Novel chemical synthesis method for adenine

A chemical synthesis, adenine technology, applied in the field of chemical synthesis of adenine, can solve the problems of many side reactions, difficult to obtain pure products, cumbersome post-processing, etc., achieve low production cost, shorten the route steps, and improve production efficiency.
CN102887899AInactive Publication Date: 2013-01-23YANGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
YANGZHOU UNIV
Publication Date
2013-01-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for synthesizing adenine represented by a formula (I), wherein the method comprises the following steps of making formamide react with diethyl malonate in an ethanol solution of sodium ethoxide to obtain a raw material 4,6-dihydroxypyrimidine represented by a formula (VI); nitrifying the 4,6-dihydroxypyrimidine to obtain 4,6-dihydroxy-5-nitropyrimidine represented by a formula (V); carrying out chlorination reaction on the 4,6-dihydroxy-5-nitropyrimidine (V) to obtain 4,6-dichloro-5-nitropyrimidine represented by a formula (IV), carrying out aminolysis reaction on the 4,6-dichloro-5-nitropyrimidine (IV) and an saturated aminoethanol solution to obtain 4,6-diamino-5-nitropyrimidine represented by a formula (III); carrying out catalytic hydrogenation on the 4,6-diamino-5-nitropyrimidine (III), and reducing a nitro group to obtain 4,5,6-triaminopyrimidine represented by a formula (II); making the 4,5,6-triaminopyrimidine (II) react with ethyl orthoformate in acetic anhydride to obtain the adenine represented by the formula (I). The method provided by the invention has the advantages of cheap and easily-obtained raw materials, mild reaction conditions, single product, high total yield, low production cost and easiness in industrial production.
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Description

technical field

[0001] The invention relates to a chemical synthesis method of adenine, in particular to a novel chemical synthesis method of adenine. Background technique

[0002] Adenine (Compound I), English name: Adenine, Chinese name: 6-aminopurine, CAS number: 73-24-5, molecular formula is C 5 h 5 N 5 . It is an important pharmaceutical raw material and intermediate. It is used for biochemical research and drug analysis such as the production of adenosine, ATP, ADP, new anti-AIDS drugs, vitamin B4 and plant growth hormone 6-benzyl adenine, and can prevent and treat leukopenia caused by various reasons. At the same time, it is also a component of nucleic acid, participates in the synthesis of RNA and DNA in organisms, and can promote white blood cell proliferation when white blood cells are lacking. It can also be used for blood storage, and other medical and biochemical research.

[0003] The currently publicly reported synthetic routes mainly include the followi...

Claims

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