Method for synthesizing (R)-1-tert-butoxycarbonyl-3-aminopiperidine by adopting transaminase catalyst and enzymatic way

A technology of tert-butoxycarbonyl and aminopiperidine, applied in the field of enzyme catalysis, can solve the problems of inability to obtain high optical purity, cumbersome procedures, complicated operations, etc., and achieves the effects of high specificity, broad application prospects and strong catalytic activity.
CN110724675AActive Publication Date: 2020-01-24ENZYMASTER NINGBO BIO ENG CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ENZYMASTER NINGBO BIO ENG CO LTD
Publication Date
2020-01-24

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Abstract

The invention relates to the technical field of enzyme catalysis, and specifically relates to a transaminase catalyst; and the invention further relates to a method for synthesizing (R)-1-tert-butoxycarbonyl-3-aminopiperidine by adopting an enzymatic way, as well as a production method of the (R)-1-tert-butoxycarbonyl-3-aminopiperidine. The method for synthesizing the (R)-1-tert-butoxycarbonyl-3-aminopiperidine by adopting the enzymatic way comprises a step of, in the presence of pyridoxal phosphate and the transaminase catalyst, allowing reaction of N-tert-butoxycarbonyl-3-piperidinone as a reaction substrate with an amino donor so as to produce the (R)-1-tert-butoxycarbonyl-3-aminopiperidine. The method for synthesizing the (R)-1-tert-butoxycarbonyl-3-aminopiperidine by adopting the enzymatic way utilizes relatively few reagents, and is mild in reaction conditions, so that tedious steps needed for chemical process synthesis are greatly simplified; and moreover, a target product withan ee value up to 99.77% or above can be obtained without performance of separation. Therefore, the transaminase catalyst and the process method utilizing the transaminase catalyst to synthesize the (R)-1-tert-butoxycarbonyl-3-aminopiperidine provided by the invention have broad application prospects as well as great market values.
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Description

technical field

[0001] The present invention relates to the technical field of enzyme catalysis, in particular to a transaminase catalyst, a method for enzymatically synthesizing (R)-1-tert-butoxycarbonyl-3-aminopiperidine, and a (R)-1- A production method of tert-butoxycarbonyl-3-aminopiperidine. Background technique

[0002] (R)-1-tert-butoxycarbonyl-3-aminopiperidine (also known as R-1-BOC-3-aminopiperidine) is an important intermediate in medicine and organic synthesis, used in the production of spices, pesticides, etc. has certain applications.

[0003] The synthetic method of existing R-1-BOC-3-aminopiperidine is mainly chemical synthesis method, Shen Dadong et al. Ethyl ester is used as a raw material to obtain the final product R-1-BOC-3 aminopiperidine through steps such as ammonolysis and oxidation. Shuai Xiaohua et al. (Shanghai Haobo Chemical Technology Co., Ltd., a method for preparing (R)- or (S)-3-aminopiperidine dihydrochloride, CN201510589806.3[P], 2015-1...

Claims

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