84 results about "Phenyl isothiocyanate" patented technology

The invention discloses a high performance fluorine rubber protective sleeve cable, which comprises fluorine rubbers, methyl vinyl silicone rubbers, epoxy resins, lated-terminated liquid nitrile rubbers, polyether urethanes, acidulation starches, precipitation method precipitated silica, modified nanometer-silicon dioxide, attapulgite, expanded vermiculite, expansible graphite, zinc oxide, tearic acids, anti-aging agents, orinated paraffins, epoxidized soybean oil, adipate [2 - (2 - butoxy ethoxy) ethyl esters, triphenyl phosphate, glycerol adipic acid ester ethers, sulphur, phenyl isothiocyanate, accelerants, Nu-ammonia propyl triethoxy silane, 2,2,3,3,4,4,4- seven fluorine butyl acrylate. The high performance fluorine rubber protective sleeve cable is excellent in oil resistance and high-low temperature resistance, perfect in ageing-resistant performance and high in strength.

The invention relates to a HPLC (high-performance liquid chromatography) detection method capable of simultaneously detecting contents of six amino acids in a donkey-hide glue blood-supplementing preparation. The method comprises the following steps: providing a donkey-hide glue blood-supplementing preparation sample; providing an amino acid standard sample; respectively adding the donkey-hide glue blood-supplementing preparation sample and the amino acid standard sample into phenylisothiocyanate-acetonitrile solution; uniformly mixing and standing, and respectively adding n-hexane; uniformlymixing and standing once again, respectively extracting lower-layer solutions, and filtering to obtain a derivatized donkey-hide glue blood-supplementing preparation sample solution and a derivatizedamino acid standard sample solution; sucking the derivatized donkey-hide glue blood-supplementing preparation sample solution and the derivatized amino acid standard sample solution, and injecting into a liquid chromatograph to perform amino acid detection. According to the invention, the contents of six major amino acids in the donkey-hide glue blood-supplementing preparation are detected by adopting reversed-phase high-performance liquid-phase, the sample treatment method is simple, the detection method has good specificity, repeatability and accuracy, and the internal quality of donkey-hide glue blood-supplementing granules can be well controlled.

The invention discloses an N-(rhodamine 6G) lactam-N'-phenylthiourea derivative. The N-(rhodamine 6G) lactam-N'-phenylthiourea derivative has the chemical structural formula shown as the specifications. The invention also discloses a preparation method of the N-(rhodamine 6G) lactam-N'-phenylthiourea derivative. The preparation method comprises the following steps of: reacting rhodamine 6G serving as a raw material with ammonia to prepare rhodamine 6G lactam; and reacting the rhodamine 6G lactam with phenylisothiocyanate to prepare the N-(rhodamine 6G) lactam-N'-phenylthiourea derivative. A fluorescent probe has the characteristics of increasing dissolution velocity in acetonitrile, enhancing stability of the pH value; stabilizing in acid alkaline environments and the like, and can serves as a probe for a fluorescent indicator of metal ions to detect heavy metal ion content and transition metal ion content of water.

The invention discloses a fluorescent probe made of rhodamine B, diethylenetriamine and PITC (phenyl isothiocyanate) as well as a preparation method and an application thereof. Specifically, rhodamine B and diethylenetriamine react firstly to form a spiro amide structure with a stable property, a nitrogen bridging fragment is introduced, and the mixture then reacts with PITC so as to introduce a sulfur atom. By means of sulphophile affinity of mercury ions, each molecule of a novel rhodamine B-phenylthiourea derivative (namely, mercury ion fluorescent probe RDTU) obtained through the scheme can be combined with two mercury ions, so that the fluorescent probe has higher selectivity and detection sensitivity. The molecules of the fluorescent probe can perform detection in a neutral buffer solution especially in water phase. Additionally, the molecules of the fluorescent probe can detect the mercury ions from mercury chloride, and has better practicability.

The invention belongs to the field of liquid crystal material preparation and relates to a fast response liquid crystal material for a liquid crystal wave-front corrector and a preparation method. The preparation method is characterized in that eight compounds such as alkyl biphenyl isothiocyanate, alkyl triple phenyl isothiocyanate, alkyl diphenyl acetylenyl isothiocyanate and alkyl phenyl diphenyl acetylenyl isothiocyanate are mixed in percentage by weight, and the mixture is heated and uniformly blended to obtain a wide-temperature nematic liquid crystal with a delta n value of 0.30-0.45 and low viscosity; the obtained liquid crystal material is manufactured into a reflection-type parallel arrangement liquid crystal box which is equivalent to a single pixel liquid crystal wave-front corrector; the thickness of a liquid crystal layer is controlled to be 1.6mum-2.0mum; the modulated quantity of a phase is ensured to be greater than one 785nm-wavelength; and the response time of the modulated quantity of a wavelength phase is 2.4ms-2.5ms under the driving of a 5V-voltage.

The invention discloses a fluorescent probe having a rapid hypochlorous acid detecting function and a preparation method and application.The fluorescent probe is a novel fluorescent probe prepared by using 4-bromine-1,8-naphthoyl dianhydride, 4-(2-aminoethyl) morpholine, piperazine and phenyl isothiocyanate as raw materials.The fluorescent probe can achieve high-selectivity and high-sensitivity rapid detection of hypochlorous acid in the mixed solution of water and a small amount of ethanol (13.6%).Compared with an existing fluorescence detection technology, the obtained fluorescent probe has high-selectivity rapid response to hypochlorous acid and low residual organic solvent content after detection, is suitable for amplification, synthesis and actual production and application and has huge application prospect in the technical fields of analytical chemistry, life science, environmental science and the like, the input cost is lower, a synthetic route is simple, and a detection device and a detection method are simple and convenient.

The invention discloses an anti-aging cable sheath material which comprises natural rubber, ethylene-propylene-diene monomer, epoxy resin, carboxyl-terminated butadieneacrylonitrile copolymer, acidulation starch, carbon black, modified nano silica, carbon nanofibers, zinc oxide, stearic acid, anti-aging agent, polytetrafluoroethylene, adipic acid, bis(2-(2-butoxyethoxy)ethyl) ester, triphenyl phosphate, sulphur, phenyl isothiocyanate, accelerator CZ, accelerator M, accelerator TMTD, lanthanum glutamate dithiocarbamate and gamma-aminopropyl triethoxysilane. The anti-aging cable sheath material is high in strength, good in aging resistance and long in service life.

The invention discloses a fluorescent probe synthesized by rhodamine B, triethylene tetramine and phenyl isothiocyanate and a preparing method and application thereof. Specifically, firstly, the rhodamine B reacts with the triethylene tetramine to form a spirocyclic amide structure which is stable in property, nitrogenous bridged segments are introduced in, and the rhodamine B reacts with the phenyl isothiocyanate, so that sulphur atoms are introduced in. By means of the thiophil property of mercury ions, each molecule in an obtained novel rhodamine B-phenylthiourea derivative RTTU can be combined with three mercury ions, and therefore high selectivity and detection sensitivity are achieved. Fluorescent probe molecules can conduct detection in a neutral buffer solution, especially an aqueous phase and can also detect the mercury ions from mercuric chloride, and higher practicability is achieved. In addition, the fluorescent probe molecules can be directly precipitated out in the preparing process, further separation and purification are not needed, and the synthesizing method is simple and convenient and easy to implement.

The invention provides a near-infrared reactive type two-photon fluorescence probe. The near-infrared reactive type two-photon fluorescence probe is a fluorescence molecule which is prepared by the reaction of 1,3,3-trimethyl-2-methylene indoline-rhodamine hydrazine and 4-morpholinyl-1,8-naphthalimides-phenyl isothiocyanate. The invention also provides a preparation method and application of the near-infrared reactive type two-photon fluorescence probe. According to the near-infrared reactive type two-photon fluorescence probe, red fluorescence in near-infrared band is transmitted, the fluorescence performance of the red fluorescence in the near-infrared band can be sensitively adjusted and controlled through mercury ion induced desulfuration-cyclization reaction of amidothiourea, ring-opening reaction of 1,3,3-trimethyl-2-methylene indoline-rhodamine lactam, and other multi-step cascade reactions, so that the sensitivity, the selectivity and the biocompatibility are high; the near-infrared reactive type two-photon fluorescence probe can be widely applied to the fields of near-infrared two-photon fluorescence imaging, two-photon fluorescence sensors, biofluorescence analysis, fluorescence labelling, environment monitoring and the like.

The invention discloses a reactive mercury ion fluorescent probe and a preparing method as well as application thereof. The method comprises the following steps: (1) 5-aminophenyl and 10, 15, 20- trisulfonate phenyl porphyrin (PNH2) is dissolved in distilled water to form solution of 7.5 mg / ml. The triphosgene is dissolved in dichloromethane to form solution of 5 MuL / mL. After the two is mixed at equal volume, react at room temperature for 3 to 5 hours and then purified, resulted to 5 -phenyl isothiocyanate base and 10, 15, 20 - trisulfate phenylporphyrin (PNCS); (2) 5 - phenyl isothiocyanate base and 10, 15, 20 - trisulfate phenylporphyrin (PNCS) and ethylenediamine derivatives are mixed in an equimolar ratio and dissolved in a mixed solvent of acetone and distilled water, to form a total concentration of 20 mg / mL solution. Finally, the solution reacts at room temperature for 6-10 hours, and after purification, the final product porphyrin-thiourea (PT) is obtained. The probe has good water solubility and shows high sensitivity and selectivity for mercury ions, and shows significant colors and fluorescence changes when detecting mercury ions. Combined with laser confocal scanning microtechnique, the probe can also be obtained the detecting imaging of the mercury ion within living cells.

The invention provides a preparation method for 1-phenyl-5-mercaptotetrazole. The preparation method takes sodium azide and phenyl isothiocyanate as a reaction raw material of preparing 1-phenyl-5-mercaptotetrazole by controlling a reaction temperature to 90-95 DEG C and reaction time to 110-130 min, so that full azido reaction of the sodium azide and phenyl isothiocyanate can be guaranteed undermilder conditions and without the use of a catalyst. The preparation method is simple in operation and small in environment pollution during production, and the use of complex production equipment isnot needed; and the preparation method is simple in post-treatment operation, low in production cost so that to realize large-scale industrial production is easy. Results of embodiments show that theyield of the target object (1-phenyl-5-mercaptotetrazole) can reach to 94.8% when the method is adopted to perform large-scale industrial production, so that actual production needs can be met.

The invention discloses a method for simultaneously determining the migration amounts of ethylenediamine, propylenediamine and hexamethylenediamine in food contact materials and products. The method is characterized by comprising the following steps of: obtaining a food simulant test solution from the food contact materials and food simulants through a migration experiment; placing the food simulant test solution in a plastic tube, adding a phenyl isothiocyanate acetonitrile solution and a triethylamine acetonitrile solution, mixing uniformly by swirling, carrying out water bath, and centrifuging the mixture through a filter membrane; making a standard curve; carrying out liquid chromatography separation and mass spectrum detection; and calculating the standard curve to obtain the concentration of ethylenediamine, 1,2-propanediamine and 1,6-hexanediamine in the test solution. According to the calculation method of the migration amounts of the to-be-measured object in the food contact material and the product thereof, the migration amounts of ethylenediamine, 1,2-propanediamine and 1,6-hexanediamine in the food contact materials and the products thereof are obtained. The method forsimultaneously determining the migration amounts of ethylenediamine, propylenediamine and hexamethylenediamine in food contact materials and products has the advantages of simple operation, high anti-interference capacity and low detection limit.

The invention discloses a fluorescence probe based on RB (rhodamine B), TEPA (tetraethylenepentamine) and PITC (phenyl isothiocyanate) as well as a preparation method and an application of the fluorescence probe. The preparation method comprises specific steps as follows: RB and TEPA react firstly to form a spiro amide structure with a stable property, a nitrogenous bridged fragment is introduced, and the mixture reacts with PITC to introduce sulfur atoms. By virtue of thiophilicity of mercuric ions, each molecule of a novel RB-phenylthiourea derivative RPTU obtained through the scheme can be bound with four mercuric ions, so that higher selectivity and detection sensitivity are achieved; and the fluorescence probe molecules can perform detection in a neutral buffer solution particularly an aqueous phase, can be further used for detecting the mercuric ions of mercuric chloride, and has better practicability.

The invention discloses an up-conversion fluorescent probe rhodamine derivative and an application thereof. The preparation method comprises the following steps: performing a reaction on rhodamine B and ethylenediamine in a nitrogen gas atmosphere and an organic solvent to obtain rhodamine-ethylenediamine; and performing a reaction on the rhodamine-ethylenediamine and phenyl isothiocyanate to obtain the up-convertion fluorescent probe rhodamine derivative. The up-conversion fluorescent probe rhodamine derivative provided by the invention has the high-efficiency down-conversion fluorescence-enhanced response recognition characteristics for mercury ions and has the high-efficiency up-conversion fluorescence-enhanced response recognition characteristics for the mercury ions when used as a fluorescent probe.

The invention discloses a method for synthesizing phenyl isothiocyanate. The method comprises the following steps: (1) heating aniline and tetramethyl thiuram disulfide in water to react so as to obtain a reaction liquid A after the reaction is finished; (2) performing salt forming reaction between the reaction liquid A obtained in the step 1 and acid, and after the reaction is finished, performing centrifugal separation to obtain a solution B and solids; (3) extracting the solution B obtained in the step (2) by using an organic solvent so as to obtain water phase and organic phase, evaporating the water phase to obtain salt of dimethylamine, and performing posttreatment on the organic phase to obtain the phenyl isothiocyanate. The synthesis method is simple to operate, phenyl isothiocyanate is generated in one step and the sulfur and dimethylamine salt generated in the production process can be used as byproducts without being discharged, so that the synthesis process is free of pollution to the environment.

The invention relates to a method for measuring glycine content in immunotoxin / antiserum. The method comprises the steps of: processing a sample in advance, removing macromolecular substances, utilizing isothiocyanato-benzene to conduct pre-column derivatization on the glycine, preparing reference solution after derivatization and sample supply solution after derivatization, and then conducting RP-HPLC (Reverse Phase High-Performance Liquid Chromatography). According to the method, the content of glycine in the immunotoxin / antiserum can be measured rapidly, simply and conveniently, so that the quality of a finished product can be evaluated.

The invention discloses a preparation method of a guanidine polymer heterogeneous catalyst as well as an application method of the guanidine polymer heterogeneous catalyst to catalytic synthesis of Warfarin and derivatives thereof. The method comprises the following steps: synthesizing thiourea by taking various primary amino compounds and phenyl isothiocyanate as raw materials, converting the thiourea into corresponding carbodiimide by utilizing 2-chlorine-1-methyl iodide pyridine, performing stirring reaction on the carbodiimide and branched polyethyleneimine at room temperature, and synthesizing a polyethyleneimine-based guanidine polymer, wherein the obtained guanidine polymer can be purified by being washed in a solvent. The prepared guanidine polymer can efficiently catalyze additionreaction of 4-hydroxycoumarin and alpha, beta-unsaturated ketone; an anticoagulant Warfarin and derivatives thereof with the yield more than 90 percent can be obtained at room temperature; meanwhile,the catalyst can be reused, and efficient and environmentally-friendly effects can be achieved. The invention provides a new approach for synthesis of the anticoagulant Warfarin.

The invention provides a method for detecting the content of gamma-aminobutyric acid in livestock and poultry tissues by a high performance binary liquid chromatography method and relates to the technical field of detecting content of gamma-aminobutyric acid. According to the method, livestock and poultry tissues are weighed; liquid nitrogen is added; grinding is performed; the operation is repeated in such a way many times until the livestock and poultry tissues are completely crushed; sample diluent is added; high-speed centrifugation is performed; supernatant fluid is taken to pass througha microporous filtering film; filter liquid is frozen and dried; a regulating solution is added; freeze drying is performed; then, derivatization agent is added; freeze drying is performed after the room temperature derivatization; a sample is obtained. The sample is dissolved again by the sample diluent to obtain a test specimen; the test specimen and a standard sample are injected into a high performance binary liquid chromatography instrument for analysis; a sample and standard sample chromatogram is obtained; the content of gamma-aminobutyric acid in the sample is calculated according to the chromatogram. The detection method has the advantages that phenyl isothiocyanate is used as a derivating agent to react with amino acid in the livestock and poultry tissues; derivatives are detected by an ultraviolet detector after binary high performance liquid phase separation; the residue of the gamma-aminobutyric acid in livestock and poultry tissues can be directly detected; the accuracy of the detection result is high.

The invention discloses a preparation method of phenyl isothiocyanate. The preparation method comprises the steps of: putting substituted aniline, carbon disulfide and potassium hydroxide in molar ratio of 1: (2-3):1 in a mechanical-chemical reactor for vibration and grinding, extracting, drying and filtering after reaction is ended, evaporating filtrate to dryness and then carrying out silica-gel column chromatography isolation, thus obtaining the phenyl isothiocyanate. According to the preparation method, reaction is completed in one step under the condition of inexistence of solvents, operation is simple, needed reaction time is short, and environment pollution is avoided; chloroformates or other high-corrosion raw materials with strong toxicity are not used for decomposing dithiocarbamate generated in a reaction process so that reaction is safe.

The invention discloses a thiourea-dipicolinamide catalyst as well as a preparation method and application thereof. The catalyst has a structural formula as shown in the specification. According to the catalyst disclosed by the invention, due to a dual catalysis mode that multiple hydrogen bonds are combined with bipyridine coordination, various synthons can be activated through different metalliccenters and multiple hydrogen bond combination sites, and then the purpose of high-selectivity synthesis of a target compound can be achieved. The preparation method comprises the following steps: mixing nitrogen-protected amino acid, bipyridine methylamine, 4-dimethylamino pyridine and 1-ethyl-(3-dimethyl amino propyl) carbonyl diimine hydrochloride to carry out reactions, obtaining an intermediate, carrying out a t-butyloxycarboryl desorption protection reaction, and finally enabling the intermediate to react with 3,5-di(trifluoromethyl) phenyl isothiocyanate, thereby obtaining the thiourea-dipicolinamide catalyst. The preparation method is wide in substrate application range, cheap and easy in chiral source acquisition and few in synthesis steps. The catalyst disclosed by the inventionis used in an asymmetric Michael addition reaction, and is capable of increasing the yield of Michael addition products and improving enantioselectivity.

The invention mainly relates to a technical scheme of realizing high-efficiency and green generation of 2-aminobenzo[4,5]thieno[3,2-d]thiazole and derivatives thereof from an oxime ester compound, anisothiocyanate compound and sulfur powder under the combined action of bialkali and dimethyl sulfoxide without the need of a transition metal for catalysis through a one-pot and multi-component process. According to the invention, with oxime ester, phenyl isothiocyanate and elemental sulfur as raw materials, and under the promotion action of bialkali and dimethyl sulfoxide, the research on three-component cyclization reaction is performed, and benzothiophene polyheterocyclic derivatives are synthesized through intermolecular cyclization under mild conditions. The method provided by the invention does not need to use the transition metal for catalysis, provides a novel path for synthesis of benzothiophene compounds, and has the characteristics of simple reaction system, mild reaction conditions, less reaction equipment, simple and convenient experiment operation, medium-to-high yield, etc.

The invention relates to a thioureas ultraviolet probe and preparation and application thereof. A structural formula of the probe is as follows. The probe is obtained by reaction between phenyl isothiocyanate and hydrazine hydrate. The thioureas ultraviolet probe is used for detecting lead ions: preparing a probe solution, adding the probe solution into a lead ion solution to be detected, making the volume constant by utilizing a solvent, standing, detecting absorbance under the wavelength of 382nm by means of an ultraviolet-visible spectrometry, and determining the content of the lead ions in the lead ion solution to be detected according to a relationship between relative ultraviolet strength and lead ion concentration. The thioureas ultraviolet probe in the invention is solid powder which is convenient to use and store, and is obtained by direct reaction between the phenyl isothiocyanate and the hydrazine hydrate. A synthesis method is simple, the yield is high, the cost is low, and the application prospect is good.

The invention discloses a method for determining glucosamine hydrochloride in healthcare foods, and belongs to the technical field of determination of glucosamine hydrochloride. The method comprises the following steps of preparing a phenyl isothiocyanate methanol solution, a buffer solution and a glacial acetic acid aqueous solution; preparing a reference solution and a sample solution; derivingthe reference solution and the sample solution, wherein the reference solution and the sample solution are derived; performing determination, wherein chromatographic conditions include a chromatographic column of C18, 4.6*250 mm and 5 [mu]m, the detection wavelength being 254 nm, the sample injection volume being 10 [mu]L, the flow rate being 1.0 mL / min and the column temperature being the room temperature; setting a gradient elution program; and injecting the derived reference solution and sample solution into a liquid chromatograph, performing online analysis according to the chromatographicconditions, recording the chromatographic peak area and performing quantification by an external standard method. The method has the advantages of strong specificity to the glucosamine hydrochloridein healthcare products, good linearity and good reproducibility.

The invention relates to a new epoxidation method of 2-benzylidene-1,3-indan diketone double bond. The method comprises the following steps of: adding 2-benzylidene-1,3-indan diketone, phenyl isothiocyanate, 3-benzyl-5-(2-ethoxy)-4-methyl thiazole chlorate and triethylamine in a molar ratio of 1:0.25:0.25:0.25 into a reaction container containing a certain amount of ethanol, stirring at room temperature until the reaction is ended, steaming and removing the ethanol, and carrying out thin layer chromatography separation on residues to obtain the epoxidized product of 2-benzylidene-1,3-indan diketone double bond. By adopting the method, the defects that substrates are destroyed due to strong oxidation property of hydrogen peroxide in the double-bond epoxidation method by using hydrogen peroxide as the epoxidation reagent and epoxidation products cannot be synthesized from highly conjugated double bonds by the method are overcome. The method is simple to operate, low in energy consumption and high in productivity, and heating is not required.

The invention discloses a method for measuring the propylamine glutamine content, belonging to the field of chromatographic analysis. In the method, octadecylsilane bonded silica is utilized as a chromatographic column stuffing, a mixed solvent of an organic phase and an aqueous phase of a phosphate buffer solution are utilized as mobile phases, and phenyl isothiocyanate is utilized as a derivatization reagent, wherein the organic phase is acetonitrile or methanol; the phosphate buffer solution is prepared in the following manner: adding water in 5ml of triethylamine to 1000ml, and adjusting the pH to 5.0-6.0 through phosphoric acid; in the mobile phase, the percent by volume of the aqueous phase is 30-50%. Compared with the prior art, the measuring method provided by the invention has the advantages of high analysis sensitivity, accurate and reliable result, and the like, thereby having good popularization and application values in the production field of propylamine glutamine injection.

The invention discloses a synthesis method of benzothiazole-nitrogen-containing heterocyclic ring hybrid, which is obtained through series reactions between a phenyl isothiocyanate compound and a nitrogen-containing heterocyclic ring compound. The synthesis method comprises the following steps of mixing the phenyl isothiocyanate compound, the nitrogen-containing heterocyclic ring compound, a catalyst iodine and solvents, and heating to 100 to 140 DEG C for reaction under an atmosphere of oxygen or air so as to obtain the benzothiazole-nitrogen-containing heterocyclic ring hybrid. The synthesis method has the advantages the raw materials are simple and easy to obtain, the operation is simple and convenient, the condition is mild, the application range of substrates is wide and the like, and has a potential industrial application prospect.

The invention mainly relates to a synthesis method of 2,5-disubstituted-1,2,4 thiadiazole-3 (2H)-thione and derivatives thereof. The 2,5-disubstituted-1,2,4 thiadiazole-3 (2H)-thione and the derivatives thereof are prepared from oxime lipid compounds, phenyl isothiocyanate compounds and elemental sulfur by a one-pot method under the promotion of an alkali in an oxygen atmosphere. The product withstable molecular structure and excellent chemical properties and the additional products thereof are prepared. The method does not need transition metal catalysis, and provides a new path for the synthesis of the 2,5-disubstituted-1,2,4 thiadiazole-3 (2H)-thioketone compounds. The method has the characteristics of simple reaction system, mild reaction conditions, less reaction equipment, simple and convenient experimental operation, medium and partial yield and the like.