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Feed additive for prevention and treatment of vomitoxin poisoning symptoms and application thereof

A feed additive and vomitoxin technology, which is applied in the field of feed additives for livestock and poultry poisoning symptoms, can solve the problems of stunted growth of livestock and poultry, complex components, etc., achieve the effects of controlling livestock and poultry diseases, simple preparation method, and protecting intestinal health

Pending Publication Date: 2019-03-29
SHANXI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of livestock and poultry growth retardation, intestinal damage and immunosuppression caused by DON is complicated with antibiotic drugs or pure Chinese medicine ingredients, so the comprehensive use of feed additives for the prevention and treatment of livestock and poultry poisoning caused by DON has not been reported.

Method used

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  • Feed additive for prevention and treatment of vomitoxin poisoning symptoms and application thereof
  • Feed additive for prevention and treatment of vomitoxin poisoning symptoms and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of the bacillus mixed powder of embodiment 1 degradation DON

[0025] 1. Preparation of Bacillus subtilis powder for degrading DON

[0026] Activation of seed solution: Inoculate the DON-degrading Bacillus subtilis original strains preserved in test tubes with 1% inoculum in a triangular flask containing LB medium, and inoculate them at a temperature of 30°C and a dissolved oxygen content of 50- 60% and a magnetic stirring speed of 120-150 r / min under aseptic conditions for 10-12 hours to activate the seed solution.

[0027] Primary fermentation: Inoculate the activated seed solution (0.5×1010CFU / mL-1.5×1010CFU / mL) in a primary fermenter with a 1% inoculation amount for cultivation (fermentation conditions are the same as when the seed solution is activated).

[0028] Secondary fermentation: the seed mother culture liquid fermented in the primary fermenter is input into the secondary fermenter containing LB medium for amplified cultivation (fermentation...

Embodiment 2

[0035] Embodiment 2 Preparation of a feed additive for preventing and treating symptoms of DON poisoning in livestock and poultry

[0036] The raw materials are composed in parts by weight as follows: 10-20 parts of DL-methionine hydroxyl analog, 6-10 parts of glutathione, 10-15 parts of immune polysaccharide, and 60-70 parts of DON-degrading bacillus mixed powder.

Embodiment 3

[0037] Example 3 Feed Additive Detoxification Experiment of DON in Broiler Feed

[0038] Select 22,500 1-day-old healthy white-feathered broiler chickens, and randomly divide them into 3 groups with 5 repetitions, each with 1,500 birds, and the initial body weight of the chickens in each group is not significant. The specific experimental design is shown in Table 1. The negative control group was a normal peanut meal basal diet without feed additives; the positive control group was a mildewed peanut meal basal diet without feed additives; the test group was a mildewed peanut meal basal diet with feed additives added. Among them, the content of DON in the diets of the positive control group and the test group was 777.62 μg / kg. In the test group, 0.01-0.05 parts by weight of the feed additive is added to the complete feed according to 100 weight of the feed. During the experiment, free access to food and water, regular disinfection, 24h light, routine immunization, the test la...

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Abstract

The invention relates to a feed additive for prevention and treatment of livestock and poultry production performance decline, product quality decline, digestive system damage and easy infection of diseases caused by vomitoxin poisoning and application thereof. The active ingredients include, by weight, 10-20 parts of a DL-methionine hydroxy analogue, 6-10 parts of glutathione, 10-15 parts of immune polysaccharide, and 60-70 parts of bacillus mixed powder for degrading vomitoxin. The active ingredients are dried, crushed and mixed to obtain the feed additive product. The product is soluble inwater, and has no toxic or side effect, no drug resistance and no pollution. Feeding experiments verify that the feed additive product provided by the invention can effectively prevent and treat livestock and poultry production performance decline caused by vomitoxin, and also can lower the livestock and poultry mortality rate, improve the intestinal tract barrier function of livestock and poultry, and improve the livestock and poultry immunity.

Description

technical field [0001] The invention belongs to the technical field of feed additives for livestock and poultry, and in particular relates to a feed additive for preventing and treating poisoning symptoms of livestock and poultry caused by vomitoxin and its application. Background technique [0002] Deoxynivalenol (DON) is a trichothecene toxin, mainly produced by Fusarium and Fusarium graminearum, widely present in contaminated grain, feed and food. Low doses of DON mainly cause symptoms such as loss of appetite, weight loss, and metabolic disorders in animals, while high doses can cause animals to vomit. DON disrupts the homeostasis of the intestinal system, damages the secretion and the immune system, and reaches the blood-brain barrier through the blood circulation to affect the central system. There are species and gender differences in the reaction of animals to DON. Male animals are more sensitive to the toxin, and pigs are the most sensitive animals to DON. Studies ...

Claims

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Application Information

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IPC IPC(8): A23K20/147A23K20/142A23K20/163A23K10/16
CPCA23K10/16A23K20/142A23K20/147A23K20/163
Inventor 贾如刘文彬曹丽蓉
Owner SHANXI UNIV
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