12 results about "Phenyl isothiocyanate" patented technology

The application provides an intermediate of a tunicamycin derivative and a synthesis method of the intermediate. The method provided by the application directly protects an amino group of prodigiosin B with phenyl isothiocyanate, then protects a hydroxyl group (a thiourea group is simultaneously subjected to an alkylation reaction), and obtains an intermediate compound with a brand-new structure, then performs a photocatalytic ring-closing reaction, then protects a 5-hydroxyl group, and finally obtains a target compound through a simple Edman degradation reaction. Compared with the prior art, the method has a short reaction route and a significantly improved yield.

The application relates to the technical field of lithium ion batteries, in particular to an electrolyte and a lithium ion battery, wherein the lithium ion battery electrolyte contains a compound with a structure shown in formula I, and the compound with the structure shown in formula I is a phenyl isothiocyanate compound. The phenyl isothiocyanate compound in the electrolyte can improve the structural stability of an electrode / electrolyte interface, and can improve the high-temperature storage gas production performance of the battery.

The present invention belongs to the technical field of preparation of oxadiazole derivatives. The present invention provides a method for preparing 2-amino-1,3,4-oxadiazole derivatives by electrocatalysis, comprising the following steps: adding 0.2mmol of benzoylhydrazide compounds, 0.4mmol of tetrabutylammonium iodide, 0.4mmol of 1,4-diazabicyclo[2.2.2]octane, 0.4mmol of sodium bicarbonate, and 6mL of acetonitrile to an electrolytic cell; then adding 0.3mmol of phenyl isothiocyanate compounds dropwise; reacting under a DC constant current between an electrode anode and an electrode cathode. The present invention adopts electrocatalysis with benzoylhydrazide and phenyl isothiocyanate as reaction substrates, acetonitrile and other cheap and less toxic reagents as solvents, and passing current to replace the oxidant in conventional reactions, thereby synthesizing oxadiazole compounds under mild and green conditions.

The invention discloses an N-aryl quinazoline thio-imidazolinone compound and a preparation method and application thereof.The N-aryl quinazoline thio-imidazolinone compound is prepared by the steps that 2-amino benzylamine and a phenyl isothiocyanate compound serve as raw materials and react in dichloromethane under the action of triethylamine to generate a 1-(2-aminobenzyl)-3-phenylthiourea compound, and the 1-(2-aminobenzyl)-3-phenylthiourea compound is subjected to post-treatment to obtain the N-aryl quinazoline thio-imidazolinone compound. And reacting the 1-(2-aminobenzyl)-3-phenylthiourea compound with ethyl glyoxylate, so as to obtain the N-aryl quinazoline and thioimidazolinone compound. The preparation method comprises the following steps of: reacting the 1-(2-aminobenzyl)-3-phenylthiourea compound with ethyl glyoxylate; the raw materials for synthesis of the compound are easy to obtain, the synthesis method is simple, and meanwhile, the compound has a good inhibition effect on the activity of crop germs, especially on sclerotinia sclerotiorum, phytophthora germs, gibberellic disease germs, magnaporthe oryzae, botrytis cinerea and rhizoctonia solani.

The present invention relates to the technical field of impurity limit detection in the fields of medicine and biochemistry, and discloses a method for detecting the limit of methylaminoacetonitrile residue. The limit detection method comprises the following steps: precisely measuring the reference solution and the test solution respectively and placing them in colorimetric tubes, adding an acetonitrile solution of triethylamine and an acetonitrile solution of phenyl isothiocyanate, mixing well with water, and heating for derivatization to obtain tube A and tube B; separately and precisely measuring equal amounts of the reference solution and the test solution and placing them in the same colorimetric tube, and operating in the same manner to obtain tube C. Looking through from top to bottom, compare the depths of the colors of the solutions in the three tubes, thereby determining whether the methylaminoacetonitrile in the sample to be tested exceeds the limit. The method for detecting the limit of methylaminoacetonitrile residue according to the present invention has high generality. The required instruments, derivatization reagents, etc. are all routinely configured by most pharmaceutical enterprises and research institutions. The operation is simple and the cost is low, and it is suitable for large-scale promotion and use.

The invention discloses a thiourea acylthiourea metal complex catalyst, a preparation method thereof and application of the thiourea acylthiourea metal complex catalyst in lactide ring-opening polymerization. The preparation method comprises the following steps: (1) condensing 3, 5-bis (trifluoromethyl) phenyl isothiocyanate and para aminobenzoic acid in dichloromethane to obtain a carboxyl-containing product A; (2) performing acylating chlorination on the product A to obtain an intermediate B; (3) reacting the intermediate B with ammonium thiocyanate to generate an isothiocyanate intermediate C; (4) reacting the intermediate C with chiral primary amine to obtain a ligand intermediate D with a chiral center; and (5) coordinating the ligand intermediate D with a zinc compound or a titanium compound in an organic solvent to obtain the target catalyst. Molecules of the catalyst contain a chiral thiourea unit and an acylthiourea metal chelating unit at the same time, so that a monomer and an initiator can be activated synergistically. When being used for ring opening polymerization of lactide, the polylactic acid with high stereoregularity and narrow molecular weight distribution can be efficiently prepared at room temperature; the carbon nanotubes are added into a reaction system, so that the polylactic acid composite material with conductivity can be obtained.

This invention discloses an electrolyte, a supercapacitor, and their application in wind power energy storage based on a silicon-sulfur synergistic multifunctional electrolyte additive, belonging to the field of supercapacitor technology. The additive is composed of 4-(triethoxysilyl)phenyl isothiocyanate and diphenylphosphimide in a mass ratio of (0.4~1.2):(0.3~0.9). Through the efficient acid removal of the isothiocyanate group, the chemical anchoring of the siloxane group, and the stabilizing effect of the phenyl conjugation, it synergizes with the flame retardant and ion transport regulation functions of the phosphorimide to construct a stable interface with high temperature resistance and high ion conductivity. The electrolyte contains the additive, a composite lithium salt (LiPF6 / LiFSI / LiPO2F2), a five-element functional solvent (FEC / EC / PC / DEC / EMC), and auxiliary film-forming components (VC / DTD / PST), which synergistically solve the problems of acid corrosion, interface instability, and solvent decomposition at high temperatures. The supercapacitor exhibits low free acidity and high capacity retention after 28 days of storage at 55°C, high capacity retention after 350 high-temperature cycles, and short self-extinguishing time, meeting the high reliability requirements of extreme operating conditions such as wind power energy storage.

According to the application of the 2-ethyoxyl phenyl isothiocyanate in old lithium ion battery capacity repair and the application of the 2-ethyoxyl phenyl isothiocyanate in lithium ion battery electrolyte, the 2-ethyoxyl phenyl isothiocyanate provided by the invention can effectively improve the discharge capacity retention ratio of the lithium ion battery, so that the cycle performance of the lithium ion battery is improved; by adding the 2-ethyoxyl phenyl isothiocyanate or the electrolyte containing the 2-ethyoxyl phenyl isothiocyanate, the discharge capacity of the old lithium ion battery is improved, the attenuation speed of the lithium ion battery is reduced, and the old lithium ion battery is reused.

The present invention relates to the field of biochemical technology, and discloses a method for detecting the limit of aminoacetonitrile residue. The limit detection method includes the following steps: sample treatment, precisely measuring a control solution and a solution to be tested into a test tube, adding an acetonitrile solution of triethylamine and an acetonitrile solution of phenyl isothiocyanate, mixing well and reacting at 40 °C for 30 min; looking through from top to bottom, comparing the depth of the color of the solutions in the two tubes, so as to determine whether the aminoacetonitrile in the sample to be tested exceeds the limit; the method for detecting the limit of aminoacetonitrile residue of the present invention provides a limit detection method with simple operation, fast and convenient, high accuracy, good repeatability, can determine the limit of the aminoacetonitrile residue amount of the sample to be tested, has great application value in the quality control of drug research and development and production, the method provided by the present invention has high generality, the required instruments, derivatization reagents, etc. are all conventional configurations of most pharmaceutical enterprises and research institutions, and its operation is simple and the cost is low.

This invention provides a 2,3-disubstituted quinazolinone compound and its preparation method, relating to the field of organic synthesis technology. The preparation method of the 2,3-disubstituted quinazolinone compound provided by this invention does not use an oxidizing agent and includes the following steps: mixing an aniline compound, a phenyl isothiocyanate compound, an indigo compound, a base, and an organic solvent, and performing a coupling addition reaction to obtain the 2,3-disubstituted quinazolinone compound. This invention can obtain 2,3-disubstituted quinazolinone compounds through a one-step coupling addition reaction. The preparation method is simple, easy to control, economical, and uses inexpensive and readily available raw materials. This invention does not use an oxidizing agent during the preparation process and has the advantage of good functional group tolerance. Furthermore, the 2,3-disubstituted quinazolinone compound prepared by this invention has a purity of 98.5%–99.9%, and has significant market potential.

The invention belongs to the technical field of synthesis of imine derivatives. The invention discloses a method for preparing a thiazolidine-2-imine derivative, which comprises the following steps: adding N-methylallylamine and phenyl isothiocyanate into an electrolytic tank, and introducing direct-current constant current to react to obtain the thiazolidine-2-imine derivative. The method provided by the invention has multiple advantages of mild conditions, simple system, greenness, environmental protection and the like. The reaction can be smoothly carried out at normal temperature, the current is used as an intangible oxidant, a strong oxidant or a metal catalyst does not need to be additionally added, the safety is high, the operation is convenient, and the cost and environmental burden can be reduced. The electrochemical process is accurately regulated and controlled in a constant current mode, side reaction can be effectively inhibited, high-selectivity cyclization conversion is carried out on isothiocyanate and allylamine, the obtained target product is stable in yield and high in purity, post-treatment can be completed only through conventional extraction and purification, and process amplification and batch preparation are facilitated.

This application discloses a method for the simultaneous detection of florfenicol and florfenicolamine. After spiked with florfenicol-D3 and florfenicolamine-D3, the sample is derivatized using phenyl isothiocyanate. Quantitative analysis is then performed using an internal standard method combined with ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UHPLC-QTS-MS / MS). This method enables the simultaneous detection of florfenicol and florfenicolamine in negative ion mode, achieving detection limits of 0.5 μg / kg and quantitation limits of 1.0 μg / kg for both. The method offers rapid analysis and high sensitivity, providing a novel technical means for the detection of florfenicol and its metabolite florfenicolamine.