Preparation method of ethyl 4,4,4-trifluoroacetoacetate

A technology of ethyl trifluoroacetoacetate and ethyl trifluoroacetate is applied in the field of preparation of ethyl 4,4,4-trifluoroacetoacetate, and can solve the problem that the end point of the dealcoholization process is difficult to control, the feeding process is difficult to control, and the solvent is difficult to control. Recycling energy consumption increases and other problems, to achieve the effect of novel preparation process, avoid severe heat release, and convenient and easy-to-obtain raw materials

Inactive Publication Date: 2014-04-02
SINOCHEM LANTIAN +1
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Problems solved by technology

In this production process: solid sodium alkali releases heat violently during the feeding process, the feeding process is difficult to control, and it is easy to cause dust pollution; using metal sodium and ethanol to prepare sodium ethoxide will generate a large amount of hydrogen, which has potential safety haz

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  • Preparation method of ethyl 4,4,4-trifluoroacetoacetate
  • Preparation method of ethyl 4,4,4-trifluoroacetoacetate
  • Preparation method of ethyl 4,4,4-trifluoroacetoacetate

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Abstract

The invention discloses a preparation method of ethyl 4,4,4-trifluoroacetoacetate. With an ethanol solution of sodium ethoxide as a catalyst and in the presence of an organic solvent, ethyl trifluoroacetate and ethyl acetate are subjected to a Claisen condensation reaction, and ethyl 4,4,4-trifluoroacetoacetate is synthesized. The method provided by the invention has the advantages of mild conditions, simple operation, relatively high conversion rate of raw materials, relatively high product selectivity, easy separation of the product, low energy consumption and the like, and is suitable for industrialized production. The prepared ethyl 4,4,4-trifluoroacetoacetate is an important pesticide and medicine intermediate, can be used for preparation of thifluzamide, fluacrypyrim, thiazopyr and other pesticides, and also can be used for preparation of befloxatone and other medicines.

Description

technical field [0001] The invention relates to a preparation method of ethyl 4,4,4-trifluoroacetoacetate. Background technique [0002] 4,4,4-Ethyl trifluoroacetoacetate (hereinafter referred to as ethyl trifluoroacetoacetate), the English name is ethyl 4,4,4-trifluoroacetoacetate, and the CAS number is 372-31-6. Molecular formula is C 6 h 7 f 3 o 3 , the molecular weight is 184.11, the density is 1.259, the melting point is -39 ℃, the boiling point is 129.5 ℃ (760 mmHg), the refractive index is 1.375-1.378, the flash point is 28 ℃, and the solubility in water is 10 g / L (20 ℃). Ethyl trifluoroacetoacetate has two configurations, enol and ketone, which can be converted freely under normal circumstances. The specific structure is as follows: Ethyl trifluoroacetoacetate is an important pesticide and pharmaceutical intermediate, which can be used to prepare pesticides such as flufenam, pyrimidin, and thiazopyr, and can also be used to prepare medicines such as beflux...

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Application Information

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IPC IPC(8): C07C69/716C07C67/343
CPCC07C67/343
Inventor 蒋强徐卫国李华戴佳亮杨汪松
Owner SINOCHEM LANTIAN
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