53 results about "Glycol-chitosan" patented technology

The invention provides a fluorescence imaging reagent for a cell membrane based on multi-site anchoring. The fluorescence imaging reagent is an ethylene glycol chitosan polymer of which a side chain contains a hydrophobic unit and a fluorescent unit. The fluorescence imaging reagent for the cell membrane is based on a multi-site anchoring technology and has the advantages of good biocompatibility, simplicity for synthesis, low cost and short dyeing time; besides, the fluorescence imaging reagent is not easily intemalized by cells and can be used as a specific tracer labeling probe of the cell membrane.

The present invention relates to a glycol chitosane derivative, a preparation method thereof and a drug delivery system comprising the same. More specifically, the invention relates to a glycol chitosan derivative, which can form nano-sized self-assembled structures and has both temperature sensitivity and biodegradability so as to be suitable for use as a drug delivery system, as well as a preparation method thereof and a drug delivery system comprising the same.

The present invention relates to a visible light-curable chitosan derivative, a hydrogel, and a preparation method therefor and, more specifically, to a visible light-curable glycol chitosan derivative which is cured by light in the visible light range and has wound healing ability, a hydrogel, and a preparation method therefor. A hydrogel obtained by cross-linkage of the visible light-curable glycol chitosan derivative according to the present invention using visible light has a wound healing effect per se, and further, a hydrogel obtained by cross-linkage in a combination of one or more growth factors has an excellent wound healing effect. In addition, a glycol chitosan hydrogel that can prevent the denaturation of contained drugs and growth factors due to the cross-linkage by visible light and is optimized for application to a wet dressing dosage form can be prepared.

The invention relates to the field of compound fertilizers and particularly relates to an efficient sustained-release compound fertilizer containing waste mushroom stalks. The fertilizer is prepared from the following raw materials in parts by weight: 10-15 parts of diatomite of 1250-2000 meshes, 6-8 parts of peanut shell fine powder, 15-18 parts of waste mushroom stalks, 4-5 parts of angelica keiskei leaves, 12-13 parts of purple potato slag, 2-4 parts of D-sodium erythorbate, 5-6 parts of galanga leaves, 4-5 parts of yeast powder, 1-3 parts of zinc sulfate, 10-12 parts of calcium superphosphate, 20-23 parts of monoammonium phosphate, 22-28 parts of urea, 3-5 parts of ferrous sulfate, 10-14 parts of xylitol slag, 1-2 parts of eugenol powder, 12-15 parts of glycol chitosan, 0.1-0.3 part of glutaraldehyde, 6-8 parts of polyvinyl alcohol, 2-4 parts of cellulose ether and 4-5 parts of auxiliaries. According to the compound fertilizer disclosed by the invention, waste materials in daily lives are fully utilized to ensure more sufficient and varied nutrients on the basis of reducing the production cost, and the diatomite and a sustained-release coating agent are used for forming double coating on the nutrients to ensure more durable fertilizer efficiency so as to obviously improve the yield and quality of crops, so that the compound is a novel green and efficient compound fertilizer.

The invention discloses a preparation method of silver-containing hydrogel. The method comprises the following steps: dissolving ethylene glycol chitosan in a solvent to prepare an ethylene glycol chitosan solution; dissolving silver nitrate in water, then adding glucan to form a stable colloidal solution, and dropwise adding a trisodium citrate solution to prepare a nano-silver colloidal solution; dissolving oxidized dextran in water to prepare an oxidized dextran solution; and uniformly mixing an ethylene glycol chitosan solution with a nano-silver colloidal solution, then adding an oxidized dextran solution to carry out Schiff base reaction, and freeze-drying to obtain the silver-containing hydrogel. The hydrogel disclosed by the invention has a uniform porous net structure, shows excellent mechanical property and antibacterial property, slowly releases silver ions, can also load medicines such as deferrimine and the like, ensures that the medicines are slowly and efficiently released, promotes revascularization, shortens a wound healing period, and has a relatively good treatment effect on refractory wounds.

The invention discloses an electret master batch material special for melt-blown cloth and a preparation method of the electret master batch material, and relates to the technical field of materials for melt-blown cloth production. The composite material is prepared from the following raw materials: polypropylene resin, an electret, a compatilizer, an antioxidant and a weather-proof agent, wherein the electret is prepared from the following components: tourmaline with the average particle size of 0.01 [mu]m-0. 05 [mu]m, polyethylene glycol and chitosan. The electret agent in the existing electret master batch material is modified, so that the melt-blown fabric produced by the electret master batch material has excellent electret durability, the expiration date of the melt-blown fabric and derived products thereof is prolonged, and the phenomenon that a die head is blocked by a machine in the melt-blown fabric production process is prevented.

The invention belongs to the field of fruit fertilizers, and particularly discloses a banana high-efficiency fertilizer with a mouthfeel-improving carbon aerogel. The fertilizer is characterized by comprising the following components in parts by weight: glycol chitosan, polyvinyl alcohol, a water-based polyurethane emulsion, a cloven extract, an osmanthus extract, eugenol, nano silicon micropowder, polyglutamic acid, amide wax, chitooligosaccharide, 400-mesh bamboo powder, dead sea black mud, soybean residues, pepper pulp, tea powder humulus lupulus, soybean protein isolate, organic-selenium-rich active ferment powder, sodium caseinate, kurarinone, tung oil, molasses, pyrauxite powder and the like. The 400-mesh bamboo powder, dead sea black mud and the like are fermented by the organic-selenium-rich active ferment powder to obtain the main material for preparing the banana organic fertilizer. The fertilizer has abundant nutrients, and is capable of regulating the soil humidity and air permeability and enhancing the fertility. The added stable mouthfeel-improving carbon aerogel is rich in the cloven extract, osmanthus extract, eugenol and polyglutamic acid, and can improve the banana flavor and implement high-efficiency culture of bananas.

Water-soluble nanoceria are described herein along with methods of making and using the same. Water-soluble nanoceria described herein comprise a cerium oxide nanoparticle and glycol chitosan. In some embodiments, water-soluble nanoceria further comprise at least one therapeutic agent and/or targeting agent that may be attached to a surface of the water-soluble nanoceria.

The invention discloses an electrochemical immunosensor for simultaneously detecting two neuroendocrine tumor markers and belongs to the technical field of electrochemical biosensing. According to thesensor, two parallel glassy carbon electrodes are used as working electrodes, and the surfaces of the electrodes are sequentially modified with a metal ion functionalized porous magnesium silicate/gold nanoparticle/polyethylene glycol/chitosan composite material and a recognition antibody. When specific binding occurs between the markers and the antibody, differentiable electric signals of the two metal ions are recorded through differential pulse voltammetry to realize simultaneous detection of CgA and CgB, and the more the markers react with the antibody, the lower the electric signals are.The electrochemical immunosensor is advantaged in that the electrochemical immunosensor is high in sensitivity and low in detection limit, the limitation of a single marker can be made up, and accuracy of neuroendocrine tumor diagnosis is improved.

The invention relates to double-crosslinking self-healing hydrogel and a preparation method thereof. According to the hydrogel, ethylene glycol chitosan and methyl cellulose serve as raw materials, hexanoylated ethylene glycol chitosan (HGC) is generated through the reaction of ethylene glycol chitosan and hexanoic anhydride, methyl cellulose is oxidized through sodium periodate to obtain oxidized methyl cellulose (DAMC), then a dynamic imine bond is formed through the Schiff base reaction of the aldehyde group of the DAMC and the amino group on the HGC, and the dynamic imine bond is formed through the Schiff base reaction of the aldehyde group of the DAMC and the amino group on the HGC. And the HGC-DAMC hydrogel is prepared and obtained. The method is mild in reaction condition, simple and safe to operate and easier to accept by researchers. The prepared HGC-DAMC hydrogel has good self-healing capability, solves the problem that the structure of the traditional hydrogel is easy to damage in the use process, can realize self-healing under the condition of no external stimulation, and reduces the use of chemical cross-linking agents. The HGC-DAMC hydrogel has potential application value in the fields of injectable drug sustained-release carriers and the like.

The invention relates to the technical field of medical treatment, in particular to a graphene nanocomposite for treating burn wound multi-drug-resistant bacterial infection, which comprises the following steps: A, designing and preparing; B, characterization performance research: (1) hydrated particle size detection, (2) photo-thermal performance detection, (3) material stability analysis, (4) material surface size and morphology size analysis, (5) Fourier transform infrared spectrum, ultraviolet-visible light absorption spectrum and Raman spectrum analysis, and (6) material component analysis. Carboxylated graphene is used as a carrier, polydopamine is loaded on the surface, ethylene glycol chitosan is cross-linked into the system to prepare a modified graphene nano material, and finally, the modified graphene nano material is loaded on GCS-PDA-coated CG through non-covalent bond binding, the efficient photo-thermal induced targeted graphene nano antibacterial material (AIBI-GCS-PDA(@) CG) is formed, alkyl radicals can be released to kill multi-drug-resistant bacteria, and a new treatment strategy is expected to be provided for infection of the multi-drug-resistant bacteria on burn wounds.

A visible light-curable chitosan derivative, a hydrogel thereof, and a preparation method therefor are disclosed. The visible light-curable glycol chitosan derivative is curable by light in the visible light range and has a wound healing activity. A hydrogel obtained by cross-linkage of the visible light-curable glycol chitosan derivative using visible light has a wound healing effect per se, and further, a hydrogel obtained by cross-linkage in a combination of one or more growth factors has an excellent wound healing effect. In addition, a glycol chitosan hydrogel that can prevent the denaturation of contained drugs and growth factors due to the cross-linkage by visible light and is optimized for application to a wet dressing dosage form can be prepared.

Disclosed is a spheroid forming culture container using a temperature-sensitive glycol chitosan derivative and a spheroid forming method using the same. In the disclosed spheroid forming culture container, a surface of a culturing space is coated with a glycol chitosan derivative having reversible sol-gel transition characteristic depending on temperature.

The invention relates to a polyethylene glycol/chitosan microsphere composite biological medical dressing and belongs to the field of medical dressings. The method includes the steps that firstly, chitosan powder and an acetic acid solution are selected, mixed and stirred to be in an emulsion state; the mixture in the emulsion state has a cross-linking reaction with ethylene glycol and a NaOH solution, reactants are washed to be neutral with deionized water, and blank chitosan microsphere carriers are obtained after suction filtration, suction extraction and drying; polyethylene glycol is dissolved in boiled water and stirred, dibenzyl isopropyl phenyl phenol emulgators and the like are added after the temperature is lowered, chitosan microspheres are added after the dibenzyl isopropyl phenyl phenol emulgators are evenly mixed and dissolved; then hydrochloric acid is added, and after being completely foamed, a mixed solution is injected into a polyethylene mold; an obtained product is taken out and repeatedly washed with distilled water, and the polyethylene glycol/chitosan microsphere composite biological medical dressing can be obtained through drying. The polyethylene glycol/chitosan microsphere composite biological medical dressing has the advantages that the healing time of a wound is short, the dressing does not adhere to the wound, and the pain of a patient is relieved; the dressing is easy to operate and low in needed cost.

The invention discloses gynecological antibacterial gelatin based on green antibacterial materials. The antibacterial gelatin is characterized by comprising the following components in parts by weightof 0.5-1.5 parts of hyperbranched glycol chitosan, 1-3 parts of 2,3,5,4'-tetrahydroxystilbene-2-O-glucoside/citronellal/(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-2-pentenoic acid/limonene-1,2-epoxide/allyloxypolyethyleneglycol copolymers, 3-5 parts of hyperbranched polyglycerol, 0.1-0.4 part of hypericum perforatum extracts, 0.1-0.3 part of porous cyclodextrin type metal organic frameworks,0.2-0.5 part of Chinese herbal medicine extracts, 0.1-0.3 part of pH adjusting agents and 50-60 parts of water. The invention also discloses a preparation method of the gynecological antibacterial gelatin based on green antibacterial materials. The gynecological antibacterial gelatin based on green antibacterial materials, disclosed by the invention, is notable in antibacterial and anti-infectioneffects, good in performance stability, excellent in biocompatibility, excellent in treatment effects of gynecological inflammation, capable of promoting regeneration and relieving pain, and being small in side effects, and safe to use, and has higher market promotion and application value.