Solid methionine hydroxy analogue calcium salt compound with antibacterial and acidizing properties and preparation method of solid methionine hydroxy analogue calcium salt compound

Abstract

The invention discloses a solid methionine hydroxy analogue calcium salt compound with antibacterial and acidizing properties and a preparation method of the solid methionine hydroxyl analogue calcium salt compound. The compound is prepared from calcium 2-hydroxy-4-(methylthio) butyrate, 2-hydroxy-4-(methylthio) butyric acid and water. A preparation method of the compound comprises the following steps: mixing an aqueous solution of liquid methionine with calcium oxide or calcium hydroxide to obtain a reaction solution, carrying out a neutralization reaction at 80-100 DEG C to obtain a liquid product, and carrying out spray drying on the liquid product to obtain the target product. According to the preparation method, the raw material ratio is scientific and reasonable, the final product powdery methionine hydroxyl analogue calcium salt compound powder is loose and good in dispersity, the yield reaches up to 99% or above, the methionine content is larger than or equal to 88 wt%, the problems that in the actual production process, methionine hydroxy analogue calcium salt is low in yield and purity, a filter cake is sticky and greasy, smoothness is poor and the like are solved, and the requirements of customers on powdery methionine and liquid methionine can both be met, so that the compound is worthy of popularization and application.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a solid methionine hydroxyl analog calcium salt complex with antibacterial and acidifying properties and a preparation method thereof. Background technique [0002] Liquid methionine, also known as methionine hydroxyl analogs, scientific name is DL-2-hydroxy-4-methylthiobutyric acid and its dimer, trimer mixture, in which the content of monomer, dimer and trimer are respectively 65%, 20%, 3%, dark brown viscous liquid, acidic. Liquid methionine is not actually an amino acid compound, but a short-chain fatty acid compound. Liquid methionine can be converted into L-methionine in animals, and L-methionine participates in animal protein synthesis and energy metabolism. The process is as follows: figure 1 shown. from figure 1 It can be seen that the biological value of liquid methionine in feeding is exactly the same as that of DL-methionine, so it can be us...

AI Technical Summary

Problems solved by technology

But there are also a series of problems: 1) It has a strong corrosive and pungent odor, and it is inconvenient to store, transport, and use, so an expensive special liquid feeding system must be used; 2) It is very viscous and flows at low temperature Poor in nature, it is not easy to mix evenly in the feed premix; 3) A large amount of heat is released when it meets water, which causes the feed to become rancid during storage and transportation; 4) It is very acidic, with a pH of about 1, and it is easy to mix with feed or premix The acid-base reaction of other ingredients in the feed will cause damage to the nutritional ingredients in the feed

The material produced by this method has high purity, but the process is more complicated due to the need for recrystallization and dehydration again

In actual production, these disclosed methods all have the problems of synthetic D, L-2-hydroxyl-4-methylthiobutyrate calcium has large viscosity, low density, poor fluency, etc., so it is difficult to fully mix with feed, and the quality of feed is low. Unstable, thus affecting the feeding effect

[0011] In addition, the above-mentioned preparation method of D,L-2-hydroxyl-4-methylthiobutyric acid generally has the following defects: once calcium oxide or calcium hydroxide reacts with 2-hydroxyl-4-methylthiobutyric acid , the reaction speed will be very fast, which will cause the pressure in the reaction vessel to increase rapidly and generate a large amount of heat, which will cause the reaction speed, pressure and temperature to be difficult to control, resulting in the coking of part of the product 2-hydroxy-4-methylthiobutyrate calcium , and wrap on the unreacted calcium oxide or calcium hydroxide to prevent its further reaction with 2-hydroxy-4-methylthiobutyric acid, thus affecting the yield and quality

However, compared with DL-methionine, the content of calcium salt of methionine hydroxyl analogue is low, and the range of application is greatly limited, which cannot meet the needs of customers.

Images