Production method of powdery methionine hydroxyl analogue with dispersion mobility

A methionine hydroxyl group and production method technology, applied in the field of feed additive preparation, can solve the problems affecting the use, adding long-term stability, etc., and achieve the effects of avoiding the difficulty of mixing uniformity, convenient operation, and increasing the mixing time

Active Publication Date: 2019-03-12
LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] We found that both the above-mentioned esters of methionine hydroxy analogs or methionine hydroxy analogs are liquid, which will inevitably affect their use, addition and long-term stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Add 160.00kg of 98% sulfuric acid (1600 moles) to the hydrolysis reactor, then slowly add 328.00kg of 80% 2-hydroxyl-4-methylsulfide to the reactor 2-hydroxy-4-methylthiobutyronitrile aqueous solution (2000 moles), control the addition speed, control the temperature of the reaction system at about 50 ° C, after the addition of 2-hydroxy-4-methylthio-butyronitrile aqueous solution, keep stirring at 50 ° C ~ 55 ° C After 30 minutes, its cyanohydrin was not detected by HPLC analysis. A 2-hydroxy-4-methylthiobutanamide sulfate aqueous solution was obtained, and the mass percentage of 2-hydroxy-4-methylthiobutanamide was 61.15%.

[0034] Add 485.33 kg of 99% isopropanol (8000 mol) by mass to the above reaction mixture, then raise the temperature to 95° C., stir and keep warm for 2 hours. After completion of the reaction, cool down to room temperature, add a total of 2100.00 kg of dichloromethane to the mixed solution obtained above in 3 times for extraction, and obtain dich...

Embodiment 2

[0037] Add 154.74kg of 95% sulfuric acid (1500 moles) in the hydrolysis reactor, then slowly add 336.41kg of 78% 2-hydroxyl-4-methylsulfide in the reactor Butyronitrile aqueous solution (2000 moles), control the addition speed, control the temperature of the reaction system at about 55°C, after adding 2-hydroxy-4-methylthiobutyronitrile aqueous solution, keep stirring at 55°C for 30 minutes, The cyanohydrin was not detected by HPLC analysis. A 2-hydroxy-4-methylthiobutyramide sulfate aqueous solution was obtained, and the mass percentage of 2-hydroxy-4-methylthiobutyramide was 60.76%.

[0038] Add 242.51 kg of 99% isopropanol (4000 mol) by mass to the above reaction mixture, then raise the temperature to 100° C., stir and keep warm for 2 hours. After completion of the reaction, cool down to room temperature, add 1538.24 kg of dichloromethane in total to the mixed solution obtained above in 3 times for extraction, and obtain dichloromethane containing 2-hydroxyl-4-methylthiobu...

Embodiment 3

[0041] Add 160.00kg of 98% sulfuric acid (1600 moles) to the hydrolysis reactor, then slowly add 328.00kg of 80% 2-hydroxyl-4-methylsulfide to the reactor 2-hydroxy-4-methylthiobutyronitrile aqueous solution (2000 moles), control the addition speed, control the temperature of the reaction system at about 50 ° C, after the addition of 2-hydroxy-4-methylthio-butyronitrile aqueous solution, keep stirring at 50 ° C ~ 55 ° C After 30 minutes, its cyanohydrin was not detected by HPLC analysis. A 2-hydroxy-4-methylthiobutanamide sulfate aqueous solution was obtained, and the mass percentage of 2-hydroxy-4-methylthiobutanamide was 61.15%.

[0042] Add 485.33 kg of 99% isopropanol (8000 mol) by mass to the above reaction mixture, then raise the temperature to 95° C., stir and keep warm for 2 hours. After completion of the reaction, cool down to room temperature, add a total of 2100.00 kg of dichloromethane to the mixed solution obtained above in 3 times for extraction, and obtain dich...

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PUM

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Abstract

The invention provides a production method of a powdery methionine hydroxyl analogue with dispersion mobility. The methionine hydroxyl analogue obtained by the method is a powdery mixture with dispersion mobility, has the characteristics of stable property and convenience in use, and moreover has the advantages of the methionine hydroxyl analogue such as an antibacterial property, breeding of fungi and salmonella in feed is inhibited, ammonium ions of amino acid in metabolism are absorbed, elimination of nitrogen is relieved, functions of an acidifying agent are fulfilled, the acidifying agentin the feed is reduced, application and transportation are facilitated, and ubiquitous problems of the methionine hydroxyl analogue such as difficulty in mixing uniformity, prolonging of mixing timeand corrosion and wear to equipment in a using process can also be avoided.

Description

technical field [0001] The invention belongs to the field of preparation of feed additives, in particular to a method for producing powdered methionine hydroxyl analogs with dispersion fluidity. Background technique [0002] Methionine hydroxy analogues are known to be used in feeding fertile animals, mainly poultry. Currently, the methionine hydroxy analogs are mainly marketed as Adisseo's Rhodimet AT 88 TM or Alimet from Novus TM brand sales. [0003] Various methods are known for the preparation of methionine hydroxy analogs by hydration of 2-hydroxy-4-methylthiobutyronitrile. Hydrolysis is carried out with mineral acids such as hydrochloric acid and sulfuric acid, or alternatively with hydrolytic enzymes. [0004] The preparation method of the 2-hydroxy-4-methylthiobutyronitrile is known, that is, it is obtained through cyanation reaction using methionaldehyde and hydrocyanic acid as raw materials. [0005] The esterified product of amino acid has been prepared fro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C323/52C07C319/20
CPCC07C319/20C07C323/52
Inventor 周荣超廖常福粟宇彭启明
Owner LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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