Application of Tripterygium wilfordii in the preparation of functional drugs for curing AIDS

A technology of tripterygium wilfordii and AIDS, which is applied in the application field of tripterygium wilfordii in the preparation of functional drugs for curing AIDS

Active Publication Date: 2021-06-29
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

What needs to be explained is that the suppression of HIV in vitro experiments and the functional cure of AIDS in clinical practice are two completely different concepts. The suppression of HIV emphasizes the suppression of virus replication in the presence of drugs, but It will rebound immediately after stopping the drug, and the functional cure of AIDS is that the rebound of the virus cannot be detected for a long time after stopping the drug

Method used

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  • Application of Tripterygium wilfordii in the preparation of functional drugs for curing AIDS
  • Application of Tripterygium wilfordii in the preparation of functional drugs for curing AIDS
  • Application of Tripterygium wilfordii in the preparation of functional drugs for curing AIDS

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Experimental program
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Embodiment Construction

[0032] Experimental steps and methods

[0033] Diagnosis and Monitoring of HIV Infection: The diagnosis of HIV infection was first screened by enzyme-linked immunosorbent assay (ELISA) and subsequently confirmed by Western blot. Viral load was measured by COBAS AmpliPrep / taqman48 real-time RT-PCR (Roche Diagnostics) with an HIV-1 detection range from 40 to 10,000,000 copies / mL at the start of treatment and at each follow-up visit. Use a six-color FACSCanto flow cytometer to detect T cell subsets and immune activation markers (BD Biosciences), CD4+T cells (CD4+CD3+), CD8+T cells (CD8+CD3+), activated T cells (CD8+CD38+ and CD8+HLA-DR+) detection.

[0034] Serum inflammatory markers: Serum inflammatory marker levels (IP-10 were determined by Luminex immunoassay ( MAP Human Cytokine / Chemokine Magnetic Bead Panel) was tested on plasma from each follow-up sample. Minimum detectable levels are based on panel instructions.

[0035] HIV nucleic acid detection: From peripheral blo...

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Abstract

The invention discloses the use of tripterygium wilfordii in the preparation of a functional drug for curing AIDS. By using high-efficiency antiretroviral drugs combined with tripterygium wilfordii to treat patients from the acute stage of AIDS, no plasma appears within 12 months after the drug is stopped. The rebound of HIV RNA, thus achieving a functional cure for AIDS.

Description

technical field [0001] The invention relates to a new application of a Chinese medicinal material or its active ingredients, in particular to the application of Tripterygium wilfordii in the preparation of a functional medicine for curing AIDS. Background technique [0002] AIDS, Acquired Immunodeficiency Syndrome (AIDS), is caused by Human Immunodeficiency Virus (Humanimmunodeficiencyvirus, HIV), also known as AIDS virus. At present, AIDS has not only become a public health problem that seriously threatens the health of our people, but also affects economic development and social stability. [0003] HIV mainly attacks the human immune system, including CD4 + T lymphocytes, macrophages and dendritic cells, etc., mainly expressed as CD4 + The number of T lymphocytes is constantly decreasing, which eventually leads to the deficiency of human cellular immunity and causes various opportunistic infections and tumors. After HlV enters the human body, it reaches the local lymph ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/37A61K31/513A61K31/675A61K31/427A61P31/18
CPCA61K31/427A61K31/513A61K31/675A61K36/37A61K2300/00
Inventor 李太生曹玮
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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