19 results about "Phenyl isothiocyanate" patented technology

The application provides an intermediate of a tunicamycin derivative and a synthesis method of the intermediate. The method provided by the application directly protects an amino group of prodigiosin B with phenyl isothiocyanate, then protects a hydroxyl group (a thiourea group is simultaneously subjected to an alkylation reaction), and obtains an intermediate compound with a brand-new structure, then performs a photocatalytic ring-closing reaction, then protects a 5-hydroxyl group, and finally obtains a target compound through a simple Edman degradation reaction. Compared with the prior art, the method has a short reaction route and a significantly improved yield.

The application relates to the technical field of lithium ion batteries, in particular to an electrolyte and a lithium ion battery, wherein the lithium ion battery electrolyte contains a compound with a structure shown in formula I, and the compound with the structure shown in formula I is a phenyl isothiocyanate compound. The phenyl isothiocyanate compound in the electrolyte can improve the structural stability of an electrode / electrolyte interface, and can improve the high-temperature storage gas production performance of the battery.

The invention belongs to the technical field of preparation of oxadiazole derivatives. The invention provides a method for preparing a 2-amino-1, 3, 4-oxadiazole derivative through electro-catalysis, which comprises the following steps: adding 0.2 mmol of benzoyl hydrazine compound, 0.4 mmol of tetrabutylammonium iodide, 0.4 mmol of 1, 4-diazabicyclo [2.2. 2] octane, 0.4 mmol of sodium bicarbonate and 6 mL of acetonitrile into an electrolytic tank; then, 0.3 mmol of a phenyl isothiocyanate compound is added dropwise; the reaction is carried out under a direct-current constant current between the electrode anode and the electrode cathode. According to the method, benzoyl hydrazine and phenyl isothiocyanate are taken as reaction substrates through electro-catalysis, reagents such as acetonitrile which is low in price and low in toxicity are taken as solvents, an oxidizing agent in a conventional reaction is replaced by a mode of introducing current, and the oxadiazole compound is synthesized under mild and green conditions.

The present invention belongs to the technical field of preparation of oxadiazole derivatives. The present invention provides a method for preparing 2-amino-1,3,4-oxadiazole derivatives by electrocatalysis, comprising the following steps: adding 0.2mmol of benzoylhydrazide compounds, 0.4mmol of tetrabutylammonium iodide, 0.4mmol of 1,4-diazabicyclo[2.2.2]octane, 0.4mmol of sodium bicarbonate, and 6mL of acetonitrile to an electrolytic cell; then adding 0.3mmol of phenyl isothiocyanate compounds dropwise; reacting under a DC constant current between an electrode anode and an electrode cathode. The present invention adopts electrocatalysis with benzoylhydrazide and phenyl isothiocyanate as reaction substrates, acetonitrile and other cheap and less toxic reagents as solvents, and passing current to replace the oxidant in conventional reactions, thereby synthesizing oxadiazole compounds under mild and green conditions.

The invention discloses an N-aryl quinazoline thio-imidazolinone compound and a preparation method and application thereof.The N-aryl quinazoline thio-imidazolinone compound is prepared by the steps that 2-amino benzylamine and a phenyl isothiocyanate compound serve as raw materials and react in dichloromethane under the action of triethylamine to generate a 1-(2-aminobenzyl)-3-phenylthiourea compound, and the 1-(2-aminobenzyl)-3-phenylthiourea compound is subjected to post-treatment to obtain the N-aryl quinazoline thio-imidazolinone compound. And reacting the 1-(2-aminobenzyl)-3-phenylthiourea compound with ethyl glyoxylate, so as to obtain the N-aryl quinazoline and thioimidazolinone compound. The preparation method comprises the following steps of: reacting the 1-(2-aminobenzyl)-3-phenylthiourea compound with ethyl glyoxylate; the raw materials for synthesis of the compound are easy to obtain, the synthesis method is simple, and meanwhile, the compound has a good inhibition effect on the activity of crop germs, especially on sclerotinia sclerotiorum, phytophthora germs, gibberellic disease germs, magnaporthe oryzae, botrytis cinerea and rhizoctonia solani.

The present invention relates to the technical field of drug quality control, and in particular to a method for detecting kanamycin in amikacin sulfate injection. The detection method comprises the following steps: S1 dilutes the amikacin sulfate injection with water, and obtains a test solution by derivatization treatment with an acetonitrile solution containing phenyl isothiocyanate and triethylamine; S2 prepares linear solutions of kanamycin sulfate of different concentrations, and obtains a reference solution by derivatization treatment; S3 elutes the test solution and the reference solution by HPLC, and then enters UV detection and detection to calculate the kanamycin content; the mobile phase used for the elution is 0.08-0.12 mol / L sodium acetate solution (pH value is 6.5±0.2)-methanol, and the volume ratio of the two is 65-75:25-35. The detection method of the present invention has low cost, can effectively separate the components to be tested, has high method sensitivity, good specificity, high precision, good accuracy, and accurate and reliable test results.

The present invention relates to the technical field of impurity limit detection in the fields of medicine and biochemistry, and discloses a method for detecting the limit of methylaminoacetonitrile residue. The limit detection method comprises the following steps: precisely measuring the reference solution and the test solution respectively and placing them in colorimetric tubes, adding an acetonitrile solution of triethylamine and an acetonitrile solution of phenyl isothiocyanate, mixing well with water, and heating for derivatization to obtain tube A and tube B; separately and precisely measuring equal amounts of the reference solution and the test solution and placing them in the same colorimetric tube, and operating in the same manner to obtain tube C. Looking through from top to bottom, compare the depths of the colors of the solutions in the three tubes, thereby determining whether the methylaminoacetonitrile in the sample to be tested exceeds the limit. The method for detecting the limit of methylaminoacetonitrile residue according to the present invention has high generality. The required instruments, derivatization reagents, etc. are all routinely configured by most pharmaceutical enterprises and research institutions. The operation is simple and the cost is low, and it is suitable for large-scale promotion and use.

The invention discloses a thiourea acylthiourea metal complex catalyst, a preparation method thereof and application of the thiourea acylthiourea metal complex catalyst in lactide ring-opening polymerization. The preparation method comprises the following steps: (1) condensing 3, 5-bis (trifluoromethyl) phenyl isothiocyanate and para aminobenzoic acid in dichloromethane to obtain a carboxyl-containing product A; (2) performing acylating chlorination on the product A to obtain an intermediate B; (3) reacting the intermediate B with ammonium thiocyanate to generate an isothiocyanate intermediate C; (4) reacting the intermediate C with chiral primary amine to obtain a ligand intermediate D with a chiral center; and (5) coordinating the ligand intermediate D with a zinc compound or a titanium compound in an organic solvent to obtain the target catalyst. Molecules of the catalyst contain a chiral thiourea unit and an acylthiourea metal chelating unit at the same time, so that a monomer and an initiator can be activated synergistically. When being used for ring opening polymerization of lactide, the polylactic acid with high stereoregularity and narrow molecular weight distribution can be efficiently prepared at room temperature; the carbon nanotubes are added into a reaction system, so that the polylactic acid composite material with conductivity can be obtained.

This invention discloses an electrolyte, a supercapacitor, and their application in wind power energy storage based on a silicon-sulfur synergistic multifunctional electrolyte additive, belonging to the field of supercapacitor technology. The additive is composed of 4-(triethoxysilyl)phenyl isothiocyanate and diphenylphosphimide in a mass ratio of (0.4~1.2):(0.3~0.9). Through the efficient acid removal of the isothiocyanate group, the chemical anchoring of the siloxane group, and the stabilizing effect of the phenyl conjugation, it synergizes with the flame retardant and ion transport regulation functions of the phosphorimide to construct a stable interface with high temperature resistance and high ion conductivity. The electrolyte contains the additive, a composite lithium salt (LiPF6 / LiFSI / LiPO2F2), a five-element functional solvent (FEC / EC / PC / DEC / EMC), and auxiliary film-forming components (VC / DTD / PST), which synergistically solve the problems of acid corrosion, interface instability, and solvent decomposition at high temperatures. The supercapacitor exhibits low free acidity and high capacity retention after 28 days of storage at 55°C, high capacity retention after 350 high-temperature cycles, and short self-extinguishing time, meeting the high reliability requirements of extreme operating conditions such as wind power energy storage.

According to the application of the 2-ethyoxyl phenyl isothiocyanate in old lithium ion battery capacity repair and the application of the 2-ethyoxyl phenyl isothiocyanate in lithium ion battery electrolyte, the 2-ethyoxyl phenyl isothiocyanate provided by the invention can effectively improve the discharge capacity retention ratio of the lithium ion battery, so that the cycle performance of the lithium ion battery is improved; by adding the 2-ethyoxyl phenyl isothiocyanate or the electrolyte containing the 2-ethyoxyl phenyl isothiocyanate, the discharge capacity of the old lithium ion battery is improved, the attenuation speed of the lithium ion battery is reduced, and the old lithium ion battery is reused.

The present invention relates to the technical field of hemoperfusion, and particularly relates to a modified filler for hemoperfusion and a preparation method thereof, including: S1. Performing argon plasma coating on pretreated polystyrene resin to obtain plasma-coated resin; S2. Adding the plasma-coated resin into an acrylic acid solution and irradiating with ultraviolet light to obtain modified plasma-coated resin; S3. Dispersing 6-monamino-β-cyclodextrin in an ethanol aqueous solution, adding phenyl isothiocyanate and triethylamine, and reacting to obtain modified cyclodextrin; S4. Mixing the modified cyclodextrin, the modified plasma-coated resin and potassium dihydrogen phosphate uniformly in deionized water, heating and reacting, and after the reaction is completed, washing and drying to obtain the modified filler for hemoperfusion. The modified filler for hemoperfusion prepared by the present invention can improve the clearance rate of uric acid, and at the same time has little influence on other substance components in the blood, and has stronger specificity.

The present invention relates to the field of biochemical technology, and discloses a method for detecting the limit of aminoacetonitrile residue. The limit detection method includes the following steps: sample treatment, precisely measuring a control solution and a solution to be tested into a test tube, adding an acetonitrile solution of triethylamine and an acetonitrile solution of phenyl isothiocyanate, mixing well and reacting at 40 °C for 30 min; looking through from top to bottom, comparing the depth of the color of the solutions in the two tubes, so as to determine whether the aminoacetonitrile in the sample to be tested exceeds the limit; the method for detecting the limit of aminoacetonitrile residue of the present invention provides a limit detection method with simple operation, fast and convenient, high accuracy, good repeatability, can determine the limit of the aminoacetonitrile residue amount of the sample to be tested, has great application value in the quality control of drug research and development and production, the method provided by the present invention has high generality, the required instruments, derivatization reagents, etc. are all conventional configurations of most pharmaceutical enterprises and research institutions, and its operation is simple and the cost is low.

This invention provides a 2,3-disubstituted quinazolinone compound and its preparation method, relating to the field of organic synthesis technology. The preparation method of the 2,3-disubstituted quinazolinone compound provided by this invention does not use an oxidizing agent and includes the following steps: mixing an aniline compound, a phenyl isothiocyanate compound, an indigo compound, a base, and an organic solvent, and performing a coupling addition reaction to obtain the 2,3-disubstituted quinazolinone compound. This invention can obtain 2,3-disubstituted quinazolinone compounds through a one-step coupling addition reaction. The preparation method is simple, easy to control, economical, and uses inexpensive and readily available raw materials. This invention does not use an oxidizing agent during the preparation process and has the advantage of good functional group tolerance. Furthermore, the 2,3-disubstituted quinazolinone compound prepared by this invention has a purity of 98.5%–99.9%, and has significant market potential.

The invention provides an application of a near-infrared hypochlorous acid fluorescent dye in ultra-sensitive urine diagnosis of acute kidney injury. Phenyl isothiocyanate (PITC) and heptamethylamine-cyanine fluorophore of a piperazine unit are integrated to form a fluorescent dye capable of specifically responding to hypochlorous acid, urine of normal people and urine of patients with acute kidney injury can be distinguished, the fluorescent dye is used for diagnosis of acute kidney injury detection, and the fluorescent dye has the advantages of ultrafast response time, ultralow detection limit, long emission wavelength, high sensitivity and the like. And the background signal is low.

The invention provides a mandelonitrile and isothiocyanate compound insecticidal composition, a preparation and application of the mandelonitrile and isothiocyanate compound insecticidal composition and the preparation. The isothiocyanate is at least one selected from the group consisting of allyl isothiocyanate, ethyl isothiocyanate, n-propyl isothiocyanate, phenyl isothiocyanate, benzyl isothiocyanate, 1-phenyl ethyl isothiocyanate and 2-phenyl ethyl isothiocyanate; the mass ratio of the mandelonitrile to the isothiocyanate is (1-16): (100-1). The composition disclosed by the invention is used for preparing a fumigant for preventing and treating warehouse pests, root-knot nematodes in soil and pine wood nematodes on pine trees, has an obvious fumigating effect on pests such as grain pests, soil nematodes and pine wood nematodes, has an obvious synergistic effect and is relatively small in dosage.

The invention belongs to the technical field of synthesis of imine derivatives. The invention discloses a method for preparing a thiazolidine-2-imine derivative, which comprises the following steps: adding N-methylallylamine and phenyl isothiocyanate into an electrolytic tank, and introducing direct-current constant current to react to obtain the thiazolidine-2-imine derivative. The method provided by the invention has multiple advantages of mild conditions, simple system, greenness, environmental protection and the like. The reaction can be smoothly carried out at normal temperature, the current is used as an intangible oxidant, a strong oxidant or a metal catalyst does not need to be additionally added, the safety is high, the operation is convenient, and the cost and environmental burden can be reduced. The electrochemical process is accurately regulated and controlled in a constant current mode, side reaction can be effectively inhibited, high-selectivity cyclization conversion is carried out on isothiocyanate and allylamine, the obtained target product is stable in yield and high in purity, post-treatment can be completed only through conventional extraction and purification, and process amplification and batch preparation are facilitated.

The invention relates to the technical field of content detection, in particular to a method for determining the content of amino acid in periplaneta americana by adopting a quantitative analysis of multi-components by single marker, which comprises the following steps: firstly, preparing a test solution from periplaneta americana powder and a hydrochloric acid solution; dissolving nine amino acids in a hydrochloric acid solution to obtain a mixed reference substance solution; taking the test solution, the blank control solution and the mixed control solution, respectively adding an acetonitrile solution of triethylamine and an acetonitrile solution of phenyl isothiocyanate, carrying out vortex mixing uniformly, then carrying out water bath in a dark place, carrying out normal hexane extraction, taking a lower-layer solution, and carrying out high performance liquid chromatography analysis; and by taking alanine as an internal standard substance, calculating relative correction factors of alanine and other eight amino acids, thereby determining the contents of nine amino acids in periplaneta americana. The method is high in analysis efficiency, stable and reliable, can be used for multi-component analysis of other medicinal materials, and is suitable for different analysis requirements, so that the application prospect is wider.

The invention relates to the field of detection, and discloses a method for determining the content of collagen on a fabric. The determination method comprises the following steps: S1, hydrolyzing a to-be-determined sample, and adjusting the pH value to 4-8 to obtain a mixed solution; s2, mixing the mixed solution with a derivatization reagent to obtain a to-be-measured solution; the derivatization reagent contains phenyl isothiocyanate and triethylamine; s3, injecting the to-be-measured liquid into a high performance liquid chromatograph, carrying out gradient elution to measure hydroxyproline and peak area thereof, and calculating according to a standard curve equation to obtain the content of collagen in the to-be-measured sample, a chromatographic column adopted in the high performance liquid chromatography is a C18 reverse chromatographic column, a mobile phase A in an eluent adopted in the gradient elution is an acetonitrile-water solution, and a mobile phase B in the eluent adopted in the gradient elution is an acetonitrile-sodium acetate water solution. The determination method can effectively improve the detection accuracy of the collagen content on the fabric.

This application discloses a method for the simultaneous detection of florfenicol and florfenicolamine. After spiked with florfenicol-D3 and florfenicolamine-D3, the sample is derivatized using phenyl isothiocyanate. Quantitative analysis is then performed using an internal standard method combined with ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UHPLC-QTS-MS / MS). This method enables the simultaneous detection of florfenicol and florfenicolamine in negative ion mode, achieving detection limits of 0.5 μg / kg and quantitation limits of 1.0 μg / kg for both. The method offers rapid analysis and high sensitivity, providing a novel technical means for the detection of florfenicol and its metabolite florfenicolamine.