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Preparation method of selenomethionine hydroxy analogue

A technology of selenomethionine hydroxyl and analogs, which is applied in the fields of amino acid feed, food and medicine, and can solve the problems of small income, unreported preparation method, difficult management and the like

Inactive Publication Date: 2019-01-18
LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The existing technical defects of selenomethionine: the existing selenomethionine preparation method, whether it is chemical synthesis method or biosynthesis method, the process conditions are relatively complicated and difficult to manage; the product concentration is low and the yield is low; the equipment scale is large and the profit Small, therefore, selenomethionine products cannot meet the supply and demand of the market, especially the demand for selenomethionine in the feed industry
Although the preparation method of selenomethionine has been reported in the existing technology, the preparation method of the hydroxyl analog of selenomethionine methionine has not been reported, thus limiting the development of selenomethionine selenoanalog

Method used

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preparation example Construction

[0047] Preparation of hydrogen selenide: In the hydrogen selenide manufacturing device, 5kg of metal selenium is put into the reaction furnace, and the reaction furnace is heated to 500 ° C. At the same time, the circulating hydrogen is combined with the hydrogen from the hydrogen source, thereby The flow is put into the reactor. The temperature of the heater / cooler on the hydrogen injection side for heating operation was set to 300°C, and the temperature of the heater / cooler on the reaction gas side for cooling operation was set to 100°C. In addition, the temperature of the hydrogen selenide trap was set at -196°C. When the capture amount of hydrogen selenide in the hydrogen selenide catcher reaches 1kg, switch the heating operation and cooling operation of the heating / cooler, and the switching of this heating and cooling operation will be performed according to the hydrogen selenide capture amount every time it reaches 1kg. The mode of switching is repeated, and the hydroge...

Embodiment 1

[0056] A preparation method of selenomethionine hydroxyl analogs, comprising the following steps:

[0057] Step (1): Selenium powder is reacted with hydrogen to obtain hydrogen selenide, and hydrogen selenide is reacted with methanol under the action of a catalyst to obtain methylselenol;

[0058] Step (2): adding methylselenol obtained in step (1) to acrolein to obtain methylselenopropionaldehyde;

[0059] Step (3): The methylselenopropionaldehyde obtained in step (2), water, and deaminated hydrocyanic acid gas mixture are subjected to a cyanidation addition reaction in the presence of a catalyst to obtain DL-2-hydroxyl -4-Methylselenobutyronitrile;

[0060] Step (4): Mix the DL-2-hydroxy-4-methylselenobutyronitrile obtained in step (3) with sulfuric acid for hydrolysis. After the hydrolysis is complete, add ammonia to neutralize ammonium bisulfate, stand still, separate Obtained: the upper layer contains an organic layer of selenomethionine hydroxyl analogue, and the lower...

Embodiment 2

[0077] A preparation method of selenomethionine hydroxyl analogs, comprising the following steps:

[0078] Step (1): Selenium powder is reacted with hydrogen to obtain hydrogen selenide, and hydrogen selenide is reacted with methanol under the action of a catalyst to obtain methylselenol;

[0079] Step (2): adding methylselenol obtained in step (1) to acrolein to obtain methylselenopropionaldehyde;

[0080] Step (3): The methylselenopropionaldehyde obtained in step (2), water, and deaminated hydrocyanic acid gas mixture are subjected to a cyanidation addition reaction in the presence of a catalyst to obtain DL-2-hydroxyl -4-Methylselenobutyronitrile;

[0081] Step (4): Mix the DL-2-hydroxy-4-methylselenobutyronitrile obtained in step (3) with sulfuric acid for hydrolysis. After the hydrolysis is complete, add ammonia to neutralize ammonium bisulfate, stand still, separate Obtained: the upper layer contains an organic layer of selenomethionine hydroxyl analogue, and the lower...

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Abstract

The invention belongs to the field of amino acid feed, food and medicines, and particularly relates to a method for preparing selenomethionine hydroxy analogue by virtue of a chemical synthesis methylseleno propanal method. The method comprises the following steps: preparing hydrogen selenide by virtue of selenium powder and hydrogen, enabling the hydrogen selenide to react with methanol, preparing methyl-hydroselenide, preparing methylseleno propanal from the methyl-hydroselenide and acraldehyde as well as relevant compounds, enabling a methylseleno propanal and hydrocyanic acid gas mixure toreact and synthesize DL-2-hydroxyl-4-methylseleno butyronitrile, performing acidolysis on DL-2-hydroxyl-4-methylseleno butyronitrile, separating and purifying, thus obtaining the selenomethionine hydroxy analogue and a byproduct ammonium sulfate. The selenomethionine hydroxy analogue has various excellent biological activities not possessed by a methionine hydroxy analogue, as well as organic trace element selenium necessary for the supplement of animal bodies, and has a para-insulin effect for supporting an oral preparation and can be used for treating diabetes, and can be applied to the fields such as medicines, nutrition healthcare and agriculture by the institute of environment and science.

Description

technical field [0001] The invention belongs to the fields of amino acid feed, food and medicine, in particular to a preparation method for chemically synthesizing selenomethionine hydroxyl analogs. Background technique [0002] Selenium is an indispensable trace element for human and animal physiology. Selenium deficiency may cause dysfunction of vital organs in animals and lead to various diseases. At present, the selenium element added in the feed is basically sodium selenite. However, because sodium selenite is inorganic selenium, the utilization rate of the animal body is low, so it is difficult to control the amount when adding it. May cause poisoning in animals. The physiological role of selenium is basically exerted by selenoproteins. A large number of studies have shown that selenium has the following physiological effects: selenium preparations have good preventive and therapeutic effects on coronary insufficiency; selenium can inhibit peroxidation, remove harmf...

Claims

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Application Information

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IPC IPC(8): C07C391/00A23K20/20A23K20/142
CPCA23K20/142A23K20/30C07C391/00
Inventor 周荣超彭启明粟宇廖常福
Owner LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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