Clean and environment-friendly production method for methionine hydroxyl analogue

A methionine hydroxyl, clean and environmentally friendly technology, applied in the chemical field, can solve the problems of difficult separation of methionine hydroxyl analogs and ammonium salts, increase of dimers and multimers, a large amount of waste water and by-products, etc., to avoid recovery and loss, High purity and less odor effect

Inactive Publication Date: 2019-01-18
LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a clean and environmentally friendly production method for methionine analogues. This method can save equipment investment and avoid the difficult problem of separation of methionine hydroxyl analogues and ammonium salts in the traditional production process. The problem of increasing polymers and polymers, solves the problem of a large amount of waste water and by-product inorganic salts produced by traditional production methods, and solves a series of problems and unfavorable factors caused by organic solvent extraction by traditional production methods

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 327.50 kg (2000 moles) of 2-hydroxy-4-methylthiobutyronitrile aqueous solution with a mass percentage of 80 wt % and 150.00 kg (1500 moles) of sulfuric acid with a mass percentage of 98 wt % were simultaneously added to the static Fully mix in the mixer, at this time the temperature rises rapidly to 45°C, and then enters the tubular reactor, the inlet temperature of the material in the tubular reactor is 48°C, the outlet temperature is 55°C, and the material stays in the tubular reactor The time is 40 minutes. The material flow in the tubular reactor is added to the enamel reaction kettle with stirring, and water is added at the same time. The amount of water added is 280.00kg. A brown homogeneous mixed solution, cooled to 60°C, the mixed solution did not appear turbid or solid. The mass percent content of the methionine hydroxyl analog was analyzed to be 39.60wt%.

[0035] The hydrolyzate obtained above is subjected to continuous chromatographic separation. During ch...

Embodiment 2

[0039] 403.08kg (2000 moles) of 2-hydroxy-4-methylthiobutyronitrile aqueous solution with a mass percentage of 65wt% and 160.00kg (1600 moles) of sulfuric acid with a mass percentage of 98wt% were simultaneously added to the static Fully mix in the mixer, at this time the temperature rises rapidly to 48°C, and then enters the tubular reactor, the inlet temperature of the material in the tubular reactor is 48°C, the outlet temperature is 60°C, and the material stays in the tubular reactor The time is 50 minutes. The material flow in the tubular reactor is added to the enamel reaction kettle with stirring, and water is added at the same time. The amount of water added is 200.00kg. A brown homogeneous mixed solution, cooled to 60°C, the mixed solution did not appear turbid or solid. The mass percent content of the methionine hydroxyl analog was analyzed to be 39.31wt%.

[0040] The hydrolyzate obtained above is subjected to continuous chromatographic separation. During chromato...

Embodiment 3

[0044] 264.65 kg (2000 moles) of 2-hydroxy-4-methylthiobutyronitrile aqueous solution with a mass percentage of 99 wt % and 210.00 kg (1500 moles) of sulfuric acid with a mass percentage of 70 wt % are simultaneously added to the static Fully mix in the mixer, at this time the temperature rises rapidly to 50°C, and then enters the tubular reactor, the inlet temperature of the material in the tubular reactor is 50°C, the outlet temperature is 60°C, and the material stays in the tubular reactor The time is 30 minutes. The material flow in the tubular reactor is added to the enamel reaction kettle with stirring, and water is added at the same time. The amount of water added is 330.00kg. After the addition, the temperature is immediately raised to 100°C for hydrolysis, and the stirring is kept for 2.5 hours to obtain yellow A brown homogeneous mixed solution, cooled to 65°C, the mixed solution did not appear turbid or solid. The mass percent content of the methionine hydroxyl ana...

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PUM

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Abstract

The invention relates to a clean and environment-friendly production method for a methionine hydroxyl analogue, aiming at solving the problems in a traditional production technological method that themethionine hydroxyl analogue and ammonium salt are difficult to separate and more methionine hydroxyl analogues are carried in the byproduct ammonium salt; the purity of the obtained ammonium salt ishigh; in a whole process, less odor is generated; the whole production process is safe, clean and environmentally friendly, and nearly no wastewater is discharged; the problem of extracting by utilizing an organic solvent in a traditional production technology is solved or the problem that a mixture of the methionine hydroxyl analogue and the ammonium salt are concentrated at high temperature sothat the methionine hydroxyl analogue is decomposed to generate odorous gas is solved; the content of a monomer in an obtained product is greater than that of a traditional production technology and the quality of the product is relatively high.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a clean and environment-friendly production method of methionine hydroxyl analogs. Background technique [0002] Methionine Hydroxy Analogue (MHA) is a highly acidic liquid organic acid containing 12 wt% water and 88 wt% active methionine hydroxy analogue (including at least 65 wt% 2-hydroxy-4 - methylthiobutyric acid monomer, and 2-hydroxy-4-methylthiobutyric acid dimer and multimer in an amount not exceeding 23% by weight). In poultry feeding, methionine hydroxy analogues exhibit properties similar to those of amino acids known to act as growth stimulators and thus become important additives for animal feed. [0003] One of the synthetic methods of methionine hydroxyl analogs is cyanohydrin hydrolysis, which is to react methylthiopropionaldehyde with hydrocyanic acid to obtain 2-hydroxyl-4-methylthiobutyronitrile, which is hydrated under the action of sulfuric acid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C319/20C07C319/28C07C323/52
CPCC07C319/20C07C319/28C07C323/52
Inventor 周荣超廖常福彭启明
Owner LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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