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4 results about "AIDS drugs" patented technology
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Proteolytic chimera targeting hiv protease and uses thereof
The application discloses a proteolysis body (PROTAC) targeting HIV protease and application thereof, the PROTAC is a polypeptide structure, a general formula is R1-L-E3L or R1-L-E3L-R2, wherein R1 is a target ligand of HIV protease, L is a GSGS linker, E3L is a ligand of VHL (von Hippel-Lindau) E3 ubiquitin ligase, and R2 is a D-configuration arginine cell penetration peptide; the PROTAC can recruit E3 ligase, specifically induce ubiquitination and degradation of HIV protease in a proteasome-dependent manner; the application further provides a gene encoding the PROTAC, a recombinant carrier, a pharmaceutical preparation and application of the gene in preparation of an anti-AIDS drug.
Owner:HENAN NORMAL UNIV
A 4-quinazolinone derivative containing a benzene sulfonamide piperazinone and a preparation method and application thereof
The application provides a 4-quinazolinone derivative containing a benzene sulfonamide piperazine ketone and a preparation method and application thereof. The derivative has the structure shown in the following general formula I. The application further relates to a preparation method of a compound containing the structure of formula I and application of the compound as an HIV-1 / HIV-2 capsid protein regulator in preparation of an anti-AIDS drug.
Owner:SHANDONG UNIV
Phenylsulfonamide piperidinone glycine derivatives, processes for their preparation and use
The application provides a benzene sulfonamide piperazine ketone glycine derivative and a preparation method and application thereof. The derivative has a structure shown in the following general formula I. The application also relates to a preparation method of a compound containing the structure of formula I and application of the compound as an HIV-1 / 2 capsid protein regulator in preparation of an anti-AIDS drug.
Owner:SHANDONG UNIV
HIV-1 capsid protein degrading agent based on hydrophobic tag technology and preparation method and application thereof
The application provides an HIV-1 capsid protein degradation agent based on a hydrophobic tag technology and a preparation method and application thereof. The HIV-1 capsid protein degradation agent has the structure shown in general formula I or II. The application further relates to a preparation method of the compound and application of the compound as the HIV-1 capsid protein degradation agent in preparation of an anti-AIDS drug.
Owner:SHANDONG UNIV