33results about How to "Simple post-reaction handling" patented technology

The invention discloses a method for preparing polyol by using bio-oil. The method comprises the following steps: firstly performing methyl esterification, namely, performing ester exchange on biolipid and methanol under the catalysis of potassium fluoride loaded magnesium oxide solid alkali, converting the obtained product into fatty acid methyl ester with small molecular weight and byproduct glycerol, filtering to recycle the catalyst, and separating lower-layer glycerol; performing epoxidation on upper-layer fatty acid methyl ester in 30% of hydrogen peroxide under the catalysis of ionic liquid so as to form epoxidized fatty acid methyl ester.; then adding the glycerol in the methyl esterification process, continuously performing alkoxide ring-opening under the catalysis of ionic liquid, introducing hydroxyl, and finally separating liquid to recycle the ionic liquid catalyst, reducing pressure and distilling the upper-layer to remove water so as to obtain low-viscosity bio-oil-based polyol. The raw material is easily available, recyclable and good in biodegradability, the preparation process is environmental friendly, the industrial three-waste emission is small, the product structure and a hydroxyl value are adjustable, the application range is wide, and the environment influence level is low.

The invention relates to a preparation method and application of mannose-grafted trimethyl chitosan.The preparation method comprises: adding N,N,N-trimethyl chitosan into an organic solvent so that the organic solvent wells, adding mannopyran phenyl isothiocyanate for full reacting, and preparing N-mannose-N,N,N-trimethyl chitosan by ethanol washing, suction filtering and vacuum drying.The invention also provides application of the preparation method of the mannose-grafted trimethyl chitosan in the preparation of drug-carrying microspheres.The preparation method of a mannose-grafted trimethyl chitosan carrier has mild conditions, and a prepared mannose-grafted trimethyl chitosan drug-carrying microsphere preparation can target dendritic cells, overcoming mucosal barriers.

The invention discloses a method for synthesis of phenylacetic acid by carbonylation of benzyl chloride. The key technology includes that: a 2-(4-amino-2-hydroxyphenyl)benzimidazole metal complex as shown in the structural formula (I) is used as a main catalyst in the reaction process, M is Co2+, Cu2+, and Zn2+, and benzimidazole Schiff base is used as a catalytic additive. The catalytic system is simple in synthesis process, has excellent catalytic activity for carbonylation of benzyl chloride, and is small in usage amount, easy to operate, low in cost, and easy for product postprocessing purification. Reaction conditions are mild and easy to achieve, and the reaction temperature is only 60-70 DEG C.

The invention discloses an energetic material 4, 4, 8, 8-tetranitroadamantane-2, 6-dinitrate and a preparation method thereof. According to the preparation method, cyclooctadiene as the raw material undergoes the steps of hydroboration-oxidation, oxidation, formylation, cyclization, nitric acid esterification, oximation, germinal nitration and the like to be finally synthesized into 4, 4, 8, 8-tetranitroadamantane-2, 6-dinitrate. Polynitroadamantane and adamantine nitrate have the advantages of symmetrical structure, high density, excellent explosion property, low sensitivity and the like, and can be widely used in the fields of explosives, propellants, pyrotechnic compositions, fuels and the like.

The invention provides a (R)-4-amino phenethyl-(2-hydroxy-2-phenylethyl)-tert-butyl carbamate synthesis method, and belongs to the technical field of drug synthesis. With the present invention, problems of low product yield, complex treatment steps, heavy environment pollution and the like of the synthesis method in the prior art are solved. The synthesis method comprises the following steps that: hydroxyl on p-nitrophenylethanol is oxidized into aldehyde to obtain p-nitrophenylacetaldehyde; amino on (R)-2-amino-1-phenylethanol and the aldehyde on the p-nitrophenylacetaldehyde are subjected to dehydration condensation reduction to obtain (R)-2-p-nitrophenylethylamine-1-phenylethanol; (Boc)2O is adopted to replace amino on the (R)-2-p-nitrophenylethylamine-1-phenylethanol; and nitro on (R)-4-nitro phenethyl-(2-hydroxy-2-phenylethyl)-tert-butyl carbamate is reduced into amino so as to obtain the final product. The synthesis method has characteristics of low production cost, high product yield, and low environmental pollution.

The invention discloses a method for asymmetric synthesis of a 3,3-disubstituted-2-oxindole compound. The method is characterized in that a 3-monosubstituted-2-oxindole compound and a 1,4-naphthoquinone compound as reaction raw materials undergo a reaction in the presence of chiral organic catalysts in air to produce the 3,3-disubstituted-2-oxindole compound. The method has mild reaction conditions and adopts easily available raw materials. The 3,3-disubstituted-2-oxindole compound obtained by the method has a very high ee value, provides a key skeleton structure for the synthesis of many natural products and drugs, and can be widely used for large-scale industrial production.

The invention discloses a synthesis method of chiral spiro-oxindole dihydropyran derivatives, specifically, dihydrofuran (pyran) and isatin derivatives β , gamma -Unsaturated α The -ketoester is a reactant, and under the catalysis of a chiral (Box) / Cu(II) complex, the product is synthesized in a trifluorotoluene solvent. The method disclosed by the invention has simple and easy raw materials, mild reaction conditions, simple and convenient post-treatment, wide range of applicable substrates, high yield, high enantioselectivity and diastereoselectivity; the product synthesized thereby has potential medicinal value.