14 results about "Trimethyl chitosan" patented technology

This invention discloses a trimethyl chitosan-hyaluronic acid-FMNL2 siRNA nanomedicine and its applications. The siRNA molecule consists of a sense strand and an antisense strand, which are anti-complementary to form a double-stranded RNA structure. Each of the sense and antisense strands independently contains two pendant deoxythymidines at its 3' end. The nanomedicine uses trimethyl chitosan as its core framework, efficiently encapsulating the siRNA molecule through electrostatic interactions, and then modifying hyaluronic acid through electrostatic interactions to form core-shell structured nanoparticles. This invention forms a complete technology chain from target validation, siRNA sequence design, nanodelivery system construction, in vivo and in vitro efficacy verification to the development of combination drug strategies. It also provides quantifiable efficacy evaluation biomarkers, offering a clear basis for clinical patient screening and efficacy monitoring.

The invention relates to the technical field of microbial fermentation, enzyme engineering and food processing, in particular to a symbiotic fermentation method for Tibetan kefir. The invention discloses a symbiotic fermentation method of Tibetan kefir, which comprises the following steps: firstly, taking honeysuckle enzymatic hydrolysate, fermented whey and the like as raw materials, and adding low-acyl gellan gum and the like to prepare a compound substrate; the Tibetan kefir bacterial sludge is subjected to resuscitation and expanding culture to obtain a secondary seed solution, the secondary seed solution is mixed with the compound matrix and then subjected to micro-aerobic fermentation twice, and lactobacillus acidophilus is added for enhanced fermentation; after the fermentation liquor is distilled and centrifuged, sodium alginate and trimethyl chitosan are cross-linked to prepare a multi-layer microcapsule, and then sterile grape juice is added for blending to obtain a finished product. According to the process, fermentation core parameters and enzymolysis and cross-linking key steps are optimized, the product has both nutrition and flavor, and technical support is provided for industrial production of non-alcoholic fermented beverages.

The invention belongs to the technical field of oral care, and particularly relates to an efficient antibacterial oral care solution and a preparation method thereof. The efficient antibacterial oral care solution is prepared from the following components in parts by weight: 0.01 to 0.5 part of zinc lactate, 0.1 to 2 parts of a plant polyphenol extract, 0.05 to 0.3 part of N-trimethyl chitosan, 0.5 to 2 parts of a buffer agent, 5 to 15 parts of a humectant, 0.05 to 0.2 part of a permeable membrane enhancer, 0.01 to 0.1 part of peppermint essence and 80 to 94 parts of deionized water, the preparation method comprises the following steps: firstly, forming a zinc-polyphenol complex from zinc lactate and a plant polyphenol extract, and then forming a stable ternary complex system from the zinc-polyphenol complex and N-trimethyl chitosan through electrostatic interaction. The technical problems that a traditional oral care solution is poor in component compatibility and short in acting time are solved, and the oral care solution has the excellent effects of synergistic antibacterial effect and lasting effect.

This invention discloses a nasal spray containing novel Iota carrageenan oligosaccharides, relating to the field of pharmaceutical formulation technology. The spray comprises: novel Iota carrageenan oligosaccharides with degrees of polymerization of 2 and 4, prepared by stepwise synergistic enzymatic hydrolysis of cellulase and carrageenase, as well as N-trimethyl chitosan, hydroxypropyl-β-cyclodextrin, green tea polyphenols, and vitamin E, etc. Its preparation process involves ultrasonic compounding to allow charged components to electrostatically self-assemble into a polyelectrolyte complex network. This invention significantly reduces system viscosity, improves atomization performance and bioavailability; by enhancing the adhesion of the drug solution to the nasal mucosa surface, the retention time of the active ingredient is extended to more than 6 hours; combined with green tea polyphenols, it achieves dual protection of physical barrier and biochemical inhibition; and the formulation exhibits high physicochemical stability, is non-irritating to the nasal mucosa, and has excellent safety.

The invention relates to an active pharmaceutical composition for treating oral ulcer and a preparation method of the active pharmaceutical composition, and belongs to the technical field of biological medicine. A trimethyl chitosan-fucus polysaccharide compound, a high-adhesion bionic carrier and poloxamer 407 are used as main adhesion and gel substrates, and are matched with isomaltooligosacharide, a menthol-beta-cyclodextrin inclusion compound, ascorbyl palmitate, glycerol and the like to prepare a medicine, and through a synergistic system of compound treatment, long-acting adhesion, safe regulation and control and micro-ecological prevention, the effect of treating the human body is achieved. The core pain points of short effect, large side effect and easy relapse of the traditional oral ulcer medicine are solved. Wherein the high-adhesion bionic carrier is a quaternary composite matrix composed of silk fibroin, a hyaluronic acid-sulfydryl derivative, a chitosan mercaptan modifier and pectin.

The application relates to the technical field of water-based paint functional additives, in particular to modified hydroxyethyl methyl cellulose ether suitable for water-based paint and a preparation method and application thereof. The modified hydroxyethyl methyl cellulose ether comprises the following components in percentage by weight: 90-95% of surface treatment type hydroxyethyl methyl cellulose ether; 5-10% of admixture; the admixture comprises the following components in parts by weight: 20-35 parts of N-trimethyl chitosan citrate; 30-45 parts of trehalose grafted polyoxyethylene-polyoxypropylene block copolymer; and 20-40 parts of dodecyl hydrophobically modified branched starch. The application overcomes the performance defects of conventional HEMC through a simple and efficient modification mode, makes the comprehensive performance of the HEMC reach the same level of mainstream HEC, meanwhile, the cost advantage of the HEMC is retained, and the large-scale application of the HEMC in a water-based paint system is realized.

The application belongs to the technical field of oral care, and particularly relates to a high-efficiency antibacterial oral care solution and a preparation method thereof. The high-efficiency antibacterial oral care solution comprises the following components in parts by weight: 0.01-0.5 parts of zinc lactate, 0.1-2 parts of plant polyphenol extract, 0.05-0.3 parts of N-trimethyl chitosan, 0.5-2 parts of a buffer, 5-15 parts of a humectant, 0.05-0.2 parts of a membrane permeation enhancer, 0.01-0.1 parts of a peppermint essence, and 80-94 parts of deionized water. The preparation method is to first form a zinc-polyphenol complex by mixing zinc lactate and plant polyphenol extract, and then form a stable ternary complex system by electrostatic interaction between the zinc-polyphenol complex and N-trimethyl chitosan. The application solves the technical problems of poor compatibility and short action time of traditional oral care solutions, and has excellent effects of synergistic antibacterial enhancement and long-lasting action.

The invention discloses tiamulin fumarate tablets capable of improving bioavailability and a preparation method of the tiamulin fumarate tablets, and belongs to the technical field of veterinary drug preparations. Every 100 kg of the tiamulin fumarate tablet is mainly prepared from the following raw materials in parts by weight: 10 to 30 kg of tiamulin fumarate, 28 to 35 kg of Soluplus, 1.2 to 2.0 kg of silicon dioxide, 0.5 to 1.1 kg of N-trimethyl chitosan (TMC), 16 to 20 kg of HPMC-AS, 3.2 to 4.0 kg of triethyl citrate, 16 to 25 kg of microcrystalline cellulose (PH102) and 3.1 to 4.3 kg of croscarmellose sodium. According to the invention, a composite enteric-solubilization-infiltration promotion system is adopted, and the innovative process of a solubilization inner core adopts co-grinding of a main drug and Soluplus, so that the water solubility of the drug is fully improved; the enteric-coated layer adopts HPMC-AS (hydroxypropyl methylcellulose acetate succinate) to solve the problem of gastric acid degradation and reduce the gastric degradation rate, so that drugs are accurately released in intestinal tracts, and the bioavailability is improved; the penetration enhancer chitosan derivative N-trimethyl chitosan (TMC) is added, so that the intestinal mucosa permeability is enhanced, and the intestinal absorption rate is increased.

This invention discloses a multifunctional SACP-PEP / TMC film, its preparation method, and its applications, belonging to the field of biomaterials technology. The preparation method includes: reacting phosphate and polyacrylic acid in the presence of calcium salt to obtain ACP nanoparticles; dispersing the ACP nanoparticles in a solvent and reacting them with a silane coupling agent to obtain surface-modified SACP nanoparticles; dissolving N,N,N-trimethylchitosan in a solvent, adding the SACP nanoparticles and functional peptides, mixing thoroughly, placing the mixture in a mold, removing the solvent, and molding to obtain the SACP-PEP / TMC film. This invention also discloses the multifunctional SACP-PEP / TMC film prepared by the above method and its applications. This invention, by constructing an antibacterial-antienzyme-remineralization multi-target intervention system, induces orderly remineralization of the collagen matrix while protecting it, achieving comprehensive strengthening of the resin-dentin bonding interface, thus providing an effective technical solution for improving clinical bonding durability.

The invention discloses a self-assembly condensation body, which is formed by self-assembly condensation of hyaluronic acid or a cross-linking compound of hyaluronic acid and an amino-containing micromolecule adjuvant, trimethyl chitosan and biomacromolecules, and the biomacromolecules are protein molecules or carriers containing protein molecule encoding genes. In the structure of the self-assembled condensation body, hyaluronic acid and trimethyl chitosan form a platform with a drug delivery function, and biomacromolecules are used as drug molecules of a delivered object. The self-assembled coacervate provided by the invention is simple and convenient in preparation method, uniform in particle size, good in biocompatibility and good in storage stability, resists gastrointestinal degradation in a mouse body, promotes in-vivo and in-vitro antigen presenting cell uptake, stimulates the mouse to generate persistent whole-body and local mucous membrane humoral immunity and cellular immunity, and improves the immunity of the mouse. Infection of pathogens on mice can be prevented, and the application prospect in preparation of oral vaccines is achieved.

The present invention relates to a tissue repair composition comprising nucleic acid and at least one substance selected from the group consisting of glycol chitosan, chitosan oligosaccharide lactate, trimethyl chitosan, methyl glycol chitosan, carboxymethyl chitosan, N-hydroxymethyl chitosan, N-hydroxypropyl chitosan, and N-hydroxypropyl ether chitosan.

The present application relates to a kind of active pharmaceutical compositions for treating oral ulcer and its preparation method, belong to biological medicine technical field, the present application with lactoferrin peptide, spilanthes acmella willd flavone and Brazil Biji extract as main active substance, with trimethyl chitosan-fucoidan complex, high adhesion biomimetic carrier and poloxamer 407 as main adhesive and gel matrix, cooperate oligoisomaltose, menthol-β-cyclodextrin inclusion compound, ascorbic acid palmitate and glycerol etc. Preparation medicine, through the synergistic system of complex treatment, long-acting adhesion, safe control, microecological prevention, solve the core pain point that traditional oral ulcer drug action is short, side effect is big, easy recurrence. High adhesion biomimetic carrier is the four-element composite matrix of silk fibroin, hyaluronic acid-mercapto derivative, chitosan thiol modifier and pectin.

The present invention relates to a composition for tissue repair comprising: a nucleic acid; and at least one substance selected from the group consisting of ethylene glycol chitosan, chitosan oligosaccharide lactate, trimethyl chitosan, methyl ethylene glycol chitosan, carboxymethyl chitosan, N-hydroxymethyl chitosan, N-hydroxypropyl chitosan, and N-hydroxypropyl ether chitosan.

The application belongs to the technical field of marine chemical engineering, and particularly relates to N,N,N-trimethyl chitosan quaternary ammonium salt containing glycine Schiff base, a preparation method and application thereof. The N,N,N-trimethyl chitosan quaternary ammonium salt containing glycine Schiff base is shown in formula (1). The application has the advantages of simple reaction equipment, easy control of reaction process, low cost of raw materials, high safety, easy popularization and industrial application. Research proves that the compound has good antioxidant activity and bacterial inhibition activity, and can be applied to the fields of agriculture, medicine and environmental protection.