecular sieve directionally adsorbs water generated by reaction, the water content is effectively reduced, the mechanical force of ball milling crushes sodium aggregated particles, the medium shearing action promotes molecular-level mixing of reactants, and dehydration side reaction caused by local overheating is inhibited, so that the purity of the product is improved. And the preparation process is efficient and environment-friendly, and the ball milling medium, the ionic liquid and the like can be recycled.

The invention discloses a method for catalytically synthesizing 1-arylmethyl-4-arylmethyl-3-hydroxypyrrole-2 (5H)-ketone and derivatives thereof, which comprises the following steps: carrying out Michael addition and 1, 4-P-Brook rearrangement cascade reaction on a 1-arylmethyl-4-arylmethylene pyrrole-2, 3-diketone compound and diethyl phosphonate in an organic solvent in the presence of a base catalyst to obtain the 1-arylmethyl-4-arylmethyl-3-hydroxypyrrole-2 (5H)-ketone and derivatives of the 1-arylmethyl-4-arylmethyl-3-hydroxypyrrole-2 (5H)-ketone and derivatives of the 1-arylmethyl-4-arylmethyl-3-hydroxypyrrole-2 (5H)-ketone. And then adding sodium ethoxide to carry out hydrolysis reaction, so as to obtain the 1-arylmethyl-4-arylmethyl-3-hydroxypyrrole-2 (5H)-ketone. According to the present invention, the one-pot reaction mode is adopted, the 3-hydroxypyrrole-2 (5H)-ketone C (4) site alkylation is achieved through the cascade reaction in one step, the used catalyst has characteristics of mild property and easy obtaining, the efficient catalytic reaction can be achieved, the target product yield is good, the economy and the environmental protection are concurrently provided, and the method is suitable for the large-scale application.

The invention discloses a plant polyphenol-based fixing agent and a preparation method and application thereof, and relates to the technical field of drilling solid waste treatment.The plant polyphenol-based fixing agent is obtained by uniformly mixing plant polyphenol with a catalyst and then adding phenyl-containing diglycidyl ether for a reaction, the plant polyphenol contains one or more benzene ring structures and has phenolic hydroxyl functional groups; the catalyst is one or more of sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide, and the addition amount of the catalyst is 1-5wt% of the total mass of the plant polyphenol and the phenyl-containing diglycidyl ether; the mass ratio of the plant polyphenol to the phenyl-containing diglycidyl ether is (2-10): 1. The technical problems that in the prior art, drilling solid waste treatment is high in cost, long in period, short in fixing time, high in leachate pollutant content and the like are solved.

This invention discloses a method for preparing olaparib-copper nanocomplexes. Hydrated copper chloride and olaparib are dissolved separately in DMF, then mixed, and the pH is adjusted to 8-9 with sodium ethoxide. Finally, trimethylamine is added to react and generate the olaparib-copper nanocomplexes. The application of the prepared olaparib-copper nanocomplexes in the preparation of drugs for treating breast cancer is also disclosed. The olaparib-copper nanocomplexes synthesized in this invention exhibit targeting and chemokinetic effects, controllable size, low effective dose, and effectively induce the killing of breast cancer cells, making them suitable for tumor treatment. This material demonstrates strong advantages in tumor-targeted drug delivery and therapy, providing an effective development pathway for the development and design of multifunctional biomaterials.

The invention provides a composite plug removal system and a plug removal method for an oilfield water injection well, and relates to the technical field of oilfield chemistry. The invention provides a composite plug removal system for a water injection well of an oil field. The composite plug removal system comprises a composite acid liquid system and an alkaline eutectic solvent system which are independently subpackaged, the composite acid liquid system comprises the following components in percentage by mass: 5-20% of vinasse pressure filtrate, 0.6-2.7% of aluminum chloride, 0.5-1% of clay stabilizer, 1-2% of corrosion inhibitor and the balance of water; the alkaline eutectic solvent system comprises a hydrogen bond acceptor (choline chloride) and a hydrogen bond donor (comprising one or more of urea, 4-dimethylaminopyridine, sodium ethoxide, sodium tert-butoxide, N, N-diisopropylethylamine and glycine). The composite plug removal system for the water injection well of the oil field provided by the invention not only can efficiently dissolve various inorganic scales, but also can thoroughly dissolve organic polymer blockage, and has the characteristics of low corrosion, low damage and high stability.

The utility model discloses a granular sodium ethoxide production device. The granular sodium ethoxide production device comprises a reaction kettle, wherein a bottom discharge port of the reaction kettle is connected with a feed port of a vertical film evaporator through a second transfer pump. A bottom discharge port of the vertical film evaporator is connected with a feed port of the retreatment kettle through a third transfer pump; and a bottom discharge port of the retreatment kettle is connected with a feed port of the horizontal film evaporator through a fifth transfer pump. A bottom discharge port of the horizontal film evaporator is connected with a feed port of the powerful mixing granulator through a sixth transfer pump; and a discharge hole of the powerful mixing granulator is connected with a packaging machine through a solid material conveyor. According to the device, three-stage drying is adopted, and the effect of improving the granularity is achieved.

The application discloses a low interfacial tension high-stable foam system for controlling the mobility of CO2 flooding of thick oil, which comprises 0.05-0.5% of a foaming agent, 0.01-1% of a thick oil active inducer and the rest of water in percentage by mass; the foaming agent is compounded by a non-ionic surfactant and an ionic surfactant at a mass ratio of 5:1-1:5; and the thick oil active inducer is one or more of sodium carbonate, ammonium carbonate, potassium carbonate, sodium hydroxide, sodium tert-butoxide, sodium tetraborate, sodium ethoxide, ethylenediamine, diisopropyl alcohol amine and triethylamine. The application can form high-stable foam in the CO2 channeling channel of the thick oil reservoir containing residual oil, effectively inhibit CO2 channeling and expand the CO2 sweeping efficiency; the application can reduce the interfacial tension between the foam system and the thick oil, and further improve the oil washing efficiency of the thick oil reservoir; and the application can use the thick oil active inducer to enhance the foam system to improve the recovery efficiency and reduce the system cost.

The invention belongs to the technical field of chemical synthesis, and discloses a preparation method of a medical intermediate, and the name of the specific compound is 3, 3-difluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester monohydrate. A brand new synthesis route is provided, and the six-step synthesis method comprises the following steps: taking 2, 4-dimethoxybenzylamine as an initial raw material, dropwise adding ethyl acrylate at the temperature of 30-40 DEG C, and stirring for reaction to obtain an intermediate 1; continuously adding benzotriazole, dropwise adding a 37% formaldehyde aqueous solution, and obtaining an intermediate 2 under the condition of room temperature; continuously adding zinc powder, controlling the temperature of the room, dropwise adding trimethylchlorosilane and ethyl bromodifluoroacetate, and stirring and reacting at room temperature to obtain an intermediate 3; continuously adding one of sodium methoxide, sodium ethoxide or potassium tert-butoxide, and stirring at room temperature to completely react to obtain an intermediate 4; adding a 16% sodium hydroxide solution while stirring, heating to 95-100 DEG C, and stirring for reaction to obtain an intermediate 5; controlling the temperature to be 10-20 DEG C, dropwise adding trifluoroacetic acid, and stirring at room temperature to react completely; and performing post-treatment on the reaction liquid to obtain a product. And a green, safe and high-yield kilogram-level process easy for industrial production is established. A stable and cheap intermediate source is provided for innovative drugs, the yield is increased, and the competitiveness of the innovative drugs is improved.

The invention relates to the technical field of organic synthesis, and particularly discloses a production and preparation method of whisky lactone. The method comprises the following steps: (1) dissolving methyl crotonate, n-valeraldehyde and sodium ethoxide in absolute ethyl alcohol, and continuously pumping a raw material solution into a microtubular reactor with a preset temperature through a peristaltic pump for reaction to obtain an effluent; and (2) mixing the effluent with hydrogen, continuously introducing the mixture into a micro-packed bed reactor filled with a modified palladium-carbon catalyst, carrying out hydrogenation reaction, and carrying out cooling, gas-liquid separation and vacuum distillation on the reaction product to obtain the whisky lactone product. The modified palladium-carbon catalyst is prepared by modifying a hydroxyapatite carrier with a composite oxide modifier, then loading palladium and performing reduction. According to the present invention, the continuous micro-reaction and fixed bed hydrogenation combined process is adopted, the specific catalyst is utilized, the reaction efficiency and the product yield are significantly improved, and the method has advantages of good selectivity, high catalyst stability, continuous and controllable process and safe operation.

This invention relates to a method for synthesizing phenylhydrazine hydrochloride, belonging to the field of pharmaceutical synthesis technology. Using palladium chloride as a catalyst and sodium ethoxide as a basic agent, under conditions of 50-55°C, an oxidative addition reaction first occurs with the bromine atom on a haloaromatic compound with a bromine atom at the para position, increasing the oxidation state of palladium and forming a highly reactive palladium intermediate. Sodium ethoxide neutralizes the generated hydrogen bromide, driving the reaction forward. The lone pair electrons on the nitrogen atom in hydrazine hydrate attack the palladium intermediate, undergoing a nucleophilic substitution reaction, attaching the nitrogen atom to the carbon atom bonded to the bromine atom. The palladium intermediate then undergoes a reduction reaction, restoring the oxidation state of palladium and generating phenylhydrazine compounds. Simultaneously, palladium chloride is regenerated and can continue to participate in the catalytic cycle. Ethanol serves as the reaction solvent, providing a homogeneous environment for the reaction. Hydrochloric acid is then added to the reaction system, where hydrogen ions combine with the nitrogen atom in the phenylhydrazine molecule to form a stable salt.

The invention belongs to the technical field of polyester recovery, and relates to a PET / PTT blended fabric depolymerization recovery method, a basic catalyst and dimethyl carbonate are adopted, and the basic catalyst is composed of a strong basic catalyst and a weak basic catalyst in a mass ratio of 2: 8-8: 2; the strong alkaline catalyst is one or more of sodium hydroxide, potassium hydroxide, potassium carbonate, sodium carbonate, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide, and the weak alkaline catalyst is one or more of potassium bicarbonate, sodium bicarbonate and sodium dihydrogen phosphate; the depolymerization recovery method disclosed by the invention is good in separation effect, the separation difficulty and the product loss are reduced, and the product purity is high.

The application discloses a synthesis method of indole-2-carboxylic acid, which is suitable for industrial production and comprises the following steps: (1) condensation: mixing o-nitrotoluene, diethyl oxalate and sodium ethoxide ethanol solution, raising to 75-85 DEG C and reacting for 1.5-3 hours, adding into water, stirring for 0.5-1.5 hours, removing ethanol, decoloring, filtering, adjusting the pH of the filtrate to 1-2, and obtaining an intermediate; (2) reduction: adding methanol to the intermediate, adding Raney nickel, raising to 55-65 DEG C, adding hydrogen and reacting, lowering to room temperature, filtering, removing methanol, lowering to 0-5 DEG C and preserving for 1-2 hours, and filtering to obtain a crude product; and (3) purification: adding water to the crude product, adjusting the pH to 8-9, decoloring, filtering, adjusting the pH to 2-3, precipitating a solid, filtering, and drying the filter cake.

The application discloses a tetrad structure emulsifier for developing solution and a preparation method thereof. The emulsifier is a novel emulsifier containing four hydrophilic head groups and four hydrophobic tail chains in a single molecule, which is prepared by the following steps: reacting 2,2-bishydroxymethyl-1,3-propanediol and phosphorus oxychloride in the presence of an acid binding agent and tetrahydrofuran, continuously reacting by dropwise adding a long-chain fatty alcohol, and treating by hydrolysis dechlorination and sodium ethoxide ethanol solution. The tetrad structure emulsifier prepared by the application has a smaller spacing between the hydrophilic head groups than common surfactants due to the strong force of covalent bond, so that the critical micelle concentration is lower, the emulsifying performance is better, and the performance in the application of the developing solution is better.