The invention relates to a novel chiral open-chain
pyridoxamine catalyst and a synthesis method and application thereof. The structural general formula of the
pyridoxamine catalyst is shown in the specification, wherein R1, R2, R3 and R4 are one of
hydrogen, C1-24
alkyl, C1-24
alkyl containing
substituent groups, substances shown in the specification and
halogen, the
substituent groups on C1-24
alkyl are a substance shown in the specification or a substance shown in the specification or a substance shown in the specification or O-Rw or S-Rw' or
halogen, and Rx, Rx', Ry, Ry', Ry'', Rz, Rz', Rw and Rw' are one of
hydrogen, methyl, ethyl, n-propyl,
isopropyl, n-butyl,
tertiary butyl, cyclopentyl, cyclohexyl, cycloheptyl, phenyl, benzyl, (1-phenyl)ethyl, 1-naphthyl, 2-naphthyl and
halogen. Compared with the prior art, the
pyridoxamine catalyst can achieve rapid and efficient synthesis of chiral
amino acid, the preparation raw materials are easy to obtain,
reaction conditions are mild, cost is low, and when the novel chiral open-chain pyridoxamine catalyst is used for a
transamination reaction, the conditions are mild, and the reaction is stable.