66 results about "Trimethyl chitosan" patented technology

The invention belongs to the technical field of medicine, and relates to an acetylcholine-receptor-mediated trimethyl chitosan-graft-polyethylene glycol / nucleic acid brain-targeting micellar and a preparation method thereof. According to the invention, trimethyl chitosan-graft-polyethylene glycol-brain-targeting functional peptide is obtained through the steps that: chitosan is sequentially subjected to quaternary ammonium modification such that trimethyl chitosan is obtained; the amino group of trimethyl chitosan is subjected to a reaction with an active group of two-end-activated polyethylene glycol, such that trimethyl chitosan-graft-polyethylene glycol is obtained; and another active group of polyethylene glycol is subjected to a reaction with brain-targeting functional peptide RVG. According to the invention, ion composite micellar is adopted as a carrier, and brain-targeting functional peptide RVG is adopted as a targeting molecule, such that nucleic acid medicine can actively target and position through blood-brain barrier and brain. The ion composite micellar provided by the invention is formed through static composition of positively charged trimethyl chitosan-graft-polyethylene glycol-brain-targeting functional peptide and negatively charged nucleic acid. With the invention, nucleic acid medicine defects such as easy in-vivo degradation, poor stability, and low transfection efficiency are solved.

The invention relates to a curcumin coated liposome preparation and a preparation method thereof. The curcumin coated liposome preparation consists of curcumin, phospholipids, cholesterol, water-soluble vitamin E and trimethyl chitosan, and can be prepared into freeze-dried powder applied to oral administration. The gastrointestinal absorption efficiency of the curcumin coated liposome is significantly higher than that of the traditional curcumin liposome preparation, so the curcumin coated liposome further improves the oral absorption of the curcumin and improve the oral bioavailability.

The invention discloses a preparation method of a supermolecule globular micelle based on an antidepressant medicament chlorpromazine. The method comprises the following steps: constructing a medicament carrier through the supermolecule interaction of amphiphilic sulfonated calix [4] arene and an antidepressant medicament chlorpromazine hydrochloride, dissolving the amphiphilic sulfonated calix [4] arene and the antidepressant medicament chlorpromazine hydrochloride in water, and uniformly mixing to obtain a nano supermolecule globular micelle solution; and non-covalently modifying a targeting agent trimethyl chitosan through a bonding site of the calix arene on the surface of the micelle to obtain the supermolecule micelle loaded with trimethyl chitosan on the surface. The preparation method has the advantages that the preparation method is simple and convenient, and fewer subjective and objective raw materials are used; the medicament load rate is high since the medicament molecules are the constructing units of the medicament carrier and the medicament molecules are immobilized; the micelle can be used for non-covalently modifying the targeting agent trimethyl chitosan through the bonding site of the surface calix arene so that the micelle has a wide application prospect in the field of targeted medicament delivery.

Multifunctional cancer targeting nanoparticles include a magnetic central core including gold coated iron oxide, an outer layer including trimethyl chitosan microspheres and folic acid and a linker between the central core and the outer layer, the linker including cysteamine. An anti-cancer drug can be supported by the outer layer. The multifunctional cancer targeting nanoparticle can provide simultaneous cancer cell diagnosis and therapy. An amount of heat and an amount of the anti-cancer drug released by the nanoparticle can be controlled by application of a magnetic field.

The invention discloses base fertilizer for a water chestnut planting field. The base fertilizer is characterized by being prepared from the following raw materials in percentage by mass: 28 percent to 32 percent of composted cattle pen manure, 8 percent to 12 percent of phosphorus fertilizer, 2 percent to 4 percent of zinc-boron fertilizer, 28 percent to 32 percent of plant ash, 20 percent to 24 percent of oilseed cake and 4 percent to 6 percent of an auxiliary material. The auxiliary material comprises the following components in parts by weight: 14 to 20 parts of modified bamboo powder, 4 to 8 parts of vermiculite powder, 5 to 9 parts of sepiolite powder, 2 to 4 parts of sodium humate, 2 to 4 parts of straw powder and 3 to 5 parts of turf. The modified bamboo powder is prepared by adopting the following process: stirring N,N,N-trimethyl chitosan, glacial acetic acid and water; dropwise adding a silver nitrate solution under a stirring state; then dropwise adding a sodium borohydride solution and stirring to obtain a prefabricated material; stirring gelatin and the water; adding sodium hydroxide and stirring; adjusting the pH (Potential of Hydrogen) value to be 7.1 to 7.5; adding succinic anhydride and stirring; drying and crushing; adding a silane coupling agent, the bamboo powder, the prefabricated material and toluene; raising the temperature, stirring, washing, drying and crushing to obtain the modified bamboo powder.

The invention provides an N-trimethyl chitosan microsphere, a preparation method thereof and application of the microsphere in reduction of dielectric loss of vegetable oil, belonging to the field ofmodified chitosan. The preparation method of the N-trimethyl chitosan microsphere comprises the following steps: carrying out hybrid reaction on chitosan with the visocisty of 0.25-0.65Pa.s, sodium iodide and N-methyl-2-pyrrolidone, then adding sodium hydroxide and methyl iodide, reacting, then carrying out ethanol precipitation, separating, and carrying out freeze drying, thereby obtaining N-trimethyl chitosan with the quaternization substitution degree of 10-20%; preparing N-trimethyl chitosan into solution, spraying into sodium polyphosphate, reacting, washing with water, adding into sodiumhydroxide solution, stirring, adding glutaraldehyde, and reacting, thereby obtaining the microsphere; and washing the microsphere with water, then sequentially eluting with organic solvents with thevolume fractions of 21-29%, 41-49%, 61-69% and 85-89%, and carrying out freeze drying. The modified chitosan prepared by adopting the method can reduce the dielectric loss of the vegetable oil.