42 results about "Methionine hydroxy analog" patented technology

The invention discloses a preparation method of a microelement methionine hydroxy analogue chelate additive, which comprises the following steps: 1) respectively putting a mixed solution of a methionine hydroxy analogue solution and water or a mixed solution of organic substances and water into a closed reaction kettle which is protected by an inert gas atmosphere, starting to stir, performing hydrolysis reaction, adding an alkaline solution, and controlling the pH value at the end point of the reaction; 2) adding basic salt or acidic salt or amphoteric salt of trace metal elements into the liquid obtained by the reaction in the step 1), further reacting, and controlling the pH value at the end point of the reaction at 5-8, thus obtaining a liquid containing a microelement methionine hydroxy analogue chelate; and 3) removing water from the liquid obtained after the reaction in the step 2) is finished, drying, and screening to obtain the microelement methionine hydroxy analogue chelate. The method disclosed by the invention maximally lowers the start-up cost, improves the production efficiency and lowers the production cost, can produce qualified products and is suitable for popularization in a wide range.

The invention discloses a plant antioxidant functional feed additive, which is prepared from the following raw materials in parts by weight: 0 to 10 parts of 2,6-di-tert-butyl-p-cresol, 1 to 10 parts of ethoxyquin, 1 to 5 parts of methionine hydroxy analog, 1 to 5 parts of talc powder, 1 to 10 parts of citric acid monohydrate, 1 to 80 parts of ampelopsis, and 5 to 20 parts of medical stones. The additive has the advantages that: the traditional natural plant ampelopsis is applied to livestock production, the ampelopsis containing natural plant anti-oxidation mould inhibitor dihydromyricetin has good effects of removing free radicals and resisting lipid peroxidation, and the problem of oxidizing grease in the feed rich in Cu<2+>, Fe<2+> and other metal ions can be solved; and therefore, the additive is a high-efficiency green functional anti-mould anti-oxidation additive product. The additive can be used as an excellent substitute product for chemically synthesized anti-mould anti-oxidation products, so that a new opportunity is brought to the development of feed industry, and establishment of a healthy culture production mode is facilitated.

The invention relates to a feed premix for yellow hair chickens. The feed premix is characterized by comprising the following raw materials in part by weight: 10-15 parts of composite vitamins, 100-120 parts of composite mineral substances, 125-150 parts of salt, 45-60 parts of choline chloride, 40-70 parts of prebiotics, 20-25 parts of coccidium-resistance drugs, 2-6 parts of complex enzyme, 25-60 parts of emulgator, 100-180 parts of lysine, 80-130 parts of methionine hydroxy analog-Ca, 10-20 parts of enramycin, 7-15 parts of antioxidants, 80-120 parts of lutein, 4-8 parts of canthaxanthin, and 50-350 parts of wheat middling. The feed premix has the advantages that the coloring of the yellow hair chickens is stable, and particularly in high-temperature summer, the good coloring of carcass can be ensured, and the coloring of feet diameters can reach more than 10 degrees of a Roche yolk color fan; a selected colorant mainly comprises the natural lutein extracted from marigold flowers, and according to the technology provided by the invention the application amount of the lutein and the canthaxanthin can be greatly reduced, thus playing a great role in protection of food safety; and the cost of pigments can be reduced greatly, and the competitiveness of yellow hair chicken production enterprises can be improved.

The invention discloses a feed capable of preventing liver and gallbladder syndromes of crucian carps under high-density raising conditions. The feed consists of the following components in percentage by weight: 15.0% of wheat, 13.0% of rice bran, 10.0% of corn alcohol lees, 15.0% of soybean meal, 6.2% of cottonseed meal, 5.6% of rapeseed meal, 2.0% of rice protein powder, 21.0% of imported fish meal, 4.0% of meat and bone meal, 2.0% of soybean oil, 1.5% of phosphatide oil, 1.7% of calcium dihydrogen phosphate, 0.2% of table salt, 0.2% of choline chloride, 0.2% of 65% lysine, 0.2% of methionine hydroxy analog-Ca, 0.1% of Vc phosphate ester, 0.1% of garlicin, 1.0% of a premix and 1.0% of a Chinese herbal medicine additive, wherein the total quantity of the components is 100%. Based on the formula technique of a traditional crucian carp feed, a Chinese herbal medicine preparation is added, besides, the dosage of vitamin C and the dosage of vitamin E are increased, through synergistic reaction of concerted application, the anti-stress capacity and the resistance of crucian carp organisms are improved, the occurrence of the liver and gallbladder syndromes of the crucian carps under the high-density raising conditions is effectively prevented, the survival rate of the crucian carps is increased, and the production levels and the economic benefits are increased.

The invention discloses a meat quality improving agent, which comprises the following components in parts by weight: 2-8 parts of vitamin E, 1-4 parts of yeast selenium, 5-20 parts of guanidinoaceticacid, 2-10 parts of anhydrous betaine, and 58-90 parts of a carrier. The pig feed based on the meat quality improving agent includes the following components in parts by weight: 50 to 70 parts of corn, 10 to 25 parts of soybean meal, 2 to 7 parts of bran, 3 to 10 parts of rice bran, 0.1 to 8 parts of rice bran meal, 0.25 to 0.4 parts of sodium chloride, 0.1 to 0.2 parts of sodium bicarbonate, 0.8to 1.3 parts of stone powder, 0.1 to 0.5 parts of calcium hydrogen phosphate, 0.25 to 0.6 parts of L-lysine sulphate and its fermentation by-product, 0.01 to 0.1 parts of methionine hydroxyl analog calcium salt, 0.01 to 0.1 parts of threonine, 0. 01 to 0.05 parts of choline chloride, 0.5 to 1 parts of the meat quality improving agent, 0.5 parts of a premix, and 0 to 1.5 parts of calcium chloride.The feed and a use scheme of the invention can improve the growth performance of fattening pigs, can enhance the antioxidant capacity of the body tissue, increases the lean meat rate, and improves thecarcass meat quality.

The invention relates to a feed additive for prevention and treatment of livestock and poultry production performance decline, product quality decline, digestive system damage and easy infection of diseases caused by vomitoxin poisoning and application thereof. The active ingredients include, by weight, 10-20 parts of a DL-methionine hydroxy analogue, 6-10 parts of glutathione, 10-15 parts of immune polysaccharide, and 60-70 parts of bacillus mixed powder for degrading vomitoxin. The active ingredients are dried, crushed and mixed to obtain the feed additive product. The product is soluble inwater, and has no toxic or side effect, no drug resistance and no pollution. Feeding experiments verify that the feed additive product provided by the invention can effectively prevent and treat livestock and poultry production performance decline caused by vomitoxin, and also can lower the livestock and poultry mortality rate, improve the intestinal tract barrier function of livestock and poultry, and improve the livestock and poultry immunity.

The invention discloses a separation and purification method for methionine hydroxy analogue synthesized through hydrolysis of cyanohydrins. The method comprises the following steps: carrying out ammonification and neutralization on hydrolysate obtained by hydrolysis of 2-hydroxy-4-methylthiobutyronitrile under the action of sulfuric acid and containing the methionine hydroxy analogue, ammonium sulfate and ammonium bisulfate, allowing ammonium sulfate to be precipitated through supersaturation and carrying out layering so as to obtain an organic layer I and a water layer I containing ammonium sulfate solid; concentrating the organic layer I so as to allow ammonium sulfate solid to be precipitated, carrying out solid-liquid separation, diluting obtained liquid through addition of water so as to obtain the commercial grade methionine hydroxy analogue, mixing the precipitated ammonium sulfate solid with the water layer I containing ammonium sulfate solid, and carrying out layering so as to obtain an organic layer II and a water layer II containing the ammonium sulfate solid; and subjecting the water layer II to solid-liquid separation and drying obtained solid so as to obtain commercial grade ammonium sulfate. The method provided by the invention is simple and easily practicable and can obtain the high-quality methionine hydroxy analogue and the commercial grade ammonium sulfate, and the recovery rates of the high-quality methionine hydroxy analogue and the commercial grade ammonium sulfate are more than 99%; and in the whole process of the method, no organic solvent is used, no waste water containing salt or organic matters is discharged, and cost and energy consumption are low.

The invention discloses a pelodiscus sinensis fodder containing low-protein fish meal added with methionine hydroxy analog-Ca. The raw material of the pelodiscus sinensis fodder comprises white fish meal, soy protein concentrate, fermented soybean meal, extruded soybean, chicken powder, squid powder, beer yeast, alpha-starch, gluten flour, zeolite powder, multivitamin, a compound mineral substance, choline chloride, glycine betaine, sodium dihydrogen phosphate and methionine hydroxy analog-Ca. According to the pelodiscus sinensis fodder disclosed by the invention, the methionine hydroxy analog-Ca is taken as the additive and is added into the pelodiscus sinensis fodder containing low-protein fish meal, so that the amino acid balance in the fodder is effectively kept, the growth promotion effect is excellent and the nutritional requirement for the growth of the pelodiscus sinensis is met. Compared with the traditional pelodiscus sinensis fodder taking fish meal as the main protein source, the pelodiscus sinensis fodder containing low-protein fish meal added with methionine hydroxy analog-Ca has the advantages that the protein content of the fodder is less than or equal to 44% and the additive amount of the fish meal is less than or equal to 26%. The fodder provided by the invention is capable of saving the dosage of the fish meal in the pelodiscus sinensis fodder and lowering the cost of the fodder, is ecological and environmentally friendly, and is capable of increasing the comprehensive breeding benefit.

The invention relates to a composite acidulant for a feed as well as a preparation method and application of the composite acidulant. The composite acidulant for a feed comprises the following components in parts by weight: 20-25 parts of fumaric acid, 9-11 parts of benzoic acid, 15-18 parts of methionine hydroxy analog-Ca, 5-7 parts of formic acid, 2-3 parts of sorbic acid, 8-11 parts of phosphoric acid, and 30-40 parts of silica gel. When being used, the composite acidulant is added to a basic ration for piggies in the proportion of the composite acidulant to the basic ration being 0.2-0.4wt% for feeding the piggies. Compare with the prior art, the composite acidulant disclosed by the invention has the advantages that the growth and development and the intestinal tract health of weaned piggies can be improved, the total number of harmful bacteria is reduced, the total number of beneficial bacteria is increased, and the composite acidulant also has the functions of improving the oxidation resistance and the immunity of animals. Besides, the composite acidulant contains mineral acid and organic acid, and the mineral acid is used, so that the addition cost is reduced, and the economic benefits are increased.

The invention provides an antioxidant applied to feedstuff fish meal. The antioxidant is prepared by fully mixing the following components in percentage by weight: 0-40% of preservatives, 2-20% of ethoxyquinoline, 0.5-10% of butylated hydroxytoluene (BHT), 1-20% of tea polyphenol, 0.5-2% of methionine hydroxy analogue and the balance of silicon dioxide. The antioxidant applied to feedstuff fish meal adopts compound additives with functions of antioxidative, bacteriostatic and preservative functions; the problems of protein putrefaction and oil oxidation in actual production and storage of the fish meal are solved; when the antioxidant is added into the fish meal, the freshness of the fish meal can be more efficiently maintained.

The invention provides special feed for breeding season of sillago sihama. The special feed comprises the following raw material by weight percent: 21.0-28.0% of fish meal, 5.0-8.0% of inkfish powder, 2.0-5.0% of krill meal, 3.0-5.0% of chicken meal, 20.0-25.0% of bean pulp, 4.0-6.0% of corn gluten meal, 1-5% of soybean protein powder, 20.0-24.0% of flour, 1.5-2.5% of soybean phospholipid, 1.0-2.0% of soybean oil, 1.5-2.5% of fish oil, 0.5-1.0% of decavitamin, 0.1-0.2% of vitamin C, 0.05-0.1% of vitamin E, 1.5-2.0% of composite mineral, 1.0-1.5% of calcium dihydrogen phosphate, 0.2-0.3% of choline chloride, 0.1-0.3% of coated lysine, 0.1-0.3% of methionine hydroxy analog-Ca, 0.1-0.2% of coated threonine, 0.1-0.2% of taurine, and 1.0-3.0% of bentonite. The feed greatly improves the growth, health and oviposition situations of sillago sihama during breeding season, and is suitable for food intake of sillago sihama during breeding season.

The invention belongs to the field of amino acid feed, food and medicines, and particularly relates to a method for preparing selenomethionine hydroxy analogue by virtue of a chemical synthesis methylseleno propanal method. The method comprises the following steps: preparing hydrogen selenide by virtue of selenium powder and hydrogen, enabling the hydrogen selenide to react with methanol, preparing methyl-hydroselenide, preparing methylseleno propanal from the methyl-hydroselenide and acraldehyde as well as relevant compounds, enabling a methylseleno propanal and hydrocyanic acid gas mixure toreact and synthesize DL-2-hydroxyl-4-methylseleno butyronitrile, performing acidolysis on DL-2-hydroxyl-4-methylseleno butyronitrile, separating and purifying, thus obtaining the selenomethionine hydroxy analogue and a byproduct ammonium sulfate. The selenomethionine hydroxy analogue has various excellent biological activities not possessed by a methionine hydroxy analogue, as well as organic trace element selenium necessary for the supplement of animal bodies, and has a para-insulin effect for supporting an oral preparation and can be used for treating diabetes, and can be applied to the fields such as medicines, nutrition healthcare and agriculture by the institute of environment and science.

The invention provides a method for synthesizing methionine hydroxy analogue by continuous and rapid hydrolysis of 2-hydroxy-4-methylthio butyronitrile. The method comprises the following steps: feeding acid and 2-hydroxy-4-methylthio butyronitrile into a microchannel reactor loading a solid catalyst for reaction, controlling the reaction temperature to be 80 to 130 DEG C and the pressure to be 0.1 to 0.5MPa, ensuring that the residence time of a reactant in a micro channel is 1 to 10min, adding water into the mixed liquid flowing out from the microchannel reactor, continuously hydrolyzing for20 to 60min, and ensuring that the reaction temperature to be 100 to 140DEG C and the reaction pressure to be 0.1 to 0.6MPa to obtain the methionine hydroxy analogue and a small amount of a byproduct, namely ammonium sulfate. By adopting the method, continuous and rapid preparation of the methionine hydroxy analogue is reazlied, the traditional intermittent tower device is avoided, the use of inorganic acid of 50 percent is reduced, no ammonium hydroxide is needed for neutralization, no organic solvent is used, and cleaness, environmental protection and sustainability are achieved; the acidolysis time of 2-hydroxy-4-methylthio butyronitrile is greatly reduced, pyrolysis polymerization of raw materials and production of by-products are reduced, and the product quality and yield are improved.

The invention discloses a feed additive for preventing fish gill hyperemia and rotted gill diseases caused by ammonia nitrogen and a feed. The feed additive comprises the following components in parts by weight: 0.3-1.09 parts of methionine hydroxy analogue, 0.009-0.0225 part of vitamin C, and 0.018-0.084 part of vitamin A. Due to the addition of the feed additive for fishes within the range, fish gill hyperemia and rotted gill diseases caused by ammonia nitrogen in water can be effectively prevented, the occurrence rate of fish gill hyperemia and rotted gill diseases can be reduced, and gills and fishes can be kept healthy. Meanwhile, the growth of the fishes can be promoted, and the efficiency of the feed can be increased. The feed additive has the advantages of convenience in use, low cost and the like.

The invention belongs to the field of preparation of feed preparations, and particularly relates to a production process and a production system of methionine and methionine hydroxyl analogues. The process compriseeds the following steps: (1) carrying out rapid unsaturated ammoniation on cyanohydrin and ammonia water to prepare a 2-amino-4-methylthio butyronitrile crude reaction solution; (2) reacting the aminobutyronitrile crude reaction liquid with a solid catalyst to obtain methionine hydrolysate; (3) filtering, deaminizing, concentrating and separating the methionine hydrolysate to obtain methionine solid and crystallization mother liquor, the solid catalyst being a cerium oxide catalyst or a solid acid catalyst. According to the production process provided by the invention, an independent cyanohydrin rapid unsaturated ammoniation strategy is adopted, and interference of materials, catalysts and reaction products in other steps on the cyanohydrin ammoniation step is avoided as much as possible, so that adverse side reactions such as cyanohydrin decomposition and excessive ammoniation are avoided.

The invention discloses a feed additive premix capable of preventing ascites syndrome (AS) in a broiler chicken, and relates to the technical field of animal science nutrition and feeding. The feed additive premix is prepared by mixing the following constituents in parts by weight: 0.2-2 parts of VC (Vitamin C), 5-15 parts of a methionine hydroxyl analogue, 1-10 parts of citric acid, 5-15 parts of arginine, 0.1-1 parts of alpha-lipoic acid, and 60-80 parts of wheat bran. The premix can be used for improving the productivity of the broiler chicken, improving the blood physical and chemical parameters of the broiler chicken and the organic antioxidant capacity to increase the physical condition of the broiler chicken, and reducing AS in the broiler chicken; the premix is better in usage effect when being utilized in winter and/or a henhouse with poor ventilation.

The invention relates to a premix feed containing organic trace elements, for chicken and a preparation method of the premixing feed. The premix feed comprises the following raw material components ofan iron glycine complex (chelated) compound, an iron amino acid complex, a zinc methionine hydroxy analog complex (chelated) compound, a manganese methionine complex (chelated) compound, a cobalt acetate premixing agent and a carrier. The invention further relates to the preparation method of the premix feed containing the organic trace elements for chicken. The preparation method comprises the following steps of adding the obtained feed to a complete formula feed for laying hens and breeding hens according to a ratio being 1-2kg/ ton for using. When the premix feed is used for the laying hens, the laying rate is high, the egg weight is high, the egg-to-feed rate is high, the strength of eggshells is high, and broken egg yield is low; and when the premix feed is used for the breeding hens, the breeding performance is high, the breeding egg fertilization rate of breeding eggs is high, the qualified rate of the breeding eggs is high, and the hatching rate is high. The premix feed disclosed by the invention has the characteristics of being high in digestivity, high in biological value, and sufficiently meets the characteristic of nutrient requirements of trace elements to the layinghens and the breeding hens, and is environmentally-friendly, so that environmental pollution pressure is reduced. The preparation method disclosed by the invention is high in mixing uniformity and simple in technology, and can effectively control the feed cost.

The invention discloses a clean preparation method of high-purity methionine hydroxyl analogue calcium salt. The clean preparation method comprises the following specific steps: adding water into 2-hydroxy-4-methylthiobutyronitrile serving as a raw material, carrying out a hydration reaction under the catalytic action of solid acid/solid alkali, adding strong acid or strong alkali for hydrolysis to obtain 2-hydroxy-4-methylthiobutyric acid, then adding CaO or Ca(OH)2, carrying out a salt forming reaction to obtain an aqueous solution of a mixture, carrying out chromatographic desalination treatment on the aqueous solution of the mixture to obtain an aqueous solution of a methionine hydroxyl analogue, and finally carrying out spray drying on the aqueous solution of the methionine hydroxyl analogue to obtain a target product. Compared with a traditional method, the method disclosed by the invention has the advantages that the step of neutralizing and alkali washing after the reaction is finished is avoided, the generation of a byproduct, namely inorganic ammonium salt is avoided, reaction is simple, conditions are mild, and the method is safe and environment-friendly; and in addition, a catalyst, namely the solid acid or solid alkali adopted in the method can be recycled, so production cost is reduced.

The invention discloses a solid methionine hydroxy analogue calcium salt compound with antibacterial and acidizing properties and a preparation method of the solid methionine hydroxyl analogue calcium salt compound. The compound is prepared from calcium 2-hydroxy-4-(methylthio) butyrate, 2-hydroxy-4-(methylthio) butyric acid and water. A preparation method of the compound comprises the following steps: mixing an aqueous solution of liquid methionine with calcium oxide or calcium hydroxide to obtain a reaction solution, carrying out a neutralization reaction at 80-100 DEG C to obtain a liquid product, and carrying out spray drying on the liquid product to obtain the target product. According to the preparation method, the raw material ratio is scientific and reasonable, the final product powdery methionine hydroxyl analogue calcium salt compound powder is loose and good in dispersity, the yield reaches up to 99% or above, the methionine content is larger than or equal to 88 wt%, the problems that in the actual production process, methionine hydroxy analogue calcium salt is low in yield and purity, a filter cake is sticky and greasy, smoothness is poor and the like are solved, and the requirements of customers on powdery methionine and liquid methionine can both be met, so that the compound is worthy of popularization and application.

The invention provides a method for treating wastewater. The method comprises the following steps: S1, performing Fenton oxidation, and removing 5-40wt% of CODs through Fenton oxidation, wherein an inflow of a Fenton oxidation reactor comprises a 50-1000ppm methionine hydroxyl analog and an oligomer thereof, 2-100ppm HCN (Hydrogen Cyanide), 1000-8000ppm formic acid, 500-12000ppm CODs (Chemical Oxygen Demands), 5-500ppm NH3-N and one or more of dimethylsulfide, dimethyl dithio, methyl mercaptan, 3-methylthiopropanal, 2-hydroxy-4-methylthio butyronitrile of which the total concentration is 50-1000ppm; S2, adjusting the pH value of the wastewater of Fenton oxidation to 4-8; S3, performing MBBR (Moving Bed Biofilm Reactor) biochemical treatment on the wastewater of which the pH value is adjusted, and removing more than 70wt% of the CODs; S4, performing solid-liquid separation on the wastewater after biochemical treatment; S5, performing reverse osmosis on a fluid after solid-liquid separation, thereby obtaining industrial water and salt water.

The invention belongs to the technical field of animal feed additive preparation, and particularly relates to a raw material composition for producing a methionine hydroxyl analogue without byproduct salt separation, a methionine hydroxyl analogue product as well as a preparation method, a production system and a feed preparation of the methionine hydroxyl analogue product. The raw material composition disclosed by the invention consists of 2-hydroxy-4-methylthio butyronitrile and calcium oxide. The raw material composition can be directly used for preparing a preparation, and the specific preparation method comprises the following steps: fully reacting a phosphoric acid solution with cyanohydrin to obtain a reaction solution containing 2-hydroxy-4-methylthiobutyric acid or a reaction solution containing a mixture of 2-hydroxy-4-methylthiobutyric acid and 2-hydroxy-4-methylthiobutyramide; and adding the calcium oxide into the reaction liquid, and fully reacting to obtain the white suspension emulsion. According to the method disclosed by the invention, the complicated and expensive separation and post-treatment operation of the methionine hydroxyl analogue and the byproduct salt in the prior art is avoided, the byproduct inorganic salt which is low in value and difficult to directly utilize is not generated, and the obtained methionine hydroxyl analogue product has better bioavailability, can be directly used for preparing feed, and has a good application prospect. And the molar ratio of the cyanohydrin to the phosphoric acid to the calcium oxide can be calculated and determined according to the nutritional requirements of different animals. The production process disclosed by the invention is simple, efficient, high in controllability and green and environment-friendly.