13 results about "Glycol-chitosan" patented technology

The present invention relates to an acetylated amphiphilic carbohydrate compound of average molecular weight 1-50 kDa which is based on a glycol chitosan, wherein the levels of acetylation can be modified. The compound can be formulated with hydrophobic compounds such as drugs. The degree of acetylation of the carbohydrate compound is optimised to maximise solubilisation of the drugs. The compound is formulated with drugs and is useful in therapy.

The ethylene glycol chitosan derivative aqueous solution shows thermal reversible sol-gel transition within the range of 21 DEG C to 54 DEG C, and the gelling temperature can be controlled through polymer concentration and substitution degree. According to the present invention, the ethylene glycol chitosan derivative hydrogel is subjected to photo-crosslinking by using ultraviolet light so as to prepare the chemically-crosslinked hydrogel with improved mechanical characteristics; the temperature-sensitive gel comprising the ethylene glycol chitosan derivative exhibits a temperature-sensitive sol-gel transition characteristic in a concentration range of 2 wt% to 6 wt%. In addition to the temperature response characteristic, the chemically crosslinked temperature-sensitive gel can also have various physical performance ranges according to different photo-crosslinking times, polymer concentrations and substitution rates, and can be expected to be used for various biomedical applications.

The invention belongs to the technical field of chemicals, and particularly provides a preparation method of calcium carbonate dimeticone chewable tablets, which comprises the following steps: 1) mixing dimeticone and superfine silica powder, adding calcium carbonate, uniformly mixing, adding aspartame, essence, mannitol, corn starch and hydroxy propyl cellulose, sieving, and uniformly mixing to obtain a base material; (2) adding ethylene glycol chitosan and guar gum into a buffer solution, uniformly stirring, adding a galactose oxidase solution and a catalase solution, reacting at room temperature, adding compound polysaccharide, and continuously uniformly mixing to obtain slurry; and 3) adding the slurry and magnesium stearate into the base material, uniformly mixing to prepare a soft material, and then granulating and tabletting to obtain the calcium carbonate dimeticone chewable tablet. The calcium carbonate dimeticone chewable tablet prepared by the invention has the advantages of stable drug release, long drug effect duration and small adverse reaction.

One aspect according to the present invention relates to: a gold nanozyme including glycol chitosan and gold particles; and a pharmaceutical composition for preventing or treating inflammatory bowel disease, the composition comprising the gold nanozyme. The gold nanozyme and the pharmaceutical composition comprising same according to one aspect of the present invention was found to inhibit the expression of inflammatory factors, inhibit the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) inside cells, and reduce the production of nitric oxide (NO) inside cells. In addition, the gold nanozyme was found to inhibit the secretion of Hight Mobility Group Box 1 (HMGB1) when further including glycyrrhizin. In addition, the gold nanozyme and the composition comprising same were found to enable the recovery of the length, weight, etc., of damaged intestines, and thus can be used in the inflammatory bowel disease prevention and / or treatment industry / market.

The present invention relates to glycyrrhizin-glycol chitosan conjugate-coated nanoparticles, islet cells, prepared using same, for transplantation, and an MRI imaging composition comprising same. If transplanted, the islet cells comprising the nanoparticles can suppress a post-transplantation immune response. The present invention can provide islet cells for transplantation that can be transplanted to a certain region by magnetic force induction and can be tracked by MRI.

The invention discloses Pickering emulsion gel based on medicine-adjuvant integration and a preparation method and application thereof.The preparation method comprises the steps that ethylene glycol chitosan is added into a whey protein solution and stirred to be uniform, then glycyrrhizic aldehyde is added, stirring and mixing are conducted, and a whey protein-ethylene glycol chitosan-glycyrrhizic aldehyde composite solution is obtained; mixing the gastrodia elata volatile oil with clove oil, and performing ultrasonic homogenization to obtain an oil phase; adding the oil phase into a whey protein-ethylene glycol chitosan-glycyrrhizic aldehyde composite solution, carrying out high-speed shearing emulsification to obtain an emulsion, then refrigerating the emulsion, and inducing whey protein to denature and gelatinize to form the Pickering emulsion gel. Based on the idea of integration of medicines and auxiliary materials, the whey protein is used as a particle stabilizer, the main medicinal components of gastrodia elata volatile oil and clove oil are used as a mixed oil phase, the dosage of the auxiliary materials is reduced, and through screening of an emulsion gel aqueous phase, the prepared Pickering emulsion is compact in gel texture and high in stability, has a slow release effect on the medicinal components, and can be used for preparing the medicinal composition. The long-acting sleep improvement effect can be realized.

To provide an optimized amphiphilic carbohydrate compound for encapsulating a hydrophobic drug based on the study on the effect of acetylation on the self-assembly of an amphiphilic chitosan derivative and the encapsulation of the drug.SOLUTION: The present invention relates to acetylated amphiphilic carbohydrates compounds with average molecular weights from 1 to 50kDa based on glycol chitosans, wherein the level of acetylation can be varied. The compound can be formulated with a hydrophobic compound, such as a drug. The degree of acetylation of the carbohydrate compound is optimized to maximize solubilization of the drug. The compounds are formulated with drugs and are useful in therapy.SELECTED DRAWING: Figure 1

The invention discloses emedastine fumarate eye drops and a preparation method thereof. The emedastine fumarate eye drops are prepared from the following raw materials: emedastine fumarate, hydrogenated lecithin, cholesterol, 7-dehydrocholesterol, sodium deoxycholate, polyethylene glycol, a chitosan derivative, poloxamer, a preservative, an isoosmotic adjusting agent, a buffer solution and water for injection. The emedastine fumarate eye drops are a system solution compounded by emedastine fumarate liposome, a nano structure and in-situ gel. The emedastine fumarate eye drops prepared by the invention can control the drug release, reduce the irritation, prolong the retention time of eyes, improve the drug availability and enhance the curative effect, so that the medication frequency or medication time is reduced, and the normal physiological environment of eyes is maintained.

The present invention relates to a tissue repair composition comprising nucleic acid and at least one substance selected from the group consisting of glycol chitosan, chitosan oligosaccharide lactate, trimethyl chitosan, methyl glycol chitosan, carboxymethyl chitosan, N-hydroxymethyl chitosan, N-hydroxypropyl chitosan, and N-hydroxypropyl ether chitosan.

The present application belongs to the field of new tobacco, and particularly relates to a paper-wall hollow tube filter stick for heat-not-burn cigarettes, which comprises paper-wall hollow tube segments and tow segments connected with each other, wherein the paper-wall hollow tube segment comprises an inner hollow tube, a hollow tube and an outer hollow tube coaxially sleeved; the inner wall of the inner hollow tube is coated with functional material A; the inner wall of the outer hollow tube is coated with functional material B; the functional material A comprises component a, wherein the component a comprises at least one of amino silicone oil, polyethylene imine, polyethylene glycol, chitosan, glucosamine and polyacrylamide; the functional material B comprises at least one of amino silicone oil and silicon dioxide nano. The present application innovatively provides a paper-wall hollow tube segment with multiple layers of composite, and innovatively provides functional material A on the innermost inner wall of the paper-wall hollow tube segment and functional material B on the inner wall of the outer tube, so that the harmful components of aldehydes in the heat-not-burn cigarettes can be effectively reduced based on the combination of the functional components A and B and the setting structure of the two, and not only this, but also the appearance and smoking taste of the heat-not-burn cigarettes can be improved.

The application belongs to the technical field of artificial biological materials, and particularly relates to a silk fibroin composite chitosan-based scaffold material with a directional porous structure and a preparation method thereof. Silk fibroin, polyethylene glycol and chitosan are mixed in a solution form in a mass ratio of 1:1-1.5:1-5, the obtained mixed solution is poured into a mold composed of an aluminum plate as a heat-conducting bottom plate and heat-insulating plates in other parts, the mold is placed in a low-temperature environment for directional freezing, the frozen silk fibroin-chitosan composite material is demolded and transferred to a vacuum freeze dryer for sublimation drying, so that the silk fibroin composite chitosan-based scaffold material with the directional porous structure is obtained.

The application provides an ion-responsive linarin nanoparticle and a preparation method and application thereof, and comprises the following steps: preparing GC-PLGA nanoparticles by nanometer precipitation method through glycol chitosan and polylactic acid-glycolic acid copolymer, incubating the GC-PLGA nanoparticles with linarin to obtain GC-PLGA-LIN nanoparticles; reacting gellan gum with methacrylic anhydride to obtain methylated gellan gum; reacting the methylated gellan gum with arginine-glycine-aspartic acid peptide to obtain MeGG-RGD; reacting the MeGG-RGD with hyaluronic acid to obtain MeGG-RGD-HA; mixing and resolubilizing the MeGG-RGD-HA and the GC-PLGA-LIN nanoparticles in water, and self-assembling to obtain the ion-responsive linarin nanoparticle MRH-GPLNP. The nanoparticle can exhibit a better protection effect on linarin, and can improve the bioavailability and stability of the linarin.

The invention provides a liquid gallium-based alloy and a preparation method and application thereof. The liquid gallium-based alloy is composed of a plurality of liquid drops, and each liquid drop comprises a liquid gallium-based alloy core and a modified coating layer arranged on the surface of the liquid gallium-based alloy core; the liquid gallium-based alloy core comprises the following components in percentage by atom: 75 to 83 at% of Ga, 13 to 17 at% of In, 0.1 to 7 at% of Sn, 0.1 to 3 at% of Zn and / or Cd, and 0.1 to 2 at% of Pb and / or Bi; the material of the modified coating layer is selected from one or more of polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, chitosan and hexadecyl trimethyl ammonium bromide; the average particle size of the liquid drops is 1-5 [mu] m, and the conductivity is greater than or equal to 3.6 * 10 < 6 > S / m. The liquid drops in the liquid gallium-based alloy are high in size uniformity and good in dispersity, agglomeration is not prone to occurring when a flexible conductive material or a flexible electronic device is prepared, and the electrical performance of the flexible conductive material or the flexible electronic device can be improved.