19 results about "Trimethyl chitosan" patented technology

This invention discloses a trimethyl chitosan-hyaluronic acid-FMNL2 siRNA nanomedicine and its applications. The siRNA molecule consists of a sense strand and an antisense strand, which are anti-complementary to form a double-stranded RNA structure. Each of the sense and antisense strands independently contains two pendant deoxythymidines at its 3' end. The nanomedicine uses trimethyl chitosan as its core framework, efficiently encapsulating the siRNA molecule through electrostatic interactions, and then modifying hyaluronic acid through electrostatic interactions to form core-shell structured nanoparticles. This invention forms a complete technology chain from target validation, siRNA sequence design, nanodelivery system construction, in vivo and in vitro efficacy verification to the development of combination drug strategies. It also provides quantifiable efficacy evaluation biomarkers, offering a clear basis for clinical patient screening and efficacy monitoring.

The invention relates to the technical field of microbial fermentation, enzyme engineering and food processing, in particular to a symbiotic fermentation method for Tibetan kefir. The invention discloses a symbiotic fermentation method of Tibetan kefir, which comprises the following steps: firstly, taking honeysuckle enzymatic hydrolysate, fermented whey and the like as raw materials, and adding low-acyl gellan gum and the like to prepare a compound substrate; the Tibetan kefir bacterial sludge is subjected to resuscitation and expanding culture to obtain a secondary seed solution, the secondary seed solution is mixed with the compound matrix and then subjected to micro-aerobic fermentation twice, and lactobacillus acidophilus is added for enhanced fermentation; after the fermentation liquor is distilled and centrifuged, sodium alginate and trimethyl chitosan are cross-linked to prepare a multi-layer microcapsule, and then sterile grape juice is added for blending to obtain a finished product. According to the process, fermentation core parameters and enzymolysis and cross-linking key steps are optimized, the product has both nutrition and flavor, and technical support is provided for industrial production of non-alcoholic fermented beverages.

The invention discloses a cooling liquid additive composition and a cooling liquid, and belongs to the technical field of cooling liquid preparation. The coolant additive composition comprises a corrosion inhibitor ZIF-8 ellagic acid nanoparticles, a heat conduction enhancer graphene oxide chitosan, dispersing agents polyethylene glycol and N-trimethyl chitosan, and an antioxidant vitamin E acetate. The invention further discloses a scheme for preparing cooling liquid by using the cooling liquid additive composition and application of the cooling liquid additive composition in a new energy automobile thermal management system. The problem that the corrosion inhibition efficiency of a traditional cooling liquid is attenuated can be effectively solved by loading natural polyphenol on a metal organic framework MOF and matching with other functional aids.

The invention belongs to the technical field of oral care, and particularly relates to an efficient antibacterial oral care solution and a preparation method thereof. The efficient antibacterial oral care solution is prepared from the following components in parts by weight: 0.01 to 0.5 part of zinc lactate, 0.1 to 2 parts of a plant polyphenol extract, 0.05 to 0.3 part of N-trimethyl chitosan, 0.5 to 2 parts of a buffer agent, 5 to 15 parts of a humectant, 0.05 to 0.2 part of a permeable membrane enhancer, 0.01 to 0.1 part of peppermint essence and 80 to 94 parts of deionized water, the preparation method comprises the following steps: firstly, forming a zinc-polyphenol complex from zinc lactate and a plant polyphenol extract, and then forming a stable ternary complex system from the zinc-polyphenol complex and N-trimethyl chitosan through electrostatic interaction. The technical problems that a traditional oral care solution is poor in component compatibility and short in acting time are solved, and the oral care solution has the excellent effects of synergistic antibacterial effect and lasting effect.

The invention discloses a polyamide reverse osmosis membrane with a high rejection rate and a preparation method thereof, and relates to the technical field of membrane separation. The preparation method comprises the following steps: selecting a polyether sulfone ultrafiltration base membrane as a supporting layer to ensure the basic characteristics of higher mechanical strength and chemical resistance, carrying out pretreatment on a lauryl sodium sulfate solution, N, N, N-trimethyl chitosan and sodium deoxycholate to enhance the hydrophilicity and provide active sites for forming polyamide by interfacial polymerization, and adding a surfactant into a water-phase solution to improve the mechanical strength and chemical resistance of the membrane. The preparation method comprises the following steps: adding an amine monomer into an oil phase solution, accelerating the diffusion rate of the amine monomer in an interfacial polymerization reaction, adding modified silicon dioxide into the oil phase solution, forming a stable organic silicon grafting layer on the surface of nano silicon dioxide, grafting tert-butylhydroquinone on the surface of nano silicon dioxide, reducing the attack of chlorine on a polyamide chain, and improving the chlorine resistance of the polyamide chain; the rejection rate of the polyamide reverse osmosis membrane on salt inorganic matters is improved by regulating and controlling surface charges of the base membrane, activating an interface and introducing an anti-chlorine group.

This invention discloses a nasal spray containing novel Iota carrageenan oligosaccharides, relating to the field of pharmaceutical formulation technology. The spray comprises: novel Iota carrageenan oligosaccharides with degrees of polymerization of 2 and 4, prepared by stepwise synergistic enzymatic hydrolysis of cellulase and carrageenase, as well as N-trimethyl chitosan, hydroxypropyl-β-cyclodextrin, green tea polyphenols, and vitamin E, etc. Its preparation process involves ultrasonic compounding to allow charged components to electrostatically self-assemble into a polyelectrolyte complex network. This invention significantly reduces system viscosity, improves atomization performance and bioavailability; by enhancing the adhesion of the drug solution to the nasal mucosa surface, the retention time of the active ingredient is extended to more than 6 hours; combined with green tea polyphenols, it achieves dual protection of physical barrier and biochemical inhibition; and the formulation exhibits high physicochemical stability, is non-irritating to the nasal mucosa, and has excellent safety.

The invention relates to an active pharmaceutical composition for treating oral ulcer and a preparation method of the active pharmaceutical composition, and belongs to the technical field of biological medicine. A trimethyl chitosan-fucus polysaccharide compound, a high-adhesion bionic carrier and poloxamer 407 are used as main adhesion and gel substrates, and are matched with isomaltooligosacharide, a menthol-beta-cyclodextrin inclusion compound, ascorbyl palmitate, glycerol and the like to prepare a medicine, and through a synergistic system of compound treatment, long-acting adhesion, safe regulation and control and micro-ecological prevention, the effect of treating the human body is achieved. The core pain points of short effect, large side effect and easy relapse of the traditional oral ulcer medicine are solved. Wherein the high-adhesion bionic carrier is a quaternary composite matrix composed of silk fibroin, a hyaluronic acid-sulfydryl derivative, a chitosan mercaptan modifier and pectin.

The application relates to the technical field of water-based paint functional additives, in particular to modified hydroxyethyl methyl cellulose ether suitable for water-based paint and a preparation method and application thereof. The modified hydroxyethyl methyl cellulose ether comprises the following components in percentage by weight: 90-95% of surface treatment type hydroxyethyl methyl cellulose ether; 5-10% of admixture; the admixture comprises the following components in parts by weight: 20-35 parts of N-trimethyl chitosan citrate; 30-45 parts of trehalose grafted polyoxyethylene-polyoxypropylene block copolymer; and 20-40 parts of dodecyl hydrophobically modified branched starch. The application overcomes the performance defects of conventional HEMC through a simple and efficient modification mode, makes the comprehensive performance of the HEMC reach the same level of mainstream HEC, meanwhile, the cost advantage of the HEMC is retained, and the large-scale application of the HEMC in a water-based paint system is realized.

The application belongs to the technical field of oral care, and particularly relates to a high-efficiency antibacterial oral care solution and a preparation method thereof. The high-efficiency antibacterial oral care solution comprises the following components in parts by weight: 0.01-0.5 parts of zinc lactate, 0.1-2 parts of plant polyphenol extract, 0.05-0.3 parts of N-trimethyl chitosan, 0.5-2 parts of a buffer, 5-15 parts of a humectant, 0.05-0.2 parts of a membrane permeation enhancer, 0.01-0.1 parts of a peppermint essence, and 80-94 parts of deionized water. The preparation method is to first form a zinc-polyphenol complex by mixing zinc lactate and plant polyphenol extract, and then form a stable ternary complex system by electrostatic interaction between the zinc-polyphenol complex and N-trimethyl chitosan. The application solves the technical problems of poor compatibility and short action time of traditional oral care solutions, and has excellent effects of synergistic antibacterial enhancement and long-lasting action.

The present invention discloses a polyamide reverse osmosis membrane with a high retention rate and a preparation method thereof, and relates to the field of membrane separation technology. By selecting a polyethersulfone ultrafiltration base membrane as a support layer, the basic characteristics of high mechanical strength and chemical resistance are guaranteed. By pre-treatment with sodium dodecyl sulfate solution, N,N,N-trimethyl chitosan and sodium deoxycholate, its hydrophilicity is enhanced, providing active sites for interfacial polymerization to form polyamide. By adding a surfactant to the aqueous phase solution, the diffusion rate of amine monomers in the interfacial polymerization reaction is accelerated. Modified silica is added to the oil phase solution to form a stable organosilicon graft layer on the surface of nano-silica. Tertiary butylhydroquinone is grafted on the surface of the nano-silica to reduce the attack of chlorine on the polyamide chain and improve its chlorine resistance. By regulating the surface charge of the base membrane, activating the interface, and introducing anti-chlorine groups, the retention rate of the polyamide reverse osmosis membrane for salt inorganic substances is improved.

The invention discloses tiamulin fumarate tablets capable of improving bioavailability and a preparation method of the tiamulin fumarate tablets, and belongs to the technical field of veterinary drug preparations. Every 100 kg of the tiamulin fumarate tablet is mainly prepared from the following raw materials in parts by weight: 10 to 30 kg of tiamulin fumarate, 28 to 35 kg of Soluplus, 1.2 to 2.0 kg of silicon dioxide, 0.5 to 1.1 kg of N-trimethyl chitosan (TMC), 16 to 20 kg of HPMC-AS, 3.2 to 4.0 kg of triethyl citrate, 16 to 25 kg of microcrystalline cellulose (PH102) and 3.1 to 4.3 kg of croscarmellose sodium. According to the invention, a composite enteric-solubilization-infiltration promotion system is adopted, and the innovative process of a solubilization inner core adopts co-grinding of a main drug and Soluplus, so that the water solubility of the drug is fully improved; the enteric-coated layer adopts HPMC-AS (hydroxypropyl methylcellulose acetate succinate) to solve the problem of gastric acid degradation and reduce the gastric degradation rate, so that drugs are accurately released in intestinal tracts, and the bioavailability is improved; the penetration enhancer chitosan derivative N-trimethyl chitosan (TMC) is added, so that the intestinal mucosa permeability is enhanced, and the intestinal absorption rate is increased.

The invention discloses a high-molecular hemostatic material and a preparation method thereof, and the preparation method of the high-molecular hemostatic material comprises the following steps: preparing a first electrospinning liquid by using a high-molecular biological material as a solute, and preparing a second electrospinning liquid by using N, N, N-trimethyl chitosan and chitosan sulfate as solutes; respectively carrying out electrostatic spinning by using the first electrospinning liquid and the second electrospinning liquid to obtain a semi-finished product film; and drying the semi-finished film to obtain the required high-molecular hemostatic material. According to the preparation method of the high-molecular hemostatic material, the prepared high-molecular hemostatic material comprises the N, N, N-trimethyl chitosan and the chitosan sulfate, and the N, N, N-trimethyl chitosan and the chitosan sulfate are hydrophilic chitosan derivatives and have good water solubility and water absorption, so that the high-molecular hemostatic material can be applied to the field of hemostatic materials. When the two are introduced into a chain segment of a high-molecular biological material, the blood absorption property and seepage absorption capacity of the material can be remarkably improved.

This invention discloses a multifunctional SACP-PEP / TMC film, its preparation method, and its applications, belonging to the field of biomaterials technology. The preparation method includes: reacting phosphate and polyacrylic acid in the presence of calcium salt to obtain ACP nanoparticles; dispersing the ACP nanoparticles in a solvent and reacting them with a silane coupling agent to obtain surface-modified SACP nanoparticles; dissolving N,N,N-trimethylchitosan in a solvent, adding the SACP nanoparticles and functional peptides, mixing thoroughly, placing the mixture in a mold, removing the solvent, and molding to obtain the SACP-PEP / TMC film. This invention also discloses the multifunctional SACP-PEP / TMC film prepared by the above method and its applications. This invention, by constructing an antibacterial-antienzyme-remineralization multi-target intervention system, induces orderly remineralization of the collagen matrix while protecting it, achieving comprehensive strengthening of the resin-dentin bonding interface, thus providing an effective technical solution for improving clinical bonding durability.

The invention discloses a self-assembly condensation body, which is formed by self-assembly condensation of hyaluronic acid or a cross-linking compound of hyaluronic acid and an amino-containing micromolecule adjuvant, trimethyl chitosan and biomacromolecules, and the biomacromolecules are protein molecules or carriers containing protein molecule encoding genes. In the structure of the self-assembled condensation body, hyaluronic acid and trimethyl chitosan form a platform with a drug delivery function, and biomacromolecules are used as drug molecules of a delivered object. The self-assembled coacervate provided by the invention is simple and convenient in preparation method, uniform in particle size, good in biocompatibility and good in storage stability, resists gastrointestinal degradation in a mouse body, promotes in-vivo and in-vitro antigen presenting cell uptake, stimulates the mouse to generate persistent whole-body and local mucous membrane humoral immunity and cellular immunity, and improves the immunity of the mouse. Infection of pathogens on mice can be prevented, and the application prospect in preparation of oral vaccines is achieved.

The present invention relates to a tissue repair composition comprising nucleic acid and at least one substance selected from the group consisting of glycol chitosan, chitosan oligosaccharide lactate, trimethyl chitosan, methyl glycol chitosan, carboxymethyl chitosan, N-hydroxymethyl chitosan, N-hydroxypropyl chitosan, and N-hydroxypropyl ether chitosan.

The present application relates to a kind of active pharmaceutical compositions for treating oral ulcer and its preparation method, belong to biological medicine technical field, the present application with lactoferrin peptide, spilanthes acmella willd flavone and Brazil Biji extract as main active substance, with trimethyl chitosan-fucoidan complex, high adhesion biomimetic carrier and poloxamer 407 as main adhesive and gel matrix, cooperate oligoisomaltose, menthol-β-cyclodextrin inclusion compound, ascorbic acid palmitate and glycerol etc. Preparation medicine, through the synergistic system of complex treatment, long-acting adhesion, safe control, microecological prevention, solve the core pain point that traditional oral ulcer drug action is short, side effect is big, easy recurrence. High adhesion biomimetic carrier is the four-element composite matrix of silk fibroin, hyaluronic acid-mercapto derivative, chitosan thiol modifier and pectin.

The present invention relates to a composition for tissue repair comprising: a nucleic acid; and at least one substance selected from the group consisting of ethylene glycol chitosan, chitosan oligosaccharide lactate, trimethyl chitosan, methyl ethylene glycol chitosan, carboxymethyl chitosan, N-hydroxymethyl chitosan, N-hydroxypropyl chitosan, and N-hydroxypropyl ether chitosan.

The invention relates to the technical field of preparation of low-ammonia deproteinized latex medical examination gloves, in particular to a low-ammonia deproteinized latex medical examination glove and a preparation method thereof.The method comprises the following steps that hevea brasiliensis juice is sieved, aminopeptidase and ficin are added, acetic acid is added to terminate enzymolysis, centrifugal concentration and vacuum distillation are performed, gingerol is added, and the low-ammonia deproteinized latex medical examination glove is obtained; graphene and hexagonal boron nitride are subjected to ultrasonic treatment, polylactic acid and glycerin are added, water bath stirring is carried out, latex and the dispersion are mixed, N-octyl-N-trimethyl chitosan is added, stirring is carried out, then 2, 6-butylated hydroxytoluene is added, a ceramic mold subjected to plasma cleaning is soaked in a coagulator and dried, the ceramic mold is soaked in 30% of composite latex and 50% of composite latex, edge curling and standing are carried out after drying, and the ceramic mold is obtained. And preheating the glove base body, electrostatically spraying the multifunctional coating liquid, curing and then carrying out ultraviolet radiation. Therefore, the problems that the low-ammonia deproteinized latex medical examination gloves are high in sensitization, poor in mechanical strength, not easy to degrade, uncomfortable to wear and the like are solved.

The application belongs to the technical field of marine chemical engineering, and particularly relates to N,N,N-trimethyl chitosan quaternary ammonium salt containing glycine Schiff base, a preparation method and application thereof. The N,N,N-trimethyl chitosan quaternary ammonium salt containing glycine Schiff base is shown in formula (1). The application has the advantages of simple reaction equipment, easy control of reaction process, low cost of raw materials, high safety, easy popularization and industrial application. Research proves that the compound has good antioxidant activity and bacterial inhibition activity, and can be applied to the fields of agriculture, medicine and environmental protection.