The invention relates to an insecticidal composition containing thiamethoxam and acetamiprid. The insecticidal composition is prepared by binary compounding of effective components, namely, thiamethoxam and acetamiprid in the mass ratio of 6: 24, 8: 22, 10: 20, 12: 18 and 14: 16; and the total mass of thiamethoxam and acetamiprid in the preparation is 1 to 80% based on the total mass of the whole preparation. The compounded insecticidal composition provided by the invention can be prepared into pesticide formulation like missible oil, suspension, wettable powder, water dispersible granules, emulsion in water and microemulsion. The insecticidal composition containing fluacrypyrim and spirodiclofen can effectively control various pests such as aphid, leafhopper, plant hopper, whitefly, white grub, potato beetle, nematode, ground beetle and leaf miner, and can be widely applied to control of pests of crops such as rice, vegetable, fruit tree, tea, beetroot, rape, potato, cotton, kidney bean, peanut, sunflower, soybean, tobacco and orange.