Polymer hemostatic material and preparation method thereof

The polymer hemostatic material prepared by electrospinning technology uses the composite spinning of collagen, N,N,N-trimethyl chitosan and chitosan sulfate to solve the problems of insufficient hemostatic effect and poor stability of existing hemostatic materials, achieving rapid hemostatic and promoting wound healing.

CN120420489APending Publication Date: 2025-08-05SHENZHEN UNIV
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Patent Information

Application Number
CN202510636031.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-16
Publication Date
2025-08-05

AI Technical Summary

Technical Problem

The existing hemostatic materials have problems such as insufficient hemostatic effect, poor stability, limited scope of application, easy to cause infection and inability to maintain hemostatic effect for a long time.

Method used

Electrostatic spinning technology is used to prepare polymer hemostatic materials, and composite spinning is formed through the combination of collagen, N,N,N-trimethyl chitosan and chitosan sulfate, which improves the blood-sucking and leachate of the material, and promotes wound healing through rapid coagulation and inhibition of inflammation.

Benefits of technology

It has achieved rapid hemostasis, inhibited inflammation, and promoted wound healing. The stability and long-term effects of the material in complex wound scenarios have been significantly improved, reducing the risk of rebleeding.

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Abstract

The invention discloses a high-molecular hemostatic material and a preparation method thereof, and the preparation method of the high-molecular hemostatic material comprises the following steps: preparing a first electrospinning liquid by using a high-molecular biological material as a solute, and preparing a second electrospinning liquid by using N, N, N-trimethyl chitosan and chitosan sulfate as solutes; respectively carrying out electrostatic spinning by using the first electrospinning liquid and the second electrospinning liquid to obtain a semi-finished product film; and drying the semi-finished film to obtain the required high-molecular hemostatic material. According to the preparation method of the high-molecular hemostatic material, the prepared high-molecular hemostatic material comprises the N, N, N-trimethyl chitosan and the chitosan sulfate, and the N, N, N-trimethyl chitosan and the chitosan sulfate are hydrophilic chitosan derivatives and have good water solubility and water absorption, so that the high-molecular hemostatic material can be applied to the field of hemostatic materials. When the two are introduced into a chain segment of a high-molecular biological material, the blood absorption property and seepage absorption capacity of the material can be remarkably improved.
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