3results about How to "High ee value" patented technology

The application discloses a kind of photocontrol chiral ligand based on diarylethene, structural general formula is as shown in following formula:After the photocontrol chiral ligand based on diarylethene synthesized in the application and rhodium catalyst coordination, when catalyzing asymmetric carbon hydrogen amidation at room temperature, higher reaction yield and higher ee value can be obtained by using ligand in open loop state to catalyze, and lower reaction yield and lower ee value can be obtained by using ligand in light stable state to catalyze.The application makes up the deficiency that there is currently lack of photo-thermal bistable photocontrol catalyst in the field of photocontrol asymmetric catalysis, and widens the application of diarylethene in photocontrol asymmetric catalysis.

This invention discloses a reductase mutant and its application in the preparation of S-Bosein. The reductase mutant differs from the amino acid sequence shown in SEQ ID NO:3 in containing one or more amino acid residues at sites Q95, L96, and G190. The reductase mutant of this invention exhibits high substrate conversion and high ee value of S-Bosein when using β-pyruvate as a substrate, making it suitable for industrial production.

The invention belongs to the technical field of chemical synthesis, and relates to a method for synthesizing a chiral alpha-non-natural aromatic amino acid derivative under visible light driving. The preparation method comprises the following steps: carrying out in-situ matching on a compound 1 and a ligand under the action of a catalyst, and then continuously carrying out photocatalytic coupling reaction on the compound 1 and a compound 2 under the action of an additive to obtain a compound 3, namely the chiral alpha-non-natural aromatic amino acid derivative. Rich types of natural carboxylic acids exist in the nature, redox active ester derived from aromatic acetic acid is adopted as an aryl donor, a guarantee is provided for structural diversity synthesis of chiral alpha-non-natural aromatic amino acid, a non-natural amino acid compound library can be enriched to a great extent, and assistance is provided for development of polypeptide innovative drugs.